The synthesis and high-resolution NMR spectroscopy of ethyl N-(2-triphenylmethylthio)ethanoyl-O-{4′-[4″-(1″-bis(2‴- chloroethyl)amino)phenyl]butanoyl}-L-seryl-S-benzyl-L-cysteine: A chelate-chlorambucil complex for use as a ligand for 99mTc radio-imaging

Canadian Journal of Chemistry

Volumn 74, Issue 8, 1996, Pages 1502-1511

  Bell, Russell A ^a   Hughes, Donald W ^a   Lock, Colin J L ^a   Valliant, John F ^a  

^a MCMASTER UNIVERSITY   (Canada)

Author keywords

Ethyl N triphenylmethylthioethanoyl O 4 4 (1 bis(2 chloroethyl)amino)phenyl butanoyl L seryl S benzyl L cysteine; NMR spectroscopy; Radio imaging agent; Synthesis

Indexed keywords

AGENTS; CHELATION; CHEMICAL BONDS; DIAGNOSTIC RADIOGRAPHY; NUCLEAR MAGNETIC RESONANCE; POLYPEPTIDES; SYNTHESIS (CHEMICAL); TECHNETIUM COMPOUNDS;

CHLORAMBUCIL; COVALENT BONDING; PEPTIDE COUPLING TECHNIQUES; RADIO IMAGING AGENTS;

AROMATIC COMPOUNDS;

CHLORMETHINE DERIVATIVE; CONTRAST MEDIUM; TECHNETIUM 99M;

ARTICLE; DRUG STRUCTURE; DRUG SYNTHESIS; NUCLEAR MAGNETIC RESONANCE;

EID: 0030221670     PISSN: 00084042     EISSN: None     Source Type: Journal    
DOI: 10.1139/v96-167     Document Type: Article

References (21)

1. E. Deutsch, M. Nicolini, and H.N. Wagner. Technetium in chemistry and nuclear medicine. Raven Press, New York. 1983.
2. F. Tisato, F. Refosco, and G. Bandolini. Coord. Chem. Rev. 135/136, 325 (1994).
3. S. Lever, K. Baidoo, and A. Mahmood. Inorg. Chim. Acta, 176, 183 (1990).
4. M. Nicolini, G. Bandoli, and U. Mazzi. Technetium in chemistry and nuclear medicine-3. Raven Press, New York. 1990.
5. J.L. Everett, J.J. Roberts, and W.C.J. Ross. J. Chem. Soc. 2386 (1953).
6. L.M. van Putten and P. Lelieveld. Eur. J. Cancer, 7, 11 (1971).
7. L. Stryer. Biochemistry. W.H. Freeman and Co., San Francisco. 1975. p. 17.
8. G. Mehta, T. Sambaiah, B.G. Maiya, M. Sirish, and A. Dattagupta. Tetrahedron Lett. 35, 4201 (1994).
9. D. Brenner, A. Davison, J. Lister-James, and A.G. Jones. Inorg. Chem. 23, 3793 (1984).
10. P.B. Barker and R. Freeman. J. Magn. Reson. 64, 334 (1985).
11. I.M. Bereton, S. Crozier, J. Field, and D.M. Dodrell. J. Magn. Reson. 93, 54 (1991).
12. M. von Kienlin, C.T.W. Moonen, A. van der Toorn, and P.C.M. van Zijl. J. Magn. Reson. 93, 423 (1991).
13. T.A. Carpenter, L.D. Colebrook, L.D. Hall, and G.K. Pierens. Magn. Reson. Chem. 30, 768 (1992).
14. A.L. Davies, J. Keeler, E.D. Laue, and D. Moskau. J. Magn. Reson. 98, 207 (1992).
15. J.R. Tolman, J. Chung, and J.H. Prestegard. J. Magn. Reson. 98, 462 (1992).
16. J. Boyd, N. Soffe, B. John, D. Plant, and R.E. Hurd. J. Magn. Reson. 98, 660 (1992).
17. R.E. Hurd and B.K. John. J. Magn. Reson. 91, 648 (1991).
18. L. Lerner and A. Bax. J. Magn. Reson. 69, 375 (1986).
19. J. Jeener, B.H. Meier, P. Bachmann, and R.R. Ernst. J. Chem. Phys. 71, 546 (1979).
20. D. Marion and K. Wuthrich. Biochem. Biophys. Res. Commun. 113, 967 (1983).
21. G. Bodenhausen, H. Kogler, and R.R. Ernst. J. Magn. Reson. 58, 370 (1984).