Potentiation of fluoxetine by aminoglutethimide, an adrenal steroid suppressant, in obsessive-compulsive disorder resistant to SSRIs: A case report

Progress in Neuro-Psychopharmacology and Biological Psychiatry

Volumn 20, Issue 6, 1996, Pages 1067-1079

  Chouinard, Guy ^a,b,c   Bélanger, Marie Claire ^a,b   Beauclair, Linda ^a,b   Sultan, Sarah ^a,b   Murphy, Beverley E P ^b  

^a Allan Memorial Institute   (Canada)

^b MCGILL UNIVERSITY   (Canada)

^c CENTRE DE RECHERCHE FERNAND SEGUIN   (Canada)

Author keywords

adrenal suppression; aminoglutethimide; clomipramine; cortisol; fluoxetine; obsessive compulsive disorder; serotonin selective reuptake inhibitor

Indexed keywords

AMINOGLUTETHIMIDE; CLOMIPRAMINE; FLUOXETINE; HYDROCORTISONE; PHENELZINE; PIMOZIDE; SERTRALINE; TRIMIPRAMINE;

ADULT; ARTICLE; CASE REPORT; COMPULSION; DRUG COMBINATION; HUMAN; MALE; OBSESSION;

EID: 0030218073     PISSN: 02785846     EISSN: None     Source Type: Journal    
DOI: 10.1016/0278-5846(96)00084-X     Document Type: Article

References (12)

1. AMERICAN PSYCHIATRIC ASSOCIATION (1980). Diagnostic and Statistical Manual of Mental Disorders (DSM-III-R), 3rd ed., revised.
2. ANANTH, J., PECKNOLD, J.C., VAN DEN STEEN, N., and ENGELSMANN, F. (1981) Double-blind comparative study of clomipramine and amitriptyline in obsessive neurosis. Prog. Neuro-Psychopharmacol. 5: 257-62.
3. CHOUINARD, G. (1992) Sertraline in the treatment of obsessive-compulsive disorder: Two double-blind, placebo-controlled studies. Int. Clin. Psychopharmacol. 7(suppl 2): 37-41.
4. CHOUINARD. G., GOODMAN, W., GREIST, J., JENIKE, M., RASMUSSEN, S., WHITE, K., HACKETT, E., GAFFNEY, M., and BICK, P.A. (1990) Results of a double-blind placebo-controlled trial of a new serotonin uptake inhibitor, sertraline, in the treatment of obsessive-compulsive disorder. Psychopharm. Bull. 26: 279-284.
5. CLOMIPRAMINE COLLABORATIVE STUDY GROUP (1991) Clomipramine in the treatment of patients with obsessive-compulsive disorder. Arch. Gen. Psychiatry. 48: 730-738
6. FONTAINE, R. and CHOUINARD, G. (1985) Fluoxetine in the treatment of obsessive-compulsive disorder. Prog. Neuro-Psychopharmacol. & Biol. Psychiatr. 9: 605-608.
7. FONTAINE, R. and CHOUINARD, G. (1989) Fluoxetine in the long-term maintenance treatment of obsessive-compulsive disorder. Psychiat. An. 19: 88-91.
8. LANDRY, P. and CHOUINARD, G. (1990) Obsessive-compulsive disorder: pathogenesis and fluoxetine treatment. Rev. Contemp. Pharmacother. 1: 61-74.
9. MELTZER, H.Y. and FANG, V.S. (1983) Cortisol determination and the dexamethasone suppression. Arch. Gen. Psychiatry. 40: 501.
10. MURPHY, B.E.P., DHAR, V., GHADIRIAN, A.M., CHOUINARD, G. and KELLER, R. (1991) Response to steroid suppression in major depression resistant to antidepressant therapy. J. Clin. Psychopharmacol. 11: 121-126.
11. SANTEN, R.J., WELLS, S.A., RUNIC, S., GUPTA, C., KENDALL, J., RUDY, E.B. and SAMOJLIK, E. (1977) Adrenal suppression with aminoglutethimide. I. Differential effects of aminoglutethimide on glucocorticoid metabolism as a rationale for use of hydrocortisone. J. Clin. Endocrinol. Metab. 45: 469-479.
12. SHAPIRO, M.F. and LEHMAN, A.F. (1983) The diagnosis of depression in different clinical settings; An analysis of the literature on the dexamethasone suppression test. J. Nerv. Ment. Dis. 171: 714-20.