The effect of gonadectomy on the clinical course of chronic experimental allergic encephalomyelitis

Clinical Neurology and Neurosurgery

Volumn 98, Issue 3, 1996, Pages 222-226

  Trooster, W J ^a   Teelken, A W ^a   Gerrits, P O ^a   Lijnema, T H ^a   Loof, J G ^a   Minderhoud, J M ^a   Nieuwenhuis, P ^a  

^a UNIVERSITY OF GRONINGEN   (Netherlands)

Author keywords

Experimental allergic encephalomyelitis; Gonadectomy; Multiple sclerosis; Sex hormone

Indexed keywords

CYCLOSPORIN A; SEX HORMONE;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DISEASE COURSE; FEMALE; GONADECTOMY; GUINEA PIG; IMMUNIZATION; MALE; MULTIPLE SCLEROSIS; NONHUMAN; OVARY; RAT; RELAPSE; SEX DIFFERENCE; SPINAL CORD; TESTIS;

EID: 0030217860     PISSN: 03038467     EISSN: None     Source Type: Journal    
DOI: 10.1016/0303-8467(96)00027-3     Document Type: Article

References (9)

1. [1] Grossman, C.J. (1984) Regulation of the immune system by sex steroids. Endocrine Rev., 5: 435-455.
2. [2] Polman, C.H., Matthaei, I., De Groot, C.J.A., Koetsier, J.C., Sminia, T., Dijkstra, C.D. (1988) Low-dose Cyclosporin A induces relapsing remitting experimental allergic encephalomyelitis in the Lewis rat. J. Neuroimmunol., 17: 209-216.
3. [3] Gerrits, P.O., Brekelmans-Bartels, M., Mast, L., 's-Gravenmade, E.M., Horobin, R.W., Holstege, G. (1992) Staining myelin and myelin-like degradation products in the spinal cords of chronic experimental allergic encephalomyelitis (Cr-EAE) rats using Sudan Black B staining of glycol methacrylate-embedded material. J. Neurosci. Meth., 45: 99-105.
4. [4] Stone, S.H., Traugott, U., Raine, C.S. (1983) Chronic experimental allergic encephalomyelitis in strain 2/N guinea pigs. Absence of resistance to nervous system changes and sex dependence of clinical disease. J. Neuroimmunol., 4: 187-199.
5. [5] Stone, S.H., Lerner, E.M., Goode, J.H. (1969) Acute and chronic autoimmune encephalomyelitis: age, strain, and sex dependency. The importance of the source of antigen. Proc. Soc. Exp. Biol. Med., 132: 341-344.
6. [6] Keith, A.B. (1978) Sex difference in Lewis rats in the incidence of recurrent experimental allergic encephalomyelitis. Nature, 272: 824-825.
7. [7] Mertin, L.A., Rumjanek, V.M. (1985) Pregnancy and the susceptibility of Lewis rats to experimental allergic encephalomyelitis. J. Neurol. Sci., 68: 15-24.
8. [8] Trooster, W.J., Teelken, A.W., Lijnema, T.H., Meyer, E., Minderhoud, J.M., Nieuwenhuis, P. (1994) Treatment of acute Experimental Allergic Encephalomyelitis in the Lewis rat with the sex hormone progesterone. Int. J. Immunopathol. Pharmacol., 7 (3): 183-192.
9. [9] Trooster, W.J., Teelken, A.W., Kampinga, J., Loof, J.G., Nieuwenhuis, P., Minderhoud, J.M. (1993) Suppression of acute EAE by the synthetic sex hormone 17-α-ethinylestradiol: an immunological study in the Lewis rat. Int. Arch. Allergy Immunol., 102: 133-140.