Antagonistic effect of D-myo-inositol-1,2,6-trisphosphate (PP56) on neuropeptide Y-induced vasoconstriction in the feline dental pulp

Archives of Oral Biology

Volumn 41, Issue 8-9, 1996, Pages 791-798

  Kim, S K ^a   Ang, L ^b   Hsu, Y Y ^b   Dorscher Kim J ^b   Kim, S ^b  

^a Kyungpook National University   (South Korea)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

D myo inositol 1,2,6 trisphosphate; laser Doppler flowmeter; neurogenic inflammation; neuropeptide Y; pulpal blood flow; sympathetic nerve

Indexed keywords

INOSITOL 1,2,6 TRISPHOSPHATE; INOSITOL 1,2,6-TRIPHOSPHATE; INOSITOL PHOSPHATE; NEUROPEPTIDE Y; NORADRENALIN; PHENTOLAMINE; VASOCONSTRICTOR AGENT;

ADRENERGIC SYSTEM; ANIMAL; ANIMAL EXPERIMENT; ARTICLE; BLOOD FLOW; BLOOD PRESSURE; CAT; CONTROLLED STUDY; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; ELECTROSTIMULATION; INTRAARTERIAL DRUG ADMINISTRATION; LASER DOPPLER FLOWMETRY; NEUROGENIC INFLAMMATION; NONHUMAN; PHYSIOLOGY; SYMPATHETIC NERVE; TOOTH PULP; VASCULARIZATION; VASOCONSTRICTION;

ANIMALS; CATS; DENTAL PULP; INJECTIONS, INTRA-ARTERIAL; INOSITOL PHOSPHATES; LASER-DOPPLER FLOWMETRY; NEUROPEPTIDE Y; REGIONAL BLOOD FLOW; VASOCONSTRICTION; VASOCONSTRICTOR AGENTS; VASOMOTOR SYSTEM;

ANIMALIA; FELIDAE; FELIS CATUS;

EID: 0030210559     PISSN: 00039969     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0003-9969(96)00061-1     Document Type: Article

References (44)

1. Adamsson M., Fallgren B. and Edvinsson L. (1992) Inhibition of neuropeptide Y-induced potentiation of noradrenaline-induced vasoconstriction by PP56 (D-myo-inositol-1,2,6-tris-phosphate). Br. J. Pharmacol. 105, 93-96.
2. Berridge M. J. and Irvine R. F. (1989) Inositol phosphates and cell signaling. Nature. 341, 197-205.
3. 2-Adrenoceptor mediated inhibition of nerve stimulation-evoked release of neuropeptide Y (NPY-like immunoreactivity) in the pithed guinea pig. Eur. J. Pharmacol. 131, 279.
4. Edvinsson L., Ekblad E., Håkanson R. and Wahlestedt C. (1984) Neuropeptide Y potentiates the effect of various vasoconstrictor agents on rabbit blood vessels. Br. J. Pharmacol. 83, 519-525.
5. Edvinsson L., Håkanson R., Wahlestedt C. and Uddman R. (1987) Effects of neuropeptide Y on the cardiovascular system. Trends Pharmacol. Sci. 8, 231-235.
6. Edwall L. and Kindlova M. (1971) The effect of sympathetic nerve stimulation on the rate of disappearance of tracers from various oral tissues. Acta Odont. Scand. 29, 397.
7. Edwall B., Gazelius B., Fazekas A., Theodorsson-Norheim F. and Lundberg J. M. (1985) Neuropeptide Y (NPY) and sympathetic control of blood flow in oral mucosa and dental pulp in the cat. Acta Physiol. Scand. 125, 253-264.
8. Ekblad E., Edvinsson L., Wahlestedt C., Uddman R., Håkanson R. and Sundler F. (1984) Neuropeptide Y co-exists and co-operates with noradrenaline in perivascular nerve fibers. Regulatory Peptides 8, 225-235.
9. Ertl G., Bauer B., Becker H. H. and Rose G. (1993) Effects of neurotensin and neuropeptide Y on coronary circulation and myocardial function in dogs. Am. J. Physiol. 264, H1062-H1068.
10. Fallgren B., Ekblad E. and Edvinsson L. (1989) Co-existence of neuropeptides and differential inhibition of vasodilator responses by neuropeptide Y in guinea pig uterine arteries. Neurosci. Lett. 100, 71-76.
11. Fried G., Thoresen M. and Samuelsson U. (1990) Effect of neuropeptide Y and noradrenaline on the uterine artery. Ann. N.Y. Acad. Sci. 611, 439-441.
12. Hoffman B. B. (1995) Basic and Clinical Pharmacology (Ed. Katzung B. G.), 6th edn, pp. 117-118. Appleton and Lange, Connecticut.
13. Jørgensen J. C. and Sejrsen P. (1990) Neuropeptide Y reduces ovarian blood flow in the rabbit. Peptides 11, 451-454.
14. Kim S. (1985) Regulation of pulpal blood flow. J. Dent. Res. 64 (Special issue), 590-596.
15. Kim S., Dörscher-Kim J. and Liu M. (1989) Microcirculation of the dental pulp and its autonomic control. Proc. Finn. Dent. Soc. 85, 279-287.
16. 133Xenon washout methods. Archs oral Biol. 35, 411-413.
17. Komaru T., Asshikawa K., Kanatsuka H., Sekiguchi N., Suzuki T. and Takishima T. (1990) Neuropeptide Y modulates vasoconstriction in coronary microvessels in the beating canine heart. Circulat. Res. 67, 1142-1151.
18. Langer S. Z. (1981) Presynaptic regulation of the release of catecholamines. Pharmacol. Rev. 32, 337-.
19. Linton-Dahlöf P. (1989) Modulatory interactions of neuropeptide Y (NPY) on sympathetic neurotransmission. Acta Physiol. Scand. 173 (Suppl), 1-85.
20. Liu M. T., Bilotto G., Markowitz K. and Kim S. (1987) Changes in coronal pulpal blood flow following a class V cavity preparation. J. Dent. Res. 66, 176 (Abstract 558).
21. Liu M., Kim S., Park D. S., Markowitz K., Bilotto G. and Dörscher-Kim J. (1990) Comparison of the effects of intra-arterial and locally applied vasoactive agents on pulpal blood flow in dog canine teeth determined by laser Doppler velocimetry. Archs oral Biol. 35, 405-410.
22. Lundberg J. M., Terenius L., Hökfelt T. and Goldstein M. (1983) High levels of neuropeptide Y in peripheral nonadrenergic neurons in various mammals including man. Neurosci. Lett. 42, 167-172.
23. Lundberg J. M., Pernow J., Tatemoto K. and Dahlöf C. (1985) Pre- and postjunctional effects of NPY on sympathetic control of rat femoral artery. Acta Physiol. Scand. 123, 511-513.
24. Lundberg J. M., Rudehill A., Sollevi A., Theodorsson-Norheim E. and Hamberger B. (1986) Frequency- and reserpine-dependent chemical coding of synaptic transmission: differential release of noradrenaline and neuropeptide Y from pig spleen. Neurosci. Lett. 63, 96-100.
25. Lundberg J. M., Franco-Cereceda A., Lacroix J.-S. and Pernow J. (1990) Neuropeptide Y and sympathetic neurotransmission. Ann. N.Y. Acad. Sci. 611, 166-174.
26. Modin A., Pernow J. and Lundberg J. M. (1993) Sympathetic regulation of skeletal muscle blood flow in the pig: a non-adrenergic component likely to be mediated by neuropeptide Y. Acta Physiol. Scand. 148, 1-11.
27. Nilsson S. F. E. (1991) Neuropeptide Y (NPY): a vasoconstrictor in the eye, brain and other tissues in the rabbit. Acta Physiol. Scand. 141, 445-467.
28. Pernow J., Saria A. and Lundberg J. M. (1986) Mechanisms of underlying pre- and postjunctional effects of neuropeptide Y in sympathetic vascular control. Acta Physiol. Scand. 126, 239-249.
29. Potter E. K., Edvinsson L. and Gustafsson T. (1992) Antagonism of pre- and postjunctional responses to neuropeptide-Y and sympathetic stimulation by D-myo-inositol-1,2,6-trisphosphate in the anesthetised dog. Eur. J. Pharmacol. 221, 307-314.
30. 2-purino-ceptors in the cardiovascular system. Circulation 84, 1-14.
31. Scott D. Jr, Scheinin A., Karjalainen S. and Edwall L. (1972) Influence of sympathetic nerve stimulation on flow velocity in pulpal vessels. Acta Odont. Scand. 30, 277-287.
32. Scott N. A., Michel M. C., Boublik J. H., Rivier J. E., Motomura S., Crum R. L., Landon M. and Brown M. R. (1990) Distinction of NPY receptors in vitro and in vivo. II. Differential effects of NPY and NPY-(18-36)1. Am. J. Physiol. 259, H174-H180.
33. Sun X., Dahlöf C., Edvinsson L. and Hedner T. (1991) D-Myo-inositol-1,2,6-trisphosphate is a selective antagonist of neuropeptide Y-induced pressure responses in pithed rat. Eur. J. Pharmacol. 204, 281-286.
34. Sun X. Y., Edvinsson L. and Hedner T. (1992) Effect of D-myo-inositol-1,2,6-trisphosphate on neuropeptide Y-induced potentiation of various vasoconstrictor agents in the rat. J. Pharmacol. Exper. Therpeut. 261, 1147-1152.
35. Tatemoto K., Carlquist M. and Mutt V. (1982) Neuropeptide Y - a novel brain peptide with structural similarities to peptide YY and pancreatic polypeptide. Nature 296, 659-660.
36. Tatemoto K. (1990) Neuropeptide Y and its receptor antagonists. Ann. N.Y. Acad. Sci. 611, 1-6.
37. Tender K. H. (1975) The effects of variations in arterial blood pressure and baroreceptor reflexes on pulpal blood flow in dogs. Archs oral Biol. 20, 345.
38. Tuor U. I., Kelly P. A. T., Edvinsson L. and McCulloch J. (1990) Neuropeptide Y and cerebral circulation. J. Cerebral Blood Flow Metab. 10, 591-601.
39. 2-adrenoceptor-mediated cardiovascular responses in the pithed rat. Br. J. Pharmacol. 100, 840-842.
40. Wahlestedt C., Grundemar L., Håkanson R., Heilig M., Shen G. H., Zokowska-Grojec Z. and Reis D. (1990) Neuropeptide Y receptor subtypes, Y1 and Y2. Ann. N.Y. Acad. Sci. 611, 7-26.
41. Wahlestedt C., Reis D. J., Yoo H., Adamsson M., Andersson D. and Edvinsson L. (1992) A novel inositol phosphate selectively inhibits vasoconstriction evoked by the sympathetic co-transmitters neuropeptide Y (NPY) and adenosine trisphosphate (ATP). Neurosci. Lett. 143, 123-126.
42. Warner M. R. and Levy M. N. (1989a) Inhibition of cardiac vagal effects by neurally released and exogenous neuropeptide Y. Circulat. Res. 65, 1536-1546.
43. Warner M. R. and Levy M. N. (1989b) Neuropeptide Y as a putative modulator of the effects on heart rate. Circulat. Res. 64, 882-889.
44. Yamaguchi I. and Kopin I. J. (1980) Blood pressure, plasma catecholamines and sympathetic outflow from the spinal cord to blood vessels in pithed rats. Am. J. Physiol. 238, 305.