Composite exon structure of an unusual Ig λ-like gene located at human 22q11 position

Mammalian Genome

Volumn 7, Issue 8, 1996, Pages 598-602

  Schiff, C ^a   Milili, M ^a   Zucman Rossi, J ^b   Djabali, M ^a   Fougereau, M ^a  

^a CENTRE D IMMUNOLOGIE DE MARSEILLE LUMINY   (France)

^b INSTITUT CURIE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BETA GLUCURONIDASE; IMMUNOGLOBULIN LAMBDA CHAIN; PRIMER DNA;

ANIMAL; ARTICLE; BIOSYNTHESIS; CHROMOSOME 22; CHROMOSOME MAP; COMPARATIVE STUDY; EXON; GENETIC MARKER; GENETIC TRANSCRIPTION; GENETICS; HAMSTER; HUMAN; HYBRID CELL; IMMUNOGLOBULIN GENE; MOLECULAR GENETICS; MOUSE; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; RAT; RESTRICTION MAPPING; SEQUENCE HOMOLOGY; SEQUENCE TAGGED SITE;

ANIMALS; BASE SEQUENCE; CHROMOSOME MAPPING; CHROMOSOMES, HUMAN, PAIR 22; CRICETINAE; DNA PRIMERS; EXONS; GENES, IMMUNOGLOBULIN; GENETIC MARKERS; GLUCURONIDASE; HUMANS; HYBRID CELLS; IMMUNOGLOBULIN LAMBDA-CHAINS; MICE; MOLECULAR SEQUENCE DATA; POLYMERASE CHAIN REACTION; RATS; RESTRICTION MAPPING; SEQUENCE HOMOLOGY, NUCLEIC ACID; SEQUENCE TAGGED SITES; TRANSCRIPTION, GENETIC;

EID: 0030215496     PISSN: 09388990     EISSN: None     Source Type: Journal    
DOI: 10.1007/s003359900177     Document Type: Article

References (33)

1. Bauer, T.R., McDermid, H.E., Budarf, M.L., Van Keuren, M.L., Blomberg, B.B. (1993). Physical location of the human immunoglobulin lambda-like genes, 14.1, 16.1, and 16.2. Immunogenetics 38, 387-399.
2. Bossy, D., Milili, M., Zucman, J., Thomas, G., Fougereau, M., Schiff, C. (1991). Organisation and expression of the λ-like genes that contribute to the μ-ψ light chain complex in human pre-B cells. Int. Immunol. 3, 1081-1090.
3. Bossy, D., Salamero, J., Olive, D., Fougereau, M., and Schiff, C. (1993). Structure, biosynthesis and transduction properties of the human μ-ψL complex: similar behavior of preB and intermediate preB-B cells in transducing ability. Int. Immunol. 5, 467-478.
4. Chang, H., Dmitrovsky, E., Hieter, P.A., Mitchell, K., Leder, P., Turoczi, L., Kirsch, I.R., Hollis, G.F. (1986). Identification of three new Igλ-like gene in man. J. Exp. Med. 163, 425-435.
5. Chissoe, S.L., Bodenteich, A., Wang, Y.F., Wang, Y.P., Burian, D., Clifton, W., Crabtree, J., Freeman, A., Iyer, K., Jian, Li., Ma, Y., McLaury, H.J., Pan, H.Q., Sarhan, O.H., Toth, S., Wang, Z., Zhang, G., Heisterkamp, N., Groffen, J., Roe, B.A. (1995). Sequence and analysis of the human ABL gene, the BCR gene, and regions involved in the Philadelphia chromosomal translocation. Genomics 27, 67-82.
6. Chomczynski, P., Sacchi, N. (1987). Single-step method of RNA isolation by acid guanidium thicyanate-phenol-choroform extraction. Anal. Biochem. 162, 156-159.
7. Croce, C.M., Huebner, K., Isobe, M., Fainstain, E., Lifshitz, B., Shtivelman, E., Canaani, E. (1987). Mapping of four distinct BCR-related loci to chromosome region 22q11: order of BCR loci relative to chronic myelogenous leukemia and acute lymphoblastic leukemia breakpoints. Proc. Natl. Acad. Sci. USA 84, 7174-7178.
8. Dariavach, P., Lefranc, G., Lefranc, M.-P. (1987). Human immunoglobulin Cλ6 gene encodes the Kern+ Oz-λ chain and Cλ4 and Cλ5 are pseudogenes. Proc. Natl. Acad. Sci. USA 84, 9074-9078.
9. Delattre, O., Azambuja, C.J., Aurias, A., Zucman, J., Peter, M., Zhang, F., Hors-Cayla, M.-C., Rouleau, G., Thomas, G. (1991). Mapping of human chromosome 22 with a panel of somatic cell hybrids. Genomics 9, 721-727.
10. Demczuk, S., Delattre, O., Vignal, A., Weissenbach, J., Thomas, G., Aurias, A. (1995). Physical mapping of 30 CA repeats on human chromosome 22. Genomics 27, 345-347.
11. Gilbert, W., Marchionni, McKnight, G. (1986). On the antiquity of introns. Cell 46, 151-154.
12. Guglielmi, P., Davi, F. (1991). Expression of a novel type of immunoglobulin Cλ transcripts in human mature B lymphocytes producing κ light chains. Eur. J. Immunol. 21, 501-508.
13. Heisterkamp, N., Groffen, J. (1988). Duplication of the her and gamma-glutamyl transpeptidase genes. Nucleic Acids Res. 16, 8045-8056.
14. Heisterkam, N., Morris, C., Groffen, J. (1989). ABR, an active BCR-related gene. Nucleic Acids Res. 17, 8821-8831.
15. Heisterkamp, N., Kaartinen, V., van Soest, S., Bokoch, G.M., Groffen, J. (1993). Human ABR encodes a protein with GAPrac activity and homology to the DBL nucleotide exchange factor domain. J. Biol. Chem. 268, 16903-16906.
16. 5 surrogate light chain on the surface of μ heavy chain-negative early precursor B cell lines. J. Exp. Med. 178, 469-478.
17. Kitamura, D., Kudo, A. Schaal, S., Müller, W., Melchers, F., Rajewsky, K. (1992). A critical role of lambda5 protein in B cell development. Cell 69, 823-831.
18. Kudo, A., Sakaguchi, N., Melchers, F. (1987). Organization of the murine Ig-related λ5 gene transcribed selectively in pre-B lymphocytes. EMBO J. 6, 103-107.
19. Mattei, M.G., Fumoux, F., Roeckel, N., Fougereau M., Schiff, C. (1991). The human pre-B specific λ-like cluster is located in the 22q11.2-22q12.3 region, distal to the IgCλ locus. Genomics 9, 544-546.
20. Mills, F.C., Brooker, J.S., Camerini-Otero, R.D. (1990). Sequences of human immunoglobulin switch regions: implications for recombination and transcription. Nucleic Acids Res. 18, 7305-7316.
21. Olsen, I., Adams, G., Watson, G., Chain, B., Abraham, D. (1993). Multi-level regulation of lysosomal gene expression in lymphocytes. Biochem. Biophys. Res. Commun. 195, 327-335.
22. Oshima, A., Kyle, J.W., Miller, R.D., Hoffman, J.W., Powell, P.P., Grubb, J.H., Sly, W.S., Tropak, M., Guise, K.S., Gravel, R.A. (1987). Cloning, sequencing, and expression of cDNA for human beta-glucuronidase. Biochemistry 84, 685-689.
23. Ron, D., Zannini, M.L., Lewis, M., Wichner, R.B., Hunt, L.T., Graziani, G., Tronnick, S.R., Aaronson, S.A., Eva, A. (1991). New Biol. 3, 372-379.
24. Rosnet, O., Schiff, C., Pebusque, M.J., Marchetto, S., Tonnelle, C., Toiron, Y., Birg, F., Birnbaum, D. (1993). Human FLT3/FLK2 gene: cDNA cloning and expression in hematopoietic cells. Blood 82, 1110-1119.
25. Sakaguchi, N., Melchers, F. (1986). λ5, a new light chain related locus selectively expressed in pre-B lymphocytes. Nature 324, 579-582.
26. Sanger, F., Nicklen, S., Coulson, A. (1977). DNA sequencing with chain-terminating inhibitors. Proc. Natl. Acad. Sci. USA 74, 5463-5467.
27. Schiff, C., Milili, M., Fougereau, M. (1989). Isolation of early immunoglobulin λ-like gene transcripts in human fetal liver. Eur. J. Immunol. 19, 1873-1878.
28. Schiff, C., Bensmana, M., Guglielmi, P., Milili, M., Lefranc, M.-P., Fougereau, M. (1990). The immunoglobulin λ-like gene cluster (14.1, 16.1 and Fλ1) contains gene(s) selectively expressed in pre-B cells and is the human counterpart of the mouse λ5 gene. Int. Immunol. 2, 201-207.
29. Schiff, C., Milili, M., Bossy, D., Tabilio, A., Falzetti, F., Gabert, J., Mannoni, P., Fougereau, M. (1991). Lambda-like and V pre-B genes expression: an early B-lineage marker of human leukemias. Blood 78, 1516-1525.
30. Schwager, J., Bürckert, N., Schwager, M., Wilson, M. (1991). Evolution of immunoglobulin light chain genes: Analysis of Xenopus IgL isotypes and their contribution to antibody diversity. EMBO J. 10, 505-511.
31. Schwartz, C.E., Stanislovitis, P., Phelan, M.C., Taylor, H.A., Stevenson, R.E. (1991). Deletion mapping of plasminogen activator inhibitor, type I (PLANHI) and beta-glucuronidase (GUSB) in 7q21-q22. Cytogenet. Cell Genet. 51, 152-153.
32. Shipley, J.M., Klinkenberg, M., Wu, B.M., Bachinsky, D.R., Grubb, J.H., Sly, W.S. (1993). Mutational analysis of a patient with mucopolysaccharidosis type VII, and identification of pseudogenes. Am. J. Hum. Genet. 52, 517-526.
33. Thompson, T.G., DiDonato, C.J., Simard, L.R., Ingraham, S.E., Burghes. A.H.M., Crawford, T.O., Rochette, C., Mendell, J.R., Wasmuth, J.J. (1995). A novel cDNA detects homozygous microdeletions in greater than 50% of type 1 spinal muscular atrophy patients. Nature Genet. 9, 56-62.