CMV infection of transplant recipients

Journal of Hepatology

Volumn 25, Issue 2, 1996, Pages 259-269

  Mutimer, David ^a  

^a QUEEN ELIZABETH HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACICLOVIR; ANTIVIRUS AGENT; CYTOMEGALOVIRUS ANTIBODY; GANCICLOVIR;

CYTOMEGALOVIRUS INFECTION; DISEASE ASSOCIATION; HUMAN; INCIDENCE; LIVER TRANSPLANTATION; MYCOSIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; REVIEW; SEPSIS;

EID: 0030221257     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-8278(96)80083-3     Document Type: Article

References (77)

1. Tanaka S, Toh Y, Minagawa H, Mori R, Sigimachi K, Minamishima Y. Reactivation of Cytomegalovirus in patients with cirrhosis: analysis of 122 cases. Hepatology. 16:1992;1409-1414.
2. Docke WD, Prosch S, Fietze E, Kimel V, Zuckerman H, Klug C, Syrbe U, Kruger DH, von Baehr R, Volk HD. Cytomegalovirus reactivation and tumour necrosis factor. Lancet. 343:1994;268-269.
3. Grundy JE, Lui SF, Super M., Berry NJ, Sweny P, Fernando ON, Moorhead J, Griffiths PD. Symptomatic Cytomegalovirus infection in seropositive kidney recipients: reinfection with donor virus rather than reactivation of recipient virus. Lancet. ii:1988;132-135.
4. Chou S. Acquisition of donor strains of Cytomegalovirus by renal-transplant recipients. NEJM. 314:1986;1418-1423.
5. Breinig MK, Zitelli B, Starzl TE, Ho M., Epstein-Barr virus. Cytomegalovirus, and other viral infections in children after liver transplantation. J Infect Dis. 156:1987;273-279.
6. Gorensek MJ, Carey WD, Vogt D, Goormastic M. A multivariate analysis of risk factors for Cytomegalovirus infection in liver transplant recipients. Gasroenterology. 98:1990;1326-1332.
7. Paya CV, Wiesner RH, Hermans PE, Larson-Keller JJ, Ilstrup DM, Krom RAF, Rettke S, Smith TF. Risk factors for cytomegalovirus and severe bacterial infections following liver transplantation: a prospective multivariate time-dependent analysis. J Hepatol. 18:1993;185-195.
8. Pillay D, Charman H, Burroghs AK, Smith M, Rolles K, Griffiths PD. Surveillance for CMV infection in orthotopic liver transplant recipeents. Transplantation. 53:1992;1261-1265.
9. Savage LH, Gonwa TA, Goldstein RM, Husberg BS, Klintmalm GB. Cytomegalovirus infection in orthotopic liver transplantation. Transplant Int. 2:1989;96-101.
10. Snydman DR, Werner BG, Dougherty NN, Griffith J, Rubin RH, Dienstag JL, Rohrer RH, Freeman R, Jenkins R, Lewis D, Hammer S, O'Rourke E, Grady GF, Fawaz K, Kaplan MM, Hoffman MA, Katz AT, Doran M. Cytomegalovirus immune globulin prophylaxisin liver transplantation. Ann Intern Med. 119:1993;984-991.
11. Stratta RJ, Shaefer MS, Markin RS, Wood RP, Kennedy EM, Langnas AN, Reed EC, Wood GL, Donovan JP, Pillen TJ, Duckworth RM, Shaw BW Jr. Clinical Patterns of Cytomegalovirus disease after liver transplantation. Arch Surg. 124:1989;1443-1450.
12. Wiens M, Lefebre B, Blumhardt G, Schmidt CA, Lohmann R, Neuhaus P. Incidence and Therapy of Cytomegalovirus disease after liver transplantation. Transplant Proc. 25:1993;1985-1986.
13. Singh N, Dummer JS, Kusne S, Breinig MK, Armstrong JA, Makowka L, Starzl TE, Ho M. Infections with cytomegalovirus and other Herpes viruses in 121 liver transplant recipients: transmission by donated organ and the effect of OKT3 antibodies. J Infect Dis. 159:1988;124-131.
14. Pillay D, Griffiths PD. Diagnosis of Cytomegalovirus infection: a review. Genitourinary Med. 68:1992;183-188.
15. Miller MJ, Bovey S, Pado K, Bruckner DA, Wagar EA. Application of PCR to multiple specimen types for diagnosis of Cytomegalovirus infection: comparison with cell culture and shell vial assay. J Clin Microbiol. 32:1994;5-10.
16. Marsano L, Perrillo RP, Flye MW, Hanto DW, Spitzer ED, Thomas JR, Murray PR, Windus DW, Brunt EM, Storch GA. Comparison of culture and serology for the diagnosis of Cytomegalovirus infection in kidney and liver transplant recipients. J Infects Dis. 161:1990;454-461.
17. Pillay D, Ali AA, Liu SF, Kops E, Sweney P, Griffiths PD. The prognostic significance of positive CMV cultures during surveillance renal transplant recipients. Transplantation. 56:1993;103-108.
18. Martin M, Manez R, Linden P, Estores D, Torre-Cisneros J, Kusne S, Ondick L, Ptachcinski R, Irish W, Kisor D, Felser I, Rinaldo C, Stiber A, Fung J, Ho M, Simmons R, Startzl T. A prospective randomised trial comparing sequential Ganciclovir-high dose acyclovir to high dose Acyclovir for prevention of Cytomegalovirus disease in adult liver transplant recipients. Transplantation. 58:1994;779-785.
19. Meyers JD, Ljungman P, Fisher LD. Cytomegalovirus excretion as a predictor of Cytomegalovirus disease after marrow transplantation: importance of Cytomegalovirus viraemia. J Infect Dis. 162:1990;373-380.
20. Paya CV, Smith TF, Ludwig J, Hermans PE. Rapid shell vial culture and tissue histology compared with serology for the rapid diagnosis of Cytomegalovirus infection in liver transplantation. Mayo Clinic Proc. 64:1989;670-675.
21. Goodrich JM, Mori M, Gleaves CA, Du Mond C, Cays M, Ebeling DF, Buhles WC, De Armond B, Meyers JD. Early treatment with ganciclovir to prevent Cytomegalovirus disease after allogeneic bone marrow transplantation. NEJM. 325:1991;1601-1607.
22. Singh N, Yu VL, Mieles L, Wagener MM, Miner RC, Gayowski T. High-dose Acyclovir compared with short-course pre-emptive Ganciclovir therapy to prevent Cytomegalovirus disease in liver transplant recipients. Ann Intern Med. 120:1994;375-381.
23. Schmidt GM, Horak DA, Niland JC, Duncan SR, Forman SJ, Zaia JA. A randomised, controlled trial of prophylactic Ganciclovir for Cytomegalovirus pulmonary infection in recipients of allogeneic bone marrow transplants. NEJM. 324:1991;1005-1011.
24. Pass RF, Griffiths PD, August AM. Antibody response to Cytomegalovirus after renal transplantation: comparison of patients with recurrent and primary infections. J Infect Dis. 147:1983;40-46.
25. Kangro HO, Griffiths PD, Huber TJ, Heath RB. Specific IgM class Antibody production following infection with Cytomegalovirus. J Med Virol. 10:1982;203-212.
26. Basson J, Tardy JC, Aymard M. Pattern of anti-Cytomegalovirus IgM antibodies determined by immunoblotting. A study of kidney graft recipients developing a primary or recurrent CMV infection. Arch Virol. 108:1989;259-270.
27. Chou S, Kim DY, Scott KM, Sewell DL. Immunoglobulin M to Cytomegalovirus in primary and reactivation infections in renal transplant recipients. J Clin Microbiol. 25:1987;52-55.
28. Rasmussen L, Kelsall D, Nelson R, Carney W, Hirsch M, Winston D, Preiksaitis J, Merigan TC. Virus-specific IgG and IgM antibodies in normal and immunocompromised subjects infected with Cytomegalovirus. J Infect Dis. 145:1982;191-199.
29. Schmidt Ca, Oettle H, Peng R, Neuhaus P, Blumhardt G, Lohmann R, Wilborn F, Osthoff K, Oertel J, Timm H, Siegert W. Comparison of polymerase chain reaction from plasma and buffy coat with antigen detection and occurrence of immunoglobulin M for the detection and occurrence of immunoglobulin M for the detection of Cytomegalovirus infection after liver transplantation. Transplantation. 59:1995;1133-1138.
30. Revello MG, Percivalle E, Zavattoni M, Parea M., Grossi P, Gerna G. Detection of human Cytomegalovirus immediate early antigen in leukocytes as a marker of viraemia in immunocompromised patients. J Med Virol. 29:1989;88-93.
31. van der Bij W, Torensma R, van Son WJ, Anema J, Schrim J, Tegzess AM, The TH. Rapid immunodiagnosis of active Cytomegalovirus infection by monoclona antibody staining of blood leucocytes. J Med Virol. 25:1988;179-188.
32. van den Berg AP, Tegzess AM, Scholten-Sampson A, Schirm J, van der Giessen M, The TH, van Son WJ. Monitoring antigenaemia is useful in guiding treatment of severe Cytomegalovirus disease after organ transplantation. Transplant Int. 5:1992;101-107.
33. Bein G, Bitsch A, Hoyer J, Steinhoff J, Fricke L, Machnik H, Dennin R, Kirchner H. A longitudinal prospective study of Cytomegalovirus pp65 antigenaemia in renal transplant recipients. Transplant Int. 6:1993;185-190.
34. van den Berg AP, Klompmaker IJ, Haagsma EB, Scholten-Sampson A, Bijleveld CMA, Schirm J, van der Giessen M, Sloof MJH, The TH. Antigenaemia in the diagnosis and monitoring of active Cytomegalovirus infection after liver transplantation. J Infect Dis. 164:1991;265-270.
35. Boland GJ, Ververs C, Hene RJ, Jambroes G, Donckerwolcke RAMG, de Gast GC. Early detection of primary Cytomegalovirus infection after heart and kidney transplantation and the influence of hyperimmune prophylaxis. Transplant Int. 6:1993;34-38.
36. van den Berg AP, van der Bij WJ, Anema J, van der Giessen M, Schirm J, Tegzess AM, The TH. Cytomegalovirus antigenaemia as a useful marker of symptomatic Cytomegalovirus infection after renal transplantation: a report of 130 consecutive patients. Transplantation. 48:1989;991-995.
37. Bevan IS, Daw RA, Day PJR, Ala FA, Walker MR. Polymerase chain reaction for detection of human Cytomegalovirus infection in a blood donor population. Br J Haematol. 78:1991;4-9.
38. Smith KL, Kulski JK, Cobain T, Dunstan RA. Detection of Cytomegalovirus in blood donors by the polymerase chain reaction. Transfusion. 497-503:1993.
39. Schmidt CA, Oettle H, Neuhaus P, Weins M, Timm H, Wilborn F, Siegert W. Demonstration of Cytomegalovirus by polymerase chain reaction after liver transplantation. Transplantation. 56:1992;872-874.
40. Delgado R, Lumbreras C, Alba C, Pedraza MA, Otero JR, Gomez R, Moreno E, Noriega AR, Paya CV. Low predictive value of polymerase chain reaction for diagnosis of Cytomegalovirus disease in liver transplant recipients. J. Clin Microbiol. 30:1992;1876-1878.
41. Kidd IM, Fox JC, Pillay D, Charman H, Griffiths PD, Emery VC. Provision of prognostic information in immunocompromised patients by routine application of the polymerase chain reaction for Cytomegalovirus. Transplantation. 56:1993;867-871.
42. Nyberg G, Bergstrom T, blohme I, Norden G, Olofsson S, Ricksten A. Clinical Evaluation in organ transplant patients of a polymerase chain reaction test for CMV DNA applied on white cells and serum. Transplant Int. 7:1994;428-433.
43. Prosch S, Kimel V, Dawydowa I, Kruger DH. Monitoring of patients for Cytomegalovirus after organ transplantation by centrifugation culture and PCR. J. Med virol. 38:1992;246-251.
44. Patel R, Smith TF, Espy M, Portela D, Wiesner RH, Krom RAF, Paya CV. A Prospective comparison of molecular diagnostic techniques for the early detection of Cytomegalovirus in liver transplant recipients. J Infect Dis. 171:1995;1010-1014.
45. Gerdes JC, Spees EK, Fitting K, Hiraki J. Prospective study utilising a quantitative polymrase chain reaction for detection of Cytomegalovirus DNA in the blood of renal transplant recipients. Transplant Proc. 25:1993;1411-1413.
46. Schafer P, Braun RW, Mohring K, Henco K, Kang J, Wendland T, Kuhn JE. Quantitative determination of human Cytomegalovirus target sequences in peripheral blood leukocytes by nested polymerase chain reaction and temperature gradient gel electrophoresis. J Gen Virol. 74:1993;2699-2707.
47. Fox JC, Griffiths PD, Emery VC. Quantification of Human Cytomegalovirus DNA using the polymerase chain reaction. J Gen Virol. 73:1992;2405-2408.
48. Mutimer DJ, Matyi-Toth A, Elias E, Shaw J, O'Donnell K, Kilgariff H, Neuberger J, Gunson B, McMaster P, Stalhandske P. Quantitation of Cytomegalovirus in the blood of liver transplant recipients. Liver Transplant Surg. 1:1995;395-400.
49. Bell R, Sheil AGR, McDonald JA, McCaughan GW. The role of CMV immune prophylaxis in patients at risk of primary CMV infection following orthotopic liver transplantation. Transplant Proc. 21:1989;3781-3782.
50. Saliba F, Arulnaden JL, Gugenheim J, Serves C, Samuel D, Bismuth A, Mathieu D, Bismuth H. CMV hyperimmune globulin prophylaxis after liver transplantation: a prospective randomised controlled study. Transplant Proc. 21:1989;2260-2262.
51. Stratta Rj, Shaefer MS, Cushing KA, Marking RS, Wood RP, Langnas AN, Reed EC, Woods GL, Donovan JP, Pillen TJ, Li S, Duckworth RM, Shaw BW Jr. Successful prophylaxis of Cytomegalovirus disease after primary CMV exposure in liver transplant recipients. Transplantation. 51:1991;90-97.
52. Stratta RJ, Shaefer MS, Cushing KA, Markin RS, Reed EC, Langnas AN, illen TJ, Shaw BW Jr. A randomised prospective trial of Acyclovir and immune globulin prophylaxis in liver transplant recipients receiving OKT3 theraphy. Arch Surg. 127:1992;55-64.
53. Glowacki LS, Smaill FM. Use of immune globulin to prevent symptomatic Cytomegalovirus disease in transplant recipients - a meta-analysis. Clin Transplant. 8:1994;10-18.
54. Mor E, Meyers BR, Yagmur O, Kishikawa K, Sheiner PA, Emre S, Schwartz ME, Miller CM. High-dose Acyclovir and intravenous immune globulin reduce the incidence of CMV disease after liver transplantation. Transplant Int. 8:1995;152-156.
55. Mollison LC, Richards MJ, Johnson PDR, Hayes K, Muckhof WJ, Jones RM, Dabkowski PD, Angus PW. High-dose Acyclovir reduces the incidence of Cytomegalovirus infection in liver transplant recipients. J Infect Dis. 168:1993;721-724.
56. Nakazato PZ, Burns W, Moore P, Garcia-Kennedy R, Cox K, Esquivel C. Viral Prophylaxis in hepatic transplantation: preliminary report of a randomised trial of Acyclovir and Ganciclovir. Transplant Proc. 25:1993;1935-1937.
57. Dunn DL, Gillingham KJ, Kramer MA, Schmidt WJ, Erice A, Balfour HH Jr, Gores PF, Gruessner RWG, Matas AJ, Payne WD, Sutherland DER, Najarian JS. A prospective randomised study of Acyclovir versus Ganciclovir plus human immune globulin prophylaxis of Cytomegalovirus infection after solid organ transplantation. Transplantation. 57:1994;876-884.
58. Balfour HH, Chace BA, Stapleton JT, Simmons RL, Fryd DS. A randomised, placebo-controlled trial of oral acyclovir for the prevention of Cytomegalovirus disease in recipients of renal allografts. NEJM. 320:1989;1381-1387.
59. Winston DJ, Wirin D, Shaked A, Busuttil RW. Randomised comparison of Ganciclovir and high-dose Acyclovir for a long-term Cytomegalovirus prophylaxis in liver transplant recipients. Lancet. 346:1995;69-74.
60. Freise CE, Pons V, Lake J, Burke E, Ascher NL, Robert JP. Comparison of 3 regimens for Cytomegalovirus prophylaxis in 147 liver transplant recipients. Transplant Proc. 23:1991;1498-1450.
61. Cohen AT, O'Grady JG, Sutherland S, Sallie R, Tan K-C, Wiliams R. Controlled trial of prophylactic versus therapeutic use of Ganciclovir after liver transplantation in adults. J Med Virol. 40:1993;5-9.
62. Chatterjee SN, Fiala M, Weiner J, Stewart JA, Stacey B, Warner N. Primary Cytomegalovirus and opportunistic infections. Incidence in renal transplant patients. JAMA. 240:1978;2446-2449.
63. Rand KH, Pollard RB, Merigan TC. Increased pulmonary superinfections in cardiac transplant patients undergoing primary Cytomegalovirus infections. NEJM. 298:1978;951-953.
64. Smyth RL, Scott JP, Borysiewicz LK, Sharples LD, Stewart S, Wreghitt TG, Gray JJ, Higenbottam TW, Wallwork J. Cytomegalovirus infection in heart-lung transplant recipients: risk factors, clinical associations, and response to treatment. J Infect Dis. 164:1991;1045-1050.
65. Bronsther O, Makowka L, Jaffe R, Demetris AJ, Breinig MK, Ho M, Esquivel CO, Gordon RD, Iwatsuki S, Tzakis A, Marsh JW Jr, Mazzaferro V, Van Thiel D, Starzl TE. Occurrence of Cytomegalovirus hepatitis in liver transplant patients. J Med Virol. 24:1988;423-434.
66. George MJ, Snydman DR, Werner BG, Dougherty NN, Griffith J, Rohrer RH, Freeman R, Jenkins R, Lewis WD. Use of Ganciclovir plus Cytomegalovirus immune globulin to treat CMV pneumonia in orthotopic liver transplant recipients. Transplant Proc. 25:1993;22-24.
67. Stratta RJ, Shaefer MS, Markin RS, Cushing KA, Donovan JP, Wood RP, Langnas AN, Reed EC, Woods GL, Zetterman RK, Sorrell MF, Pillen TJ, Shaw BW Jr. Ganciclovir therapy for viral disease in liver transplant recipients. Clin Transplant. 5:1991;287-293.
68. Harbison MA, De Girolami PC, Jenkins RL, Hammer SM. Ganciclovir therapy of severe Cytomegalovirus infections in solid-organ transplant recipients. Transplantation. 46:1988;82-88.
69. Bitsch A, Kirchner H, Dennin R, Hoyer J, Fricke L, Steinhoff J, Sack K, Bein G. The long persistence of CMV DNA in the blood of renal transplant patients after recovery from CMV infection. Transplantation. 56:1993;108-113.
70. Fietze E, Prosch S, Reinke P, Stein J, Docke W-D, Staffa G, Loning S, Devaux S, Emmrich F, Von Baehr R, Kruger DH, Volk HD. Cytomegalvirus infection in transplant recipients. Transplantation. 58:1994;675-680.
71. Tilg H, Vogel W, Aulitzky WE, Herold M, Konigsrainer A, Margreiter R, Huber C. Evaluation of cytokines and cytokine-induced secondary messages in sera of patients after liver transplantation. Transplantation. 49:1990;1074-1080.
72. Stein J, Volk HD, Liebenthal C, Kruger DH, Prosch S. Tumour Necrosis factor alpha stimulates the activity of the human Cytomegalovirus major immediate early enhancer/promoter in immature monocytic cells. J Gen Virol. 74:1993;2333-2338.
73. Sheron N, Goka J, Wendon J, Keays R, Keane H, Alexander G, Wiliams R. Highly elevated plasma cytokines in fulminant hepatic failure: correlations with multiorgan failure and death. Hepatology. 12:1990;939.
74. Manez R, White LT, Linden P, Kusne S, Martin M, Kramer D, Demetris AJ, Van Thiel DH, Starzl TE, Duquesnoy RJ. The influence of HLA matching on Cytomegalovirus hepatitis and chronic rejection after liver transplantation. Transplantation. 55:1993;1067-1071.
75. O'Grady JG, Alexander GJM, Sutherland S, Donaldson PT, Harvey F, Portmann B, Calne RY, Williams R. Cytomegalovirus infection and donor/recipient HLA antigens: interdependent co-factors in pathogenesis of vanishing bileduct syndrome after liver transplantation. Lancet. ii:1988;302-305.
76. Candinas D, Gunson BK, Nightingale P, Hubscher S, McMaster P, Neuberger JM. Sex mismatch as a risk factor for chronic rejection of liver allografts. Lancet. 346:1995;1117-1121.
77. Paya CV, Wiesner RH, Hermans PE, Larson-Keller JJ, Ilstrup DM, Krom RAF, Moore SB, Ludwig J, Smith TF. Lack of association between Cytomegalovirus infection, HLA matching and the vanishing bile duct syndrome after liver transplantation. Hepatology. 16:1992;66-70.