The panic-inducing properties of the cholecystokinin tetrapeptide CCK4 in patients with panic disorder

European Neuropsychopharmacology

Volumn 6, Issue 3, 1996, Pages 187-194

  Van Megen, Harold J G M ^a   Westenberg, Herman G M ^a   Den Boer, Johan A ^a   Kahn, René S ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

CCK4; Human study; Neuropeptide; Panic disorder

Indexed keywords

4 HYDROXY 3 METHOXYPHENYLETHYLENE GLYCOL; CHOLECYSTOKININ RECEPTOR BLOCKING AGENT; PLACEBO; TETRAGASTRIN;

ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; LOCUS CERULEUS; MALE; PANIC; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL;

EID: 0030220613     PISSN: 0924977X     EISSN: None     Source Type: Journal    
DOI: 10.1016/0924-977X(96)00018-1     Document Type: Article

References (54)

1. Abelson, J.L. and Nesse, R.M. (1990) Cholecystokinin-4 and panic. Arch. Gen. Psychiat. 47, 395.
2. Abelson, J.L., Nesse, R.M. and Vinik, A. (1991) Stimulation of corticotropin release by pentagastrin in normal subjects and patients with panic disorder. Biol. Psychiat. 29, 1220-1223.
3. Abelson, J.L., Nesse, R.M. and Vinik, A. (1994) Pentagastrin infusion in patients with panic disorder. II. Neuroendocrinology. Biol. Psychiat. 36, 84-96.
4. American Psychiatric Association (1987) Diagnostic and Statistical Manual of Mental Disorders (DSM-IIIR). Washington, DC.
5. Appleby, I., Klein, D.F., Sachar, E. and Levitt, M. (1981) Biochemical indices of lactate-induced panic: a preliminary report. In: Klein DF, Rabkin (Eds.), Anxiety: New Research and Changing Concepts. Raven, New York.
6. Asmundson, G.J.G. and Stein, M.B. (1994) Vagal attenuation in panic disorder: an assessment of parasympatic nervous system functioning and subjective reactivity to respiratory manipulations. Psychosom. Med. 56, 187-194.
7. Bradwejn, J., Koszycki, D. and Meterissian, G. (1990) Cholecystokinin tetrapeptide induces panic attacks in patients with panic disorder. Can. J. Psychiat. 35, 83-85.
8. Bradwejn, J., Koszycki, D. and Shriqui, C. (1991) Enhanced sensitivity to cholecystokinin tetrapeptide in panic disorder. Arch. Gen. Psychiat. 48, 603-610.
9. Bradwejn, J., Koszycki, D., Annable, L., Couëtoux du Tertre, A., Reines, S. and Karkanias, C. (1992) A dose-ranging study of the behavioral and cardiovascular effects of CCK-4 in panic disorder. Biol. Psychiat. 32, 903-912.
10. Bradwejn, J., Koszycki, D., Couetoux du Tertre, A., Van Megen, H.J.G.M., Westenberg, H.G.M., Den Boer, J.A., Karkanias, C. and Haigh, J. (1994) The panicogenic effects of cholecystokinin tetrapeptide are antagonized by L-365,260, a central cholecystokinin receptor antagonist in patients with panic disorder. Arch. Gen. Psychiatry 51, 486-493.
11. Chambless, D.L., Caputo, G.C., Bright, P. and Gallanghar, R. (1984) Assessment of fear in agoraphobics: the bodily sensations questionnaire and the agoraphobic cognition questionnaire. J. Consul. Clin. Psychiatry 6, 1090-1097.
12. Chopin, Ph. and Briley, M. (1993) The benzodiazepine antagonist flumazenil blocks the effects of CCK receptor agonists and antagonists in the elevated plus-maze. Psychopharmacology 110, 409-414.
13. Clark, D.A. (1988) A cognitive model of panic attacks. In: S. Rachmann and J.D. Maser (Eds.), Panic. Psychological Perspectives, Lauwrence Erlbaum Ass., Publ., Hillsdale, pp. 71-89.
14. Charney, D.S., Heninger, G.R. and Redmond, D.E. (1983) Yohimbine induced and increased noradrenergic function in humans: effects of diazepam and clonidine. Life Sci. 33, 19-29.
15. Costall, B., Domeney, A.M., Hughes, J., Kelly, M.E., Naylor, R.J. and Woodruff, G.N. (1991) Anxiolytic effects of CCK-B antagonists. Neuropeptides 19 (Suppl.), 65-73.
16. Cowley, D.S., Hyde, T.S., Dager, S.R. and Dunner, D.L. (1987) Lactate infusion: the role of baseline anxiety. Psychiat. Res. 21, 169-179.
17. 125I-Bolton-Hunter labelled cholecystokinin binding in human brain. Neuropeptides 11, 249-252.
18. Csonka, E., Fekete, M., Nagy, G.Y., Szanto-Fekete, M., Telegdy, G., Penke, B. and Kovacs, K. (1988) Anxiogenic effect of cholecystokinin in rats. Peptides 249-252.
19. Daugé, V., Steimes, P., Derrien, M., Beau, N., Roques, B.P. and Féger, J. (1989) CCK-8 effects on motivational and emotional states of rats involve CCK-A receptors of the postero-median part of the nucleus accumbens. Pharmacol. Biochem. Behav. 34, 157-163.
20. Degli Uberti, E.C., Transforini, G., Margutti, A.R. and Pansini, R. (1983) Effect of pentagastrin on adenocorticotropin hormone and thyroid-stimulating hormone release in normal subjects. Hormone Res. 17, 74-77.
21. De Montigny, C. (1989) Cholecystokinin tetrapeptide induces panic like attacks in healthy volunteers. Arch. Gen. Psychiatry 46, 511-517.
22. Den Boer, J.A., Westenberg, H.G.M., Klompmakers, A.A. and van Lint, L.E.M. (1989) Behavioral biochemical and neuroendocrine concomitants of lactate-induced panic anxiety. Biol. Psychiatry 26, 612-622.
23. Dooley, D.J. and Klamt, I. (1993) Differential profile of the CCK-B receptor antagonist CI-988 and diazepam in the four-plate test. Psychopharmacology 112, 452-454.
24. Dourish, C.T., Rycroft, W. and Iversen, S.D. (1989) Postponement of satiety by blockade of brain cholecystokinin (CCK-B) receptors. Science 235, 1509-1511.
25. Emson, P.C., Rehfeld, J.F. and Rossor, M.N. (1982) Distribution of cholecystokinin in the human brain. J. Neurochem, 38, 1177-1179.
26. Fried, M., Schwizer, W., Beglinger, C., Keller, U., Jansen, J.B. and Lamers, C.B. (1991) Physiological role of cholecystokinin on post-prandial insulin secretion and gastric meal emptying in man. Studies with the cholecystokinin receptor agonist loxiglumide. Diabetologia 34, 721-726.
27. Goddard, A.W., Woods, S.W., Sholomskas, D.E., Goodman, W.K., Charney, D.S. and Heninger, G.R. (1993) Effects of serotonin reuptake inhibitor fluvoxamine on yohimbine-induced anxiety in panic disorder. Psychiat. Res. 48, 119-133.
28. B receptors mediate the regulation of exploratory behaviour in the rat. Eur. J. Pharmacol. 193, 379-381.
29. Harro, J., Pold, M. and Vasar, E. (1990) Anxiogenic-like action of caerulein, a CCK-8 receptor agonist in the mouse: influence of acute and subchronic diazepam treatment. Naunyn-Schmiedeberg's Arch. Pharmacol. 341, 62-67.
30. Hsiao, S., Katsuura, G. and Itoh, S. (1984) Cholecystokinin tetrapeptide, proglumide and open-field behaviour in rats. Life Sci. 34, 2165-2168.
31. Hökfelt, T., Skirrboil, L. and Everitt, B. (1985) Distribution of cholecystokinin-like immunoreactivity in the nervous system: co-existence with classical neurotransmitters and other neuropeptides, Trans. NY Acad. Sci. 448, 255-274.
32. Hughes, J., Boden, P., Costall, B., Domeney, A., Kelly, E., Horwell, D.C., Hunter, J.C., Pinnock, R.D. and Woodruff, G.N. (1990) Development of the class of selective cholecystokinin type B receptor antagonist having anxiolytic activity. Proc. Natl. Acad. Sci. USA 87, 6728-6732.
33. Kahn, R.S., Asnis, G.M., Wetzler, S. and Van Praag, H.M. (1988) Neuroendocrine evidence for serotonin receptor hypersensitivity in panic disorder. Psychopharmacology 96, 360-364.
34. Kendrick, K., Leng, G. and Higuchi, T. (1991) Noradrenaline, dopamine and serotonin release in the paraventricular and supraoptic nuclei of the rat in response to intravenous cholecystoklinin injections. J. Neuroendocrinol. 3, 139-144.
35. Liebowitz, M.R., Gorman, J.M., Fyer, A.J., Levitt, M., Dillon, D. and Levy, G. (1985) Lactate provocation of panic attacks. II. Biochemical and physiological findings. Arch. Gen. Psychiatry 42, 709-719.
36. Lines, C., Challenor, J. and Traub, M. (1995) Cholecystokinin and anxiety in normal volunteers: an investigation of the anxiogenic properties of pentagastrin and reversal bycholecystokinin receptor subtype B antagonist L-365,260. Br. J. Pharmacol. 39, 235-242.
37. Moran, T.H., Robinson, P.H., Goldrich, M.S. and McHugh, P.R. (1986) Two brain cholecystokinin receptors: implications for behavioral actions. Brain Res. 362, 175-179.
38. Morley, J.E., Levine, A.S., Kneip, N.J. and Grace, M. (1982) The effects of vagotomy on the satiety effects of neuropeptides and nalaxone. Life Sci. 30, 1943-1947.
39. Palmour, R.M., Bradwejn, J. and Ervin, F.R. (1992) The anxiogenic effects of CCK-4 in monkeys are reduced by CCK-B antagonists, benzodiazepines or adenosine A2 agonists. Eur. Neuropsychopharmacol. 2, 193-195.
40. Powell, K.R. and Barrett, J.E. (1991) Evaluation of the effect of PD 134308 (CI-988), a CCK-B antagonist, on the punished responding of squirrel monkeys. Neuropeptides 19, 75-78.
41. Rasmussen, K., Helton, D.R., Berger, J.E. and Scearce, E. (1993) The CCK-B antagonist LY288513 blocks effects of the diazepam withdrawal on auditory startle. Neuroreport 5, 154-156.
42. Rehfeld, J.F. (1985) Neural cholecystokinin: one or multiple transmitters? Short review. J. Neurochem. 44, 1-10.
43. Rex, A., Fink, H. and Marsden, C.A. (1994) Effects of BOC-CCK-4 and L-365,260 on cortical 5-HT release in guinea pigs on exposure to the elevated plus maze. Neuropharmacology 33, 559-565.
44. Rupniak, N.M.J., Schaffer, L., Siegl, P. and Iversen, S.D. (1993) Failure of intravenous pentagastrin challenge to induce panic-like effects in Rhesus monkeys. Neuropeptides 25, 115-119.
45. Sanderson, W.C., Rapee, R.M. and Barlow, D.H. (1989) The influence of an illusion of control on panic attacks induced via inhalation of 5.5% carbon dioxide-enriched air. Arch. Gen. Psychiatry 46, 157-162.
46. Singh, L., Field, M.J., Hughes, J., Menzies, R., Oles, R.J., Vass, C.A. and Woodruff, G.N. (1991) The behaviour properties of CI-988, a selective cholecystokinin receptor antagonist. Br. J. Pharmacol. 104, 239-245.
47. Targum, S.D. and Marshall, L.E. (1989) Fenfluramine provocation of anxiety in patients with panic disorder. Psychiat. Res. 28, 295-306.
48. Thijssen, J.H.H., Van den Berg, J.H.M. and Adlercreutz, J. (1980) Determination of cortisol in human plasma: evaluation and comparison of seven assays. Clin. Chim. Acta 100, 39-46.
49. Vanderhaeghen, J.J., Signeau, J.C. and Gepts, W. (1975) New peptide in the vertebrate CNS reacting with antigastrin antibodies. Nature 257, 604-605.
50. Van Megen, H.J.G.M., Westenberg, H.G.M. and Den Boer, J.A. (1994a) Pentagastrin induced panic attacks; enhanced sensitivity in panic disorder patients. Psychopharmacology 114, 449-455.
51. Van Megen, H.J.G.M., Westenberg, H.G.M. and Den Boer, J.A. (1994b) Effect of the selective serotonin reuptake inhibitor (SRRI) fluvoxamine on CCK-4 induced panic attacks. CINP 1994 Psychopharmacol. 10, 270.
52. Woodruff, G.N. and Hughes, J. (1991) Cholecystokinin antagonists. Annu. Rev. Pharmacol. Toxicol. 31, 469-501.
53. Woods, S.W., Charney, D.S., McPerson, C.A., Gradman, A.H. and Heninger, G.R. (1987) Situational panic attacks. Behavioural, physiologic and biochemical characterization. Arch. Gen. Psychiatry 44, 365-375.
54. Woods, S.W., Charney, D.S., Goodman, W.K. and Heniger, G.R. (1988) Carbon dioxide-induced anxiety: behavioral, physiologic, and biochemical effects of carbon dioxide in patients with panic disorder and healthy volunteers. Arch. Gen. Psychiatry 45, 43-52.