-
2
-
-
0030006284
-
Wiskott - Aldrich syndrome protein, a novel effector for the GTPase CDC42Hs, is implicated in actin polymerization
-
of special interest. This report shows that WASP is an effector of CDC42Hs and is involved in actin polymerization.
-
Symons M, Derry JMJ, Karlak B, Jiang S, Lemahieu V, McCormick F, Francke U, Abo A. Wiskott - Aldrich syndrome protein, a novel effector for the GTPase CDC42Hs, is implicated in actin polymerization. of special interest Cell. 84:1996;723-734 This report shows that WASP is an effector of CDC42Hs and is involved in actin polymerization.
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(1996)
Cell
, vol.84
, pp. 723-734
-
-
Symons, M.1
Derry, J.M.J.2
Karlak, B.3
Jiang, S.4
Lemahieu, V.5
McCormick, F.6
Francke, U.7
Abo, A.8
-
3
-
-
0029348814
-
The Btk subfamily of cytoplasmic tyrosine kinases: Structure, regulation, and function
-
Rawlings DJ, Witte ON. The Btk subfamily of cytoplasmic tyrosine kinases: structure, regulation, and function. Semin Immunol. 7:1995;237-246.
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(1995)
Semin Immunol
, vol.7
, pp. 237-246
-
-
Rawlings, D.J.1
Witte, O.N.2
-
4
-
-
0028847330
-
Impaired expansion of mouse B-cell progenitors lacking Btk
-
of outstanding interest. See annotation [5].
-
Kerner JD, Appleby MW, Mohr RN, Chien S, Rawlings DJ, Maliszewski CR, Witte ON, Perlmutter RM. Impaired expansion of mouse B-cell progenitors lacking Btk. of outstanding interest Immunity. 3:1995;301-312 See annotation [5].
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(1995)
Immunity
, vol.3
, pp. 301-312
-
-
Kerner, J.D.1
Appleby, M.W.2
Mohr, R.N.3
Chien, S.4
Rawlings, D.J.5
Maliszewski, C.R.6
Witte, O.N.7
Perlmutter, R.M.8
-
5
-
-
0028847329
-
Defective B-cell development and function in Btk-deficient mice
-
of outstanding interest. Along with [4], this paper demonstrates that Btk knockout mice have a phenotype similar to that of X-immunodeficient mice and less severe than that of XLA patients. This indicates that B-cell development is more dependent on Btk in humans than in mice.
-
Khan WN, Alt FW, Gerstein RM, Malynn BA, Larsson I, Rathbun G, Davidson L, Müller S, Kantor AB, Herzenberg LA, Rosen FS, Sideras P. Defective B-cell development and function in Btk-deficient mice. of outstanding interest Immunity. 3:1995;283-299 Along with [4], this paper demonstrates that Btk knockout mice have a phenotype similar to that of X-immunodeficient mice and less severe than that of XLA patients. This indicates that B-cell development is more dependent on Btk in humans than in mice.
-
(1995)
Immunity
, vol.3
, pp. 283-299
-
-
Khan, W.N.1
Alt, F.W.2
Gerstein, R.M.3
Malynn, B.A.4
Larsson, I.5
Rathbun, G.6
Davidson, L.7
Müller, S.8
Kantor, A.B.9
Herzenberg, L.A.10
Rosen, F.S.11
Sideras, P.12
-
6
-
-
0027535980
-
B-cell developmental defects in X-linked immunodeficiency
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Narendran A, Ramaden D, Tanaka T, Wu GE, Paige CJ. B-cell developmental defects in X-linked immunodeficiency. Int Immunol. 5:1993;139-144.
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(1993)
Int Immunol
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, pp. 139-144
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Narendran, A.1
Ramaden, D.2
Tanaka, T.3
Wu, G.E.4
Paige, C.J.5
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7
-
-
0018836083
-
Synergistic genetic defect in B-lymphocyte function
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Bona C, Mond JJ, Paul WE. Synergistic genetic defect in B-lymphocyte function. J Exp Med. 151:1980;224-234.
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(1980)
J Exp Med
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, pp. 224-234
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-
Bona, C.1
Mond, J.J.2
Paul, W.E.3
-
8
-
-
0022467651
-
Early arrest of B-cell development in nude, X-linked immune-deficient mice
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Karagogeos D, Rosenberg N, Wortis HH. Early arrest of B-cell development in nude, X-linked immune-deficient mice. Eur J Immunol. 16:1986;1125-1130.
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(1986)
Eur J Immunol
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, pp. 1125-1130
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-
Karagogeos, D.1
Rosenberg, N.2
Wortis, H.H.3
-
9
-
-
0027980301
-
Binding of Bruton's tyrosine kinase to Fyn, Lyn, or Hck through a Src homology 3 domain-mediated interaction
-
Cheng G, Ye Zheng-S, Baltimore D. Binding of Bruton's tyrosine kinase to Fyn, Lyn, or Hck through a Src homology 3 domain-mediated interaction. Proc Natl Acad Sci USA. 91:1994;8152-8155.
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(1994)
Proc Natl Acad Sci USA
, vol.91
, pp. 8152-8155
-
-
Cheng, G.1
Ye Zheng-S2
Baltimore, D.3
-
10
-
-
0029100647
-
An SH3-binding site conserved in Bruton's tyrosine kinase and related tyrosine kinases mediates specific protein interactions in vitro and in vivo
-
Yang W, Malek SN, Desiderio S. An SH3-binding site conserved in Bruton's tyrosine kinase and related tyrosine kinases mediates specific protein interactions in vitro and in vivo. J Biol Chem. 270:1995;20832-20840.
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(1995)
J Biol Chem
, vol.270
, pp. 20832-20840
-
-
Yang, W.1
Malek, S.N.2
Desiderio, S.3
-
11
-
-
0028060150
-
Temporal differences in the activation of three classes of non-transmembrane protein tyrosine kinase following B-cell antigen receptor surface engagement
-
Saouaf SJ, Mahajan S, Rowley RB, Kut S, Fargnoli J, Burkhardt AL, Tsukada S, Witte ON, Bolen JB. Temporal differences in the activation of three classes of non-transmembrane protein tyrosine kinase following B-cell antigen receptor surface engagement. Proc Natl Acad Sci USA. 91:1994;9524-9528.
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(1994)
Proc Natl Acad Sci USA
, vol.91
, pp. 9524-9528
-
-
Saouaf, S.J.1
Mahajan, S.2
Rowley, R.B.3
Kut, S.4
Fargnoli, J.5
Burkhardt, A.L.6
Tsukada, S.7
Witte, O.N.8
Bolen, J.B.9
-
12
-
-
0030038840
-
Activation of Btk by a phosphorylation mechanism initiated by Src family kinases
-
of special interest. See annotation [13].
-
Rawlings DJ, Scharenberg AM, Park H, Wahl MI, Lin S, Kato RM, Fluckiger AC, Witte ON, Kinet JP. Activation of Btk by a phosphorylation mechanism initiated by Src family kinases. of special interest Science. 271:1996;822-825 See annotation [13].
-
(1996)
Science
, vol.271
, pp. 822-825
-
-
Rawlings, D.J.1
Scharenberg, A.M.2
Park, H.3
Wahl, M.I.4
Lin, S.5
Kato, R.M.6
Fluckiger, A.C.7
Witte, O.N.8
Kinet, J.P.9
-
13
-
-
0029087567
-
Src family protein tyrosine kinases induce autoactivation of Bruton's tyrosine kinase
-
of special interest. This paper and [12] show that Btk can be activated by src-family kinases and suggest that Btk is downstream of src-family kinases in B-cell signal transduction pathways.
-
Mahajan S, Fargnoli J, Burkhardt AL, Kut SA, Saouaf SJ, Bolen JB. Src family protein tyrosine kinases induce autoactivation of Bruton's tyrosine kinase. of special interest Mol Cell Biol. 15:1995;5304-5311 This paper and [12] show that Btk can be activated by src-family kinases and suggest that Btk is downstream of src-family kinases in B-cell signal transduction pathways.
-
(1995)
Mol Cell Biol
, vol.15
, pp. 5304-5311
-
-
Mahajan, S.1
Fargnoli, J.2
Burkhardt, A.L.3
Kut, S.A.4
Saouaf, S.J.5
Bolen, J.B.6
-
14
-
-
0030152357
-
Regulation of Btk function by a major autophosphorylation site within the SH3 domain
-
of special interest. This paper demonstrates that the major autophosphorylation site of Btk is in the SH3 domain. Mutation of this site increases the ability of activated forms of Btk to transform fibroblasts, indicating that Btk signaling is modulated by phosphorylation at this site.
-
Park HP, Wahl M, Afar DA, Turck C, Rawlings DJ, Tam C, Scharenberg AS, Kinet J-P, Witte ON. Regulation of Btk function by a major autophosphorylation site within the SH3 domain. of special interest Immunity. 4:1996;515-525 This paper demonstrates that the major autophosphorylation site of Btk is in the SH3 domain. Mutation of this site increases the ability of activated forms of Btk to transform fibroblasts, indicating that Btk signaling is modulated by phosphorylation at this site.
-
(1996)
Immunity
, vol.4
, pp. 515-525
-
-
Park, H.P.1
Wahl, M.2
Afar, D.A.3
Turck, C.4
Rawlings, D.J.5
Tam, C.6
Scharenberg, A.S.7
Kinet J-P8
Witte, O.N.9
-
15
-
-
0028999058
-
Activation of Bruton's tyrosine kinase (Btk) by a point mutation in its pleckstrin homology (PH) domain
-
of special interest. This report describes an activating mutation in the PH domain of Btk. This allele will be a useful tool for defining signaling pathways mediated by Btk.
-
Li T, Tsukada S, Satterthwaite A, Havlik MH, Park H, Takatsu K, Witte ON. Activation of Bruton's tyrosine kinase (Btk) by a point mutation in its pleckstrin homology (PH) domain. of special interest Immunity. 2:1995;451-460 This report describes an activating mutation in the PH domain of Btk. This allele will be a useful tool for defining signaling pathways mediated by Btk.
-
(1995)
Immunity
, vol.2
, pp. 451-460
-
-
Li, T.1
Tsukada, S.2
Satterthwaite, A.3
Havlik, M.H.4
Park, H.5
Takatsu, K.6
Witte, O.N.7
-
16
-
-
0028784215
-
Multiple defects in the immune system of Lyn-deficient mice, culminating in autoimmune disease
-
of outstanding interest. See annotation [18].
-
Hibbs ML, Tarlinton DM, Armes J, Grail D, Hodgson G, Maglitto R, Stacker SA, Dunn AR. Multiple defects in the immune system of Lyn-deficient mice, culminating in autoimmune disease. of outstanding interest Cell. 83:1995;301-311 See annotation [18].
-
(1995)
Cell
, vol.83
, pp. 301-311
-
-
Hibbs, M.L.1
Tarlinton, D.M.2
Armes, J.3
Grail, D.4
Hodgson, G.5
Maglitto, R.6
Stacker, S.A.7
Dunn, A.R.8
-
17
-
-
0028806216
-
Impaired proliferation of peripheral B cells and indication of autoimmune disease in lyn-deficient mice
-
of outstanding interest. See annotation [18].
-
Nishizumi H, Taniuchi I, Yamanashi Y, Kitamura D, Llic D, Mori S, Watanabe T, Yamamoto T. Impaired proliferation of peripheral B cells and indication of autoimmune disease in lyn-deficient mice. of outstanding interest Immunity. 3:1995;549-560 See annotation [18].
-
(1995)
Immunity
, vol.3
, pp. 549-560
-
-
Nishizumi, H.1
Taniuchi, I.2
Yamanashi, Y.3
Kitamura, D.4
Llic, D.5
Mori, S.6
Watanabe, T.7
Yamamoto, T.8
-
18
-
-
0028984841
-
T in interleukin-5 receptor signaling
-
of outstanding interest. This paper, [16] and [17] describe studies using lyn- and fyn-deficient mice which indicate that these two src family kinases have at least some non-overlapping roles in B-cell development and function.
-
T in interleukin-5 receptor signaling. of outstanding interest J Exp Med. 182:1995;811-820 This paper, [16] and [17] describe studies using lyn- and fyn-deficient mice which indicate that these two src family kinases have at least some non-overlapping roles in B-cell development and function.
-
(1995)
J Exp Med
, vol.182
, pp. 811-820
-
-
Appleby, M.W.1
Kerner, J.D.2
Chien, S.3
Maliszewski, C.R.4
Bondadaá, S.5
Perlmutter, R.M.6
-
19
-
-
0028783322
-
Syk tyrosine kinase required for mouse viability and B cell development
-
of outstanding interest. See annotation [20].
-
Cheng AM, Rowley B, Pao W, Hayday A, Bolen JB, Pawson T. Syk tyrosine kinase required for mouse viability and B cell development. of outstanding interest Nature. 378:1995;303-306 See annotation [20].
-
(1995)
Nature
, vol.378
, pp. 303-306
-
-
Cheng, A.M.1
Rowley, B.2
Pao, W.3
Hayday, A.4
Bolen, J.B.5
Pawson, T.6
-
20
-
-
0028889302
-
Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk
-
of outstanding interest. This paper, along with [19] shows that syk is critical for murine B-cell development beyond the pre-B cell stage.
-
Turner M, Mee PJ, Costello PS, Williams O, Price AA, Duddy LP, Furlong MT, Geahlen RLG, Tybulewicz VLJ. Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk. of outstanding interest Nature. 378:1995;298-302 This paper, along with [19] shows that syk is critical for murine B-cell development beyond the pre-B cell stage.
-
(1995)
Nature
, vol.378
, pp. 298-302
-
-
Turner, M.1
Mee, P.J.2
Costello, P.S.3
Williams, O.4
Price, A.A.5
Duddy, L.P.6
Furlong, M.T.7
Geahlen, R.L.G.8
Tybulewicz, V.L.J.9
-
21
-
-
0029617615
-
Structure of the high affinity complex of inositol triphosphate with a phospholipase C pleckstrin homology domain
-
Ferguson KM, Lemmon MA, Schlessinger J, Sigler PB. Structure of the high affinity complex of inositol triphosphate with a phospholipase C pleckstrin homology domain. Cell. 83:1995;1037-1046.
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(1995)
Cell
, vol.83
, pp. 1037-1046
-
-
Ferguson, K.M.1
Lemmon, M.A.2
Schlessinger, J.3
Sigler, P.B.4
-
22
-
-
0028564915
-
The pleckstrin homology domain of Bruton tyrosine kinase interacts with protein kinase C
-
Yao L, Kawakami Y, Kawakami T. The pleckstrin homology domain of Bruton tyrosine kinase interacts with protein kinase C. Proc Natl Acad Sci USA. 91:1994;9175-9179.
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(1994)
Proc Natl Acad Sci USA
, vol.91
, pp. 9175-9179
-
-
Yao, L.1
Kawakami, Y.2
Kawakami, T.3
-
24
-
-
0028246440
-
Binding of G protein βγ-subunits to pleckstrin homology domains
-
Touhara K, Inglese J, Pitcher JA, Shawi G, Lefkowitz RJ. Binding of G protein βγ-subunits to pleckstrin homology domains. J Biol Chem. 269:1994;10217-10220.
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(1994)
J Biol Chem
, vol.269
, pp. 10217-10220
-
-
Touhara, K.1
Inglese, J.2
Pitcher, J.A.3
Shawi, G.4
Lefkowitz, R.J.5
-
25
-
-
0028173394
-
Binding of the βγ subunits of heterotrimeric G-proteins to the PH domain of Bruton's tyrosine kinase
-
Tsukada S, Simon M, Witte O, Katz A. Binding of the βγ subunits of heterotrimeric G-proteins to the PH domain of Bruton's tyrosine kinase. Proc Natl Acad Sci USA. 91:1994;11256-11260.
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(1994)
Proc Natl Acad Sci USA
, vol.91
, pp. 11256-11260
-
-
Tsukada, S.1
Simon, M.2
Witte, O.3
Katz, A.4
-
26
-
-
0029098389
-
The protein product of the c-cbl protooncogene is phosphorylated after B-cell receptor stimulation and binds the SH3 domain of Bruton's tyrosine kinase
-
Cory GOC, Lovering RC, Hinshelwood S, MacCarthy-Morrogh L, Levinsky RJ, Kinnon C. The protein product of the c-cbl protooncogene is phosphorylated after B-cell receptor stimulation and binds the SH3 domain of Bruton's tyrosine kinase. J Exp Med. 182:1995;611-615.
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(1995)
J Exp Med
, vol.182
, pp. 611-615
-
-
Cory, G.O.C.1
Lovering, R.C.2
Hinshelwood, S.3
MacCarthy-Morrogh, L.4
Levinsky, R.J.5
Kinnon, C.6
-
27
-
-
0029124883
-
Similarity of sli-1, a regulator of vulval development in C. elegans, to the mammalian proto-oncogene c-bl
-
Yoo CH, Lee J, Jongeward GD, Sternberg PW. Similarity of sli-1, a regulator of vulval development in C. elegans, to the mammalian proto-oncogene c-bl. Science. 269:1995;1102-1105.
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(1995)
Science
, vol.269
, pp. 1102-1105
-
-
Yoo, C.H.1
Lee, J.2
Jongeward, G.D.3
Sternberg, P.W.4
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28
-
-
0027403374
-
Interleukin-2 receptor γ chain mutation results in X-linked severe combined immunodeficiency in humans
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Noguchi M, Yi H, Rosenblatt HM, Filipovich AH, Adelstein S, Modi WS, McBride OW, Leonard WJ. Interleukin-2 receptor γ chain mutation results in X-linked severe combined immunodeficiency in humans. Cell. 73:1993;145-157.
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(1993)
Cell
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, pp. 145-157
-
-
Noguchi, M.1
Yi, H.2
Rosenblatt, H.M.3
Filipovich, A.H.4
Adelstein, S.5
Modi, W.S.6
McBride, O.W.7
Leonard, W.J.8
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29
-
-
0028183408
-
The molecular basis of X-linked severe combined immunodeficiency: The role of the interleukin-2 receptor γ chain as a common γ chain, γc
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Leonard WJ, Noguchi M, Russell SM, McBride OW. The molecular basis of X-linked severe combined immunodeficiency: the role of the interleukin-2 receptor γ chain as a common γ chain, γc. Immunol Rev. 138:1994;61-86.
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(1994)
Immunol Rev
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Leonard, W.J.1
Noguchi, M.2
Russell, S.M.3
McBride, O.W.4
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30
-
-
0028221433
-
Utilization of the β and γ chains of the IL-2 receptor by the novel cytokine IL-15
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Giri JG, Ahdieh M, Eisenman J, Shanebeck K, Grabstein K, Kumaki S, Namen A, Park LS, Cosman D, Anderson D. Utilization of the β and γ chains of the IL-2 receptor by the novel cytokine IL-15. EMBO J. 13:1994;2822-2830.
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EMBO J
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, pp. 2822-2830
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Giri, J.G.1
Ahdieh, M.2
Eisenman, J.3
Shanebeck, K.4
Grabstein, K.5
Kumaki, S.6
Namen, A.7
Park, L.S.8
Cosman, D.9
Anderson, D.10
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31
-
-
0028171065
-
Interaction of IL-2Rβ and γc chains with JAK1 and JAK3: Implications for X-SCID and X-CID
-
Russell SM, Johnston JA, Noguchi M, Kawamura M, Bacon CM, Friedmann M, Berg M, McVicar DW, Witthuhn BA, Silvennoinen O, et al. Interaction of IL-2Rβ and γc chains with JAK1 and JAK3: implications for X-SCID and X-CID. Science. 266:1994;1042-1045.
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Science
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, pp. 1042-1045
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Russell, S.M.1
Johnston, J.A.2
Noguchi, M.3
Kawamura, M.4
Bacon, C.M.5
Friedmann, M.6
Berg, M.7
McVicar, D.W.8
Witthuhn, B.A.9
Silvennoinen, O.10
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32
-
-
0027993022
-
Functional activation of Jak1 and Jak3 by selective association with IL-2 receptor subunits
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Miyazaki T, Kawahara A, Fujii H, Nakagawa Y, Minami Y, Liu Zhao-J, Oishi I, Silvennoinen O, Witthuhn BA, Ihle JN, Taniguchi T. Functional activation of Jak1 and Jak3 by selective association with IL-2 receptor subunits. Science. 266:1994;1045-1047.
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Science
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Miyazaki, T.1
Kawahara, A.2
Fujii, H.3
Nakagawa, Y.4
Minami, Y.5
Liu Zhao-J6
Oishi, I.7
Silvennoinen, O.8
Witthuhn, B.A.9
Ihle, J.N.10
Taniguchi, T.11
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33
-
-
0028114542
-
Prevention of T cell anergy by signaling through the γc chain of the IL-2 receptor
-
Boussiotis VA, Barber DL, Nakarai T, Freeman GJ, Gribben JG, Bernstein GM, D'Andrea AD, Ritz J, Nadler LM. Prevention of T cell anergy by signaling through the γc chain of the IL-2 receptor. Science. 266:1994;1039-1042.
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Science
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-
Boussiotis, V.A.1
Barber, D.L.2
Nakarai, T.3
Freeman, G.J.4
Gribben, J.G.5
Bernstein, G.M.6
D'Andrea, A.D.7
Ritz, J.8
Nadler, L.M.9
-
34
-
-
0028857954
-
Mutation of JAK3 in a patient with SCID: Essential role of JAK3 in lymphoid development
-
of outstanding interest. A patient with autosomal SCID similar to X-SCID is shown to have mutations in JAK3, indicating that JAK3 is a critical component of γc signaling pathways
-
Russell SM, Tayebi N, Nakajima H, Riedy MC, Roberts JL, Aman MJ, Migone Thi-S, Noguchi M, Market ML, Buckley RH, et al. Mutation of JAK3 in a patient with SCID: essential role of JAK3 in lymphoid development. of outstanding interest Science. 270:1995;797-800 A patient with autosomal SCID similar to X-SCID is shown to have mutations in JAK3, indicating that JAK3 is a critical component of γc signaling pathways.
-
(1995)
Science
, vol.270
, pp. 797-800
-
-
Russell, S.M.1
Tayebi, N.2
Nakajima, H.3
Riedy, M.C.4
Roberts, J.L.5
Aman, M.J.6
Migone Thi-S7
Noguchi, M.8
Market, M.L.9
Buckley, R.H.10
-
35
-
-
0028840706
-
Defective lymphoid development in mice lacking JAK3
-
of outstanding interest. See annotation [37].
-
Nosaka T, Van Deursen JMA, Tripp RA, Theirfelder WE, Witthuhn BA, McMickle AP, Doherty PC, Grosveld GC, Ihle JN. Defective lymphoid development in mice lacking JAK3. of outstanding interest Science. 270:1995;800-802 See annotation [37].
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(1995)
Science
, vol.270
, pp. 800-802
-
-
Nosaka, T.1
Van Deursen, J.M.A.2
Tripp, R.A.3
Theirfelder, W.E.4
Witthuhn, B.A.5
McMickle, A.P.6
Doherty, P.C.7
Grosveld, G.C.8
Ihle, J.N.9
-
36
-
-
0028799457
-
Defects in B-lymphocyte maturation and T-lymphocyte activation in mice lacking JAK 3
-
of outstanding interest. See annotation [37].
-
Thomis DC, Gurniak CB, Tivol E, Ahrpe AH, Berg LJ. Defects in B-lymphocyte maturation and T-lymphocyte activation in mice lacking JAK 3. of outstanding interest Science. 270:1995;794-797 See annotation [37].
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(1995)
Science
, vol.270
, pp. 794-797
-
-
Thomis, D.C.1
Gurniak, C.B.2
Tivol, E.3
Ahrpe, A.H.4
Berg, L.J.5
-
37
-
-
0029550822
-
Developmental defects of lymphoid cells in JAK3 kinase-deficient mice
-
of outstanding interest. Mice deficient in JAK3 described in in this paper and [35, 36] have a similar phenotype to γc knockout mice, indicating that JAK3 is a critical component of γc signaling pathways.
-
Park SY, Saijo K, Takahashi T, Osawa M, Arase H, Hirayama N, Miyake K, Nakauchi H, Shirasawa T, Saito T. Developmental defects of lymphoid cells in JAK3 kinase-deficient mice. of outstanding interest Immunity. 3:1995;771-782 Mice deficient in JAK3 described in in this paper and [35, 36] have a similar phenotype to γc knockout mice, indicating that JAK3 is a critical component of γc signaling pathways.
-
(1995)
Immunity
, vol.3
, pp. 771-782
-
-
Park, S.Y.1
Saijo, K.2
Takahashi, T.3
Osawa, M.4
Arase, H.5
Hirayama, N.6
Miyake, K.7
Nakauchi, H.8
Shirasawa, T.9
Saito, T.10
-
38
-
-
0028925778
-
Defective lymphoid development in mice lacking expression of the comon cytokine receptor γ chain
-
of outstanding interest. See annotation [40].
-
Cao X, Shores EW, Hu-Li J, Anver MR, Kelsall BL, Russell SM, Drago J, Noguchi M, Grinberg A, Bloom ET, et al. Defective lymphoid development in mice lacking expression of the comon cytokine receptor γ chain. of outstanding interest Immunity. 2:1995;223-238 See annotation [40].
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(1995)
Immunity
, vol.2
, pp. 223-238
-
-
Cao, X.1
Shores, E.W.2
Hu-Li, J.3
Anver, M.R.4
Kelsall, B.L.5
Russell, S.M.6
Drago, J.7
Noguchi, M.8
Grinberg, A.9
Bloom, E.T.10
-
39
-
-
13344282747
-
Modulation of hematopoiesis in mice with a truncated mutant of the interleukin-2 receptor γ chain
-
of outstanding interest. See annotation [40].
-
Ohbo K, Suda T, Hashiyama M, Mantani A, Ikebe M, Miyakawa K, Moriyama M, Nakamura M, Katsuki M, Takahashi K, et al. Modulation of hematopoiesis in mice with a truncated mutant of the interleukin-2 receptor γ chain. of outstanding interest Blood. 87:1996;956-967 See annotation [40].
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(1996)
Blood
, vol.87
, pp. 956-967
-
-
Ohbo, K.1
Suda, T.2
Hashiyama, M.3
Mantani, A.4
Ikebe, M.5
Miyakawa, K.6
Moriyama, M.7
Nakamura, M.8
Katsuki, M.9
Takahashi, K.10
-
40
-
-
0028878330
-
Lymphoid development in mice with a targeted deletion of the interleukin 2 receptor γ chain
-
of outstanding interest. This paper, along with [38, 39], demonstrates that mutation of γc in mice blocks both T and B cell development. Humans lacking γc have normal numbers of B cells, indicating that mice are more dependent on γc than humans for B lymphopoiesis.
-
DiSanto JP, Muller W, Guy-Grand D, Fischer A, Rajewsky K. Lymphoid development in mice with a targeted deletion of the interleukin 2 receptor γ chain. of outstanding interest Proc Natl Acad Sci USA. 92:1995;377-381 This paper, along with [38, 39], demonstrates that mutation of γc in mice blocks both T and B cell development. Humans lacking γc have normal numbers of B cells, indicating that mice are more dependent on γc than humans for B lymphopoiesis.
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 377-381
-
-
DiSanto, J.P.1
Muller, W.2
Guy-Grand, D.3
Fischer, A.4
Rajewsky, K.5
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41
-
-
0028929565
-
Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a non-redundant cytokine
-
of outstanding interest. Mice deficient in IL-7, shown here, have a similar phoenotype to γc knockout mice. This suggests that the block in lymphoid development in γc-deficient mice is a result of lack of signaling by IL-7 and not the other cytokines whose receptors share γc.
-
Von Freeden-Jeffry U, Vieira P, Lucian LA, McNeil T, Burdach SEG, Murray R. Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a non-redundant cytokine. of outstanding interest J Exp Med. 181:1995;1519-1526 Mice deficient in IL-7, shown here, have a similar phoenotype to γc knockout mice. This suggests that the block in lymphoid development in γc-deficient mice is a result of lack of signaling by IL-7 and not the other cytokines whose receptors share γc.
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(1995)
J Exp Med
, vol.181
, pp. 1519-1526
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-
Von Freeden-Jeffry, U.1
Vieira, P.2
Lucian, L.A.3
McNeil, T.4
Burdach, S.E.G.5
Murray, R.6
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42
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-
0027988545
-
Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice
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Peschon JJ, Morrissey PJ, Grabstein KH, Ramsdell FJ, Maraskovsky E, Gliniak BC, Park LS, Ziegler SF, Williams DE, Ware CB, et al. Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice. J Exp Med. 180:1994;1955-1960.
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(1994)
J Exp Med
, vol.180
, pp. 1955-1960
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-
Peschon, J.J.1
Morrissey, P.J.2
Grabstein, K.H.3
Ramsdell, F.J.4
Maraskovsky, E.5
Gliniak, B.C.6
Park, L.S.7
Ziegler, S.F.8
Williams, D.E.9
Ware, C.B.10
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43
-
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0025899598
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Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting
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Schorle H, Holtschke T, Hunig T, Schimpl A, Horak I. Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting. Nature. 352:1991;621-624.
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Nature
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Schorle, H.1
Holtschke, T.2
Hunig, T.3
Schimpl, A.4
Horak, I.5
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44
-
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0026328818
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Generation and analysis of interleukin-4-deficient mice
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Kühn R, Rajewsky K, Müller W. Generation and analysis of interleukin-4-deficient mice. Science. 254:1991;707-710.
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(1991)
Science
, vol.254
, pp. 707-710
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-
Kühn, R.1
Rajewsky, K.2
Müller, W.3
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45
-
-
0028486131
-
Mice deficient for the CD40 ligand
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Xu J, Foy TM, Laman JD, Elliott EA, Dunn JJ, Waldschmidt TJ, Elsemore J, Noelle RJ, Flavell RA. Mice deficient for the CD40 ligand. Immunity. 1:1994;423-431.
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(1994)
Immunity
, vol.1
, pp. 423-431
-
-
Xu, J.1
Foy, T.M.2
Laman, J.D.3
Elliott, E.A.4
Dunn, J.J.5
Waldschmidt, T.J.6
Elsemore, J.7
Noelle, R.J.8
Flavell, R.A.9
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46
-
-
0028447437
-
The immune response in CD40-deficient mice: Impaired immunoglobulin class switching and germinal center formation
-
Kawabe T, Naka T, Yoshida K, Tanaka T, Fujiwara H, Suematsu S, Yoshida N, Kishimoto T, Kikutani H. The immune response in CD40-deficient mice: impaired immunoglobulin class switching and germinal center formation. Immunity. 1:1994;167-178.
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(1994)
Immunity
, vol.1
, pp. 167-178
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Kawabe, T.1
Naka, T.2
Yoshida, K.3
Tanaka, T.4
Fujiwara, H.5
Suematsu, S.6
Yoshida, N.7
Kishimoto, T.8
Kikutani, H.9
-
47
-
-
0027930707
-
The role of CD40 in the regulation of humoral and cell-mediated immunity
-
Durie FH, Foy TM, Masters SR, Laman JD, Noelle RJ. The role of CD40 in the regulation of humoral and cell-mediated immunity. Immunol Today. 15:1994;406-411.
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(1994)
Immunol Today
, vol.15
, pp. 406-411
-
-
Durie, F.H.1
Foy, T.M.2
Masters, S.R.3
Laman, J.D.4
Noelle, R.J.5
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48
-
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0028525548
-
CD40 ligand - CD40 interaction in Ig isotype switching in mature and immature human B cells
-
Aversa G, Punnonen J, Carballido JM, Cocks BG, De Vries JE. CD40 ligand - CD40 interaction in Ig isotype switching in mature and immature human B cells. Semin Immunol. 6:1994;295-301.
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(1994)
Semin Immunol
, vol.6
, pp. 295-301
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-
Aversa, G.1
Punnonen, J.2
Carballido, J.M.3
Cocks, B.G.4
De Vries, J.E.5
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49
-
-
0029055061
-
Generation of memory B cells and plasma cells in vitro
-
of special interest. This report describes an in vitro system for driving late stages of B cell differentiation. CD40L drives the production of memory cells. Plasma cells are generated in the absence of CD40L.
-
Arpin C, Déchanet J, Kooten CV, Merville P, Grouard G, Brière F, Banchereau J, Liu Yong-J. Generation of memory B cells and plasma cells in vitro. of special interest Science. 268:1995;720-722 This report describes an in vitro system for driving late stages of B cell differentiation. CD40L drives the production of memory cells. Plasma cells are generated in the absence of CD40L.
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(1995)
Science
, vol.268
, pp. 720-722
-
-
Arpin, C.1
Déchanet, J.2
Kooten, C.V.3
Merville, P.4
Grouard, G.5
Brière, F.6
Banchereau, J.7
Liu Yong-J8
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50
-
-
0029149860
-
T - B cell interaction inhibits spontaneous apoptosis of mature lymphocytes in Bcl-2-deficient mice
-
Nakayama K, Nakayama K, Dustin LB, Loh DY. T - B cell interaction inhibits spontaneous apoptosis of mature lymphocytes in Bcl-2-deficient mice. J Exp Med. 182:1995;1101-1110.
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(1995)
J Exp Med
, vol.182
, pp. 1101-1110
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-
Nakayama, K.1
Nakayama, K.2
Dustin, L.B.3
Loh, D.Y.4
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51
-
-
0029091387
-
Induction of bcl-x by CD40 engagement rescues slg-induced apoptosis in murine B cells
-
Wang Z, Karras JG, Howard RG, Rothstein TL. Induction of bcl-x by CD40 engagement rescues slg-induced apoptosis in murine B cells. J Immunol. 155:1995;3722-3725.
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(1995)
J Immunol
, vol.155
, pp. 3722-3725
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-
Wang, Z.1
Karras, J.G.2
Howard, R.G.3
Rothstein, T.L.4
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52
-
-
0029670773
-
Bcl-x exhibits regulated expression during B-cell development and activation and modulates lymphocyte survival in transgenic mice
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Grillot DAM, Merino R, Pena JC, Fanslow WC, Finkelman FD, Thompson CB, Núñez G. bcl-x exhibits regulated expression during B-cell development and activation and modulates lymphocyte survival in transgenic mice. J Exp Med. 183:1996;381-391.
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(1996)
J Exp Med
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-
Grillot, D.A.M.1
Merino, R.2
Pena, J.C.3
Fanslow, W.C.4
Finkelman, F.D.5
Thompson, C.B.6
Núñez, G.7
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53
-
-
0029073035
-
Activation of the B-cell surface receptor CD40 induces A20, a novel zinc finger protein that inhibits apoptosis
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Sarma V, Lin Z, Clark L, Rust BM, Tewari M, Noelle RJ, Dixit VM. Activation of the B-cell surface receptor CD40 induces A20, a novel zinc finger protein that inhibits apoptosis. J Biol Chem. 270:1995;12343-12346.
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(1995)
J Biol Chem
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, pp. 12343-12346
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-
Sarma, V.1
Lin, Z.2
Clark, L.3
Rust, B.M.4
Tewari, M.5
Noelle, R.J.6
Dixit, V.M.7
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54
-
-
0028865583
-
CD40 ligation induces Apo-1/Fas expression on human B lymphocytes and facilitates apoptosis through the Apo-1/Fas pathway
-
Schattner EJ, Elkon KB, Yoo Dae-H, Tumang J, Krammer PH, Crow MK, Friedman SM. CD40 ligation induces Apo-1/Fas expression on human B lymphocytes and facilitates apoptosis through the Apo-1/Fas pathway. J Exp Med. 182:1995;1557-1565.
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(1995)
J Exp Med
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, pp. 1557-1565
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-
Schattner, E.J.1
Elkon, K.B.2
Yoo Dae-H3
Tumang, J.4
Krammer, P.H.5
Crow, M.K.6
Friedman, S.M.7
-
55
-
-
0028799935
-
Fas ligation induces apoptosis of CD40-activated human B lymphocytes
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Garrone P, Neidhardt Eve-M, Garcia E, Galibert L, Van Kooten C, Banchereau J. Fas ligation induces apoptosis of CD40-activated human B lymphocytes. J Exp Med. 182:1995;1265-1273.
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(1995)
J Exp Med
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, pp. 1265-1273
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-
Garrone, P.1
Neidhardt Eve-M2
Garcia, E.3
Galibert, L.4
Van Kooten, C.5
Banchereau, J.6
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56
-
-
0030048133
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A dual role for both CD40-ligand and TNF-α in controlling human B cell death
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Lens SMA, Tesselaar K, Den Drijiver BFA, Van Oers MHJ, Van Lier RAW. A dual role for both CD40-ligand and TNF-α in controlling human B cell death. J Immunol. 156:1996;507-514.
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J Immunol
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Lens, S.M.A.1
Tesselaar, K.2
Den Drijiver, B.F.A.3
Van Oers, M.H.J.4
Van Lier, R.A.W.5
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57
-
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0029062080
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Regulation of germinal center B cell differentiation
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Lagresle C, Bella C, Daniel PT, Krammer PH, Defrance T. Regulation of germinal center B cell differentiation. J Immunol. 154:1995;5746-5756.
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(1995)
J Immunol
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, pp. 5746-5756
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Lagresle, C.1
Bella, C.2
Daniel, P.T.3
Krammer, P.H.4
Defrance, T.5
-
58
-
-
0028920079
-
Protection against Fas-dependent Th1-mediated apoptosis by antigen receptor engagement in B cells
-
Rothstein TL, Wang JKM, Panka DJ, Foote LC, Wang Z, Stanger B, Cui H, Ju Shyr T, Marshak-Rothstein A. Protection against Fas-dependent Th1-mediated apoptosis by antigen receptor engagement in B cells. Nature. 374:1995;163-165.
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(1995)
Nature
, vol.374
, pp. 163-165
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-
Rothstein, T.L.1
Wang, J.K.M.2
Panka, D.J.3
Foote, L.C.4
Wang, Z.5
Stanger, B.6
Cui, H.7
Ju Shyr, T.8
Marshak-Rothstein, A.9
-
59
-
-
0028915948
-
Defective signalling through the T- and B-cell antigen receptors in lymphoid cells lacking the vav proto-oncogene
-
of special interest. See annotation [60].
-
Zhang R, Alt FW, Davidson L, Orkin SH, Swat W. Defective signalling through the T- and B-cell antigen receptors in lymphoid cells lacking the vav proto-oncogene. of special interest Nature. 374:1995;470-473 See annotation [60].
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(1995)
Nature
, vol.374
, pp. 470-473
-
-
Zhang, R.1
Alt, F.W.2
Davidson, L.3
Orkin, S.H.4
Swat, W.5
-
60
-
-
0028956337
-
Defective antigen receptor-mediated proliferation of B and T cells in the absence of Vav
-
of special interest. This paper and [59] shows that vav is required for antigen receptor signaling, but not B cell development.
-
Tarakhovsky A, Turner M, Schaal S, Mee PJ, Duddy LP, Rajewsky K, Tybulewicz VLJ. Defective antigen receptor-mediated proliferation of B and T cells in the absence of Vav. of special interest Nature. 374:1995;467-470 This paper and [59] shows that vav is required for antigen receptor signaling, but not B cell development.
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(1995)
Nature
, vol.374
, pp. 467-470
-
-
Tarakhovsky, A.1
Turner, M.2
Schaal, S.3
Mee, P.J.4
Duddy, L.P.5
Rajewsky, K.6
Tybulewicz, V.L.J.7
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61
-
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0029151248
-
Antigen-receptor induced clonal expansion and deletion of lymphocytes are impaired in mice lacking hs1 protein, a substrate of the antigen-receptor-coupled tyrosine kinases
-
Taniuchi I, Kitamura D, Maekawa Y, Fukuda T, Kishi H, Watanabe T, Kishi H, Watanabe T. Antigen-receptor induced clonal expansion and deletion of lymphocytes are impaired in mice lacking hs1 protein, a substrate of the antigen-receptor-coupled tyrosine kinases. EMBO J. 14:1995;3664-3678.
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(1995)
EMBO J
, vol.14
, pp. 3664-3678
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-
Taniuchi, I.1
Kitamura, D.2
Maekawa, Y.3
Fukuda, T.4
Kishi, H.5
Watanabe, T.6
Kishi, H.7
Watanabe, T.8
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62
-
-
0028158091
-
B cells from CBA/N mice do not proliferate following ligation of CD40
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Hasbold J, Klaus GG. B cells from CBA/N mice do not proliferate following ligation of CD40. Eur J Immunol. 24:1994;152-157.
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(1994)
Eur J Immunol
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Hasbold, J.1
Klaus, G.G.2
-
63
-
-
0028936733
-
Involvement of CRAF1, a relative of TRAF, in CD40 signaling
-
of special interest. This report indicates that the CRAF1/TRAF1 family is required for CD40 signaling.
-
Cheng G, Cleary AM, Ye Zheng-S, Hong DI, Lederman S, Baltimore D. Involvement of CRAF1, a relative of TRAF, in CD40 signaling. of special interest Science. 267:1995;1494-1498 This report indicates that the CRAF1/TRAF1 family is required for CD40 signaling.
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(1995)
Science
, vol.267
, pp. 1494-1498
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-
Cheng, G.1
Cleary, A.M.2
Ye Zheng-S3
Hong, D.I.4
Lederman, S.5
Baltimore, D.6
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64
-
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0028878977
-
The Epstein - Barr virus transforming protein LMP1 engages signaling proteins for the tumor necrosis factor receptor family
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Mosialos G, Birkenbach M, Yalamanchili R, Van Arsdale T, Ware C, Kieff E. The Epstein - Barr virus transforming protein LMP1 engages signaling proteins for the tumor necrosis factor receptor family. Cell. 80:1995;389-399.
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Cell
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, pp. 389-399
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Mosialos, G.1
Birkenbach, M.2
Yalamanchili, R.3
Van Arsdale, T.4
Ware, C.5
Kieff, E.6
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65
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0027943499
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A novel RING finger protein interacts with the cytoplasmic domain of CD40
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Hu HM, O'Rourke K, Boguski MS, Dixit VA. A novel RING finger protein interacts with the cytoplasmic domain of CD40. J Biol Chem. 269:1994;30069-30072.
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J Biol Chem
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Hu, H.M.1
O'Rourke, K.2
Boguski, M.S.3
Dixit, V.A.4
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66
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0027937223
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Isolation of a novel gene mutated in Wiskott - Aldrich syndrome
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Derry JMJ, Ochs HD, Francke U. Isolation of a novel gene mutated in Wiskott - Aldrich syndrome. Cell. 78:1994;635-644.
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Cell
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Derry, J.M.J.1
Ochs, H.D.2
Francke, U.3
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67
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0029126878
-
Wiskott - Aldrich syndrome protein physically associates with Nck through Src homology 3 domains
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Rivero-Lezcano OM, Marcilla A, Sameshima JH, Robbins KC. Wiskott - Aldrich syndrome protein physically associates with Nck through Src homology 3 domains. Mol Cell Biol. 15:1995;5725-5731.
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(1995)
Mol Cell Biol
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, pp. 5725-5731
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Rivero-Lezcano, O.M.1
Marcilla, A.2
Sameshima, J.H.3
Robbins, K.C.4
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