Effects of continuous infusion fentanyl citrate on cerebrovascular and systemic prostanoids in postsurgical newborn piglets

Journal of Investigative Medicine

Volumn 44, Issue 6, 1996, Pages 362-369

  Modanlou, Houchang D ^a,c   Pan, Ting ^b   Riaz, Hassan ^b   Samson, Tom ^b   Sheikh, Rizwan ^b   Beharry, Kay ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b LONG BEACH MEMORIAL MEDICAL CENTER   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Cerebrovascular and systemic vasoconstriction; Fentanyl; Postsurgical newborns; Prostanoids

Indexed keywords

FENTANYL; NARCOTIC ANALGESIC AGENT; PROSTAGLANDIN;

ANIMAL; ARTICLE; BLOOD; CAROTID ARTERY; CEREBROSPINAL FLUID; INTRAVENOUS DRUG ADMINISTRATION; NEWBORN; SWINE;

ANALGESICS, OPIOID; ANIMALS; ANIMALS, NEWBORN; CAROTID ARTERIES; FENTANYL; INFUSIONS, INTRAVENOUS; PROSTAGLANDINS; SWINE;

EID: 0030209798     PISSN: 17088267     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. Anand KJS, Sippell WG, Aynsley-Green A. Randomized trial of fentanyl anesthesia in preterm babies undergoing surgery: effects on the stress response. Lancet 1987;1:243-8.
2. Anand KJS, Hickey PR. Pain and its effects in the human neonate and fetus. N Engl J Med 1987;317:1321-9.
3. Truog R, Anand KJS. Management of pain in the postoperative neonate. Clin Perinatol 1989;16:61-78.
4. Arnold JH, Truog RD, Orav EJ, Scavone JM, Hershenson MB. Tolerance and dependence in neonates sedated with fentanyl during extracorporeal membrane oxygenation. Anesthesiol 1990;73:1136-40.
5. Arnold JH, Truog RD, Scavone JM, Fenton T. Changes in the pharmacodynamic response to fentanyl in neonates during continuous infusion. J Pediatr 1991;119:639-43.
6. Shafer A, White PF, Schüttler J, Rosenthal MH. Use of fentanyl infusion in the intensive care unit: tolerance to its anesthetic effects? Anesthesiology 1983;59:246-8.
7. Katz R, Kelly HW. Pharmacokinetics of continuous infusions of fentanyl in critically ill children. Crit Care Med 1993;21:995-1000.
8. Hickey PR, Hansen DD, Wessel DL, Lang P, Jones RA. Pulmonary and systemic hemodynamic responses to fentanyl in infants. Anesth Analg 1985;64:483-6.
9. Collins C, Koren G, Crean P, Klein J, Roy WL, MacLeod SM. Fentanyl pharmacokinetics and hemodynamic effects in preterm infants during ligation of patent ductus arteriosus. Anesth Analg 1985;64:1078-80.
10. Leffler CW, Busija DW. Prostanoids and pial arteriolar diameter in hypotensive newborn pigs. Am J Physiol 1987;252(Heart Circ Physiol 21):H687-91.
11. Armstead WM, Mirro R, Busija DW, Leffler CW. Prostanoids modulate opioid cerebrovascular responses in newborn pigs. J Pharmacol Exp Ther 1990;255:1083-9.
12. Chemtob S, Beharry K, Rex J, Varma DR, Aranda JV. Prostanoids determine the range of cerebral blood flow autoregulation of newborn piglets. Stroke 1990;21:777-84.
13. Chemtob S, Beharry K, Rex J, Varma DR, Aranda JV. Changes in cerebrovascular prostaglandins and thromboxane as a function of systemic blood pressure. Cerebral blood flow autoregulation of the newborn. Circ Res 1990;67:674-82.
14. Chemtob S, Laudignon N, Beharry K, Rex J. Varma D, Wolfe L, Aranda JV. Effects of prostaglandins and indomethacin on cerebral blood flow and cerebral oxygen consumption on conscious newborn piglets. Dev Pharmacol Ther 1990;14:1-14.
15. Kumar K, Morgan DJ. Determination of fentanyl and alfentanil in plasma by high-performance liquid chromatography with ultraviolet detection. J Chromatogr A 1987;419:464-8.
16. Gauntlett IS, Fisher DM, Hertzka RE, Kuhls E, Spellman MJ, Rudolph C. Pharmacokinetics of fentanyl in neonatal humans and lambs: effects of age. Anesthesiology 1988;69:683-7.
17. Irazusta J, Pascucci R, Perlman N. Wessell D. Effects of fentanyl administration on respiratory system compliance in infants. Crit Care Med 1993;21:1001-4.
18. Yaster M. The response of fentanyl in neonatal anesthesia. Anesthesiology 1987;66:433-5.
19. Hug CC, Murphy MR. Fentanyl disposition in cerebrospinal fluid and plasma and its relationship to ventilatory depression in the dog. Anesthesiology 1979;50:342-9.
20. Koehntop DE, Rodman JH, Brundage DM, Hegland MG, Buckley JJ. Pharmacokinetics of fentanyl in neonates. Anesth Analg 1986;65:227-32.
21. Shafer SL, Varvel JR. Pharmacokinetics, pharmacodynamics, and rational opioid selection. Anesthesiology 1991;74:53-63.
22. Clotz MA, Nahata MC. Clinical uses of fentanyl, sufentanyl, and alfentanyl. Clinical Pharmact 1991;10:581-93.
23. Willens JS, Myslinski NR. Pharmacodynamics, pharmacokinetics, and clinical uses of fentanyl, sufentanyl, and alfentanyl. Heart Lung 1993;22:239-51.
24. Poklis A. Fentanyl: a review for clinical and analytical toxicologists. Clinical Toxicology 1995;33(5):439-47.
25. Yaster M, Koehler RC, Traystman RJ. Effects of fentanyl on peripheral and cerebral hemodynamics in neonatal lambs. Anesthesiology 1987;66:524-30.
26. Carlsson C, Smith DS, Keykhah MM, Englebach I, Harp JR. The effects of high-dose fentanyl on cerebral circulation and metabolism in rats. Anesthesiology 1982;57:375-80.
27. Michenfelder JD, Theye RA. Effects of fentanyl, droperidol and innovar on canine cerebral metabolism and blood flow. Br J Anaesth 1971;43:630-6.
28. McPherson RW, Traystman RJ. Fentanyl and cerebral vascular responsivity in dogs. Anesthesiology 1984;60:180-6.
29. Leffler CW, Busija DW. Arachidonic acid metabolites and perinatal cerebral hemodynamics. Semin Perinatol 1987;11:31-42.
30. Monitto CL, Kurth CD. The effect of fentanyl, sufentanyl, and alfentanyl on cerebral arterioles in piglets. Anesth Analg 1993;76:985-9.