Role of rate-limiting enzymes of nucleotide metabolism in taurocholate-induced DNA synthesis inhibition

Journal of Hepatology

Volumn 25, Issue 2, 1996, Pages 191-199

  Monte, Maria J ^a   Barbero, Emilio R ^a   Villanueva, Gloria R ^a   Serrano, Maria A ^a   Marin, Jose J G ^a  

^a UNIVERSITY OF SALAMANCA   (Spain)

Author keywords

Dihydropyrimidine dehydrogenase; Hydroxyurea; Partial hepatectomy; Ribonucleotide reductase; Thymidine; Thymidine kinase

Indexed keywords

DIHYDROPYRIMIDINE DEHYDROGENASE; HYDROXYUREA; TAUROCHOLIC ACID; THYMIDINE; THYMIDINE KINASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DNA SYNTHESIS; LIVER REGENERATION; MALE; NONHUMAN; NUCLEOTIDE METABOLISM; PARTIAL HEPATECTOMY; PRIORITY JOURNAL; RAT;

EID: 0030221189     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-8278(96)80073-0     Document Type: Article

References (35)

1. Barbero E.R., Herrera M.C., Monte M.J., Serrano M.A., Marin J.J.G. Role of amidation in bile acid effect on DNA synthesis by the regenerating mouse liver. Am J Physiol. 268:1995;G1051-G1059.
2. Marin J.J.G., Barbero E.R., Herra M.C., Tabernero A., Monte M.J. Bile acid-induced modifications in DNA synthesis by the regenerating perfused rat liver. Hepatology. 18:1993;1182-1192.
3. Combettes C., Dumont M., Berthon B., Erlinger S., Claret M. Effect of the bile acid taurolithocholate on cell calcium in saponin-treated rat hepatocytes. FEBS Lett. 227:1988;161-166.
4. + exchange in rat liver basolateral plasma membrane vesicles. J Clin Invest. 80:1987;684-690.
5. + exchange activity in rat hepatocytes: role in regulation of intracellular pH. Am J Physiol. 256:1989;G44-G52.
6. + antiport and its role in cell regulation. Verna R., Blumenthal R., Frati L. Bioengineered Molecules: Basic and Clinical Aspects. 1:1989;97-107 Raven Press, New York.
7. Koch K.S., Leffert H.L. Increased sodium ion influx is necessary to initiate rat hepatocyte proliferation. Cell. 18:1979;153-163.
8. Haussinger D., Lang F. Cell volume in the regulation of hepatic function: a mechanism for metabolic control. Biochim Biophys Acta. 1071:1991;331-350.
9. Furukawa T., Naitoh Y., Kohno H., Tokunaga R., Taketani S. Iron deprivation decreases ribonucleotide reductase activity and DNA synthesis. Life Sci. 50:1992;2059-2065.
10. ++) iron - a potential physiologic role for bite salts in iron absorption. J Lab Clin Med. 116:1990;76-86.
11. Kuebbing D., Werner R. A model for the compartmentation of de novo and salvage thymidine nucleotide pools in mammalian cells. Proc Natl Acad Sci USA. 72:1975;3333-3336.
12. Newton A. A pool size problem associated with the use of tritiated thymidine. Nature. 194:1962;886-887.
13. Statoscik R.N., Jenkins W.H., Mendelsohn M.L. Availability of tritated thymidine after iv administration. Nature. 202:1964;456-458.
14. Van der Borght T.M., Lambotte L.E., Pauwels S.A., Dive C.C. Uptake of thymidine labeled on carbon: 2. A potential index of liver regeneration by positron emission tomography. Hepatology. 12:1990;113-118.
15. Snyder R.D. Consequences of the depletion of cellular deoxynucleoside triphosphate pools on the excision-repair process in cultured human fibroblasts. Mutat Res. 200:1988;193-199.
16. Marin J.J.G., Tabernero A., Barriocanal F.P., Barbero E.R., Eleno N. Plasma membrane-bound carbonic anhydrase activity in the regenerating rat liver. Biochim Biophys Acta. 1061:1991;9-14.
17. Higgins G.H., Anderson R.M. Experimental pathology of liver 1. Restoration of liver of white rat following partial surgical removal. Arch Path. 12:1931;186-202.
18. Marin J.J.G., Dumont M., Corbic M., De Couet G., Erlinger S. Effect of acid-base balance and acetazolamide on ursodeoxycholate-induced biliary bicarbonate secretion. Am J Physiol. 248:1985;G20-G27.
19. Miller L.L., Thy C.G., Watson M.E., Bale W.F. The dominant role of the liver in plasma protein synthesis. J Exp Med. 94:1951;431-445.
20. Marin J.J.G., Bravo P., Barriocanal F.P., El-Mir M.Y., Villanueva G.R. Hyperglycemia-induced cholestasis in the isolated perfused rat liver. Hepatology. 14:1991;184-191.
21. Burton K. A study of the conditions and mechanisms of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid. Biochem J. 62:1956;315-322.
22. Koji T., Terayama H. Arginase as one of the inhibitory principles in the density-dependent as well as plasma-mediated inhibition of liver cell growth in vitro. Exp Cell Res. 155:1984;359-370.
23. Litteria M. The effects of sex and neonatal androgenization on thymidine kinase activity and DNA content in the cerebellum of the rat. Brain Res. 181:1980;401-412.
24. Yarbrough J.D., Grimley J.M., Karl P.L. The relationship of ornithine decarboxylase and thymidine kinase to mirex-induced liver growth. Am J Physiol. 251:1986;G859-G865.
25. Kwon N.S., Stuehr D.J., Nathan C.F. Inhibition of tumor cell ribonucleotide reductase by macrophage-derived nitric oxide. J Exp Med. 174:1991;761-767.
26. Kaneko M., Fujimoto S., Kikugawa M., Kontani K., Tamaki N. Effect of dietary protein on pyridimidine metabolizing enzymes in rats. J Nutr Sci Vitamin. 37:1991;517-528.
27. Markwel M.A.K., Haas S.M., Bieber L.L., Tolbert M.E. A modification of the Lowry procedure to simplify protein determination in membrane and lipoprotein samples. Anal Biochem. 87:1978;206-210.
28. Weber G., Queener S.F., Ferdinandus J.A. Control of gene expression in carbohydrate, pyrimidine and DNA metabolism. Adv Enzyme Regul. 9:1971;63-95.
29. vitro uptake of thymidine. Cell Tissue Kinet. 15:1982;521-528.
30. Pels Rijcken W.R., Hooghwinke G.J.I.M., Ferwerda W. Pyrimidine metabolism and sugar nucleotide synthesis in rat liver. Biochem J. 266:1990;777-783.
31. Krakoff J.H., Brown N.C., Reichard P. Inhibition of ribonucleoside diphosphate reductase by hydroxyurea. Cancer Res. 1559-1565:1968.
32. Rabes H.M., Iseler G., Czichos S., Tuczek H.V. Synchronization of hepatocellular DNA synthesis in regenerating rat liver by continuous infusion of hydroxyurea. Cancer Res. 37:1977;1105-1111.
33. Röttgen V., Rabes H.M. Deoxyribonucleoside triphosphate pools in regenerating rat liver: effect of hydroxyurea and exogenous deoxypyrimidines. Biochim Biophys Acta. 992:1989;349-354.
34. Hoglund C., Pontis E., Reichard P. Effects of deoxycytidine kinase deficiency on substrate cycles between deoxyribonucleosides and their 5′-phosphates. Cancer Res. 48:1988;3681-3687.
35. Meuth M. The molecular basis of mutations induced by deoxyribonucleoside triphosphate pool imbalances in mammalian cells. Exp Cell Res. 181:1989;305-316.