Nonsecretory Apoptotic Killing by Human NK Cells

Journal of Immunology

Volumn 157, Issue 3, 1996, Pages 1117-1126

  Vujanovic, Nikola L ^a,b   Nagashima, Shigeki ^a,b   Herberman, Ronald B ^a,b   Whiteside, Theresa L ^a,b  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PITTSBURGH CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; CHROMIUM; INTERLEUKIN 1;

APOPTOSIS; ARTICLE; CELL CULTURE; CELL LINE; CYTOTOXICITY; FLOW CYTOMETRY; HUMAN; IMMUNOLOGY; LYMPHOCYTE SUBPOPULATION; METABOLISM; NATURAL KILLER CELL; NECROSIS;

APOPTOSIS; CALCIUM; CELL LINE; CHROMIUM; CYTOTOXICITY, IMMUNOLOGIC; FLOW CYTOMETRY; HUMANS; INTERLEUKIN-1; KILLER CELLS, NATURAL; LYMPHOCYTE SUBSETS; NECROSIS; TUMOR CELLS, CULTURED;

EID: 0030210525     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. Trinchieri, G. 1989. Biology of natural killer cells. Adv. Immunol. 47:187.
2. Chambers, W. H., and C. S. Brissette-Storkus. 1995. Hanging in the balance: natural killer cell recognition of target cells. Chem. Biol. 2:429.
3. Lanier, L. L., and J. H. Phillips. 1996. Inhibitory MHC class I receptors on NK and T cells. Immunol. Today 17:86.
4. Liebson, P. J. 1995. Viewpoint: Signal transduction during natural killer cell activation. Nat. Immun. 14:117.
5. Berke, G. 1995. The CTL's kiss of death. Cell 81:9.
6. Podack, E. R., H. Hengartner, and M. G. Lichtenheld. 1991. A central role for perforin in cytolysis? Annu. Rev. Immunol. 9:129.
7. Young, J. D.-E. 1989. Killing of target cells by lymphocytes: a mechanistic view. Physiol. Rev. 69:250.
8. Gorelik, E., B. Rosen, D. Copeland, B. Weatherly, and R. B. Herberman. 1984. Evaluation of the role of natural killer cells in radiation-induced leukemogenesis in mice. J. Natl. Cancer Inst. 72:1397.
9. Gorelik, E., and R. B. Herberman. 1986. Role of natural killer (NK) cells in the control of tumor growth and metastatic spread. In Cancer Immunology: Innovative Approaches to Therapy. R. B. Herberman, ed. Martinus Nijhoff Publishers, Boston, p. 151.
10. Wiltrout, R. H., R. B. Herberman, S.-R. Zhang, M. A. Chirigos, J. R. Ortaldo, K. M. Green, Jr., and J. E. Talmadge. 1985. Role of organ-associated NK cells in decreased formation of experimental metastases in lung and liver. J. Immunol. 134:4267.
11. Riccardi, C., T. Barlozzari, A. Santoni, R. B. Herberman, and C. Cesarini. 1981. Transfer of cyclophosphamide-treated mice of natural killer (NK) cells and in vivo natural reactivity against tumors. J. Immunol. 126:1284.
12. Whiteside, T. L., and R. B. Herberman. 1995. The role of natural killer cells in immune surveillance of cancer. Curr. Opin. Immunol. 7:704.
13. Kagi, D., F. Vignaux, B. Ledermann, K. Burki, V. Depraetere, S. Nagata, H. Hengartner, and P. Golstein. 1994. Fas and perforin pathways as major mechanisms of T cell-mediated cytotoxicity. Science 265:528.
14. Walsh, C. M., M. Matloubian, C.-C. Liu, R. Ueda, C. G. Kurahara, J. L. Christensen, M. T. F. Huang, J. D.-E. Young, R. Ahmed, and W. R. Clark. 1994. Immune function in mice lacking perforin gene. Proc. Natl. Acad. Sci. USA 91:10854.
15. Arase, H., N. Arase, and T. Saito. 1995. Fas-mediated cytotoxicity by freshly isolated natural killer cells. J. Exp. Med. 181:1235.
16. Vujanovic, N. L., S. Yasumura, H. Hirabayashi, W.-C. Lin, S. Watkins, R. B. Herberman, and T. L. Whiteside. 1995. Antitumor activity of subsets of human IL-2-activated natural killer cells in solid tissues. J. Immunol. 154:282.
17. Kurt-Jones, E. A., D. I. Beller, S. B. Mizel, and E. R. Unanue. 1985. Identification of a membrane-associated interleukin 1 in macrophages. Proc. Natl. Acad. Sci. USA 82:1204.
18. Vujanovic, N. L., H. Rabinowich, Y. J. Lee, L. Jost, R. B. Herberman, and T. L. Whiteside. 1993. Distinct phenotypic and functional characteristics of human natural killer cells obtained by rapid interleukin 2-induced adherence to plastic. Cell. Immunol. 151:133.
19. Matzinger, P. 1991. The JAM test: a simple assay for DNA fragmentation and cell death. J. Immunol. Methods 145:185.
20. Pross, H. F., M. G. Baines, P. Rubin, P. Shragge, and M. S. Patterson. 1981. Spontaneous human lymphocyte-mediated cytotoxicity against tumor target cells. XI. The quantitation of natural killer cell activity. J. Clin. Immunol. 1:51.
21. Zychlinsky, A., L. M. Zheng, C.-C. Liu, and J. D. Young. 1991. Cytolytic lymphocytes induce both apoptosis and necrosis in target cells. J. Immunol. 146:393.
22. Gorczyca, W., J. Gong, and Z. Darzynkiewicz. 1993. Detection of DNA breaks in individual apoptotic cells by the in situ terminal deoxynucleotidyl transferase and nick translation assays. Cancer Res. 53:1945.
23. Takayama, H., G. Trenn, and M. V. Sitkovsky. 1987. A novel cytotoxic T lymphocyte activation assay: optimized conditions for antigen receptor-triggered granule enzyme secretion. J. Immunol. Methods 104:183.
24. Vitolo, D., N. L. Vujanovic, H. Rabinowich, M. Schlesinger, R. B. Herberman, and T. L. Whiteside. 1993. Rapid II-2-induced adherence of human natural killer cells: expression of mRNA for cytokines and IL-2 receptors in adherent NK cells. J. Immunol. 151:1926.
25. Shi, L., R. P. Kraut, R. Aebersold, and A. H. Greenberg. 1992. A natural killer cell granule protein that induces DNA fragmentation and apoptosis. J. Exp. Med. 175:553.
26. Savill, J., V. Fadok, P. Henson, and C. Haslett. 1993. Phagocyte recognition of cells undergoing apoptosis. Immunol. Today 14:131.
27. Henkart, P. 1986. Mechanism of NK cell mediated cytotoxicity. In Cancer Immunology: Innovative Approaches to Therapy. R. B. Herberman, ed. Martinus Nijhoff Publishers, Boston, p. 123.
28. Nakajima, H., H. Park, and P. A. Henkart. 1995. Synergistic role of granzymes A and B in mediating target cell death by RBL mast cell tumors also expressing cytolysin/perforin. J. Exp. Med. 181:1037.
29. Ucker, P. S. 1991. Death by suicide: one way to go in mammalian cellular development? New Biol. 3:103.
30. Herberman, R. B., C. W. Reynolds, and J. R. Ortaldo. 1986. Mechanism of cytotoxicity by natural killer (NK) cells. Annu. Rev. Immunol. 4:651.