Induction of mono-oxygenase activity in prostaglandin H synthase-competent ovine seminal vesicle cell cultures by 2,3,7,8-tetrachlorodibenzo-p-dioxin

Toxicology in Vitro

Volumn 10, Issue 4, 1996, Pages 415-421

  Schuhmacher, U S ^a   Foth, J ^a,b   Seiderer, C ^a,c   Cikryt, P ^a,d   Degen, G H ^a  

^a Inst fur A   (Germany)

^b Inst Dr Nuss ^*  (Germany)

^c UNIVERSITY OF WÜRZBURG   (Germany)

^d Hessisches Landesamt fur Umwelt und Geologie   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; PROSTAGLANDIN SYNTHASE; UNSPECIFIC MONOOXYGENASE;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL GROWTH; CONTROLLED STUDY; ENZYME INDUCTION; IN VITRO STUDY; MALE; NONHUMAN; SEMINAL VESICLE; SHEEP;

EID: 0030219125     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/0887-2333(96)00017-3     Document Type: Article

References (29)

1. Bradford M. M. (1976) A rapid and sensitive method for the quantitation of microgram quantities of proteins utilizing a principle of protein dye binding. Analytical Biochemistry 72, 248-254.
2. Christ E. J. and Van Dorp D. A. (1972) Comparative aspects of prostaglandin biosynthesis in animal tissues. Biochimica et Biophysica Acta 270, 537-545.
3. Degen G. H. (1993) SEMV cell cultures: a model for studies of prostaglandin-H synthase-mediated metabolism and genotoxicity of xenobiotics. Toxicology Letters 67, 187-200.
4. Degen G. H., Eling T. E. and McLachlan J. A. (1982) Oxidative metabolism of diethyl-stilbestrol by prostaglandin synthetase. Cancer Research 42, 919-923.
5. Degen G. H., Gerber M. M. and Schuhmacher U. S. (1995) Investigations on the competence of seminal vesicle cell cultures and their use for in vitro micronucleus-and cytotoxicity assays. 15. Jahrestagung der Gesellschaft für Umwelt-und Mutationsforschung (GUM) Tierversuche in der Mutations-und Krebsforschung: Notwendigkeit und in vitro Alternativen. p. 21. Abstracts. Gmunden am Traunsee, Austria.
6. Eling T. E., Thompson D. C., Foureman G. L., Curtis J. F. and Hughes M. F. (1990) Prostaglandin H synthase and xenobiotic oxidation. Annual Review of Pharmacology and Toxicology 30, 1-45.
7. Foth J. and Degen G. H. (1991) Prostaglandin H synthase dependent metabolism of diethylstilbestrol by ram seminal vesicle cell cultures. Archives of Toxicology 65, 344-347.
8. Foth J., Schnitzler R., Jager M., Koob M., Metzler M. and Degen G. H. (1992) Characterization of sheep seminal vesicle cells - a new tool for studying genotoxic effects in vitro. Toxicology in Vitro 6, 219-225.
9. Freyberger A., Schnitzler R., Schiffmann D. and Degen G. H. (1987) Prostaglandin-H-synthase competent cells derived from ram seminal vesicles: a tool for studying cooxidation of xenobiotics. Molecular Toxicology 1, 503-512.
10. Göttlicher M., Cikryt P. and Wiebel F. J. (1990) Inhibition of growth by 2,3,7,8-tetra-chlorodibenzo-p-dioxin in 5L rat hepatoma cells is associated with the presence of Ah receptor. Carcinogenesis 11, 2205-2210.
11. Göttlicher M., Friesel H., Hecker E. and Cikryt P. (1989) Affinity of anthracene, benz[a]anthracene and derivatives to the rat hepatic cytosolic aromatic hydrocarbon (Ah) receptor. Journal of Cancer Research and Clinical Oncology, 115, Suppl. S9.
12. Guengerich F. G. and Shimada T. (1991) Oxidation of toxic and carcinogenic chemicals by human cytochrome P-450 enzymes. Chemical Research in Toxicology 4, 391-407.
13. Hammond D. K. and Strobel H. W. (1992) Ethoxyresorufin O-deethylase activity in intact human cells. Toxicology in Vitro 6, 41-46.
14. Harper P. A., Golas C. L. and Okey A. B. (1988) Characterization of the Ah receptor and aryl hydrocarbon hydroxylase induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin and benz(a)anzthracene in the human A431 squamous cell carcinoma line. Cancer Research 48, 2388-2395.
15. Harris M., Zacharewski T. and Safe S. (1990) Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin and related compounds on the occupied nuclear estrogen receptor in MCF-7 human breast cancer cells. Cancer Research 50, 3579-3584.
16. Knutson J. C. and Poland A. (1980) 2,3,7,8-Tetrachlorodibenzo-p-dioxin: failure to demonstrate toxicity in twenty-three cultured cell types. Toxicology and Applied Pharmacology 54, 377-383.
17. Kraemer S. A., Meade E. A. and DeWitt D. L. (1992) Prostaglandin endoperoxide synthase gene structure: identification of the transcriptional start site and 5′-flanking regulatory sequences. Archives of Biochemistry and Biophysics 293, 391-400.
18. Labarca C. and Paigen K. (1980) A simple, rapid and sensitive DNA assay procedure. Analytical Biochemistry 102, 344-352.
19. Lipp H.-P., Schrenk D., Wiesmüller T., Hagenmaier H. and Bock K. W. (1992) Assessment of biological activities of mixtures of polychlorinated dibenzo-p-dioxins (PCDDs) and their constituents in human HepG2 cells. Archives of Toxicology 66, 220-223.
20. Marple L., Brunck R. and Blaine K. M. (1986) Water solubility of 2,3,7,8-tetrachloro-p-dioxin. Environmental Science and Technology 20, 180-182.
21. Muster W. (1992) Biochemische Untersuchungen zu den nicht-gentoxischen Wirkungen des kompletten Kanzerogens 2-Acetylaminoflouren in vivo und in vitro (dissertation). Universität Würzburg.
22. Okey A. B. (1990) Enzyme induction in the cytochrome P-450 system. Pharmacology and Therapeutics 45, 241-298.
23. Okey A. B., Riddick D. S. and Harper P. A. (1994) The Ah receptor: mediator of the toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and related compounds. Toxicology Letters 70, 1-22.
24. Schrenk D., Lipp H.-D., Wiesmüller T., Hagenmaier H. and Bock K. W. (1991) Assessment of biological activities of mixtures of polychlorinated dibenzo-p-dioxins: comparison between defined mixtures and their constituents. Archives of Toxicology 65, 114-118.
25. Seiderer C. (1995). Untersuchungen zum molekularen Wirkmechanismus von 2,3,7,8-Tetrachlordibenzoparadioxin im Modellsystem der Dioxin-empfindlichen 5L-Rattenhepatomzellinie (dissertation). Universität Würzburg.
26. Smith B. J., Curtis J. F. and Eling T. E. (1991) Bioactivation of xenobiotics by prostaglandin H synthase. Chemico-Biological Interactions 79, 245-264.
27. Shopsis C. and Eng B. (1985) Rapid cytotoxicity testing using a semi-automated protein determination on cultured cells. Toxicology Letters 26, 1-8.
28. Wortelboer H. M., De Kruif C. A., Van Iersel A. A. J., Falke H. E., Noordhoek J. and Blaauboer B. J. (1990) The isoenzyme pattern of cytochrome P450 in rat hepatocytes in primary culture, comparing different enzyme activities in microsomal incubations and intact monolayers. Biochemical Pharmacology 40, 2525-2534.
29. Yang J. H., Rhim J. S. and Dritschilo A. (1992) Characterization of transformed human keratinocyte cell line by TCDD. In 12th International Symposium on Dioxins and Related Compounds. Vol. 1. Organohalogen Compounds. pp. 243-246. Tampere, 24-28 August 1992. Finnish Institute of Occupational Health, Helsinki.