Tetrahydroaminoacridine-induced apoptosis in rat hepatocytes

Toxicology in Vitro

Volumn 10, Issue 4, 1996, Pages 383-393

  Fariss, M W ^a   Mumaw, V R ^b   Walton, L P ^b  

^a WASHINGTON STATE UNIVERSITY   (United States)

^b VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TACRINE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; ELECTRON MICROSCOPY; LIVER CELL; LIVER TOXICITY; MALE; NONHUMAN; PROTEIN SYNTHESIS INHIBITION; RAT;

EID: 0030217961     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/0887-2333(96)00034-3     Document Type: Article

References (31)

1. Ahlin A., Adem A., Junthe T., Ohman G. and Nyback H. (1992) Pharmacokinetics of tetrahydroaminoacridine: relations to clinical and biochemical effects in Alzheimer patients. International Clinical Psychopharmacology 7, 29-36.
2. Al Casey S., Brewster D., Viau C. and Acosta D. (1995) Effect of glutathione depletion and oxidative stress on the in vitro cytotoxicity of velnacrine maleate. Toxicology Letters 76, 257-265.
3. Boylan J. J., Egle J. L. and Guzelian P. S. (1978) Cholestyramine: Use as a new therapeutic approach for chlordecone (Kepone) poisoning. Science 199, 893-897.
4. Buhl S. N., Jackson K. Y., Lubinski R. and Vanderlinde R. E. (1977) Optimal conditions for assaying human LDH by the lactate-pyruvate reaction: Arrhenius relationships for LDH isoenzymes 1 and 5. Clinical Cliemistry 23, 1289-1295.
5. Cohn W. J., Boylan J. J., Blanke R. V., Fariss M. W., Howell J. R. and Guzelian P. S. (1978) Treatment of chlordecone (Kepone) toxicity with cholestyramine. New England Journal of Medicine 298, 243-248.
6. Conrad M. and Topal M. D. (1986) Induction of deletion and insertion mutations by 9-aminoacridine. Journal of Biological Chemistry 261, 16226-16232.
7. Dogterom P., Nagelkerke J. F. and Mulder G. J. (1988) Hepatotoxicity of tetrahydroaminoacridine in isolated rat hepatocytes: effect of glutathione and vitamin E. Biochemical Pharmacology 37, 2311-2313.
8. Dorko K., Freeswick P. D., Bartoli F., Cicolese L., Bordsley B. A., Tzakis A. and Nussler A. K. (1994) A new technique for isolating and culturing human hepatocytes from whole or split livers not used for transplantation. Journal of Cell Transplantation 3, 387-395.
9. Eagger S. A., Levy R. and Sahakian B. J. (1991) THA in Alzheimer's disease. Lancet 337, 889-992.
10. Egle J. L., Fernandez S. B., Guzelian P. S. and Borzelleca J. F. (1978) Distribution and excretion of chlordecone (Kepone) in the rat. Drug Metabolism and Disposition 6, 91-99.
11. El Dareer S. M., Kalin J. R., Tillery K. F. and Hill D. L. (1985) Dispositon of 9-aminoacridine in rats dosed orally or intravenously and in monkeys dosed topically. Journal of Toxicology and Environmental Health 15, 789-799.
12. Faa G., Ledda-Columbano G. M., Ambu R., Congiu T., Coni P., Riva A. and Columbano A. (1994) An electron microscopic study of apoptosis induced by cycloheximide in rat liver. Liver 14, 270-278.
13. Fariss M. W., Brown M. K., Schmitz J. A. and Reed D. J. (1985) Mechanism of chemical-induced toxicity 1. Use of a rapid centrifugation technique for the separation of viable and non-viable hepatocytes. Toxicology and Applied Pharmacology 79, 283-295.
14. Fariss M. W., Johnsen S. A., Walton L. P., Mumaw V. R. and Ray S. D. (1994) Tetrahydroaminoacridine-induced ribosomal changes and inhibition of protein synthesis in rat hepatocyte suspensions. Hepatology 20, 240-246.
15. Goodman M. F., Bessman M. J. and Bachur N. R. (1974) Adriamycin and daunorubicin inhibition of mutant T4 DNA polymerases. Proceedings of the National Academy of Sciences of the U.S.A 71, 1193-1196.
16. Green V. J., Pirmohamed M., Kitteringham N. R., Knapp M. J. and Park B. K. (1995) Glutathione S-transferase mu genotype in Alzheimer's patients with THA transaminitis. British Journal of Clinical Pharmacology 39, 411-415.
17. Hasselgren P. O., Pedersen P., Sax H. C., Warner B. W. and Fisher J. E. (1988) Methods for studying protein synthesis and degradation in liver and skeletal muscle. Journal of Surgical Research 45, 389-415.
18. Knapp M. J., Knopman D. S., Solomon P. R., Pendlebury W. W., Davis C. S. and Gracon S. I. (1994) A 30-week randomized controlled trial of high-dose THA in patients with Alzheimer's disease. Journal of the American Medical Association 271, 985-991.
19. Kropko M. L., Wold S. and Theiss J. C. (1992) Comparative bacterial mutagenicity of THA and selected aminoacridine compounds. Environmental and Molecular Mutagesis Suppl. 20, 32.
20. Ledda-Columbano G. M., Coni P., Faa G., Manenti G. and Columbano A. (1992) Rapid induction of apoptosis in rat liver by cycloheximide. American Journal of Pathology 140, 545-549.
21. Luqman W. A. (1994) THA for Alzheimer's disease. (Letter). Journal of the American Medical Association 272, 1896.
22. McNally W., Roth M., Young R., Bockbrader H. and Chang T. (1989) Quantitative whole-boly autoradiographic determination of THA tissue distribution in rats following intravenous or oral dose. Pharmaceutical Research 6, 924-930.
23. Ni R., Tomita Y., Matsuda K., Ichihara A., Ishimura K., Ogasawara J. and Nagata S. (1994) Fas-mediated apoptosis in primary cultured mouse hepatocytes. Experimental Cell Research 215, 332-337.
24. O'Brien J. T., Eagger S. and Levy R. (1991) Effects of tetrahydroaminoacridine on liver function in patients with Alzheimer's disease. Age and Ageing 20, 129-131.
25. Shaddock J. G., Feuers R. J., Chou M. W., Swenson D. H. and Casciano D. A. (1995) Genotoxicity of THA in primary hepatocytes isolated from B6C3F1 mice and aged ad libitum and calorie restricted Fischer 344 rats. Mutation Research 344, 79-88.
26. Thompson C. B. (1995) Apoptosis in the pathogenesis and treatment of disease. Science 267, 1456-1462.
27. Topal M. D. (1984) Molecular mechanisms of chemical mutagenesis: 9-aminoacridine inhibits DNA replication in vitro by destabilizing the DNA growing point and interacting with the DNA polymerase. Biochemistry 23, 2367-2372.
28. Tyson C. A. and Green C. E. (1987) Cytotoxicity measures: choices and methods. In The Isolated Hepatocyte. Use in Toxicology and Xenobiotic Biotransformations. Edited by E. J. Rauckman and G. M. Padilla. pp. 119-158. Academic Press Inc., Orlando, FL.
29. Viau C. J., Curren R. D. and Wallace K. (1993) Cytotoxicity of THA and velnacrine metabolites in cultured rat, dog and human hepatocytes. Drug and Chemical Toxicology 16, 227-239.
30. Watkins P. B., Zimmerman H. J., Knapp M. J., Gracon S. I. and Lewis K. W. (1994) Hepatotoxic effects of THA administration in patients with Alzheimer's disease. Journal of the American Medical Association 271, 992-998.
31. Winker M. A. (1994) THA for Alzheimer's disease. Which patient, what dose? (Editorial). Journal of the American Medical Association 271, 1023-1024.