메뉴 건너뛰기




Volumn 6, Issue 4, 1996, Pages 395-402

RNA localization and the development of asymmetry during Drosophila oogenesis

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA;

EID: 0030218008     PISSN: 0959437X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-437X(96)80059-1     Document Type: Article
Times cited : (65)

References (59)
  • 1
    • 0026537051 scopus 로고
    • The origin of pattern and polarity in the Drosophila embryo
    • 1. St Johnston D, Nüsslein-Volhard C: The origin of pattern and polarity in the Drosophila embryo. Cell 1992, 68:201-219.
    • (1992) Cell , vol.68 , pp. 201-219
    • St Johnston, D.1    Nüsslein-Volhard, C.2
  • 2
    • 0027405717 scopus 로고
    • Germline cysts: Communes that work
    • 2. Spradling A: Germline cysts: communes that work. Cell 1993, 72:649-651.
    • (1993) Cell , vol.72 , pp. 649-651
    • Spradling, A.1
  • 3
    • 0025687551 scopus 로고
    • Bag-of-Marbles: A Drosophila gene required to initiate both male and female gametogenesis
    • 3. McKearin D, Spradling A: Bag-of-Marbles: a Drosophila gene required to initiate both male and female gametogenesis. Genes Dev 1990, 4:2242-2251.
    • (1990) Genes Dev , vol.4 , pp. 2242-2251
    • McKearin, D.1    Spradling, A.2
  • 4
    • 0029116370 scopus 로고
    • A role for the Drosophila bag-of-marbles protein in the differentiation of cystoblasts from germline stem cells
    • 4. McKearin D, Ohlstein B: A role for the Drosophila bag-of-marbles protein in the differentiation of cystoblasts from germline stem cells. Development 1995, 121:2937-2947. Bam protein localizes to the spectrosome of germline stem cells and the cystoblast and to the fusome of two to sixteen cell cysts. An immunologically distinct form of the protein is also present in the cytoplasm from the cystoblast to the eight cell cyst stage. As the absence of a fusome does not produce the same phenotype as bam mutants, the cytoplasmic form of the protein seems to be required for the formation of cysts with more than two interconnected cells.
    • (1995) Development , vol.121 , pp. 2937-2947
    • McKearin, D.1    Ohlstein, B.2
  • 5
    • 0029671193 scopus 로고    scopus 로고
    • Encore, a gene required for the regulation of germ line mitosis and oocyte differentiation during Drosophila oogenesis
    • 5. Hawkins NC, Thorpe J, Schüpbach T: encore, a gene required for the regulation of germ line mitosis and oocyte differentiation during Drosophila oogenesis. Development 1996, 122:281-290. Mutations in encore cause the germline cells to go through one extra mitosis to produce 32 cell cysts. This phenotype correlates with an extension of bam expression further down the germarium and is suppressed by bam mutations. This suggests that the number of divisions in a cyst is controlled by the presence of cytoplasmic Bam protein. In addition, most encore alleles produce a second, cold-sensitive phenotype in which the cyst contains the correct number of cells but the oocyte begins to take on the appearance of a nurse cell.
    • (1996) Development , vol.122 , pp. 281-290
    • Hawkins, N.C.1    Thorpe, J.2    Schüpbach, T.3
  • 6
    • 0027264593 scopus 로고
    • A central role for microtubules in the differentiation of Drosophila oocytes
    • 6. Theurkauf W, Alberts B, Jan Y, Jongens T: A central role for microtubules in the differentiation of Drosophila oocytes. Development 1993, 118:1169-1180.
    • (1993) Development , vol.118 , pp. 1169-1180
    • Theurkauf, W.1    Alberts, B.2    Jan, Y.3    Jongens, T.4
  • 7
    • 0026337934 scopus 로고
    • Female sterile mutations on the 2nd chromosome of Drosophila melanogaster. 2. Mutations blocking oogenesis or altering egg morphology
    • 7. Schüpbach T, Wieschaus E: Female sterile mutations on the 2nd chromosome of Drosophila melanogaster. 2. Mutations blocking oogenesis or altering egg morphology. Genetics 1991, 129:1119-1136.
    • (1991) Genetics , vol.129 , pp. 1119-1136
    • Schüpbach, T.1    Wieschaus, E.2
  • 8
    • 0025720487 scopus 로고
    • Requirement for phosphorylation and localization of the Bicaudal-D protein in Drosophila oocyte differentiation
    • 8. Suter B, Steward R: Requirement for phosphorylation and localization of the Bicaudal-D protein in Drosophila oocyte differentiation. Cell 1991, 67:917-926.
    • (1991) Cell , vol.67 , pp. 917-926
    • Suter, B.1    Steward, R.2
  • 9
    • 0028270542 scopus 로고
    • Null alleles reveal novel requirements for Bic-D during Drosophila oogenesis and zygotic development
    • 9. Ran B, Bopp R, Suter B: Null alleles reveal novel requirements for Bic-D during Drosophila oogenesis and zygotic development. Development 1994, 120:1233-1242.
    • (1994) Development , vol.120 , pp. 1233-1242
    • Ran, B.1    Bopp, R.2    Suter, B.3
  • 10
    • 0028214601 scopus 로고
    • The Drosophila fusome, a germline-specific organelle, contains membrane skeletal proteins and functions in cyst formation
    • 10. Lin H, Yue L, Spradling A: The Drosophila fusome, a germline-specific organelle, contains membrane skeletal proteins and functions in cyst formation. Development 1994, 120:947-956.
    • (1994) Development , vol.120 , pp. 947-956
    • Lin, H.1    Yue, L.2    Spradling, A.3
  • 11
    • 0023245565 scopus 로고
    • Modulation of spectrin actin assembly by erythrocyte adducin
    • 11. Gardner K, Bennett V: Modulation of spectrin actin assembly by erythrocyte adducin. Nature 1987, 328:359-362.
    • (1987) Nature , vol.328 , pp. 359-362
    • Gardner, K.1    Bennett, V.2
  • 12
    • 0023600841 scopus 로고
    • Erythrocyte adducin: A calmodulin regulated actin bundling protein that stimulates spectrin actin binding
    • 12. Mische S, Mooseker M, Morrow J: Erythrocyte adducin: a calmodulin regulated actin bundling protein that stimulates spectrin actin binding. J Cell Biol 1987, 105:2837-2845.
    • (1987) J Cell Biol , vol.105 , pp. 2837-2845
    • Mische, S.1    Mooseker, M.2    Morrow, J.3
  • 13
    • 0028907681 scopus 로고
    • Fusome asymmetry and oocyte determination in Drosophila
    • 13. Lin H, Spradling AC: Fusome asymmetry and oocyte determination in Drosophila. Dev Genet 1995, 16:6-12. This careful study of the organization of the germarium shows that the fusome, which connects the cells of a germline cyst, arises from the cystoblast structure called the spectrosome. During the first division of the cystoblast, the spectrosome is inherited by only one daughter cell. The asymmetric distribution of the spectrosome might therefore play a role in determining which of the two cells with four ring canals will subsequently become determined to develop as the oocyte.
    • (1995) Dev Genet , vol.16 , pp. 6-12
    • Lin, H.1    Spradling, A.C.2
  • 14
    • 0028828689 scopus 로고
    • Homeless is required for RNA localization in Drosophila oogenesis and encodes a new member of the DE-H family of RNA dependent ATPases
    • 14. Gillespie DE, Berg CA: homeless is required for RNA localization in Drosophila oogenesis and encodes a new member of the DE-H family of RNA dependent ATPases. Genes Dev 1995, 9:2495-2508. homeless encodes a member of the DE-H family of helicases and exhibits homology to a number of splicing factors. Mutations in this gene produce egg chambers in which the oocyte often fails to localize correctly to the posterior. Mutants also disrupt mRNA localization in vitellogenic stages, and this may be a consequence of changes in the organization of the microtubule network.
    • (1995) Genes Dev , vol.9 , pp. 2495-2508
    • Gillespie, D.E.1    Berg, C.A.2
  • 15
    • 0028126502 scopus 로고
    • Role of oocyte position in establishment of anterior-posterior polarity in Drosophila
    • 15. Gonzalez-Reyes A, St Johnston D: Role of oocyte position in establishment of anterior-posterior polarity in Drosophila. Science 1994, 266:639-642.
    • (1994) Science , vol.266 , pp. 639-642
    • Gonzalez-Reyes, A.1    St Johnston, D.2
  • 16
    • 0029062580 scopus 로고
    • Polarisation of both major body axes in Drosophila by gurken-torpedo signalling
    • 16. Gonzalez-Reyes A, Elliott H, St Johnston D: Polarisation of both major body axes in Drosophila by gurken-torpedo signalling. Nature 1995, 375:654-658. Gurken signalling to torpedo/DER plays a critical role in establishing the A-P axis, in addition to its well established role in the D-V pathway. Once the oocyte has reached the posterior of a cyst, it induces the adjacent terminal follicle cells to adopt a posterior fate in a process that requires gurken in the germline and torpedo/DER in the soma. These terminal follicle cells will subsequently signal back to the germline to polarize the microtubule cytoskeleton within the oocyte. This cytoskeletal rearrangement also directs the movement of the nucleus and gurken mRNA to the anterior, where gurken signals to induce dorsal follicle cell fate. Thus, polarization of the A-P axis is a prerequisite for the establishment of D-V polarity.
    • (1995) Nature , vol.375 , pp. 654-658
    • Gonzalez-Reyes, A.1    Elliott, H.2    St Johnston, D.3
  • 17
    • 0029058415 scopus 로고
    • Cornichon and the EGF receptor signaling process are necessary for both anterior-posterior and dorsal-ventral pattern formation in Drosophila
    • 17. Roth S, Neuman-Silberberg FS, Barcelo G, Schüpbach T: cornichon and the EGF receptor signaling process are necessary for both anterior-posterior and dorsal-ventral pattern formation in Drosophila. Cell 1995, 81:967-978. The sequence of cornichon reveals a novel gene of unknown function in the gurken/torpedo signalling pathway. gurken-dependent signalling between the oocyte and the follicle cells is not only required for D-V but also for A-P axis determination. (See also [16••]).
    • (1995) Cell , vol.81 , pp. 967-978
    • Roth, S.1    Neuman-Silberberg, F.S.2    Barcelo, G.3    Schüpbach, T.4
  • 18
    • 0027368350 scopus 로고
    • The Drosophila dorsoventral patterning gene gurken produces a dorsally localized RNA and encodes a TGFα-like protein
    • 18. Neuman-Silberberg FS, Schüpbach T: The Drosophila dorsoventral patterning gene gurken produces a dorsally localized RNA and encodes a TGFα-like protein. Cell 1993, 75:165-174.
    • (1993) Cell , vol.75 , pp. 165-174
    • Neuman-Silberberg, F.S.1    Schüpbach, T.2
  • 19
    • 0024510368 scopus 로고
    • The Drosophila EGF-receptor homolog (DER) gene is allelic to faint-little ball, a locus essential for embryonic development
    • 19. Schejter E, Shilo B-Z: The Drosophila EGF-receptor homolog (DER) gene is allelic to faint-little ball, a locus essential for embryonic development. Cell 1989, 56:1093-1104.
    • (1989) Cell , vol.56 , pp. 1093-1104
    • Schejter, E.1    Shilo, B.-Z.2
  • 20
    • 0024544624 scopus 로고
    • The maternal ventralizing locus torpedo is allelic to faint little ball, an embryonic lethal, and encodes the Drosophila EGF receptor homolog
    • 20. Price JV, Clifford RJ, Schüpbach T: The maternal ventralizing locus torpedo is allelic to faint little ball, an embryonic lethal, and encodes the Drosophila EGF receptor homolog. Cell 1989, 56:1085-1092.
    • (1989) Cell , vol.56 , pp. 1085-1092
    • Price, J.V.1    Clifford, R.J.2    Schüpbach, T.3
  • 21
    • 0025986767 scopus 로고
    • Role of neurogenic genes in establishment of follicle cell fate and oocyte polarity during oogenesis in Drosophila
    • 21. Ruohola H, Bremer KA, Baker D, Swedlow JR, Jan LY, Jan YN: Role of neurogenic genes in establishment of follicle cell fate and oocyte polarity during oogenesis in Drosophila. Cell 1991, 66:433-449.
    • (1991) Cell , vol.66 , pp. 433-449
    • Ruohola, H.1    Bremer, K.A.2    Baker, D.3    Swedlow, J.R.4    Jan, L.Y.5    Jan, Y.N.6
  • 22
    • 0028607056 scopus 로고
    • RNA localization along the anteroposterior axis of the Drosophila oocyte requires PKA-mediated signal transduction to direct normal microtubule organization
    • 22. Lane ME, Kalderon D: RNA localization along the anteroposterior axis of the Drosophila oocyte requires PKA-mediated signal transduction to direct normal microtubule organization. Genes Dev 1994, 8:2986-2995.
    • (1994) Genes Dev , vol.8 , pp. 2986-2995
    • Lane, M.E.1    Kalderon, D.2
  • 23
    • 0026451223 scopus 로고
    • Reorganization of the cytoskeleton during Drosophila oogenesis: Implications for axis specification and intercellular transport
    • 23. Theurkauf W, Smiley S, Wong M, Alberts B: Reorganization of the cytoskeleton during Drosophila oogenesis: implications for axis specification and intercellular transport. Development 1992, 115:923-936.
    • (1992) Development , vol.115 , pp. 923-936
    • Theurkauf, W.1    Smiley, S.2    Wong, M.3    Alberts, B.4
  • 24
    • 0020687068 scopus 로고
    • Multiple effects of colchicine on oogenesis in Drosophila: Induced sterility and switch of potential oocyte to nurse cell developmental pathway
    • 24. Koch EA, Spitzer RH: Multiple effects of colchicine on oogenesis in Drosophila: induced sterility and switch of potential oocyte to nurse cell developmental pathway. Cell Tissue Res 1983, 228:21-32.
    • (1983) Cell Tissue Res , vol.228 , pp. 21-32
    • Koch, E.A.1    Spitzer, R.H.2
  • 25
    • 0028075207 scopus 로고
    • Dorsoventral axis formation in Drosophila depends on the correct dosage of the gene gurken
    • 25. Neuman-Silberberg FS, Schüpbach T: Dorsoventral axis formation in Drosophila depends on the correct dosage of the gene gurken. Development 1994, 120:2457-2463.
    • (1994) Development , vol.120 , pp. 2457-2463
    • Neuman-Silberberg, F.S.1    Schüpbach, T.2
  • 26
    • 0029014816 scopus 로고
    • The role of fs (1) K10 in the localization of the mRNA of the TGFα homolog gurken within the Drosophila oocyte
    • 26. Serano TL, Karlin-McGinness M, Cohen RS: The role of fs (1) K10 in the localization of the mRNA of the TGFα homolog gurken within the Drosophila oocyte. Mech Dev 1995, 51:183-192.
    • (1995) Mech Dev , vol.51 , pp. 183-192
    • Serano, T.L.1    Karlin-McGinness, M.2    Cohen, R.S.3
  • 27
    • 0023644991 scopus 로고
    • Germ line and soma cooperate during oogenesis to establish the dorsoventral pattern of egg shell and embryo in Drosophila melanogaster
    • 27. Schüpbach T: Germ line and soma cooperate during oogenesis to establish the dorsoventral pattern of egg shell and embryo in Drosophila melanogaster. Cell 1987, 49:699-707.
    • (1987) Cell , vol.49 , pp. 699-707
    • Schüpbach, T.1
  • 28
    • 0029591416 scopus 로고
    • Signaling pathways that establish the dorsal-ventral pattern of the Drosophila embryo
    • 28. Morisato D, Anderson K: Signaling pathways that establish the dorsal-ventral pattern of the Drosophila embryo. Annu Rev Gen 1995, 29:371-399.
    • (1995) Annu Rev Gen , vol.29 , pp. 371-399
    • Morisato, D.1    Anderson, K.2
  • 29
    • 0029558233 scopus 로고
    • mRNA localisation during development
    • 29. Micklem DM: mRNA localisation during development. Dev Biol 1995, 172:377-395.
    • (1995) Dev Biol , vol.172 , pp. 377-395
    • Micklem, D.M.1
  • 30
    • 0011725057 scopus 로고
    • Cytoskeletal mechanisms of RNA localization during Drosophila oogenesis
    • Edited by Lipshitz H, Heidelberg: Springer-Verlag
    • 30. Stephenson EC: Cytoskeletal mechanisms of RNA localization during Drosophila oogenesis. In Localized RNAs. Edited by Lipshitz H, Heidelberg: Springer-Verlag; 1995:63-76.
    • (1995) Localized RNAs , pp. 63-76
    • Stephenson, E.C.1
  • 31
    • 0028798670 scopus 로고
    • Microtubules are a general component of mRNA localisation systems in Drosophila oocytes
    • 31. Pokrywka NJ, Stephenson EC: Microtubules are a general component of mRNA localisation systems in Drosophila oocytes. Dev Biol 1995, 167:363-370. The effects of various cytoskeletal inhibitors on mRNA localization during oogenesis are described. Drugs affecting the microtubule network, but not microfilaments, abrogated mRNA localization to and within the oocyte up to stage 10.
    • (1995) Dev Biol , vol.167 , pp. 363-370
    • Pokrywka, N.J.1    Stephenson, E.C.2
  • 32
    • 0028971736 scopus 로고
    • A small predicted stem-loop structure mediates oocyte localization of Drosophila K10 mRNA
    • 32. Serano TL, Cohen RS: A small predicted stem-loop structure mediates oocyte localization of Drosophila K10 mRNA. Development 1995, 121:3809-3818. K10 mRNA localization to the oocyte depends on a 47 nucleotide long sequence in the 3′-UTR, termed the TLS, which is predicted to form a stem loop structure. Mutagenesis experiments show that it is the secondary structure of the TLS rather than its primary sequence which is required for localization. The same localization pathway might be important for other mRNAs localized to the oocyte early, as a similar sequence is found in the 3′-UTR of orb mRNA.
    • (1995) Development , vol.121 , pp. 3809-3818
    • Serano, T.L.1    Cohen, R.S.2
  • 33
    • 0029116371 scopus 로고
    • Gratuitous mRNA localization in the Drosophila oocyte
    • 33. Serano TL, Cohen RS: Gratuitous mRNA localization in the Drosophila oocyte. Development 1995, 121:3013-3021. The K10 mRNA localization to the oocyte, but not to the anterior, is essential for K10 function. K10 mRNA localized to the posterior by the oskar 3′-UTR, to the anterior by the bicoid 3′-UTR, or completely unlocalized rescues a K10 mutant. The transient localization to the anterior cortex of the oocyte is observed with many mRNAs and therefore seems a default step in the microtubule-dependent localization pathway to the oocyte.
    • (1995) Development , vol.121 , pp. 3013-3021
    • Serano, T.L.1    Cohen, R.S.2
  • 34
    • 0024786410 scopus 로고
    • Multiple steps in the localization of bicoid RNA to the anterior pole of the Drosophila oocyte
    • 34. St Johnston D, Driever W, Berleth T, Richstein S, Nüsslein-Volhard C: Multiple steps in the localization of bicoid RNA to the anterior pole of the Drosophila oocyte. Development 1989, 107(suppl):13-19.
    • (1989) Development , vol.107 , Issue.SUPPL. , pp. 13-19
    • St Johnston, D.1    Driever, W.2    Berleth, T.3    Richstein, S.4    Nüsslein-Volhard, C.5
  • 35
    • 0027264595 scopus 로고
    • RNA regulatory element BLE1 directs the early steps of bicoid mRNA localization
    • 35. MacDonald PM, Kerr K, Smith JL, Leask A: RNA regulatory element BLE1 directs the early steps of bicoid mRNA localization. Development 1993, 118:1233-1243.
    • (1993) Development , vol.118 , pp. 1233-1243
    • MacDonald, P.M.1    Kerr, K.2    Smith, J.L.3    Leask, A.4
  • 36
    • 0028846515 scopus 로고
    • Exl protein specifically binds BLE1, a bicoid mRNA localization element, and is required for one phase of its activity
    • 36. MacDonald PM, Leask A, Kerr K: exl protein specifically binds BLE1, a bicoid mRNA localization element, and is required for one phase of its activity. Proc Natl Acad Sci USA 1995, 92:10787-10791.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 10787-10791
    • MacDonald, P.M.1    Leask, A.2    Kerr, K.3
  • 37
    • 0025826161 scopus 로고
    • Oskar organizes the germ plasm and directs localization of the posterior determinant nanos
    • 37. Ephrussi A, Dickinson LK, Lehmann R: Oskar organizes the germ plasm and directs localization of the posterior determinant nanos. Cell 1991, 66:37-50.
    • (1991) Cell , vol.66 , pp. 37-50
    • Ephrussi, A.1    Dickinson, L.K.2    Lehmann, R.3
  • 38
    • 0025814789 scopus 로고
    • Oskar mRNA is localized to the posterior pole of the Drosophila oocyte
    • 38. Kim-Ha J, Smith JL, MacDonald PM: oskar mRNA is localized to the posterior pole of the Drosophila oocyte. Cell 1991, 66:23-34.
    • (1991) Cell , vol.66 , pp. 23-34
    • Kim-Ha, J.1    Smith, J.L.2    MacDonald, P.M.3
  • 39
    • 0026659735 scopus 로고
    • Induction of germ cell formation by Oskar
    • 39. Ephrussi A, Lehmann R: Induction of germ cell formation by Oskar. Nature 1992, 358:387-392.
    • (1992) Nature , vol.358 , pp. 387-392
    • Ephrussi, A.1    Lehmann, R.2
  • 40
    • 0028406293 scopus 로고
    • Transient posterior localization of a kinesin fusion protein reflects antero-posterior polarity of the Drosophila oocyte
    • 40. Clark I, Giniger E, Ruohola-Baker H, Jan L, Jan Y: Transient posterior localization of a kinesin fusion protein reflects antero-posterior polarity of the Drosophila oocyte. Curr Biol 1994, 4:289-300.
    • (1994) Curr Biol , vol.4 , pp. 289-300
    • Clark, I.1    Giniger, E.2    Ruohola-Baker, H.3    Jan, L.4    Jan, Y.5
  • 41
    • 0028144963 scopus 로고
    • Drosophila cytoplasmic dynein, a microtubule motor that is asymmetrically localized in the oocyte
    • 41. Li MG, McGrail M, Serr M, Hays TS: Drosophila cytoplasmic dynein, a microtubule motor that is asymmetrically localized in the oocyte. J Cell Biol 1994, 126:1475-1494.
    • (1994) J Cell Biol , vol.126 , pp. 1475-1494
    • Li, M.G.1    McGrail, M.2    Serr, M.3    Hays, T.S.4
  • 42
    • 0028787443 scopus 로고
    • Regulation of cytoplasmic dynein function in vivo by the Drosophila Glued complex
    • 1 which encodes the Drosophila homologue of the p150 subunit of dynactin, co-localizes with cytoplasmic dynein to the pro-oocyte in region 2b germaria and to the posterior of the oocyte at stage 9. In a particular combination of dynein mutant alleles, neither Glued nor dynein localize to the posterior of the oocyte
    • (1995) J Cell Biol , vol.131 , pp. 411-425
    • McGrail, M.1    Gepner, J.2    Silvanovich, A.3    Ludmann, S.4    Serr, M.5    Hays, T.S.6
  • 43
    • 0025778124 scopus 로고
    • Two different microtubule-based motor activities with opposite polarities in kinetochores
    • 43. Hyman AA, Mitchison TJ: Two different microtubule-based motor activities with opposite polarities in kinetochores. Nature 1991, 351:206-211.
    • (1991) Nature , vol.351 , pp. 206-211
    • Hyman, A.A.1    Mitchison, T.J.2
  • 44
    • 0026758070 scopus 로고
    • Kinesin and cytoplasmic dynein binding to brain microsomes
    • 44. Yu H, Toyoshima I, Steuer E, Sheetz M: Kinesin and cytoplasmic dynein binding to brain microsomes. J Biol Chem 1992, 267:20457-20464.
    • (1992) J Biol Chem , vol.267 , pp. 20457-20464
    • Yu, H.1    Toyoshima, I.2    Steuer, E.3    Sheetz, M.4
  • 45
    • 0029151640 scopus 로고
    • Requirement for Drosophila cytoplasmic tropomyosin in oskar mRNA localization
    • 45. Erdelyi M, Michon AM, Guichet A, Glotzer JB, Ephrussi A: Requirement for Drosophila cytoplasmic tropomyosin in oskar mRNA localization. Nature 1995, 377:524-527. A P-element screen for grandchildless mutations uncovered the requirement for cytoplasmic tropomyosin in pole plasm formation. In tropomyosin mutants, most oskar mRNA accumulates at the anterior of the oocyte and very little is translocated to the posterior. As the general organization of the cytoskeleton seems intact in mutants, this is the first evidence that actin filaments are involved in the localization of oskar mRNA.
    • (1995) Nature , vol.377 , pp. 524-527
    • Erdelyi, M.1    Michon, A.M.2    Guichet, A.3    Glotzer, J.B.4    Ephrussi, A.5
  • 46
    • 0029977564 scopus 로고    scopus 로고
    • Lack of Drosophila cytoskeletal tropomyosin affects head morphogenesis and the accumulation of oskar mRNA required for germ cell formation
    • 46. Tetzlaff MT, Jäckle H, Pankratz MJ: Lack of Drosophila cytoskeletal tropomyosin affects head morphogenesis and the accumulation of oskar mRNA required for germ cell formation. EMBO J 1996, 15:1247-1254. Cytoplasmic tropomyosin is required for oskar mRNA localization to the posterior (see also [45••]). In addition, the authors describe the isolation of a null allele and its zygotic phenotype, a defect in head involution.
    • (1996) EMBO J , vol.15 , pp. 1247-1254
    • Tetzlaff, M.T.1    Jäckle, H.2    Pankratz, M.J.3
  • 47
    • 0028973402 scopus 로고
    • Cappuccino, a Drosophila maternal effect gene required for polarity of the egg and embryo, is related to the vertebrate limb deformity locus
    • 47. Emmons S, Phan H, Calley J, Chen W, James B, Manseau L: cappuccino, a Drosophila maternal effect gene required for polarity of the egg and embryo, is related to the vertebrate limb deformity locus. Genes Dev 1995, 9:2482-2494. The product of the cappuccino gene is related to the formin family, with the highest homology to the limb deformity gene. Mutations in cappuccino induce premature ooplasmic streaming, thereby causing A-P defects by dislodging oskar and bicoid mRNA. The D-V patterning defects are attributed to an unknown effect of cappuccino, as gurken mRNA remains localized in cappuccino alleles. Premature ooplasmic streaming can also be induced by cytochalasin D treatment, suggesting a role of for actin in the organization of the oocyte microtubule cytoskeleton.
    • (1995) Genes Dev , vol.9 , pp. 2482-2494
    • Emmons, S.1    Phan, H.2    Calley, J.3    Chen, W.4    James, B.5    Manseau, L.6
  • 48
    • 0024723365 scopus 로고
    • Cappuccino and spire: Two unique maternal-effect loci required for both the anteroposterior and dorsoventral patterns of the Drosophila embryo
    • 48. Manseau LJ, Schüpbach T: cappuccino and spire: two unique maternal-effect loci required for both the anteroposterior and dorsoventral patterns of the Drosophila embryo. Genes Dev 1989, 3:1437-1452.
    • (1989) Genes Dev , vol.3 , pp. 1437-1452
    • Manseau, L.J.1    Schüpbach, T.2
  • 49
    • 0027945945 scopus 로고
    • Premature microtubule-dependent cytoplasmic streaming in cappuccino and spire mutant oocytes
    • 49. Theurkauf WE: Premature microtubule-dependent cytoplasmic streaming in cappuccino and spire mutant oocytes. Science 1994, 265:2093-2096.
    • (1994) Science , vol.265 , pp. 2093-2096
    • Theurkauf, W.E.1
  • 50
    • 0028354293 scopus 로고
    • The mago nashi locus encodes an essential product required for germ plasm assembly in Drosophila
    • 50. Newmark PA, Boswell RE: The mago nashi locus encodes an essential product required for germ plasm assembly in Drosophila. Development 1994, 120:1303-1313.
    • (1994) Development , vol.120 , pp. 1303-1313
    • Newmark, P.A.1    Boswell, R.E.2
  • 51
    • 0025885105 scopus 로고
    • Staufen, a gene required to localize maternal RNAs in the Drosophila egg
    • 51. St Johnston D, Beuchle D, Nüsslein-Volhard C: staufen, a gene required to localize maternal RNAs in the Drosophila egg. Cell 1991, 66:51-63.
    • (1991) Cell , vol.66 , pp. 51-63
    • St Johnston, D.1    Beuchle, D.2    Nüsslein-Volhard, C.3
  • 53
    • 0028639195 scopus 로고
    • Staufen protein associates with the 3′UTR of bicoid mRNA to form particles that move in a microtubule-dependent manner
    • 53. Ferrandon D, Elphick L, Nüsslein-Volhard C, St Johnston D: Staufen protein associates with the 3′UTR of bicoid mRNA to form particles that move in a microtubule-dependent manner. Cell 1994, 79:1221-1232.
    • (1994) Cell , vol.79 , pp. 1221-1232
    • Ferrandon, D.1    Elphick, L.2    Nüsslein-Volhard, C.3    St Johnston, D.4
  • 54
    • 0029041105 scopus 로고
    • NMR solution structure of a dsRNA binding domain from Drosophila staufen protein reveals homology to the N-terminal domain of ribosomal, protein S5
    • 54. Bycroft M, Grünert S, Murzin AG, Proctor M, St Johnston D: NMR solution structure of a dsRNA binding domain from Drosophila staufen protein reveals homology to the N-terminal domain of ribosomal, protein S5. EMBO J 1995, 14:3563-3571. The NMR structure of the dsRBD 3 of Staufen is homologous to the ribosomal protein S5. This domain therefore has an ancient origin. The dsRBD has a three stranded β-sheet flanked on either side by a helix. A number of point mutations which abolish RNA binding implicate one face of the domain in the interaction with RNA.
    • (1995) EMBO J , vol.14 , pp. 3563-3571
    • Bycroft, M.1    Grünert, S.2    Murzin, A.G.3    Proctor, M.4    St Johnston, D.5
  • 55
    • 0029030017 scopus 로고
    • Localized Bicaudal-C RNA encodes a protein containing a KH domain, the RNA binding motif of FMR1
    • 55. Mahone M, Saffman EE, Lasko PF: Localized Bicaudal-C RNA encodes a protein containing a KH domain, the RNA binding motif of FMR1. EMBO J 1995, 14:2043-2055. Bicaudal-C mRNA is expressed in the ovary and localized to the oocyte. Alleles of Bicaudal-C show defects in the migration of a subset of follicle cells and in oskar mRNA translocation from the anterior to the posterior. The sequence of Bicaudal-C contains an unusual combination of five KH domains, a receptor tyrosine kinase domain and a transmembrane domain.
    • (1995) EMBO J , vol.14 , pp. 2043-2055
    • Mahone, M.1    Saffman, E.E.2    Lasko, P.F.3
  • 56
    • 0029085434 scopus 로고
    • Localization of oskar RNA regulates oskar translation and requires Oskar protein
    • 56. Rongo C, Gavis ER, Lehmann R: Localization of oskar RNA regulates oskar translation and requires Oskar protein. Development 1995, 121:2737-2746. Two isoforms of oskar (long and short) are produced from the same RNA. Mutations abolishing oskar mRNA localization do not produce Oskar protein because of a translational repression element in the 3′-UTR. Staufen and Oskar are required to maintain the localization of oskar mRNA at the posterior.
    • (1995) Development , vol.121 , pp. 2737-2746
    • Rongo, C.1    Gavis, E.R.2    Lehmann, R.3
  • 57
    • 0028863317 scopus 로고
    • Translational control of oskar generates short OSK, the isoform that induces pole plasm assembly
    • 57. Markussen FH, Michen AM, Breitwieser W, Ephrussi A: Translational control of oskar generates short OSK, the isoform that induces pole plasm assembly. Development 1995, 121:3723-3732. Two isoforms of Oskar (long and short) are produced from the same RNA by alternative usage of two AUG codons. Many posterior group genes affect oskar mRNA expression, by either abolishing translation completely or shifting the ratio of the two isoforms. The short form has full oskar activity and appears to be localized preferentially to the pole cells in embryogenesis. The long form on its own fails to rescue oskar mutants, even though it can maintain oskar mRNA localization.
    • (1995) Development , vol.121 , pp. 3723-3732
    • Markussen, F.H.1    Michen, A.M.2    Breitwieser, W.3    Ephrussi, A.4
  • 58
    • 0029065026 scopus 로고
    • The intracellular localization of messenger RNAs
    • 58. St Johnston D: The intracellular localization of messenger RNAs. Cell 1995, 81:161-170.
    • (1995) Cell , vol.81 , pp. 161-170
    • St Johnston, D.1
  • 59
    • 0029936348 scopus 로고    scopus 로고
    • Identification of cis-acting sequences that control nanos RNA localization
    • 59. Gavis ER, Curtis D, Lehmann R: Identification of cis-acting sequences that control nanos RNA localization. Dev Biol 1996, 176:36-50.
    • (1996) Dev Biol , vol.176 , pp. 36-50
    • Gavis, E.R.1    Curtis, D.2    Lehmann, R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.