Detection of N7-Methyldeoxyguanosine Adducts in Human Pulmonary Alveolar Cells

American Journal of Respiratory Cell and Molecular Biology

Volumn 15, Issue 2, 1996, Pages 216-223

  Petruzzelli, Stefano ^a,b   Tavanti, Laura M ^a   Celi, Alessandro ^a   Giuntini, Carlo ^a  

^a UNIVERSITY OF PISA   (Italy)

^b CISANELLO HOSPITAL   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

7 METHYL 2' DEOXYGUANOSINE 3' MONOPHOSPHATE; 7-METHYL-2'-DEOXYGUANOSINE 3'-MONOPHOSPHATE; ALKYLATING AGENT; DEOXYGUANOSINE PHOSPHATE; DIAGNOSTIC AGENT; DNA; PHOSPHORUS;

ADULT; AGED; ARTICLE; CHEMISTRY; CYTOLOGY; DNA ADDUCT; DRUG EFFECT; EPITHELIUM; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; LUNG ALVEOLUS; LUNG LAVAGE; MALE; MIDDLE AGED; RADIATION EXPOSURE; RADIATION RESPONSE; SMOKING; TWO DIMENSIONAL GEL ELECTROPHORESIS;

ADULT; AGED; ALKYLATING AGENTS; BRONCHOALVEOLAR LAVAGE FLUID; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DEOXYGUANINE NUCLEOTIDES; DNA; DNA ADDUCTS; DOSE-RESPONSE RELATIONSHIP, RADIATION; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; EPITHELIUM; FEMALE; HUMANS; MALE; MIDDLE AGED; PHOSPHORUS RADIOISOTOPES; PULMONARY ALVEOLI; SMOKING;

EID: 0030211211     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/ajrcmb.15.2.8703477     Document Type: Article

References (41)

1. International Agency for Research on Cancer. 1986. IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans, Vol. 38, Tobacco Smoking, IARC, Lyon.
2. Bartsch, H., and R. Montesano. 1984. Relevance of nitrosamines in human cancer. Carcinogenesis 5:1381-1393.
3. Hecht, S. S., and D. Hoffmann. 1991. N-Nitroso compounds and tobacco-induced cancers in man. In Relevance to Human Cancer of N-Nitroso Compounds, Tobacco Smoke and Mycotoxins. I. K. O'Neill, J. Chen, and H. Bartsch, editors. International Agency for Research on Cancer, Lyon. 54-61.
4. Perera, F. P., and R. Santella. 1993. Carcinogenesis. In Molecular Epidemiology. Principles and Practices. P. A. Schulte, and F. P. Perera, editors. Academic Press, San Diego, 277-300.
5. Castonguay, A., G. D. Stoner, H. A. J. Schut, and S. S. Hecht. 1983. Metabolism of tobacco-specific N-nitrosamines by cultured human tissues. Proc. Natl. Acad. Sci. USA 80:6694-6697.
6. 6-methylguanine and 7-methylguanine, in respiratory and other tissues of rat, mouse and Syrian golden hamster exposed to 4-(N-nitrosomethylamino)-1-(3-pyridyl)-1-butanone. Carcinogenesis 15:2023-2029.
7. Ronai, Z. A., S. Gradia, L. A. Peterson, and S. S. Hecht. 1993. G to A transitions and G to T transversion in codon 12 of the Ki-ras oncogene isolated from mouse lung tumors induced by 4-(N-nitrosomethylamino)-1-(3-pyridyl)-1-butanone (NNK) and related DNA methylating and pyridyloxobutylating agents. Carcinogenesis 14:2419-2422.
8. Hemminki, K. 1983. Nucleic acid adducts of chemical carcinogens and mutagens. Arch. Toxicol. 52:249-285.
9. 32P-postlabeling assay of N-methyldeoxyguanosine. Cancer Res. 50:6580-6584.
10. Mustonen, R., and K. Hemminki. 1992. 7-Methylguanine levels in DNA of smokers' and non-smokers' total white blood cells, granulocytes and lymphocytes. Carcinogenesis 13:1951-1955.
11. 32P-postlabeling assay. Carcinogenesis 14:545-550.
12. Bianchini, F., R. Montesano, D. E. G. Shuker, J. Cuzick, and C. P. Wild. 1993. Quantification of 7-methyldeoxyguanosine using immunoaffinity purification and HPLC with electrochemical detection. Carcinogenesis 14:1677-1682.
13. 32P-postlabeling analysis of 7-methylguanine in human bronchial and lymphocyte DNA. Carcinogenesis 14:151-154.
14. Van Schooten, F. J., M. J. X. Hillebrand, F. E. van Leeuwen, N. van Zandwijk, H. M. Jansen, L. den Engelse, and E. Kriek. 1992. Polycyclic aromatic hydrocarbon-DNA adducts in white blood cells from lung cancer patients: no correlation with adduct levels in lung. Carcinogenesis 13: 987-993.
15. Bianchini, F., and C. Wild. 1994. Comparison of 7-medG formation in white blood cells, liver and target organs in rats treated with methylating carcinogens. Carcinogenesis 15:1137-1141.
16. Petruzzelli, S., P. Bernard, P. Paoletti, A. Rane, C. Giuntini, and G. M. Pacifici. 1988. Presence of epoxide hydrolase and glulathione S-transferase in human pulmonary alveolar macrophages. Eur. J. Clin. Pharmacol. 34:419-421.
17. Belinsky, S. A., C. M. White, T. R. Devereux, J. A. Swenberg, and M. W. Anderson. 1987. Cell selective alkylation of DNA in rat lung following low dose exposure to the tobacco specific carcinogen 4-(N-nitrosomethylamino)-1-(3-pyridyl)-1-butanone. Cancer Res. 47:1143-1148.
18. 6-Methylguanine-DNA methyltransferase and uracil DNA glycosylase in human broncho-alveolar cells and peripheral blood mononuclear cells from tobacco smokers and non-smokers. Carcinogenesis 12:1389-1394.
19. Izzotti, A., G. A. Rossi, M. Bagnasco, and S. De Flora. 1991. Benzn[a]pyrene diolepoxide-DNA adducts in alveolar macrophages in smokers. Carcinogenesis 12:1281-1285.
20. Weston, A., J. C. Willey, R. Modali, E. M. McDowell, J. Resau, B. Light, A. Haugen, D. L. Mann, B. F. Trump, and C. C. Harris. 1989. Differential DNA sequence deletions from chromosome 3, 11, 13, and 17 in squamous-cell carcinoma, large-cell carcinoma, and adenocarcinoma of the human lung. Proc. Natl. Acad. Sci. USA 86:5099-5103.
21. Lawley, P. D., and P. Brookes. 1963. Further studies on the alkylation of nucleic acids and their constituent nucleotides. Biochem. J. 89:127-138.
22. Dunn, B. P., S. Vedal, R. H. C. San, W.-F. Kwan, B. Nelems, D. A. Enarson, and H. F. Stich. 1991. DNA adducts in bronchial biopsies. Int. J. Cancer 48:485-492.
23. Murphy, S. E., A. Palomino, S. S. Hecht, and D. Hoffmann. 1990. Dose-response study of DNA and hemoglobin adduct formation by 4-(N-nitrosomethylamino)-1-(3-pyridyl)-1-butanone in F-344 rats. Cancer Res. 50:5446-5452.
24. Blussé van Oud Alblas, A., and R. van Furth. 1979. Origin, kinetics, and characteristics of pulmonary macrophages in the normal steady state. J. Exp. Med. 149:1504-1518.
25. Agius, R. M., A. Rutman, R. K. Knight, and P. J. Cole. 1986. Human pulmonary alveolar macrophages with smokers' inclusions: their relation to the cessation of cigarette smoking. Br. J. Exp. Pathol. 67:407-413.
26. Fels, A. O. S., and Z. A. Conn. 1986. The alveolar macrophage. J. Appl. Physiol. 60:353-369.
27. 3H]benzo[a]pyrene by cultured human bronchus and cultured human pulmonary alveolar macrophages. Lab. Invest. 38:217-224.
28. Devereux, T. R., M. W. Anderson, and S. A. Belinski. 1988. Factors regulating activation and DNA alkylation by 4-(N-nitrosomethylamino)-1-(3-pyridyl)-1-butanone and nitrosodimethylamine in rat lung and isolated lung cells, and the relationship to carcinogenicity. Cancer Res. 48: 4215-4221.
29. Crespi, C. L., B. W. Penman, H. V. Gelboin, and F. J. Gonzalez. 1991. A tobacco smoke-derived nitrosamine, 4-(N-nitrosomethylamino)-1-(3-pyridyl)-1-butanone, is activated by multiple human cytochrome P450s including the polymorphic human cytochrome P4502D6. Carcinogenesis 12:1197-1201.
30. Smith, T. J., Z. Guo, F. J. Gonzalez, F. P. Guengerich, G. D. Stoner, and C. S. Yang. 1992. Metabolism of 4-(N-nitrosomethylamino)-1-(3-pyridyl)-1-butanone in human lung and liver microsomes and cytochrome P-450 expressed in hepatoma cells. Cancer Res. 52:1757-1763.
31. Guo, Z., T. J. Smith, P. E. Thomas, and C. S. Yang. 1992. Metabolism of 4-(N-nitrosomethylamino)-1-(3-pyridyl)-1-butanone by inducible and constitutive cytochrome P450 enzymes in rats. Arch. Biochem. Biophys. 298:279-286.
32. Hsu, I. C., C. C. Harris, M. M. Lipsky, and B. F. Trump. 1987. Cell and species differences in metabolic activation of chemical carcinogens. Mutation Res. 177:1-7.
33. Degan, P., R. Montesano, and C. P. Wild. 1988. Antibodies against 7-methyldeoxyguanosine: its detection in rat peripheral blood lymphocyte DNA and potential application to molecular epidemiology. Cancer Res. 48:5065-5070.
34. Horsfall, M. J., A. J. E. Gordon, P. A. Burns, M. Zielenska, G. M. E. van der Vliet, and B. W. Glickman. 1990. Mutational specificity of alkylating agents and the influence of DNA repair. Environ. Mol. Mutagen. 15:107-122.
35. Fischer, S., B. Spiegelhalder, J. Eisenbarth, and R. Preussmann. 1990. Investigation on the origin of tobacco-specific nitrosamines in mainstream smoke of cigarettes. Carcinogenesis 11:723-730.
36. Park, J.-W., and B. N. Ames. 1988. 7-Methylguanine adducts in DNA are normally present at high levels and increase on aging: analysis by HPLC with electrochemical detection. Proc. Natl. Acad Sci. USA 85:7467-7470.
37. Hecht, S. S., S. G. Carmella, S. E. Murphy, S. Akerkar, K. D. Brunnemann, and D. Hoffmann. 1993. A tobacco-specific lung carcinogen in the urine of men exposed to cigarette smoke. J. Engl. J. Med. 329: 1543-1546.
38. Schut, H. A. J., and K. T. Shiverick. 1992. DNA adducts in humans as dosimeters of exposure to environmental, occupational, or dietary genotoxins. FASEB J. 6:2942-2951.
39. 32P-postlabeling assay. Carcinogenesis 13:1053-1074.
40. McLemore, T. L., R. R. Martin, L. R. Pickard, R. R. Springer, N. P. Wray, K. L. Toppel, K. L. Mattox, G. A. Guinn, E. T. Cantrell, and D. L. Busbee. 1978. Analysis of aryl hydrocarbon hydroxylase activity in human lung tissue, pulmonary macrophages and blood lymphocytes. Cancer 41:2292-2300.
41. 32P-postlabeling assay. Carcinogenesis 12:503-508.