Interaction of BW A868C, a prostanoid DP-receptor antagonist, with two receptor subtypes in the rabbit isolated saphenous vein

Prostaglandins

Volumn 52, Issue 2, 1996, Pages 125-139

  Lydford, Simon J ^a   McKechnie, Kenneth C W ^a   Leff, Paul ^a  

^a ASTRAZENECA   (United Kingdom)

Author keywords

biphasic Schild plot; BW A868C; BW245C; prostanoid DP receptors; Rabbit isolated saphenous vein

Indexed keywords

3 BENZYL 5 (6 CARBOXYHEXYL) 1 (2 CYCLOHEXYL 2 HYDROXYETHYLAMINO)HYDANTOIN; 5 (6 CARBOXYHEXYL) 1 (3 CYCLOHEXYL 3 HYDROXYPROPYL)HYDANTOIN; PROSTAGLANDIN D2; PROSTAGLANDIN E2; PROSTANOID RECEPTOR; RECEPTOR SUBTYPE;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG EFFECT; NONHUMAN; RABBIT; SAPHENOUS VEIN; VASODILATATION; VENOCONSTRICTION;

ANIMALIA; ORYCTOLAGUS CUNICULUS;

EID: 0030221225     PISSN: 00906980     EISSN: None     Source Type: Journal    
DOI: 10.1016/0090-6980(96)00058-5     Document Type: Article

References (41)

1. 1. Kennedy, I., Coleman, R.A., Humphrey, P.P.A., Levy, G.P. and Lumley, P. Studies of the Characterization of Prostanoid Receptors: A Proposed Classification. Prostaglandins, 24: 667-689, 1982.
2. 2. Coleman, R.A., Humphrey, P.P.A., Kennedy, I. and Lumley, P. Prostanoid receptors - the development of a working classification. Trends Pharmacol. Sci., 5: 303-306, 1984.
3. 2 sensitive (EP-) receptors in smooth muscle. Br. J. Pharmacol., 91: 323P, 1987.
4. 2 sensitive (EP) receptors in smooth muscle. Br. J. Pharmacol., 91: 407P, 1987.
5. 5. Coleman, R.A., Grix, S.P., Head, S.A., Louttit, J.B., Mallett, A. and Sheldrick, R. L. A novel inhibitory prostanoid receptor in piglet saphenous vein. Prostaglandins, 47: 151-168, 1994.
6. 4 subtype. FEBS Lett., 364: 339-341, 1995.
7. 2 subtype. Mol. Pharmacol., 46: 213-220, 1994.
8. 3 subtype. J. Biol. Chem., 267: 6463-6466, 1992.
9. 1 subtype of prostaglandin E receptor. J. Biol. Chem., 268: 20175-20178, 1993.
10. 10. Sugimoto, Y., Hasumoto, K., Namba, T. et al. Cloning and expression of a cDNA for mouse prostaglandin F receptor. J. Biol. Chem., 269: 1356-1360, 1994.
11. 11. Namba, T., Oida, H., Sugimoto, Y. et al. cDNA cloning of a mouse prostacyclin receptor. Multiple signaling pathways and expression in thymic medulla. J. Biol. Chem., 269: 9986-9992, 1994.
12. 2 receptor. Nature, 349: 617-629, 1991.
13. 13. Hirata, M., Kakizuka, A., Aizawa, M., Ushikubi, F. and Narumiya, S. Molecular characterization of a mouse prostaglandin D receptor and functional expression of the cloned gene. Proc. Natl. Acad. Sci., 91: 11192-11196, 1994.
14. 14. Boie, Y., Sawyer, N., Slipetz, D.M., Metters, K.M. and Abramovitz, M. Molecular Cloning and characterization of the human prostanoid DP-receptor. J. Biol. Chem., 270: 18910-18916, 1995.
15. 15. Whittle, B.J.R., Moncada, S., Mullane, K. and Vane, J.R. Platelet and cardiovascular activity of hydantoin BW245C, a potent prostaglandin analogue. Prostaglandins, 25: 205-223, 1983.
16. 2-receptor. Prostaglandins, 35: 855-868, 1988.
17. 2 receptors. Prostaglandins, 40: 119-130, 1990.
18. 18. Macintyre, D.E. and Gordon, J.L. Discrimination between platelet prostaglandin receptors with a specific antagonist of bisenoic Prostaglandins,. Thromb. Res., 11: 705-713, 1977.
19. 19. Keery, R.J. and Lumley, P. AH6809, a prostaglandin DP-receptor blocking drug on human platelets. Br. J. Pharmacol., 94: 745-754, 1988.
20. 20. Giles, H., Leff, P., Bolofo, M.L., Kelly, M.G. and Robertson, A.D. The classification of prostaglandin DP-receptors in platelets and vasculature using BW A868C, a novel, selective and potent competitive antagonist. Br. J. Pharmacol., 96: 291-300, 1989.
21. 2-responsive cell line from bovine embryonic trachea. Br. J. Pharmacol., 99: 13-14, 1990.
22. 2 in freshly isolated nonchromaffin cells from bovine adrenal medulla. Biochim. Biophys. Acta, 1176: 148-154, 1993.
23. 23. Coleman, R.A., Kennedy, I., Humphrey, P.P.A., Bunce, K.T. and Lumley, P. Prostanoids and their receptors. In: Comprehensive Medicinal Chemistry, Vol 3: Membranes and Receptors, edited by Emmett, J.C.: Pergammon Press, Oxford, pp. 643-714, 1990.
24. 2 vasodepressor responses in the rat in vivo by the novel, selective antagonist, BW A868C. Br. J. Pharmacol., 96: 307-312, 1989.
25. 2. Prostaglandins, 35: 277-300, 1988.
26. 2α, to conscious mice. Brain Research, 510: 26-32, 1990.
27. 2. Invest. Ophthalmol. Vis. Sci., 31: 138-146, 1990.
28. 28. Lydford, S.J., McKechnie, K.C.W. and Dougall, I.G. Pharmacological studies on prostanoid receptors in the rabbit isolated saphenous vein: A comparison with the rabbit isolated ear artery. Br. J. Pharmacol., 117, 13-20, 1996.
29. 29. Pöch, G. and Holzmann, S. Quantitative estimation of overadditive and underadditive drug effects by means of theoretical, additive dose-response curves. J. Pharm. Meth., 4: 179-188, 1980.
30. 30. Crack, B.E., Pollard, C.P., Beukers, M.W. et al. Pharmacological and biochemical analysis of FPL 67156, a novel, selective inhibitor of ecto-ATPase. Br. J. Pharmacol., 114: 475-481, 1995.
31. 31. Lemoine, H. and Kaumann, A.J. A model for the interaction of competitive antagonists with two receptor-subtypes characterized by a Schild-plot with apparent slope unity. Naunyn-Schmiedeberg's Arch. Pharmacol., 322: 111-120, 1983.
32. 32. Senior, J., Marshall, K., Sangha, R. and Clayton, J.K. In vitro characterization of prostanoid receptors on human myometrium at term pregnancy. Br. J. Pharmacol., 108: 501-506, 1993.
33. 33. Fernandes, B. and Crankshaw, D.J. Functional characterization of the prostanoid DP receptor in human myometrium. Eur. J. Pharmacol., 283: 73-81, 1995.
34. 2 and BW245C activation of human platelet adenylate cyclase. Br. J. Pharmacol., 96: 301-306, 1989.
35. 35. Kenakin, T.P. Competitive antagonism. In: Pharmacologic analysis of drug-receptor interactions. Raven Press, New York, pp 278-322, 1993.
36. 36. Szabadi, E. A model of two functionally antagonistic receptors activated by the same agonist. J. Theor. Biol., 69: 101-112, 1977.
37. 2. Br. J. Pharmacol., 104: 541-549, 1991.
38. 2. Circ., 72: 1208-1218, 1985.
39. 39. Smith, G.C.S., Coleman, R.A. and McGrath, J.C. Characterization of dilator prostanoid receptors in the foetal rabbit ductus arteriosus. J. Pharmacol. Exp. Ther., 271: 390-396, 1994.
40. 2 sensitive (EP-) receptor in the rat isolated trachea. Br. J. Pharmacol., 112: 133-136, 1994.
41. 41. Lydford, S.J., McKechnie, K. and Leff, P. Interaction of BW A868C with two receptor-subtypes in the rabbit saphenous vein. In: Abstracts for the IX International Conference on Prostaglandins, and Related Compounds. pp85, 1994.