Variable influence of heparin and contrast agents on platelet function as assessed by the in vitro bleeding time

Thrombosis Research

Volumn 83, Issue 3, 1996, Pages 265-277

  Melton, Laura G ^a   Dehmer, Gregory J ^a   Tate, David A ^a   Muga, Kathleen M ^a   Meehan, Ann ^a   Gabriel, Don A ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

angiography; contrast media; heparin; platelets

Indexed keywords

DIATRIZOATE; HEPARIN; IOHEXOL;

ADULT; AGED; ANGIOCARDIOGRAPHY; ANTICOAGULATION; ARTICLE; BLEEDING TENDENCY; BLEEDING TIME; DRUG EFFECT; FEMALE; HEART CATHETERIZATION; HUMAN; IMAGE ENHANCEMENT; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL;

EID: 0030220722     PISSN: 00493848     EISSN: None     Source Type: Journal    
DOI: 10.1016/0049-3848(96)00135-1     Document Type: Article

References (64)

1. ROSENBERG R.D. Actions and interactions of antithrombin and heparin. New Engl J Med. 292:1975;146-151.
2. GABRIEL D.A., JONES M.R., REECE N.S., BOOTHROYD E., BASHORE T. Platelet and fibrin modification by radiographic contrast media. Circ Res. 68:1991;881-887.
3. FIDLAR E., JACQUES L.B. The effect of commercial heparin on the platelet count. J Lab Clin Med. 33:1948;1410-1423.
4. SALZMAN E.W., ROSENBERG R.D., SMITH M.H., LINDON J.N. Effect of heparin and heparin fractions on platelet aggregation. J Clin Invest. 65:1980;64-73.
5. WESTWICK J., SCULLY M.F., POLL C., KAKKAR V.V. Comparison of the effects of low molecular weight heparin and unfractionated heparin on activation of human platelets in vitro. Thromb Res. 42:1986;435-447.
6. EIKA C. On the mechanism of platelet aggregation induced by heparin, protamine and polybrene. Scand J Haematol. 9:1972;248-250.
7. SABA H.I., SABA S.R., MORELLI G.A. Effect of heparin on platelet aggregation. Am J Hematol. 17:1984;295-306.
8. KELTON J.G. Heparin-induced thrombocytopenia. Haemostasis. 16:1986;173-186.
9. COPLEY A.L., ROBB T.P. Studies on platelets III: the effect of heparin in vivo on the platelet count in mice and dogs. Am J Clin Path. 12:1942;563-570.
10. BELL W.R., TOMASULA P.A., ALVING B.M., DUFFY T.P. Thrombocytopenia occurring during the administration of heparin: a prospective study of 52 patients. Ann Intern Med. 85:1976;155-160.
11. NELSON J.C., LERNER R.G., GOLDSTEIN R., CAGIN N.A. Heparin-induced thrombocytopenia. Arch Int Med. 138:1978;548-552.
12. MALCOM I.D., WIGMORE T.A., STEINBRECHER U.P. Heparin-associated thrombocytopenia. Canadian Med Assoc J. 120:1979;1086-1088.
13. POWERS P.J., CUTHBERT D., HIRSH J. Thrombocytopenia found uncommonly during heparin therapy. JAMA. 241:1979;2396-2397.
14. KING D.J., KELTON J.G. Heparin associated thrombocytopenia. Ann Intern Med. 100:1984;535-540.
15. CHANG J.C. White clot syndrome associated with heparin-induced thrombocytopenia: a review of 23 cases. Heart and Lung. 16:1987;403-407.
16. SIE P., FERNANDEZ F., CARANOBE C., GABAIG A.M., BONEW B. Inhibition of thrombin induced platelet aggregation and serotonin release by antithrombin III and heparin cofactor II in the presence of standard heparin, dermatan sulfate, and pentosan polysulfate. Thromb Res. 35:1984;231-236.
17. LJUNGBEREG B., BEBING H., EGBERG N., JOHNSSON H. Immediate effect of heparin and LMW heparin on some platelet and endothelial derived factors. Thromb Res. 51:1988;209-217.
18. FERNANDEZ F., N'GUYEN P., VAN RYN-MCKENNA J., OFOSU F., HIRSH J., BUCHANAN M. Haemorrhagic doses of heparin and other glycosaminoglycans induce a platelet defect. Thromb Res. 43:1986;491-495.
19. VAN RYN-MCKENNA J., OFOSUN F.A., HIRSH J., BUCHANAN M.R. Antithrombotic and bleeding effects of glycosaminoglycans with different degrees of sulphation. Br J Haematol. 71:1989;265-269.
20. JOHN L.C.H., REES G.M., KOVACS I.B. Inhibition of platelet function by heparin. J Thorac Cardiovasc Surg. 105:1993;816-822.
21. HELDEN D., MEILKE C.H., RODVIEN R. Impairment by heparin of primary hemostasis and platelet (C14) 5-hyproxytryptamine. Br J Haemotal. 36:1977;427-436.
22. SOBEL M., ADELMAN B. Characterization of platelet binding of heparins and other glysocaminoglycans. Thromb Res. 50:1988;815-826.
23. GOGSTAD G.O., SOLUM N.O., KRUTNES M.B. Heparin binding platelet proteins demonstrated by crossed affinity immunoelectrophoresis. Br J Haematology. 53:1983;563-573.
24. WOLF H., GLASSL H., WICK G. Identification of binding site for heparin and other polysulfated glycosaminoglycans on human thrombocytes. Int Arch Allergy Appl Immun. 80:1986;231-238.
25. GOROG P., AHMED A. Haemostatometer: A new in vitro technique for assessing haemostatic activity of blood. Thromb Res. 34:1984;341-357.
26. GOROG P. A new, ideal technique to monitor thrombolytic therapy. Angiology. 37:1986;99-105.
27. MUGA K.M., MELTON L.G., GABRIEL D.A. A flow dynamic technique used to assess global hemostasis. Blood Coag and Fibrinolysis. 6:1995;73-78.
28. LOTSPEICH-STEININGER, C.A., STIENE-MARTIN, E.A. and KOEPKE, J.A., ed. Clinical Hematology: principles, procedures, correlations. Philadelphia, PA: J B Lippincott, 1992:
29. MELTON L.G., MUGA K.M., GABRIEL D.A. Effect of contrast media on in vitro bleeding time: assessment by a hollow fiber instrument. Acad Radiol. 2:1995;239-243.
30. DAWSON P., HEWITT P., MACKIE I.J., MACHIN S.J., AMIN S., BRADSHAW A. Contrast, coagulation and fibrinolysis. Invest Radiol. 21:1986;248-252.
31. STORMORKEN H., SKOLPE J.O., TESTART M.C. Effect of various contrast media on coagulation, fibrinolysis and platelet function: an in vitro and in vivo study. Invest Radiol. 21:1986;348-354.
32. CHRONOS N.A.F., GOODALL A.H., WILSON D.J., SIGWART U., BULLER N.P. Profound platelet degranulation is an important side effect of some types of contrast media used in interventional cardiology. Circulation. 88:1993;2035-2044.
33. GRABOWSKI E.F. A hematologist's view of contrast media, clotting in angiography syringes and thrombosis during coronary angiography. Am J Cardiol. 66:1990;23F-25F.
34. DOOREY A.J., STILLABOWER M.E., GALE N., GOLDENBERG E.M. Catastrophic thrombus development despite systemic heparinization during coronary angioplasty: Possible relationship to nonionic contrast. Clin Cardiol. 15:1992;117-120.
35. GROLLMAN J., LIU C., ASTONE R., LURIE M. Thromboembolic complications in coronary angiography associated with the use of nonionic contrast media. Cathet Cardiovasc Diagn. 14:1988;159-164.
36. DAVIDSON, C.J., MARK, D.B., PEIPER, K.S., KISSLO, K., HLATKY, M.A., GABRIEL, D.A. and BASHORE, T.M. Thrombotic and cardiovascular complications related to nonionic contrast media during cardiac catheterization: Analysis of 8,517 patients. Am J Cardiol 1481-1484, 1990.
37. GASPERETTI C.M., FELDMAN M.D., BURWELL L.R., ANGELLO D.A., HAUGH K.H., OWEN R.M., POWERS E.R. Influence of contrast media on thrombus formation during coronary angioplasty. J Am Coll Cardiol. 18:1991;443-450.
38. ESPLUGAS E., CEQUIER A., JARA F., MAURI J., SOLER T., SALA J., SABATE X. Risk of thrombosis during coronary angioplasty with low osmolality contrast agents. Am J Cardiol. 68:1991;1020-1024.
39. PIESSENS J.H., STAMMEN F., VROLIX M.C., GLAZIER J.J., BENIT E., GEEST H.D., WILLEMS J.L. Effect of an ionic versus a nonionic low osmolar contrast agent on the thrombotic complications of coronary angioplasty. Cathet Cardiovasc Diagn. 28:1993;99-105.
40. investigators, AGUIRRE F.V., TOPOL E.J., DONOHUE T.J., KERN M.J., LEIMBERGER J.D., CALIFF R.M. Impact of ionic and non-ionic contrast media on post-PTCA ischemic complications: Results from an EPIC trial. J Am Coll Cardiol. 25:1995;8A. (abstract).
41. KOVACS I.B., HUTTON R.A., KERNOFF P.B.A. Hemostatic evaluation in bleeding disorders from native blood: clinical experience with the Haemostatometer. Am J Pathol. 91:1989;271-279.
42. NEMERSON Y., TURITTO V.T. The Effect of flow on hemostasis and thrombosis. Thromb and Haemostas. 66:1991;272-276.
43. GOROG P., KAKKAR V.V. Transient effect of aspirin on collagen-induced platelet accumulation. Am J Clin Pathol. 86:1986;311-316.
44. GOROG P., KOVACS I.B. Coagulation of flowing native blood: Advantages over stagnant (tube) clotting tests. Thromb Res. 64:1991;611-619.
45. JOHN L.C.H., REES G.M., KOVACS I.B. Effect of heparin on in vitro platelet reactivity in cardiac surgical patients: A comparative assessment by whole blood platelet aggregometry and haemostatometry. Thromb Res. 66:1992;649-656.
46. KOVACS I.B., GOROG P. Simultaneous measurement of all thrombosis parameters from native human blood: Usefulness in monitoring efficacy and complications of thrombolytic therapy. Angiology. 41:1990;829-835.
47. PETERS N.S., ABRAMS L.S.M., DYMOND D.S., KOVACS I.B. Platelet hyperreactivity and inefficient spontaneous thrombolysis in patients at high risk from an acute coronary event. Cardiovasc Res. 23:1989;567-572.
48. RATNATUNGA C.P., EDMONDSON S.F., REES G.M., KOVACS I.B. High-dose aspirin inhibits shear-induced platelet reaction involving thrombin generation. Circulation. 85:1992;1077-1082.
49. VACEK J.L., BELLINGER R.L., PHELIX J. Heparin bolus therapy during cardiac catheterization. Am J Cardiol. 62:1988;1314-1317.
50. DOUGHERTY K.G., GAOS C.M., BUSH H.S., LEACHMAN D.R., FERGUSON J.J. Activated clotting times and activated partial thromboplastin times in patients undergoing coronary angioplasty who receive bolus doses of heparin. Cathet Cardiovasc Diagn. 26:1992;260-263.
51. OGILBY J.D., KOPELMAN H.A., KLEIN L.W., AGARWAL J.B. Adequate heparinization during PTCA: Assessment using activated clotting times. Cathet Cardiovasc Diagn. 18:1989;206-209.
52. ING J.J., SMITH D.C., BULL B.S. Differing mechanisms of clotting inhibition ionic and nonionic contrast agents. Radiology. 172:1989;345-348.
53. COROT C., PERRIN J.M., BELLEVILLE J., AMIEL M., ELOY R. Effect of iodinated contrast media on blood clotting. Invest Radiol. 24:1989;390-393.
54. BELLEVILLE J., BAQUET J., PAUL J., CLENDINNEN G., ELOY R. In vitro study of the inhibition of coagulation induced by different radiocontrast molecules. Thromb Res. 38:1985;149-162.
55. GRANGER C.B., GABRIEL D.A., REESE N.S., BOOTHROYD E., HARDING M.B., HARRISON K., KONG Y., BASHORE T.M. Fibrin modification by ionic and nonionc contrast media during cardiac catheterization. Am J Cardiol. 69:1992;821-823.
56. GABRIEL D.A., JONES M.A., REESE N., BOOTHROYD E., BASHORE T.M. Platelet and fibrin modification by radiographic contrast media. Circ Res. 68:1991;881-887.
57. ELOY R., COROT C., BELLEVILLE J. Contrast media for angiography: Physiochemical properties, pharmacokinetics and biocompatibility. Clinical Materials. 7:1991;89-107.
58. GRABOWSKI E.F., RODRIGUEZ M., MCDONNELL S.L. Platelet adhesion/aggregation in an in vitro model of coronary artery stenosis. Cathet Cardiovasc Diagn. 28:1993;65-71.
59. SHERRY S. Clinical aspects of antiplatelet therapy. Semin Haematol. 22:1985;125-134.
60. MINAR E., EHRINGER H., JUNG M., KOPPENSTEINER R., STUMPFEN A. Lack of influence of low-dose acetylsalicylic acid (100 mg daily) on platelet survival time, β-thromboglobulin and platelet factor 4 in patients with peripheral arterial occlusive disease. Thromb Res. 52:1988;219-226.
61. KUPPER A.J.F., VERHEUGT F.W.A., PEELS C.H., GALEMA T.W., HOLLANDER W., ROOS J.P. Effect of low dose acetylsalicylic acid on the frequency and hematologic activity of left ventricular thrombus in anterior wall acute myocardial infarction. Am J Cardiol. 63:1989;917-920.
62. BOYSEN G., SOELBERG S.P., JUHLER M., ANDERSEN A.R., BOAS J., OLSEN J.S., JOENSEN P. Danish very-low-dose aspirin after carotid endarterectomy trial. Stroke. 19:1988;1211-1215.
63. GABRIEL D.A., REECE N.S., LI X., WITTE J.H., MUGA K.M. Electrophoretic light scattering studies on the interaction of fibrinogen with resting and activated human platelets. Blood Coag Fibrinolysis. 4:1993;397-403.
64. the Co-investigators of the National Heart LaBIPTCAR, DETRE K., HOLUBKOV R., KELSEY S.et al. Percutaneous transluminal coronary angioplasty in 1985-1986 and 1977-1981: the National Heart, Lung and Blood Institute Registry. N Engl J Med. 318:1988;265-270.