Islet amyloid polypeptide/amylin contents in pancreas change with increasing age in genetically obese and diabetic mice

Diabetes Research and Clinical Practice

Volumn 33, Issue 3, 1996, Pages 153-158

  Takada, Kazushi ^a   Kanatsuka, Azuma ^a   Tokuyama, Yoshiharu ^a   Yagui, Kazuo ^a   Nishimura, Masahiko ^b   Saito, Yasushi ^a   Makino, Hideichi ^a  

^a CHIBA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

amylin; genetically diabetic mouse; islet amyloid polypeptide; non insulin dependent (type 2) diabetes mellitus

Indexed keywords

AMYLIN;

AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; MALE; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY;

EID: 0030221133     PISSN: 01688227     EISSN: None     Source Type: Journal    
DOI: 10.1016/0168-8227(96)01294-6     Document Type: Article

References (17)

1. [1] Westermark, P., Wernstedt, C., Wilander, E., Hayden, D.W., O'Brien, T.J. and Johnson, K.H. (1987) Amyloid fibrils in human insulinoma and islets of Langerhans of the diabetic cat are derived from a neuropeptide-like protein also present in normal islet cells. Proc. Natl. Acad. Sci. USA 84, 3881-3885.
2. [2] Cooper, G.J.S., Willis, A.C., Clark, A., Turner, R.C., Sim, R.B. and Reid, K.M. (1987) Purification and characterization of peptide from amyloid-rich pancreases of type 2 diabetic patients. Proc. Natl. Acad. Sci. USA 84, 8628-8632.
3. [3] Sanke, T., Bell, G.I., Sample, C., Rubenstein, A.H. and Steiner, D.F. (1988) An islet amyloid peptide is derived from an 89-amino acid precursor proteolytic processing. J. Biol. Chem. 263, 17243-17246.
4. [4] Kanatsuka, A., Makino, H., Yamaguchi, T. et al. (1992) Islet amyloid polypeptide/amylin in pancreatic β-cell line derived from transgenic mouse insulinoma. Diabetes 41, 1409-1414.
5. [5] Kanatsuka, A., Makino, H., Ohsawa, H., Tokuyama, Y., Yamaguchi, T., Yoshida, S. and Adachi, M. (1989) Secretion of islet amyloid polypeptide in response to glucose. FEBS Lett. 259, 199-201.
6. [6] Cooper, G.J.S., Leighton, G.D., Dimitriadis, G.D. et al. (1988) Amylin found in amyloid deposits human type 2 diabetes mellitus may be a hormone that regulates glycogen metabolism in skeletal muscle. Proc. Natl. Acad. Sci. USA 85, 7763-7766.
7. [7] Ohsawa, H., Kanatsuka, A., Yamaguchi, T., Makino, H. and Yoshida. S. (1989) Islet amyloid polypeptide inhibits glucose-stimulated insulin secretion from isolated rat pancreatic islets. Biochem. Biophys. Res. Commun. 160, 961-967.
8. [8] Westermark, P., Wilandar, E., Westermark, G.T. and Johnson, K.H. (1987) Islet amyloid polypeptide-like immunoreactivity in the islet β-cells of type 2 (non-insulin-dependent) diabetic and non-diabetic individuals. Diabetologia 30, 887-892.
9. [9] Clark, A., Saad, M.F., Nezzer, T., Uren, C., Knowler, W.C., Bennett, P.H. and Turner, R.C. (1990) Islet amyloid polypeptide in diabetic and non-diabetic Pima Indians. Diabetologia 33, 285-289.
10. [10] Ohsawa, H., Kanatsuka, A., Mizuno, Y. et al. (1992) Islet amyloid polypeptide-derived amyloid deposition increases along with the duration of type 2 diabetes mellitus. Diabetes Res. Clin. Pract. 15, 17-22.
11. [11] Bray, G.A. and York, D.A. (1979) Hypothalamic and genetic obesity in experimental animals: an autonomic and endocrine hypothesis. Physiol. Rev. 59, 719-809.
12. [12] Coleman, D.L. (1978) Obesity and diabetes. Two mutant genes causing diabetes-obesity syndromes in mice. Diabetologia 14, 141-148.
13. [13] Bailey, C.J., Day, C., Bray, G.A., Lipson, L.G. and Flatt, P.R. (1986) Role of adrenal glands in the development of abnormal glucose and insulin homeostasis in genetically obese (ob/ob) mice. Horm. Metab. Res. 18, 357-360.
14. [14] Tokuyama, Y., Kanatsuka, A., Yamaguchi, T. et al. (1993) Islet amyloid polypeptide/amylin contents in pancreata increase in genetically obese and diabetic mice. Horm. Metab. Res. 25, 289-291.
15. [15] Tokuyama, Y., Kanatsuka, A., Ohsawa, H. et al. (1991) Hypersecretion of islet amyloid polypeptide from pancreatic islets of ventromedial hypothalamic-lesioned rats and obese Zucker rats. Endocrinology 128, 2739-2744.
16. [16] Bretherton-Watt, D., Ghatei, M.A., Bloom, S.R. et al. (1989) Altered islet amyloid polypeptide (amylin) gene expression in rat models of diabetes. Diabetologia 32, 881-883.
17. [17] Eriksson, J., Nakazato, M., Miyazato, M., Shiomi, K., Matsukura, S. and Groop, L. (1992) Islet amyloid polypeptide plasma concentrations in individuals at increased risk of developing type 2 (non-insulin-dependent) diabetes mellitus. Diabetologia 35, 291-293.