Pre-thymic transcription of TCR genes by adult murine bone marrow cells

Molecular Immunology

Volumn 33, Issue 11-12, 1996, Pages 957-964

  Wang, Tong Gang ^a   Lybarger, Lonnie ^a   Soloff, Rachel ^a   Dempsey, Deborah ^b   Chervenak, Robert ^a  

^a LOUISIANA STATE UNIV MEDICAL CENTER   (United States)

^b Biomed Res Inst of Northwest L   (United States)

Author keywords

Precursor T cells; Recombinase activating genes; T cell antigen receptor genes

Indexed keywords

RECOMBINASE; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ARTICLE; BONE MARROW; FLOW CYTOMETRY; GENE REARRANGEMENT; LYMPHOCYTE MIGRATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE; T LYMPHOCYTE RECEPTOR GENE; THYMUS;

ANIMALS; BONE MARROW; BONE MARROW CELLS; CELL DIFFERENTIATION; CELL LINE; GENES, RAG-1; MALE; MICE; MICE, INBRED STRAINS; MICE, MUTANT STRAINS; RECEPTORS, ANTIGEN, T-CELL; THYMUS GLAND; TRANSCRIPTION, GENETIC;

MURINAE;

EID: 0030221685     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0161-5890(96)00048-X     Document Type: Article

References (33)

1. Allison J. P. (1993) γδ T-cell development. Curr. Opin. Immun. 5, 241-246.
2. Alt F. W., Blackwell T. K., DePinho R. A., Reth M. G. and Yancopoulos G. D. (1986) Regulation of genome rearrangement events during lymphocyte differentiation. Immunol. Rev 89, 5-30.
3. Chervenak R., Dempsey D., Soloff R. S. and Smithson G. (1992) In vitro growth of bone marrow-resident T cell precursors supported by mast cell growth factor and IL-3. J. Immun. 149, 2851-2856.
4. Chervenak R., Dempsey D., Soloff R. S., Wolcott R. M. and Jennings S. R. (1993) The expression of CD4 by T cell precursors resident in both the thymus and the bone marrow. J. Immun. 151, 4486-4493.
5. Chirgwin J. M., Przybyla A. E., MacDonald R. J. and Rutter W. J. (1979) Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry 18, 5294-5299.
6. Chomczynski P. and Sacchi N. (1987) Single-step method of RNA isolation by acid guanidium thiocyanate-phenolchloroform extraction. Analyt. Biochem. 162, 156-159.
7. Chun J. J., Schatz D. G., Oettinger M. A., Jaenisch R. and Baltimore D. (1991) The recombination activating gene-1 transcript is present in the murine central nervous system. Cell 64, 189-200.
8. de Villartay J. P., Mossalayi D., de Chasseval R., Dalloul A. and Debre P. (1991) The differentiation of human pro-thymocytes along the TCR-αβ pathway in vitro is accompanied by the site-specific deletion of the TCR-δ locus. Int. Immun. 3, 1301-1305.
9. Farrar J. J., Fuller-Farrar J., Simon P., Hilliker M., Stadler B. M. and Farrar W. L. (1980) Thymoma production of T cell growth factor. J. Immun. 125, 2555-2558.
10. Godfrey D. I. and Zlotnik A. (1993) Control points in early T cell development. Immun. Today 14, 547-553.
11. Goldman J. P., Spencer D. M. and Raulet D. H. (1993) Ordered rearrangement of variable region genes of the T cell receptor γ locus correlates with transcription of the unrearranged genes. J. Exp. Med. 177, 729-739.
12. Haas W. and Tonegawa S. (1992) Development and selection of γδ T cells. Curr. Opin. Immun. 4, 147-155.
13. Heilig J. S. and Tonegawa S. (1986) Diversity of murine gamma genes and expression in fetal and adult T lymphocytes. Nature 322, 836-840.
14. Itohara S., Nakanishi N., Kanagawa O., Kubo R, and Tonegawa S. (1989) Monoclonal antibodies specific to native murine T-cell receptor γδ: Analysis of γδ T-cells in thymic ontogeny and peripheral lymphoid organs. Proc. Natn. Acad. Sci. U.S.A. 86, 5094-5098.
15. Itohara S., Mombaerts P., Lafaille J., Rastan S., Gardiner E. M., Chae S., Clarke A. R., Hooper M. L., Farr A. and Tonegawa S. (1993) T cell receptor δ gene mutant mice: Independent generation of αβ T cells and programmed rearrangements of γδ TCR genes. Cell 72, 337-348.
16. Lennon G. G. and Perry R. P. (1990) The temporal order of appearance of transcripts from unrearranged and rearranged Ig genes in murine fetal liver. J. Immun. 144, 1983-1987.
17. Lutzker S., Rothman P., Pollack R., Coffman R. and Alt F. W. (1988) Mitogen-and IL-4-regulated expression of germline Igγ2b transcripts: Evidence for directed heavy chain class switching. Cell 53, 177-184.
18. Mombaerts P., Iacomini J., Johnson R. S., Herrup K., Tonegawa S. and Papaioannou V. E. (1992) RAG-1-deficient mice have no mature B and T lymphocytes. Cell 68, 869-877.
19. Nandi D. and Allison J. P. (1991) Phenotypic analysis and γδ-T cell receptor repertoire of murine T cells associated with the vaginal epithelium. J. Immun. 147, 1773-1778.
20. Pardoll D. M., Fowlkes B. J., Lechler R. I., Germain R. N. and Schwartz R. H. (1987) Early genetic events in T cell development analyzed by in situ hybridization. J. Exp. Med. 165, 1624-1638.
21. Pearse M., Wu L., Egerton M., Wilson A., Shortman K. and Scollay R. (1989) A murine early thymocyte developmental sequence is marked by transient expression of the interleukin 2 receptor. Proc. Natn. Acad. Sci. U.S.A. 86, 1614-1618.
22. Philpott K. L., Viney J. L., Kay G., Rastan S., Gardiner E. M., Chan S., Hayday A. C. and Owen M. J. (1992) Lymphoid development in mice congenitally lacking T cell receptor αβ expressing cells. Science 256, 1448-1452.
23. Pretell J., Greenfield R. S. and Tevethia S. S. (1979) Biology of simian virus 40 (SV40) transplantation antigen (TrAg). V. In vitro demonstration of SV40 TrAg in SV40 infected non-permissive mouse cells by the lymphocyte mediated cytotoxicity assay. Virology 97, 32-41.
24. Soloff R. S., Wang T. G., Lybarger L., Dempsey D. and Chervenak R. (1995) Transcription of the TCRβ locus initiates in adult murine bone marrow. J. Immun. 154, 3888-3901.
25. Spangrude G. J. and Weissman I. L. (1988) Mature T cells generated from single thymic clones are phenotypically and functionally heterogenous. J. Immun. 141, 1877-1890.
26. lo bone marrow cells repopulate the thymus. J. Exp. Med. 167, 1671-1683.
27. Spangrude G. J., Heimfeld S. and Weissman I. L. (1988b) Purification and characterization of mouse hematopoietic stem cells. Science 241, 58-62.
28. Spangrude G. J., Aihara Y., Weissman I. L. and Klein J. (1988c) The stem cell antigens SCA-I and SCA-2 subdivide thymic and peripheral T lymphocytes into unique subsets. J. Immun. 141, 3697-3707.
29. Spangrude G. J., Klein J., Heimfeld S., Aihara Y. and Weissman I. L. (1989) Two monoclonal antibodies identify thymic-repopulating cells in mouse bone marrow. J. Immun. 142, 425-430.
30. Stavnezer J., Radcliffe G., Lin Y. C., Nietupski J., Bergren L., Sitia R. and Severinson E. (1988) Immunoglobulin heavy-chain switching may be directed by prior induction of transcripts from constant-region genes. Proc. Natn. Acad. Sci. U.S.A. 85, 7704-7708.
31. Wu L., Antica M., Johnson G. R., Scollay R. and Shortman K. (1991a) Developmental potential of the earliest precursor cells from the adult mouse thymus. J. Exp. Med. 174, 1617-1627.
32. Wu L., Scollay R., Egerton M., Pearse M., Spangrude G. J. and Shortman K. (1991b) CD4 expressed on earliest T-lineage precursor cells in the adult murine thymus. Nature 349, 71-74.
33. H gene segments. Cell 40, 271-281.