The binding of chimeric peptides to GM1 ganglioside enables induction of antibody responses after intranasal immunization

Vaccine

Volumn 14, Issue 11, 1996, Pages 1077-1082

  Delmas, Agnès ^a   Partidos, Charalambos D ^a  

^a LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

Author keywords

Cholera toxin; Ganglioside GM1; Intranasal immunization; Synthetic peptide

Indexed keywords

CHIMERIC PROTEIN; CHOLERA TOXIN B SUBUNIT; GANGLIOSIDE GM1; SYNTHETIC PEPTIDE;

ANIMAL EXPERIMENT; ANTIBODY RESPONSE; ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; IMMUNIZATION; IMMUNOGENICITY; INTRANASAL DRUG ADMINISTRATION; LYMPHOCYTE ACTIVATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; RESPIRATORY SYNCYTIAL PNEUMOVIRUS;

EID: 0030219036     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/0264-410X(95)00239-W     Document Type: Article

References (24)

1. 1 Steward, M.W. and Howard, C. Synthetic peptides: a next generation of vaccines? Immunol. Today 1987, 8, 51-58
2. 2 Milich, D.R. Synthetic T and B recognition sites: implications for vaccine development. Adv. Immunol. 1989, 45, 195-264
3. 3 de Aizpurua, H.J. and Russell-Jones, G.J. Oral vaccination: Identification of classes of proteins that provoke an immune response upon oral feeding. J. Exp. Med. 1988, 167, 440-451
4. 4 Spangler, B.D. Structure and function of cholera toxin and the related Escherichia coli heat-labile enterotoxin. Microbiol. Rev. 1992, 56, 622-647
5. 5 Dertzbaugh, M.T. and Elson, C.O. Spriggs, D.R. Koff, W.C. Topics in Vaccine Adjuvant Research, 1991, 119. CRC Press, Boca Raton, FL
6. 6 Gill, D.M. The arrangement of subunits in cholera toxin. Biochemistry 1976, 15, 1242-1248
7. 7 Svennerholm, A.M., Lange, S. and Holmgren, J. Correlation between intestinal synthesis of specific immunoglobulin A and protection against experimental cholera in mice. Infect. Immun. 1978, 21, 1-6
8. 8 Guyon-Gruaz, A., Delmas, A., Pédoussaut, S. et al. Oral immunization with a synthetic peptide of cholera toxin B subunit. Obtention of neutralizing antibodies. Eur. J. Immunol. 1986, 159, 525-528
9. 9 Delmas, A., Gruaz-Guyon, A., Pédoussaut, S., Pierre, P., Rivaille, P. and Vaerman, J.P. Neutralization of cholera toxin by rat IgA secretory antibodies induced by a free synthetic peptide. Biochem. Biophys. Res. Commun. 1989, 159, 707-712
10. 10 Pédoussaut, S., Delmas, A., Milhaud, G., Rivaille, P. and Gruaz-Guyon, A. Oral immunization with a free peptide from cholera toxin: local protection and IgA production. Molec. Immunol. 1989, 26, 115-119
11. 11 Pierce, N.F. The role of antigen form and function in the primary and secondary intestinal immune responses to cholera toxin and toxoids in rats. J. Exp. Med. 1978, 148, 195-206
12. 12 Trudel, M., Nadon, F., Séguin, C. and Binz, H. Protection of Balb/c mice from respiratory syncytial virus infection by immunization with a synthetic peptide derived from the G protein. Virology 1991, 185, 749-757
13. 13 Atherton, E. and Sheppard, R.C. Rickwood, D. Hames, B.D. Solid Phase Peptide Synthesis: A Practical Approach, 1989. IRL Press
14. 14 Ellman, G.L. Tissue sulfhydryl groups. Arch. Biochem. Biophys. 1959, 82, 70-77
15. 15 Engvall, E. and Perlmann, P. Enzyme-linked immunosorbent assay (ELISA) quantitative assay of immunoglobulin G. Immunochemistry 1971, 8, 871-874
16. 16 Svennerholm, A.M. and Holmgren, J. Identification of Escherichia coli heat-labile enterotoxin by means of a ganglioside immunosorbent assay (GM1-ELISA) procedure. Curr. Microbiol. 1978, 1, 19-23
17. 17 Cox, J.H., Ivany, J., Young, D.B., Lamb, J.R., Syred, A.D. and Francis, M.J. Orientation of epitopes influences the immunogenicity of synthetic peptides dimers. Eur. J. Immunol. 1988, 1, 2015-2019
18. 18 Partidos, C.D., Stanley, C.M. and Steward, M.W. The effect of orientation of epitopes on the immunogenicity of chimeric synthetic peptides representing measles virus protein sequences. Molec. Immunol. 1992, 29, 651-658
19. 19 Levely, M.E., Mitchell, M.A. and Nicholas, J.A. Synthetic immunogens constructed from T-cell and B-cell stimulating peptides (T:B chimeras): preferential stimulation of unique T and B cell specificities is influenced by immunogen configuration. Cell. Immunol. 1990, 125, 65-78
20. 20 Partidos, C.D., Stanley, C.M. and Steward, M.W. The influence of orientation and number of copies of T and B cell epitopes on the specificity and affinity of antibodies induced by chimeric peptides. Eur. J. Immunol. 1992, 22, 2675-2680
21. 21 Sixma, T.K., Pronk, S.E., Kalk, K.H. et al. Crystal structure of a cholera toxin-related heat-labile enterotoxin from E. coli. Nature 1991, 351, 371-377
22. 22 Sixma, T.K., Pronk, S.E., Kalk, K.H., van Zanten, B.A.M., Berghuis, A.M. and Hol, W.G.J. Lactose binding to heat-labile enterotoxin revealed by X-ray crystallography. Nature 1992, 355, 561-564
23. 23 Dertzbaugh, M.T. and Elson, C.O. Reduction in oral immunogenicity of cholera toxin B subunit by N-terminal peptide addition. Infect. Immun. 1992, 61, 384-390
24. 24 Umesaki, Y. and Setoyama, H. Immune responses of mice to orally administered asialo GM1-specific rabbit IgG in the presence or absence of cholera toxin. Immunology 1992, 75, 386-388