Is There Increased Fertility in Adult Males with the Sickle Cell Trait?

Human Biology

Volumn 68, Issue 4, 1996, Pages 555-562

  Ezeh, Uchechukwu O ^a   Modebe, Onyechi ^b,c  

^a JESSOP HOSPITAL FOR WOMEN   (United Kingdom)

^b UNIVERSITY OF NIGERIA   (Nigeria)

^c BAHRAIN DEFENCE FORCE HOSPITAL   (Bahrain)

Author keywords

Fertility; Gonadotropins; Polymorphism; Semen; Sickle cell trait; Testosterone

Indexed keywords

GONADOTROPIN; TESTOSTERONE;

ADULT; ANTHROPOMETRY; ARTICLE; BLOOD; CHEMISTRY; FERTILITY; GENETIC POLYMORPHISM; GENETICS; HUMAN; MALE; NIGERIA; PHYSIOLOGY; SICKLE CELL TRAIT; SPERM;

ADULT; ANTHROPOMETRY; FERTILITY; GONADOTROPINS, PITUITARY; HUMANS; MALE; NIGERIA; POLYMORPHISM, GENETIC; SEMEN; SICKLE CELL TRAIT; TESTOSTERONE;

EID: 0030215328     PISSN: 00187143     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. Allison, A.C. 1954a. The distribution of the sickle cell trait in East Africa and elsewhere, and its apparent relationship to the incidence of subtertian malaria. Trans. R. Soc. Trop. Med. Hyg. 48:312-318.
2. Allison, A.C. 1954b. Protection afforded by the sickle cell trait against subtertian malarial infection. Br. Med. J. 1:290-294.
3. Allison, A.C. 1956. The sickle cell and hemoglobin C in some African populations. Ann. Hum. Genet 21:67-89.
4. Ashcroft, M.T., W.E. Miall, and P.F. Milner. 1969. A comparison between the characteristics of Jamaican adults with normal hemoglobin and those with sickle cell trait. Am. J. Epidemiol. 90:236-243.
5. Ashcroft, M.T., P. Desai, S.A. Richardson et al. 1976. Growth, behavior, and educational achievement of Jamaican children with sickle-cell trait. Br. Med. J. 1:1371-1373.
6. August, G.P., M.M. Grumbach, and S.L. Kaplan. 1972. Hormonal changes in puberty. III. Correlation of plasma testosterone, LH, FSH, testicular size, and age with male pubertal development. J. Clin. Endocrinol. Metab. 34:319-326.
7. Cannon, D.S.H. 1958. Malaria and prematurity in western region of Nigeria. Br. Med. J. 2:877-878.
8. Dada, O.A., and E.U. Nduka. 1980. Endocrine function and hemoglobinopathies: Relation between sickle cell gene and circulating levels of testosterone, luteinizing hormone (LH), and follicle stimulating hormone (FSH) in adult males. Clin. Chim. Acta. 105:269-273.
9. Eaton, J.W., and J.I. Mucha. 1971. Increased fertility in males with sickle cell trait? Nature 231:456-457.
10. Edington, G.M., and E.J. Watson-Williams. 1965. Sickling, hemoglobin C, glucose-6-phosphate dehydrogenase deficiency, and malaria in western Nigeria. In Abnormal Hemoglobins in Africa, J.H.P. Jonix, ed. Oxford, England: Blackwell Scientific Publishers, 393-401.
11. Eliasson, R. 1971. Standards for investigation of human semen. Andrologie 3:49-64.
12. Firschien, I.L. 1961. Population dynamics of the sickle cell trait in the Black Caribs of British Honduras, Central America. Am. J. Med. Genet. 13:233-254.
13. Fleming, A.F., A. Akintude, A.D.E. Attai et al. 1985. Malaria and hemoglobin genotype in young Nigerian children. Ann. Trop. Med. Parasitol. 79:1-5.
14. Friedman, M.J., and W. Trager. 1981. The biochemistry of resistance to malaria. Sci. Am. 244:154-164.
15. Hamilton, P.J.S., D.A.M. Gebbie, N.E. Wilks et al. 1972. The role of malaria, folic acid deficiency, and hemoglobin AS in pregnancy in Mulago hospital. Trans. R. Soc. Trop. Med. Hyg. 66:594-602.
16. Jilly, P. 1969. Anemia in paturient women with special reference to malaria infection of the placenta. Ann. Trop. Med. Parasitol. 63:109-116.
17. Katz, S.H., B. Lubin, and D. Armstrong. 1974. Growth of adolescents with sickle cell trait. Lancet 1:814-815.
18. Kramer, M.S., Y. Rooks, and H.A. Pearson. 1978. Growth and development in children with sickle-cell trait: A prospective study of matched pairs. New Engl. J. Med. 299:686-689.
19. Liu, D.Y., and H.W. Baker. 1992. Tests of human sperm function and fertilization in vitro. Fertil Steril. 58:465-483.
20. Livingstone, F.B. 1957. Sickling and malaria. Br. Med. J. 1:762-763.
21. Livingstone, F.B. 1973. Malaria and human polymorphisms. Annu. Rev. Genet. 5:33-64.
22. Luzzatto, L., E.S. Nwachuku-Jarrett, and S. Reddy. 1970. Increased sickling of parasitized erythrocytes as a mechanism of resistance to malaria in sickle cell trait. Lancet 1:319-321.
23. MacLeod, J., and R.S. Hotchkiss. 1941. The effect of hyperpyrexia upon spermatozoa counts in men. Endocrinology 28:780-784.
24. Madrigal, L. 1989. Hemoglobin genotype, fertility, and the malaria hypothesis. Hum. Biol. 61:311-325.
25. Marengo-Rowe, A.J. 1965. Rapid electrophoresis and quantitation of hemoglobins on cellulose acetate. J. Clin. Pathol. 18:790-792.
26. McCormack, M.K., S. Scarr-Salapatek, H. Polesky et al. 1975. A comparison of the physical and intellectual development of black children with and without sickle-cell trait. Pediatrics 56:1021-1025.
27. Mieusset, R., L. Bujan, M. Plantavid et al. 1989. Increased levels of follicle stimulating hormone and luteinizing hormone associated with intrinsic testicular hyperthermia in oligospermic infertile men. J. Clin. Endocrinol. Metab. 68:419-425.
28. Modebe, O., and U.O. Ezeh. 1995. Effect of age on testicular function in adult males with sickle cell anemia. Fertil. Steril. 63:907-912.
29. Modebe. O., and S.A. Ifenu. 1993. Growth retardation in homozygous sickle cell disease: Role of calorie intake and possible gender-related differences. Am. J. Hematol. 44:149-154.
30. Osegbe, D.N., O. Akinyaju, and E.O. Amaku. 1981. Fertility in males with sickle cell anemia. Lancet 2:275-276.
31. Roberts, D.F., and A.E. Boyo. 1960. On the stability of hemoglobin gene frequencies in West Africa. Ann. Hum. Genet. 24:375-378.
32. Robinson, A.R., M. Robson, A.P. Harrison et al. 1957. A new technique for differentiation of hemoglobin. J. Lab. Clin. Med. 50:745-752.
33. Steinberger, E, and W.J. Dixon. 1959. Some observations on the effect of heat on the testicular germinal epithelium. Fertil. Steril. 10:578-595.