Separate cis-acting elements determine the expression of mouse Dbx gene in multiple spatial domains of the central nervous system

Mechanisms of Development

Volumn 58, Issue 1-2, 1996, Pages 193-202

  Lu, Sangwei ^a,c   Shashikant, Cooduvalli S ^a   Ruddle, Frank H ^a,b  

^a YALE UNIVERSITY   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Enhancer; Forebrain patterning; Oculomotor nerve; Transgenic analysis

Indexed keywords

DNA FRAGMENT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; EMBRYO; FOREBRAIN; GENE DELETION; GENE EXPRESSION; HOMEOBOX; MESENCEPHALON; MOUSE; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; OCULOMOTOR NERVE; PRIORITY JOURNAL; REPORTER GENE; RHOMBENCEPHALON; SPINAL CORD; TRANSCRIPTION INITIATION; TRANSGENE;

EID: 0030217984     PISSN: 09254773     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0925-4773(96)00576-X     Document Type: Article

References (23)

1. Bulfone, A., Puelles, L., Porteus, M.H., Frohman, M.A., Martin, G. and Rubenstein, J.L.R. (1993) Spatially restricted expression of DIx-1, DIx-2 (Tes-1), Gbx-2, and Wnt-3 in the embryonic day 12.5 mouse forebrain defines potential transverse and longitudinal segmental boundaries. J. Neurosci. 13, 3155-3172.
2. Bulfone, A., Smiga, S.M., Shimamura, K., Peterson, A., Puelles, L. and Rubenstein., J.L.R. (1995) T-brain-1: a homolog of Brachyury whose expression defines molecularty distinct domains within the cerebral cortex. Neuron 15, 63-78.
3. De Robertis, E.M. (1994) The homeobox in cell differentiation and evolution. In Duboule, D. (ed.), Guide Book to the Homeobox Genes. Oxford University Press, Oxford, pp. 13-23.
4. Echelard, Y., Vassileva, G. and McMahon, A.P. (1994) Cis-acting regulatory sequences governing Wnt-1 expression in the developing mouse CNS. Development 120, 2213-2224.
5. Gordon, J.W. and Ruddle, F.H. (1983) Gene transfer into mouse embryos: production of transgenic mice by pronulear injection. Methods Enzymol. 101, 411-433.
6. Krumlauf, R. (1994) Hox genes in vertebrate development. Cell 78, 191-201.
7. Leber, S.M. and Sanes, J.R. (1995) Migratory paths of neurons and glia in the embryonic chick spinal cord. J. Neurosci. 15, 1236-1248.
8. Leber, S.M., Breedlove, S.M. and Sanes, J.R. (1990) Lineage, arrangement, and death of clonally related motorneurons in chick spinal cord. J. Neurosci. 10, 2451-2462.
9. Logan, C., Khoo, W.K., Cado, D. and Joyner, A.L. (1993) Two enhancer regions in En-2 locus direct expression to the mid/hindbrain region and mandibular myoblasts. Development 117, 905-916.
10. Lu, S., Bogarad, L.D., Murtha, M.T. and Ruddle, F.H. (1992) Expression pattern of a murine homeobox gene, Dbx, displays extreme spatial restriction in embryonic forebrain and spinal cord. Proc. Natl. Acad. Sci. USA 89, 8053-8057.
11. Lu, S., Wise, T.L. and Ruddle, F.H. (1994) Mouse homeobox gene Dbx: sequence, gene structure and expression pattern during midgestation. Mech. Dev. 47, 187-195.
12. Porteus, M.H., Bulfone, A., Ciaranello, R.D. and Rubenstein, J.L.R. (1991) Isolation and characterization of a novel cDNA clone encoding a homeodomain that is developmentally regulated in the ventral forebrain. Neuron 7, 221-229.
13. Price, M., Lemaistre, M., Pischetola, M., Di Lauro, R. and Duboule, D. (1991) A mouse gene related to Distal-less shows a restricted expression in the developing forebrain. Nature 351, 748-751.
14. Price, M., Lazzaro, D., Pohl, T., Mattei, M.G., Ruther, U., Olivo, J.C., Duboule, D. and Di Lauro, R. (1992) Regional expression of the homeobox gene Nkx-2.2 in the developing mammalian forebrain. Neuron 8, 241-255.
15. Puelles, L. and Rubenstein J.L.R. (1993) Expression patterns of homeobox genes and other putative regulatory genes in embryonic forebrain suggest a neuromeric organization. Trends Neurosci. 16, 472-479.
16. Püschel, A.W., Balling, R. and Gruss, P. (1991) Separate elements cause lineage restriction and specify boundaries of Hox-1.1 expression. Development 112, 279-289.
17. Rakic, P. (1972) Mode of cell migration to the superficial layer of fetal monkey neocortex. J. Comp. Neurol. 145, 61-84.
18. Rakic, P and Sidman, R.L. (1969) Telencephalic origin of pulvinar neurons in the fetal human brain. Z. Anat. Entwicklungsgesch. 129, 53-82.
19. Rubenstein, J.L. and Puelles, L. (1994) Homeobox gene expression during development of the vertebrate brain. Curr. Top. Dev. Biol. 29, 1-63.
20. Sambrook, J., Fritsch, E.F. and Maniatis, T. (1989) Molecular Cloning: a Laboratory Manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
21. Simeone, A., Gulisano, M., Acamopora, D., Stornaiuolo, A., Rambaldi, M. and Boncinelli, E. (1992a) Two vertebrate homeobox genes related to the Drosophila empty spiracles gene are expressed in the embryonic cerebral cortex. EMBO J. 11, 2541-2550.
22. Simeone, A., Acampora, D., Gulisano, M., Stornaiuolo, A. and Boncinelli, E. (1992b) Nested expression domains of four homeobox genes in the developing rostral brain. Nature 358, 687-690.
23. Simeone, A., D'Apice, M.R., Nigro, V., Casanova, D., Graziani, F., Acampora, D. and Avantaggiato, V. (1994) Orthopedia, a novel homeobox containing gene expressed in the developing CNS of both mouse and Drosophila. Neuron 13, 83-101.