Actions of methoxylated amphetamine hallucinogens on serotonergic neurons of the brain

Progress in Neuro-Psychopharmacology and Biological Psychiatry

Volumn 20, Issue 6, 1996, Pages 951-965

  Penington, Nicholas J ^a  

^a SUNY DOWNSTATE MEDICAL CENTER   (United States)

Author keywords

5 HT; DOI; dorsal raphe nucleus; phenethylamine hallucinogens; serotonin

Indexed keywords

4 IODO 2,5 DIMETHOXYAMPHETAMINE; AMPHETAMINE; GLUTAMIC ACID; PHENETHYLAMINE; PSYCHEDELIC AGENT; SEROTONIN;

ANIMAL CELL; BRAIN; NERVE CELL; NONHUMAN; RAT; REVIEW;

EID: 0030218870     PISSN: 02785846     EISSN: None     Source Type: Journal    
DOI: 10.1016/0278-5846(96)00076-0     Document Type: Article

References (37)

1. ADELL, A., CARCELLER, A., and ARTIGAS, F. (1993) In Vivo Brain dialysis study of the somatodendritic release of serotonin in the raphe nuclei of the rat: Effects of 8-Hydroxy-2-(Di-n-Propylamino)tetralin. J.Neurochem. 60: 1673-1681.
2. + conductance. Brain Res. 305: 181-185.
3. ASHBY, C.R., EDWARDS, E., HARKINS, K and WANG R.Y. (1989) Effects of (±)-DOI on medial prefrontal cortical cells: A microiontophoretic study. Brain Res. 498: 393-399.
4. AUGUSTINE, G.J., CHARLTON, M.P. and SMITH, S.J. (1987) Calcium action in synaptic transmitter release. Ann. Rev. Neurosci. 10: 633-693.
5. BARABAN, J.M. and AGHAJANIAN, G.K. (1980) Suppression of firing activity of 5-HT neurons in the dorsal raphe by alpha-adrenoceptor antagonists. Neuropharmacol. 19: 355-363.
6. BOBKER, D.H. and WILLIAMS, J.T. (1989) Serotonin augments the cationic current Ih in central neurons. Neuron 2:1535-1540.
7. 1C receptor agonist. J. Pharm. Exp. Ther. 258: 891-896.
8. DEDEOGLU A. and FISHER LA. (1991) Central and peripheral injections of the 5-HT2 agonist, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane, modify cardiovascular function through different mechanisms. J. Pharmacol. Exp.Ther. 259(3): 1027-34.
9. FOOTE, W.E., SHEARD, M.H., and AGHAJANIAN, G.K. (1969) Comparison of the effects of LSD and amphetamine on midbrain raphe units. Nature 222: 567-569.
10. FREEDMAN, D.X. and HALARIS, A.E. (1978) Monoamines and the biochemical mode of action of LSD at synapses. In Psycopharmacology a Generation of Progress. M.A. Lipton, A.L. DiMascio, and K.F. Killam (Eds) pp 347-359, Raven New York.
11. GADDUM, J.H. and HAMEED, K.A. (1957) Drugs which antagonize 5-hydroxytryptamine. Br. J. Pharmacol. 12: 323-328.
12. 3H-serotonin : correlations with serotonergic impulse flow J.Pharmacol.Exp. Ther. 193: 785-795.
13. GARRATT JC. ALREJA M. and AGHAJANIAN GK. (1993) LSD has high efficacy relative to serotonin in enhancing the cationic current Ih: Intracellular studies in rat facial motoneurons. Synapse. 13(2):123-34.
14. GARRATT J.C., KIDD E.J., WRIGHT I.K. and MARSDEN C.A (1991) Inhibition of 5-hydroxytryptamine neuronal activity by the 5-HT agonist, DOI. Eur J. Pharmacol. 199(3): 349-55.
15. GLENNON, R.A., TITELER, M. and MCKENNEY, J.D. (1984) Evidence for 5-HT2 involvement in the mechanism of action of hallucinogenic agents. Life Sci. 35: 2505-2511.
16. GINZEL, K.H. and MAYER-GROSS, W. (1956) Prevention of psychological effects of d-lysergic acid diethylamide (LSD-25) by its 2-brom derivative (BOL 148). Nature (Lond) 178: 210-212.
17. GLENNON R.A. (1987) Central serotonin receptors as targets for drug research. J. Med. Chem. 30 (1):1-12.
18. HAIGLER, H.J. and AGHAJANIAN, G.K. (1973 ) Mescaline and LSD: Direct and indirect effects on serotonin containing neurons in the brain. Eur. J. Pharmacol. 21: 53-60.
19. KIDD E.J. GARRAT J.C. and MARSDEN C.A (1991) Effects of repeated treatment with 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) on the autoregulatory control of dorsal raphe 5-HT neuronal firing and cortical 5-HT release. Eur. J. Pharmacol. 200(1): 131-9.
20. KREISS, D.S., and LUCKI, I. (1994) Differential regulation of serotonin (5-HT) release in the striatum and hippocampus by 5-HT1A autoreceptors of the dorsal and median raphe nuclei. J. Pharm. Exp. Ther. 269: 1268-1279.
21. LARKMAN, P.M. and KELLY, J.S. (1992) Ionic mechanisms mediating 5-hydroxytryptamine- and noradrenaline-evoked depolarization of adult rat facial motoneurones. J.Physiol. 456: 473-490.
22. PENINGTON, N.J. (1986) 5-HT and phenethylamine hallucinogens in CNS. Ph.D. Thesis University of Alberta. Canada.
23. 1A receptors may play a role in hallucinogenesis. J. Pharmacol. Exp. Ther. 269: 3, 1160-1165.
24. PENINGTON, N.J and KELLY, J.S. (1990). Serotonin receptor activation reduces calcium current in an acutely dissociated adult central neuron. Neuron 4: 751-758.
25. 1A receptors on dorsal raphe neurons of the adult rat. J. Physiol. (London).469: 387-406.
26. PENINGTON, N.J. and REIFFENSTEIN, R.J. (1986a) Direct comparison of hallucinogenic phenethylamines and D-amphetamine on dorsal raphe neurones. Eur.J.Pharmacol. 122: 373-377.
27. PENINGTON, N.J. and REIFFENSTEIN, R.J. (1986b) Possible involvement of serotonin receptors in the facilitatory effect of a hallucinogenic phenethylamine on single facial motoneurones Can.J.Physiol.Pharmacol. 64: 1302-1310.
28. RASMUSSEN K. and AGHAJANIAN, G.K. (1988) Potency of antipsychotics in reversing the effects of a hallucinogenic drug on locus coeruleus neurons correlates with 5-HT2 binding affinity. Neuropsychopharmacol. 1 (2):101-7.
29. RASMUSSEN K. and AGHAJANIAN, G.K. (1990) Serotonin excitation of facial motoneurons: receptor subtype characterization. Synapse 5 (4) 324-332.
30. SHULGIN, A.T. (1975) Psychotomimetic drugs: Structure-activity relationships. In: Handbook of Psychopharmacology. L.L Iversen, S.D. Iversen, and S.H. Snyder. (Eds) vol 2, p243-333 Plenum Press, New York.
31. TRULSON, M.E. and JACOBS, B.L. (1979) Dissociations between the effects of LSD on behavior and raphe unit activity in freely moving cats. Science 205: 515-518.
32. VALENTINO, RJ. PAGE, ME. and CURTIS, AL. (1991) Activation of noradrenergic locus coeruleus neurons by hemodynamic stress is due to local release of corticotropin-releasing factor. Brain Research. 555 (1):25-34.
33. VANHOUTTE, P.M. (1987) Cardiovascular effects of serotonin. J. Cardiovas. Pharmacol. 10 (Supp 13) S8-11.
34. WANG, R.Y., and AGHAJANIAN, G.K. (1977) Antidromically identified serotonergic neurons in the rat midbrain raphe: evidence for collateral inhibition. Brain Research 132: 186-193.
35. WEINER, N. (1972) Pharmacology of central nervous system stimulants. In: Drug abuse: Proceedings of the International Conference, C.J.D Zarafonetis (Ed) pp 243-251, Lea and Febiger Philadelphia.
36. WILLIAMS, J.T, COLMERS, W.F. and PAN, Z.Z. (1988) Ligand and voltage activated inwardly rectifying currents in dorsal raphe neurons in vitro J.Neurosci. 8: 3499-3506.
37. 2 agonist, DOI, on 5-HT neuronal firing in the dorsal raphe nucleus and 5-HT release and metabolism in the frontal cortex. Brit. J. Pharmacol. 99 (2):221-2.