In vivo effects of fluconazole on lymphocyte subpopulations of the thymus and spleen in mice: Flow cytometry analysis

International Journal of Immunopharmacology

Volumn 18, Issue 8-9, 1996, Pages 449-457

  Liu, J ^a   Mengel, K ^a   Friedberg, K D ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Flow cytometry; Fluconazole; Lymphocyte subpopulations

Indexed keywords

FLUCONAZOLE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BODY WEIGHT; CELL COUNT; CONTROLLED STUDY; DOSE RESPONSE; FEMALE; FLOW CYTOMETRY; IMMUNE SYSTEM; LYMPHOCYTE SUBPOPULATION; MOUSE; NONHUMAN; ORAL DRUG ADMINISTRATION; ORGAN WEIGHT; PHENOTYPE; PRIORITY JOURNAL; SPLEEN CELL; THYMOCYTE;

ANIMALS; ANTIGENS, CD3; ANTIGENS, CD4; ANTIGENS, CD8; BODY WEIGHT; FEMALE; FLOW CYTOMETRY; FLUCONAZOLE; INTUBATION, GASTROINTESTINAL; LYMPHOCYTE COUNT; LYMPHOCYTE SUBSETS; MICE; MICE, INBRED BALB C; ORGAN SIZE; RECEPTORS, ANTIGEN, B-CELL; SPLEEN; THYMUS GLAND;

EID: 0030209195     PISSN: 01920561     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0192-0561(96)00049-5     Document Type: Article

References (13)

1. Bennett, J. E. (1990). Antimicrobial agents. In The Pharmacological Basis of Therapeutics (eds Gilman, A.G., Rall, T.W., Nies, A.S. and Taylor, P.), 8th edn, pp. 1165-1175. Pergamon Press, New York.
2. Brammer, K.W. & Tarbit, M.H. (1987), A review of the pharmacokinetics of fluconazole (UK-49,858) in laboratory animals and man. In Recent Trends in the Discovery, Development and Evaluation of Antifungal Agents (ed. Fromtling, R.A.), pp. 93-102. J.R. Prous Science Publishers, S.A..
3. Büchner, T. & Roos, N. (1992) Antifungal treatment strategy in leukemia patients, Ann. Hematol., 65, 153-161.
4. Drummond, D. C., Wong, C. W., Whitman, L. M. & McCormack, J. G. (1995) The effect of amphotericin B, fluconazole and miconazole on neutrophil and lymphocyte function in a guinea pig model. J. Antimicrob. Chemother., 36, 375-384.
5. Grant, S. M. & Clissold, S. P. (1990) Fluconazole, a review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in superficial and systemic mycoses. Drugs. 39. 877-916.
6. Marriott, M.S. and Richardson, K. (1987) The discovery and mode of action of fluconazole. In Recent Trends in the Discovery, Development and Evaluation of Antifungal Agents (ed. Fromtling, R. A.), pp. 93-102. J.R. Prous Science Publishers, S.A..
7. Miyauchi, A., Hiramine, C., Tanaka, S. & Hojo, K. (1990) Differential effects of a single dose of cyclophosphamide on T cell subsets of the thymus and spleen in mice: flow cytofluorometry analysis. Tohoku J. exp. Med., 162, 147-167.
8. Pawelec, G., Ehninger, G., Rehbein, A., Schaudt, K. & Jaschonek, K. (1991) Comparison of the immunosuppressive activities of the antimycotic agents itraconazole, fluconazole, ketoconazole and miconazole on human T-cells. Int. J. Immunopharmac., 13, 299-304.
9. Richardson, K., Cooper, K., Marriott, M. S., Tarbit, M. H., Troke, P. F. & Whittle, P. J. (1990) Discovery of fluconazole, a novel antifungal agent. Rev. infect. Dis., 12(Suppl. 13). s267-s271.
10. Senior, D. S. & Shaw, T. B. (1988) In vitro effects of fluconazole (UK-49,858) and ketoconazole on mouse lymphocyte proliferation and on Candida blastospore destruction by human polymorphonuclear leukocytes. Int. J. Immunopharmac., 10, 169-173.
11. Tachibana, M., Noguchi, Y. & Monro A. M. (1987). Toxicology of fluconazole in experimental animals. In Recent Trends in the Discovery, Development and Evaluation of Antifungal Agents (ed. Fromtling. R.A.), pp 93-102. J.R. Prous Science Publishers, S.A..
12. Vuddhakul, V., Mai, G. T., McCormack, J. G., Seow, W. K. & Thong, Y. H. (1990) Suppression of neutrophil and lymphoproliferative responses in vitro by itraconazole but not fluconazole. Int. J. Immunopharmac., 12, 639-645.
13. Yamaguchi, H., Abe, S. & Tokuda, Y. (1993) Immunomodulating activity of antifungal drugs. Ann. N. Y. Acad. Sci., 685, 447-457.