Prazosin inhibits MK-801-induced hyperlocomotion and dopamine release in the nucleus accumbens

European Journal of Pharmacology

Volumn 309, Issue 1, 1996, Pages 1-11

  Mathé, Jan M ^a   Nomikos, George G ^a   Hildebrand, Bengt E ^a   Hertel, Peter ^a   Svensson, Torgny H ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

Author keywords

1 Adrenoceptor antagonist; Dizocilpine maleate; Locomotion; Microdialysis; NMDA receptor

Indexed keywords

3,4 DIHYDROXYPHENYLACETIC ACID; 5 HYDROXYINDOLEACETIC ACID; ALPHA 1 ADRENERGIC RECEPTOR BLOCKING AGENT; DIZOCILPINE; DOPAMINE; HOMOVANILLIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; PRAZOSIN;

ANIMAL EXPERIMENT; ARTICLE; BEHAVIOR; CONTROLLED STUDY; DOPAMINE METABOLISM; DOPAMINE RELEASE; DOSE TIME EFFECT RELATION; DRUG INHIBITION; HYPERACTIVITY; LOCOMOTION; MALE; MESOLIMBIC DOPAMINERGIC SYSTEM; MICRODIALYSIS; NONHUMAN; NUCLEUS ACCUMBENS; PRIORITY JOURNAL; PSYCHOSIS; RAT; STRESS; SUBCUTANEOUS DRUG ADMINISTRATION;

EID: 0030222087     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/0014-2999(96)00315-9     Document Type: Article

References (63)

1. Ålander, T., N.-E. Andén and M. Grabowska-Andén, 1980, Metoclopramide and sulpiride as selective blocking agents of pre-and postsynaptic dopamine receptors, Naunyn-Schmiedeberg's Arch. Pharmacol. 312, 145.
2. Andén, N.-E., B. Gomes, B. Persson and G. Trolin, 1978, R 28935 and prazosin: effects on central and peripheral alpha-adrenoceptor activity and on blood pressure, Naunyn-Schmiedeberg's Arch. Pharmacol. 302, 299.
3. Andersson, J.L., M. Marcus, G.G. Nomikos and T.H. Svensson, 1994, Prazosin modulates the changes in firing pattern and transmitter release induced by raclopride in the mesolimbic, but not in the nigrostriatal dopaminergic system, Naunyn-Schmiedeberg's Arch. Pharmacol. 349, 236.
4. Bean, A.J. and R.H. Roth, 1991, extracellular dopamine and neurotensin in rat prefrontal cortex in vivo: effects of median forebrain bundle stimulation frequency, stimulation pattern and dopamine autoreceptors, J. Neurosci. 11, 2694.
5. Bubser, M., U. Keseberg, P.K. Notz and W.J. Schmidt, 1992, Differential behavioral and neurochemical effects of competitive and non-competitive NMDA receptor antagonists in rats, Eur. J. Pharmacol. 229, 75.
6. Carlsson, M. and A. Carlsson, 1989, The NMDA antagonist MK-801 causes marked locomotor stimulation in monoamine depleted mice, J. Neural Transm. 75, 221.
7. Chergui, K., P.J. Charléty, H. Akaoka, C.F. Saunier, J.-L. Brunet, M. Buda, T.H. Svensson and G. Chouvet, 1993, Tonic activation of NMDA receptors causes spontaneous burst discharge of rat midbrain dopamine neurons in vivo, Eur. J. Neurosci. 5, 137.
8. Chergui, K., G.G. Nomikos, J.M. Mathé, F. Gonon and T.H. Svensson, 1996, Burst stimulation of the median forebrain bundle selectively increases Fos-like immunoreactivity in the limbic forebrain of the rat, Neuroscience 72, 141.
9. Clark, C.R., G.M. Geffen and L.B. Geffen, 1987, Catecholamines and attention. I: animal and clinical studies, Neurosci. Biobehav. Rev. 11, 341.
10. Clineschmidt, B.V., G.E. Martin, P.R. Bunting and N.L. Papp, 1982, Central sympathomimetic activity of (+ )-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine (MK-801), a substance with potent anticonvulsant, central sympathomimetic, and apparent anxiolytic properties, Drug. Dev. Res. 2, 135.
11. Cohen, B.M. and J.F. Lipinski, 1986, In vivo potencies of antipsychotic drugs in blocking alpha 1 and dopamine D2 receptors: implications for drug mechanism of action, Life Sci. 39, 2571.
12. Contreras, P.C., J.B. Monahan, T.H. Lanthorn, L.M. Pullan, D.A. DiMaggio, G.E. Handelmann, N.M. Gray and T.L. O'Donohue, 1987, Phencyclidine: physiological actions, interactions with excitatory amino acids and endogenous ligands, Mol. Neurobiol. 1, 191.
13. Criswell, H.E., K.B. Johnson, R.A. Mueller and G.R. Breese, 1993, Evidence for involvement of brain dopamine and other mechanisms in the behavioral action of the N-methyl-D-aspartic acid antagonist MK-801 in control and 6-hydroxydopamine-lesioned rats, J. Pharmacol. Exp. Ther. 265, 1001.
14. 1-adrenergic receptor antagonists for the treatment of hypertension: role of vascular alpha receptors in the control of peripheral resistance, Am. Heart J. 116, 133.
15. Dai, H., K. Gebhardt and R.J. Carey, 1995, Time course effects of MK-801: the relationship between brain neurochemistry and behavior, Brain Res. Bull. 36, 175.
16. Deutch, A.Y., W.A. Clark and R.H. Roth, 1990, Prefrontal cortical dopamine depletion enhances the responsiveness of mesolimbic dopamine neurons to stress, Brain Res. 521, 311.
17. Dunnett, S.B. and T.W. Robbins, 1992, The functional role of mesotelencephalic dopamine systems, Biol. Rev. 67, 491.
18. Ericson, E., J. Samuelsson and S. Ahlénius, 1991, Photocell measurements of rat locomotor activity, J. Pharmacol. Meth. 25, 111.
19. Fessler, R.G., R.D. Sturgeon and H.Y. Meltzer, 1980, Effects of phencyclidine and methylphenidate on d-amphetamine-induced behaviors in reserpine pretreated rats, Pharmacol. Biochem. Behav. 13, 835.
20. French, E.D., A. Mura and T. Wang, 1993, MK-801, phencyclidine (PCP) and PCP-like drugs increase burst firing in rat A10 dopamine neurons: comparison to competitive NMDA antagonists, Synapse 13, 108.
21. Gonon, F.G., 1988, Nonlinear relationship between inpulse flow and dopamine released by rat midbrain dopaminergic neurons as studied by in vivo electrochemistry, Neuroscience 24, 19.
22. Grenhoff, J. and T.H. Svensson, 1993, Prazosin modulates the firing pattern of dopamine neurons in rat ventral tegmental area, Eur. J. Pharmacol. 233, 79.
23. Grenhoff, J., M. Nisell, S. Ferré, G. Aston-Jones and T.H. Svensson, 1993, Noradrenergic modulation of midbrain dopamine cell firing elicited by stimulation of the locus coeruleus in the rat, J. Neural Transm. 93, 11.
24. 1-adrenergic effects on dopamine neurons recorded intracellularly in the rat midbrain slice, Eur. J. Neurosci. 7, 1707.
25. Hertel, P., J.M. Mathé, G.G. Nomikos, M. Iurlo, A.A. Mathé and T.H. Svensson, 1996, Effects of d-amphetamine and phencyclidine on behavior and extracellular concentrations of neurotensin and dopamine in the ventral striaum and the medial prefrontal cortex of the rat, Behav. Brain Res. 72, 103.
26. 1-noradrenergic receptor antagonist, has no effect on symptoms but increases autonomic arousal in schizophrenic patients, Psychiatry Res. 11, 193.
27. Hucker, H.B., J.E. Hutt, S.D. White, B.H. Arison and A.G. Zacchei, 1983, Disposition and metabolism of (+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine in rats, dogs, and monkeys, Drug Metab. Disp. 11, 54.
28. Jaskiw, G.E., F. Karoum, W.J. Freed, I. Phillips, J.E. Kleinman and D.R. Weinberger, 1990, Effect of ibotenic acid lesions of the medial prefrontal cortex on amphetamine-induced locomotion and regional brain catecholamine concentrations in the rat, Brain Res. 534, 263.
29. Javitt, D.C. and S.R. Zukin, 1991, Recent advances in the phencyclidine model of schizophrenia, Am. J. Psychiatry 148, 1301.
30. 125I]HEAT, J. Comp. Neurol. 231, 190.
31. Kalivas, P.W., P. Duffy and J. Barrow, 1989, Regulation of the mesocorticolimbic dopamine systems by glutamic acid receptor subtypes, J. Pharmacol. Exp. Ther. 251, 378.
32. Kashihara, K., T. Hamamura, K. Okumura and S. Otsuki, 1990, Effect of MK-801 on endogenous dopamine release in vivo, Brain Res. 528, 80.
33. Kashiwa, A., T. Nishikawa, K. Nishikawa, K. Nishijima, A. Umino and K. Takahashi, 1995, Dizocilpine (MK-801) elicits a tetrodotoxin-sensitive increase in extracellular release of dopamine in rat medial prefrontal cortex, Neurochem. Int. 26, 269.
34. Kornhuber, J., M. Weller, 1995, Predicting psychotomimetic properties of PCP-like NMDA receptor antagonists, in: Schizophrenia, Alfred Benzon Symposium, eds. R. Fog, J. Gerlach and R. Hemmingsen (Munksgaard, Copenhagen) Vol. 38, p. 314.
35. Löscher, W., R. Annies and D. Hönack, 1993, Comparison of competitive and uncompetitive NMDA receptor antagonists with regard to monoaminergic neuronal activity and behavioral effects in rats, Eur. J. Pharmacol. 242, 263.
36. Maas, J.W., S.A. Contreras, A.L. Miller, N. Berman, C.L. Bowden, M.A. Javors, E. Seleshi and S. Weintraub, 1993, Studies of catecholamine meatbolism in schizophrenia/psychosis-I, Neuropsychopharmacology 8, 97.
37. Martin, P., A. Svensson, A. Carlsson and M.L. Carlsson, 1994, On the roles of dopamine D-1 vs. D-2 receptors for the hyperactivity response elicited by MK-801, J. Neural Transm. (Gen. Sect.) 95, 113.
38. Mereu, G., V. Lilliu, P. Vargui, A.L. Muntoni, M. Diana and G.L. Gessa, 1995, Depolarization inactiviation of dopamine neurons: an artefact?, J. Neurosci. 15, 1144.
39. Moghaddam, B., 1994, Recent findings in support of the excitatory amino acid hypothesis of schizophrenia, Prog. Neuro-Psychopharmacol. Biol. Psychiat. 18, 859.
40. Murase, S., J.M. Mathé, J. Grenhoff and T.H. Svensson, 1993, Effects of dizocilpine (MK-801) on rat midbrain dopamine cell activity: differential actions related to anatomical localization, J. Neural Transm. (Gen. Sect.) 91, 13.
41. Narayanan, S., A. Dalia, L.J. Wallace and N.J. Urtesky, 1994, The stimulation of locomotion by MK-801 is mediated by the activation of meso-limbic dopaminergic neurons, Soc. Neurosci. (Abstr.) 663.20.
42. Nomikos, G.G., G. Damsma, D. Wenkstern and H.C. Fibiger, 1989, Acute effects of buproprion on extracellular dopamine concentrations in rat striatum and nucleus accumbens studied by in vivo microdialysis, Neuropsychopharmacology 2, 273.
43. Nomikos, G.G., M. Iurlo, J.L. Andersson, K. Kimura and T.H. Svensson, 1994, Systemic administration of amperozide, a new atypical antipsy-chotic drug, preferentially increases dopamine release in the rat medial prefrontal cortex, Psychopharmacology 115, 147.
44. Ögren, S.O. and M. Goldstein, 1994, Phencyclidine-and dizocilpine-induced hyperlocomotion are differentially mediated, Neuropsychopharmacology 11, 167.
45. Ouagazzal, A., A. Nieoullon and M. Amalric, 1994, Locomotor activation induced by MK-801 in the rat: postsynaptic interactions with dopamine receptors in the ventral striatum, Eur. J. Pharmacol. 251, 229.
46. Pawlowski, L., J.M. Mathé and T.H. Svensson, 1990, Phencyclidine activates rat A10 dopamine neurons but reduces burst activity and causes regularization, Acta Physiol. Scand. 139, 529.
47. Paxinos, G. and C. Watson, 1986, The Rat Brain in Stereotaxic Coordinates, 2nd edn. (Academic Press, London).
48. Peroutka, S.J. and S.H. Snyder, 1980, Relationship of neuroleptic drug effects at brain dopamine, serotonin, α-adrenergic, and histamine receptors to clinical potency, Am. J. Psychiatry 137, 1518.
49. Raffa, R.B., M.E. Ortegön, D.M. Robisch and G.E. Martin, 1989, In vivo demonstration of the enhancement of MK-801 by L-glutamate, Life Sci. 44, 1593.
50. Rao, T.S., H.S. Kim, J. Lehmann, L.L. Martin and P.L. Wood, 1990, Interactions of phencyclidine receptor agonist MK-801 with dopaminergic system: regional studies in the rat, J. Neurochem. 54, 1157.
51. Sharp, T., T. Zetterström, T. Ljungberg and U. Ungerstedt, 1987, A direct comparison of amphetamine induced behaviours and regional brain dopamine release in the rat using intracerebral dialysis. Brain Res. 410, 322.
52. Sommermeyer, H., J. Frielingsdorf and A. Knorr, 1995, Effects of prazosin on the dopaminergic neurotransmission in rat brain, Eur. J. Pharmacol. 276, 267.
53. Svensson, A., M.L. Carlsson and A. Carlsson, 1995a, Crucial role of the accumbens nucleus in the neurotransmitter interactions regulating motor control in mice, J. Neural Transm. (Gen. Sect.) 101, 127.
54. 1-adrenoreceptor antagonism, J. Clin. Psychopharmacol. 15 (Suppl. 1), 11S.
55. Van Kammen, D.P. and M. Kelley, 1991, Dopamine and norepinephrine activity in schizophrenia, Schizophrenia Res. 4, 173.
56. Van Kammen, D.P., H. Ågren, J.K. Yao, D.T. O'Connor, J. Gurklis and J.L. Peters, 1994, Noradrenergic activity and prediction of psychotic relapse following haloperidol withdrawal in schizophrenia, Am. J. Psychiatry 151, 379.
57. 1 receptors, Brain Res. 622, 325.
58. Weihmuller, F.B., S.J. O'Dell, B.N. Cole and J.F. Marshall, 1991, MK-801 attenuates the dopamine-releasing but not the behavioral effects of methamphetamine: an in vivo microdialysis study, Brain Res. 549, 230.
59. Willins, D.L., S. Nayaranan, L.J. Wallace and N.J. Uretsky, 1993, The role of dopamine and AMPA/kainate receptors in the nucleus accumbens in the hypermotility response to MK-801, Pharmacol. Biochem. Behav. 46, 881.
60. Wolf, M.E., F.J. White and X.-T. Hu, 1993, Behavioral sensitization to MK-801 (dizocilpine): neurochemical and electrophysiological correlates in the mesoaccumbens dopamine system, Behav. Pharmacol. 4, 429.
61. Wong, E.H.F., J.A. Kemp, T. Priestley, A.R. Knight, G.N. Woodruff and L.L. Iversen,1986, The anticonvulsant MK-801 is a potent N-methyl-D-aspartate antagonist, Proc. Natl. Acad. Sci. USA 83, 7104.
62. Zhang, J., L.A. Chiodo and A.S. Freeman, 1992, Electrophysiological effects of MK-801 on rat nigrostriatal and mesoaccumbal dopaminergic neurons. Brain Res. 590, 153.
63. Zhang, J., L.A. Chiodo and A.S. Freeman, 1993, Effects of phencyclidine, MK-801 and 1,3-di-(2-toly1)guanidine on non-dopaminergic midbrain neurons, Eur. J. Pharmacol. 230, 371.