Impact of sar and agr on methicillin resistance in Staphylococcus aureus

FEMS Microbiology Letters

Volumn 141, Issue 2-3, 1996, Pages 255-260

  Durán, S Píriz ^a   Kayser, F H ^b   Berger Bachi B ^b  

^a UNIVERSITY OF EXTREMADURA   (Spain)

^b UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

Global regulator; mecA; PBP1; PBP3; Penicillin binding protein; Staphylococcus aureus

Indexed keywords

CEFOXITIN; CELL MEMBRANE PROTEIN; IMIPENEM; METICILLIN; OXACILLIN; PENICILLIN BINDING PROTEIN; PROTEIN;

ARTICLE; COLONY FORMING UNIT; IMMUNOBLOTTING; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PENICILLIN RESISTANCE; PRIORITY JOURNAL; STAPHYLOCOCCUS AUREUS;

METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS AUREUS;

EID: 0030221872     PISSN: 03781097     EISSN: None     Source Type: Journal    
DOI: 10.1016/0378-1097(96)00231-5     Document Type: Article

References (17)

1. [1] Berger-Bächi, B. (1995) Factors affecting methicillin resistance in Staphylococcus aureus. Int. J. Antimicrob. Agents 6, 13-21.
2. [2] Novick, R.P., Ross, H.F., Projan, S.J., Kornblum, J., Kreiswirth, B. and Moghazeh, S. (1993) Synthesis of staphylococcal virulence factors is controlled by a regulatory RNA molecule. EMBO J. 12, 3967-3975.
3. [3] Cheung, A.L., Koomey, J.M., Butler, C.A., Projan, S.J. and Fischetti, V.A. (1992) Regulation of exoprotein expression in Staphylococcus aureus by a locus (sar) distinct from agr. Proc. Natl. Acad. Sci. USA 89, 6462-6466.
4. [4] Smeltzer, M.S., Hart, M.E. and Iandolo, J.J. (1993) Phenotypic characterization of xpr, a global regulator of extracellular virulence factors in Staphylococcus aureus. Infect. Immun. 61, 919-925.
5. [5] Cheung, A.L. and Projan, S.J. (1994) Cloning and sequencing of sarA of Staphylococcus aureus, a gene required for the expression of agr. J. Bacteriol. 176, 4168-4172.
6. [6] Heinrichs, J.H., Bayer, M.G. and Cheung, A.L. (1996) Characterization of the sar locus and its interaction with agr in Staphylococcus aureus. J. Bacteriol. 178, 418-423.
7. [7] Cheung, A.L., Eberhardt, K.J., Chung, E., Jeaman M.R., Sullam, P.M., Ramos, M. and Bayer, A.S. (1994) Diminished virulence of a sar(-)/agr(-) mutant of Staphylococcus aureus in the rabbit model of endocarditis. J. Clin. Invest. 94, 1815-1822.
8. [8] Berger-Bächi, B. and Kohler, M.L. (1983) A novel site on the chromosome of Staphylococcus aureus influencing the level of methicillin resistance: genetic mapping. FEMS Microbiol. Lett. 20, 305-309.
9. [9] Baker, C.N., Stocker, S.A., Culver, D.H. and Thornsberry, C. (1991) Comparison of the E-test to agar dilution, broth microdilution, and agar diffusion susceptibility testing techniques by using a special challenge set of bacteria. J. Clin. Microbiol. 29, 533-538.
10. [10] Berger-Bächi, B., Strässle, A. and Kayser, F.H. (1986) Characterization of an isogenic set of methicillin-resistant and susceptible mutants of Staphylococcus aureus. Eur. J. Clin. Microbiol. 5, 697-701.
11. [11] Ryffel, C., Strässle, A., Kayser, F.H. and Berger-Bächi, B. (1994) Mechanisms of heteroresistance in methicillin-resistant Staphylococcus aureus. Antimicrob. Agents Chemother. 38, 724-728.
12. [12] Henze, U.U. and Berger-Bächi, B. (1995) Staphylococcus aureus penicillin-binding protein 4 and intrinsic beta-lactam resistance. Antimicrob. Agents Chemother. 39, 2415-2422.
13. [13] Chambers, H.F., Sachdeva, M.J. and Hackbarth, C.J. (1994) Kinetics of penicillin binding to penicillin-binding proteins of Staphylococcus aureus. Biochem. J. 301, 139-144.
14. [14] Hackbarth, C.J., Kocagoz, T., Kocagoz, S. and Chambers, H.F. (1995) Point mutations in Staphylococcus aureus PBP 2 gene affect penicillin-binding kinetics and are associated with resistance. Antimicrob. Agents Chemother. 39, 103-106.
15. [15] Tomasz, A., Drugeon, H.B., de Lencastre, H.M., Jabes, D. and McDougall, L. (1989) New mechanism for methicillin resistance in Staphylococcus aureus: clinical isolates that lack the PBP 2a gene and contain normal penicillin-binding proteins with modified penicillin-binding capacity. Antimicrob. Agents Chemother. 33, 1869-1874.
16. [16] Berger-Bächi, B. (1983) Insertional inactivation of staphylococcal methicillin resistance by Tn551. J. Bacteriol. 154, 479-487.
17. [17] Ryffel, C., Kayser, F.H. and Berger-Bächi, B. (1992) Correlation between regulation of mecA transcription and expression of methicillin resistance in staphylococci. Antimicrob. Agents Chemother. 36, 25-31.