Epinephrine Infusion Does Not Enhance Net Muscle Glycogenolysis during Prolonged Aerobic Exercise

Canadian Journal of Applied Physiology

Volumn 21, Issue 4, 1996, Pages 271-283

  Wendling, Paula S ^a   Peters, Sandra J ^a   Heigenhauser, George J F ^b   Spriet, Lawrence L ^a  

^a UNIVERSITY OF GUELPH   (Canada)

^b MCMASTER UNIVERSITY   (Canada)

Author keywords

Blood glucose; Blood lactate; Lipolysis; Muscle metabolism; Plasma catecholamines

Indexed keywords

ADRENALIN; ADRENERGIC RECEPTOR STIMULATING AGENT; FATTY ACID; GLYCEROL; GLYCOGEN; LACTIC ACID DERIVATIVE;

ADIPOSE TISSUE; ADULT; ARTICLE; BIOPSY; BLOOD; CLINICAL TRIAL; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFECT; EXERCISE; EXERCISE TEST; FEMALE; GLUCOSE BLOOD LEVEL; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; LIPID METABOLISM; LIVER; MALE; METABOLISM; PATHOLOGY; PHYSIOLOGY; RANDOMIZED CONTROLLED TRIAL; SKELETAL MUSCLE; VEIN;

ADIPOSE TISSUE; ADRENERGIC AGONISTS; ADULT; BIOPSY; BLOOD GLUCOSE; EPINEPHRINE; EXERCISE; EXERCISE TEST; FATTY ACIDS, NONESTERIFIED; FEMALE; GLYCEROL; GLYCOGEN; HUMANS; INFUSIONS, INTRAVENOUS; LACTATES; LIPID METABOLISM; LIVER; MALE; MUSCLE, SKELETAL; VEINS;

EID: 0030208360     PISSN: 10667814     EISSN: None     Source Type: Journal    
DOI: 10.1139/h96-024     Document Type: Article

References (33)

1. Adebonojo, F.O., Coates, P.M., and Cortner, J.A. (1982). Hormone-sensitive lipase in human adipose tissue, isolated adipocytes, and cultured adipocytes. Pediatr. Res. 16: 982-988.
2. Ahlborg, G. (1985). Mechanism for glycogenolysis in nonexercising human muscle during and after exercise. Am. J. Physiol. 248(Endocrinol. Metab.): E540-E545.
3. Arnall, D. A., Marker, J.C., Conlee, R.K., and Winder, W.W. (1986). Effect of infusing epinephrine on liver and muscle glycogenolysis during exercise in rats. Am. J. Physiol. 250(Endocrinol. Metab.): E641-E649.
4. Bergmeyer, H.U. (1974). Methods of Enzymatic Analysis. New York. Academic Press.
5. Bergstrom, J. (1975). Percutaneous needle biopsy of skeletal muscle in physiological and clinical research. Scand. J. Clin. Lab. Invest. 35: 609-615.
6. Bonen, A., McDermott, J.C., and Hutber, C.A. (1989). Carbohydrate metabolism in skeletal muscle: An update of current concepts. Int. J. Sports Med. 10: 385-401.
7. Bonen, A., Megeney, L.A., McCarthy, S.C., McDermott J.C., and Tan, M.H. (1992). Epinephrine administration stimulates GLUT4 translocation but reduces glucose transport in muscle. Biochim. Biophys. Res. Commun. 187: 685-691.
8. Chesley, A., Hultman E., and Spriet, L.L. (1995). Effects of epinephrine infusion on muscle glycogenolysis during intense aerobic exercise. Am. J. Physiol. 268(Endocrinol. Metab.): E127-E134.
9. Ehrsam, R.E., Heigenhauser, G.J.F., and Jones, N.L. (1982). Effect of respiratory acidosis on metabolism in exercise. J. Appl. Physiol. 53: 63-69.
10. Essig, D., Costill, D.L., and Van Handel, P.J. (1980). Effects of caffeine ingestion on utilization of muscle glycogen and lipid during leg ergometer cycling. Int. J. Sports Med. 1: 86-90.
11. Festoff, B.W., Oliver, K.L., and Reddy, N.B. (1977). In vitro studies of skeletal muscle membranes: Adenylate cyclase of fast and slow twitch muscle and the effects of denervation. J. Memb. Biol. 32: 331-343.
12. Forsberg, A.M., Nilsson, E., Werneman, J., Bergström, J., and Hultman, E. (1991). Muscle composition in relation to age and sex. Clin. Sci. 81: 249-256.
13. Galbo, H. (1983). Hormonal and Metabolic Adaptation to Exercise. New York: Georg Thieme Verlag.
14. Graham, T.E., and Spriet, L.L. (1991). Performance and metabolic responses to a high caffeine dose during prolonged exercise. J. Appl. Physiol. 71: 2292-2298.
15. Harris, R.C., Hultman, E., and Nordesjö, L.-O. (1974). Glycogen, glycolytic intermediates and high-energy phosphates determined in biopsy samples of musculus quadriceps femoris of man at rest. Methods and variance of results. Scand. J. Clin. Lab. Invest. 33: 109-120.
16. Jansson, E., and Kaijser, L. (1982). Effect of diet on the utilization of blood-borne and muscular substrates during exercise in man. Acta Physiol. Scand. 115: 19-30.
17. Jansson, E., Hjemdahl, P., and Kaijser, L. (1986). Epinephrine-induced changes in muscle carbohydrate metabolism during exercise in male subjects. J. Appl. Physiol. 60: 1466-1470.
18. Johnson, L.N. (1992). Glycogen phosphorylase: Control by phosphorylation and allosteric effectors. FASEB J. 6: 2274-2282.
19. Kjaer, M., Christensen, N.J., Sonne, B., Richter, E.A., and Galbo, H. (1985). The effect of exercise on epinephrine turnover in trained and untrained man. J. Appl. Physiol. 59: 1061-1067.
20. Kjaer, M., Bangsbo, J., Lortie, G., and Galbo, H. (1988). Hormonal response to exercise in man: Influence of hypoxia and physical training. Am. J. Physiol. 254(Reg. Comp. Integrative): R197-R203.
21. Kjaer, M., Kiens, B., Hargreaves, M., and Richter, E.A. (1991). Influence of active muscle mass on glucose homeostasis during exercise in humans. J. Appl. Physiol. 71: 552- 557.
22. Kjaer, M., Engfred, K., Fernandes, A., Secher, N.H., and Galbo, H. (1993). Regulation of hepatic glucose production during exercise in humans: role of sympathoadrenergic activity. Am. J. Physiol. 265(Endocrinol. Metab.): E275-E283.
23. Lavoie, C., Péronnet, F., and Chiasson, J.L. (1992). Role of the sypathoadrenal system in the regulation of glycogen metabolism in resting and exercising skeletal muscles. Horm. Metab. Res. 14: 266-271.
24. McDermott, J,C., Elder, G.C.B., and Bonen, A. (1987). Adrenal hormones enhance glycogenolysis in nonexercising muscle during exercise. J. Appl. Physiol. 63: 1275-1283.
25. Newsholme, E.A., and Leech, A.R. (1983). Biochemistry for the Medical Sciences. Toronto: Wiley.
26. Ren, J-M., and Hultman, E. (1990). Regulation of phosphorylase a activity in human skeletal muscle. J. Appl. Physiol. 69: 919-923.
27. Richter, E.A., Ruderman, N.B., Gavras, H., Belur, E.R., and Galbo, H. (1982). Muscle glycogenolysis during exercise: Dual control by epinephrine and contractions. Am. J. Physiol. 242(Endocrinol. Metab.): E25-E32.
28. Spriet, L.L., Ren, J.M., and Hultman, E. (1988). Epinephrine infusion enhances muscle glycogenolysis during prolonged electrical stimulation. J. Appl. Physiol. 64: 1439- 1444.
29. Spriet, L.L., MacLean, D.A., Dyck, D.J., Hultman, E., Cederblad, G., and Graham, T.E. (1992). Caffeine ingestion and muscle metabolism during prolonged exercise in humans. Am. J. Physiol. 262(Endocrinol. Metab.): E891-E898.
30. Stainsby, W.N., Sumners, C., and Eitzman, P.D. (1985). Effects of catecholamines on lactic acid output during progressive working contractions. J. Appl. Physiol. 59: 1809- 1814.
31. Townsend, R.R., Klein, S., and Wolfe, R.R. (1994). Changes in lipolytic sensitivity following repeated epinephrine infusion in humans. Am. J. Physiol. 266(Endocrinol. Metab.): E155-E160.
32. Vaha-Eskeli, K.K., Erkkola, R.U., Scheinin, M., and Seppanen, A. (1992). Effects of short- term thermal stress on plasma catecholamine concentrations and plasma renin activity in pregnant and nonpregnant women. Am. J. Obs. Gyn. 197: 785-789.
33. Weiker, H., Feraudi, M., Hagele, H., and Pluto, R. (1984). Electrochemical determination of catecholamines in urine and plasma separations with HPLC. Clin. Chem. Acta 141: 17-25.