Pheromone transduction in the vomeronasal organ

Current Opinion in Neurobiology

Volumn 6, Issue 4, 1996, Pages 487-493

  Liman, Emily R ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PHEROMONE;

MOLECULAR CLONING; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR GENE; REVIEW; SECOND MESSENGER; SIGNAL TRANSDUCTION; VOMERONASAL ORGAN;

EID: 0030219765     PISSN: 09594388     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-4388(96)80054-7     Document Type: Article

References (63)

1. Meredith M, O'Connell RJ. Efferent control of stimulus access to the hamster vomeronasal organ. J Physiol (Lond). 286:1979;301-316.
2. Barber PC, Raisman G. Cell division in the vomeronasal organ of the adult mouse. Brain Res. 141:1977;58-66.
3. Wysocki CJ. Neurobehavioral evidence for the involvement of the vomeronasal system in mammalian reproduction. Neurosci Biobehav Res. 3:1978;301-341.
4. Keverne EB. Pheromonal influences on the endocrine regulation of reproduction. Trends Neurosci. 6:1983;381-384.
5. Meredith M. Sensory processing in the main and the accessory olfactory systems: comparisons and contrasts. J Steroid Biochem Mol Biol. 39:1991;601-614.
6. Halpern M. The organization and function of the vomeronasal system. Annu Rev Neurosci. 10:1987;325-362.
7. Wysocki CJ, Meredith M. The vomeronasal system. Finger TE, Silver WL. Neurobiology of Taste and Smell. 1987;125-150 John Wiley & Sons, New York.
8. Karlson P, Luscher M. `Pheromones': a new term for a class of biologically active substances. Nature. 183:1959;55-56.
9. Powers JB, Winans SS. Vomeronasal organ: critical role in mediating sexual behavior of the male hamster. Science. 187:1975;961-963.
10. Moran DT, Jafek BW, Rowley JC. The vomeronasal (Jacobson's) organ in man: ultrastructural and frequency of occurrence. J Steroid Biochem Mol Biol. 39:1991;545-552.
11. Stensaas LJ, Lavker RM, Monti-Bloch L, Grosser BI, Berliner DL. Ultrastructure of the human vomeronasal organ. J Steroid Biochem Mol Biol. 39:1991;671-679.
12. Garcia-Velasco J, Mondragom M. The incidence of the vomeronasal organ in 1000 human subjects and its possible clinical significance. J Steroid Biochem Mol Biol. 39:1991;561-563.
13. Monti-Bloch L, Jennings-White C, Dolberg DS, Berliner DL. The human vomeronasal system. Psychoneuroendocrinology. 19:1994;673-686.
14. McClintock M. Menstrual synchrony and suppression. Nature. 229:1971;244-245.
15. Getchell TV, Shepherd GM. Adaptive properties of olfactory receptors analysed with odour pulses of varying durations. J Physiol (Lond). 282:1978;541-560.
16. Tucker D. Nonolfactory responses from the nasal cavity: Jacobson's organ and the trigeminal system. Beidler LM. Chemical Senses Part 1 - Olfaction. 4:1971;151-181 Springer-Verlag, Berlin.
17. Inouchi J, Wang D, Jiang XC, Kubie J, Halpern M. Electrophysiological analysis of the nasal chemical senses in garter snakes. Brain Behav Evol. 41:1993;171-182.
18. Trotier D, Doving KB, Rosin J. Voltage-dependent currents in microvillar receptor cells in the frog vomeronasal organ. Eur J Neurosci. 5:1993;995-1002.
19. Liman ER, Corey DP. Electrophysiological characterization of chemosensory neurons from the mouse vomeronasal organ. of special interest J Neurosci. 1996; In a first report of patch-clamp recordings from mammalian vomeronasal neurons, the authors describe differences between the electrical properties of vomeronasal neurons and olfactory neurons, including differences in firing properties and in voltage-gated currents. In addition, they report that there is no evidence of cyclic-nucleotide-gated channels in vomeronasal neurons.
20. Taniguchi M, Kashiwayanagi M, Kurihara K. Intracellular dialysis of cyclic nucleotides induces inward currents in turtle vomeronasal receptor neurons. of special interest J Neurosci. 16:1996;1239-1246 Using turtle vomeronasal receptors in a slice preparation, the authors report the presence of a cyclic-nucleotide-gated current that resembles the olfactory cAMP-gated current. Further work will need to establish whether these cells really are the equivalent of mammalian vomeronasal cells (i.e. by using molecular tools to examine the expression of receptors and transduction components), and, if so, to describe in more detail the properties of this cyclic-nucleotide-gated current.
21. Lynch JW, Barry PH. Action potentials initiated by single channels opening in a small neuron (rat olfactory receptor). Biophys J. 55:1989;755-768.
22. + pump, which hyperpolarizes the membrane potential. This allows the cells to maintain a high input resistance at the resting potential, and thus to be sensitive to small transduction currents.
23. Buck LB. Information coding in the olfactory system. of special interest Annu Rev Neurosci. 19:1996;517-544 A comprehensive review of the current state of understanding of transduction and information coding in the olfactory system, with emphasis on molecular approaches.
24. Jiang XC, Inouchi J, Wang D, Halpern M. Purification and characterization of a chemoattractant from electric shock-induced earthworm secretion, its receptor binding, and signal transduction through the vomeronasal system of garter snakes. J Biol Chem. 265:1990;8736-8744.
25. Luo Y, Lu S, Chen P, Wang D, Halpern M. Identification of chemoattractant receptors and G-proteins in the vomeronasal system of garter snakes. J Biol Chem. 269:1994;16867-16877.
26. Novotny N, Jemiolo B, Harvey S. Chemistry of rodent pheromones: molecular insights into the chemical signalling in mammals. Macdonald DW, Muller-Schwarze D, Natynczuk SE. Chemical Signals in Vertebrates. 5:1990;1-22 Oxford University Press, Oxford.
27. Singer AG. A chemistry of mammalian pheromones. J Steroid Biochem Mol Biol. 39:1991;627-632.
28. Taniguchi M, Kashiwayanagi M, Kurihara K. Intracellular injection of inositol 1,4,5-trisphosphate increases a conductance in membranes of turtle vomeronasal receptor neurons in the slice preparation. Neurosci Lett. 188:1995;5-8.
29. Buck L, Axel R. A novel multigene family may encode odorant receptors: a molecular basis for odor recognition. Cell. 65:1991;175-187.
30. Dulac C, Axel R. A novel family of genes encoding putative pheromone receptors in mammals. of outstanding interest Cell. 83:1995;195-206 A groundbreaking study describing putative pheromone receptors in the vomeronasal organ. With no structural information available, a cloning strategy was based on the assumption that individual cells would express different receptors. A novel family of seven-transmembrane receptors was identified that bears no sequence identity to any other known receptors and is expressed exclusively in the vomeronasal organ.
31. Kishimoto J, Cox H, Keverne EB, Emson PC. Cellular localization of putative odorant receptor mRNAs in olfactory and chemosensory neurons: a non-radioactive in situ hybridization study. Mol Brain Res. 23:1994;33-39.
32. Brady G, Barbara M, Iscove N. Representative in vitro cDNA amplification from individual hemopoietic cells and colonies. Methods Mol Cell Biol. 2:1990;17-25.
33. Troemel ER, Chou JH, Dwyer ND, Colbert HA, Bargmann CI. Divergent seven transmembrane receptors are candidate chemosensory receptors in C. elegans. Cell. 83:1995;207-218.
34. Reed RR. Signaling pathways in odorant detection. Neuron. 8:1992;205-209.
35. Ronnett GV, Snyder SH. Molecular messengers of olfaction. Trends Neurosci. 15:1992;508-513.
36. Liman ER, Buck LB. A second subunit of the olfactory cyclic nucleotide-gated channel confers high sensitivity to cAMP. Neuron. 13:1994;611-621.
37. Bradley J, Li J, Davidson N, Lester H, Zinn K. Heteromeric olfactory cyclic nucleotide-gated channels: a subunit that confers increased sensitivity to cAMP. Proc Natl Acad Sci USA. 91:1994;8890-8894.
38. Ryba NJ, Tirindelli R. A novel GTP-binding protein γ-subunit, G γ 8, is expressed during neurogenesis in the olfactory and vomeronasal neuroepithelia. of special interest J Biol Chem. 270:1995;6757-6767 Reports the cloning of a novel G-protein γ subunit (γ 8) that is expressed in the olfactory epithelium and vomeronasal organ. Based on the temporal, and spatial distribution of γ 8, the authors suggest that it is likely to play a role in development.
39. αolf or the cyclic-nucleotide-gated channel subunit 1 (or α), and adenylyl cyclase III expression is restricted to supporting cells. Subunit 2 (or β) of the cyclic-nucleotide-gated channel is expressed in mature vomeronasal neurons.
40. Wu YM, Tirindelli R, Ryba NJP. Evidence for different chemosensory signal transduction pathways in olfactory and vomeronasal neurons. of special interest Biochem Biophys Res Commun. 220:1996;900-904 The authors present similar findings to [39], using different methods.
41. αo.
42. αo in non-overlapping portions of the epithelium and of adenylyl cyclase II throughout the epithelium.
43. Johnson EW, Eller PM, Jafek BW, Norman AW. Calbindin-like immunoreactivity in two peripheral chemosensory tissues of the rat: taste buds and the vomeronasal organ. Brain Res. 572:1992;319-324.
44. Kishimoto J, Keverne EB, Emson PC. Calretinin, calbindin-D28k and parvalbumin-like immunoreactivity in mouse chemoreceptor neurons. Brain Res. 610:1993;325-329.
45. Hille B. G-protein-coupled mechanisms and nervous signaling. Neuron. 9:1992;187-195.
46. Ache B, Zhainazarov A. Dual second-messenger pathways in olfactory transduction. Curr Opin Neurobiol. 5:1995;461-466.
47. Sternweis PC. The active role of βγ in signal transduction. Curr Opin Cell Biol. 6:1994;198-203.
48. Wickman K, Clapham DE. Ion channel regulation by G-proteins. Physiol Rev. 75:1995;865-885.
49. Bertmar G. Evolution of vomeronasal organs in vertebrates. Evolution. 35:1981;359-366.
50. Eisthen HL. Phylogeny of the vomeronasal system and of receptor cell types in the olfactory and vomeronasal epithelia of vertebrates. Microsc Res Tech. 23:1992;1-21.
51. o in the accessory olfactory bulb of the rat. J Neurosci. 12:1992;1275-1279.
52. Fernandez-Fewell GD, Meredith M. c-fos expression in vomeronasal pathways of mated or pheromone-stimulated male golden hamsters: contributions from vomeronasal sensory input and expression related to mating performance. J Neurosci. 14:1994;3643-3654.
53. Wysocki CJ, Wellington JL, Beauchamp GK. Access of urinary nonvolatiles to the mammalian vomeronasal organ. Science. 207:1980;781-783.
54. Mucignat-Caretta C, Caretta A, Cavaggioni A. Acceleration of puberty onset in female mice by male urinary proteins. J Physiol (Lond). 486:1995;517-522.
55. Henzel WJ, Rodriguez H, Singer AG, Stults JT, Macrides F, Agosta WC, Niall H. The primary structure of aphrodisin. J Biol Chem. 263:1988;16682-16687.
56. Pevsner J, Reed RR, Feinstein PG, Snyder SH. Molecular cloning of odorant-binding protein: member of a ligand carrier family. Science. 241:1988;336-339.
57. Khew-Goodall Y, Grillo M, Getchell ML, Danho W, Getchell TV, Margolis FL. Vomeromodulin, a putative pheromone transporter: cloning, characterization, and cellular localization of a novel glycoprotein of lateral nasal gland. FASEB J. 5:1991;2976-2982.
58. Dear TN, Boehm T, Keverne EB, Rabbits TH. Novel genes for potential ligand-binding proteins in subregions of the olfactory mucosa. EMBO J. 10:1991;2813-2819.
59. Miyawaki A, Matsushita F, Ryo Y, Mikoshiba K. Possible pheromone-carrier of two lipocalin proteins in the vomeronasal organ. EMBO J. 13:1994;5835-5842.
60. Rama Krishna NS, Getchell ML, Getchell V. Expression of the putative pheromone and odorant transporter vomeromodulin mRNA and protein in nasal chemosensory Mucosae. J Neurosci Res. 39:1994;243-259.
61. Bocskei Z, Groom CR, Flower DR, Wright CE, Phillips SE, Cavaggioni A, Findlay JB, North AC. Pheromone binding to two rodent urinary proteins revealed by X-ray crystallography. Nature. 360:1992;186-188.
62. Raming K, Krieger J, Strotmann J, Boekhoff I, Kubick S, Baumstark C, Breer H. Cloning and expression of odorant receptors. Nature. 361:1993;353-356.
63. Vaccarezza OL, Sepich LN, Tramezzani JH. The vomeronasal organ of the rat. J Anat. 132:1981;167-185.