In Vitro and in Vivo Action of Antisense RNA

Applied Biochemistry and Biotechnology - Part B Molecular Biotechnology

Volumn 6, Issue 1, 1996, Pages 7-15

  Nellen, Wolfgang ^a,b   Sczakiel, Georg ^c  

^a MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

^b UNIVERSITY OF KASSEL   (Germany)

^c GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

Antisense RNA; Antisense RNA in vivo; RNA annealing; RNA modifying proteins

Indexed keywords

COMPLEMENTARY RNA; PROTEIN;

ANIMAL; BINDING SITE; COMPUTER; CONFORMATION; HUMAN; METABOLISM; REVIEW;

ANIMALS; BINDING SITES; COMPUTERS; HUMANS; NUCLEIC ACID CONFORMATION; PROTEINS; RNA, ANTISENSE;

EID: 0030203333     PISSN: 10736085     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02762319     Document Type: Review

References (49)

1. Stein, C. A. and Krieg, A. M. (1994) Problems in interpretation of data derived from in vitro and in vivo use of antisense oligonucleotides. Antisense Res. Dev. 4, 67-69.
2. Heidenreich, O., Kang, S.-H., Xu, X., and Nerenberg, M. (1995) Application of antisense technology to therapeutics. Mol. Med. Today 1, 128-133.
3. Tabler M. (1993) Antisense RNA in plants: a tool for analysis and suppression of gene function, in Morphogenesis in Plants (Roubelakis, K. A. and Tran Thanh, K., eds.), Plenum, New York, pp. 327-258.
4. Flavell, R. B. (1994) Inactivation of gene expression in plants as a consequence of specific sequence duplication. Proc. Natl. Acad. Sci. USA 91, 3490-3496.
5. Grierson, D., Fray, R. G., Hamilton, A. J., Smith, C. J. S., and Watson, C. F (1991) Does cosuppression of sense genes in transgenic plants involve antisense RNA? TIBTECH 9, 122,123.
6. van der Krol, A. R., Mol, J. N. M., and Stuitje, A. R. (1988) Antisense genes in plants: an overview. Gene 72, 45-50.
7. Grierson, D., Tucker, G., and Lycette, G., eds., RNA-Mediated Gene Silencing. Nottingham University Press, Nottingham, UK, in press.
8. Eguchi Y., Itoh T., and Tomizawa J.-I. (1991) Antisense RNA. Annu. Rev. Biochem. 60, 631-652.
9. He, L., Soederbom, F., Wagner, E. G. H., Binnie, U., Binns, N., and Masters, M. (1993) PcnB is required for the rapid degradation of RNAI, the antisense RNA that controles the copy number of coIE1-related plasmids. Mol. Microbiol. 9, 1131-1142.
10. Marino, J. P., Gregorian, R. S., Csankovszki, G., and Crothers, D. M. (1995) Bent helix formation between RNA hairpins with complementary loops. Science 268, 1448-1454.
11. Wagner, E. G. H. and Simons, R. W. (1994) Antisense RNA control in bacteria, phage and plasmids. Annu. Rev. Microbiol., 48, 713-742.
12. Lee., R. C., Feinbaum, R. L., and Ambros, V. (1993) The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementary to lin-14. Cell 75, 843-854.
13. Wightman, B., Ha, I., and Ruvkun, G. (1993) Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans. Cell 75, 855-862.
14. Bester, A. J., Kennedy, D. S., and Heywood, S. M. (1975) Two classes of translational control RNA: their role in the regulation of protein synthesis. Proc. Natl. Acad. Sci. USA 72, 1523-1527.
15. Heywood, S. M. (1986) tcRNA as a naturally occurring antisense RNA in eukaryotes. Nucleic Acids Res. 14, 6771.
16. Zezza, D. J. and Heywood, S. M. (1986) Analysis of tcRNA102 associated with myosin heavy chain mRNPs in control and dystrophic chick pectoralis muscle. J. Biol. Chem. 261, 7461-7465.
17. Chang, Y., Spicer, D. B., and Sonenshein, G. E. (1991) Effects of IL-3 on promoter usage, attenuation and antisense transcription of the c-myc oncogene in the IL-3 dependent Ba/F3 early pre-B cell line. Oncogene 6, 1979-1982.
18. Farnham, P. J., Abrams, J. M., and Schimke, R. T. (1985) Opposite-strand RNAs from the 5′ flanking region of the mouse dihydrofolate reductase gene. Proc. Natl. Acad. Sci. USA 82, 3978-3982.
19. Krystal, G. W., Armstrong, B. C., and Battey, J. F. (1990) N-myc mRNA forms an RNA-RNA duplex with endogenous antisense transcript. Mol. Cell. Biol. 10, 4180-4191.
20. Rivkin, M., Rosen, K. M., and Villa-Komaroff, L. (1993) Identification of an antisense transcript from the IGF-II locus in the mouse. Mol. Rep. Dev. 35, 394-397.
21. Swiatek, P. J. and Gridley, T. (1993) Perinatal lethality and defects in hindbrain development in mice homozygous for a targeted mutation of the zinc finger gene Krox20. Genes Dev. 7, 2071-2084.
22. Hsieh-Li, H. M., Witte, D. P., Weinstein, M., Branford, W., Li, H., Small, K., and Potter, S. S. (1995) Hoxa 11 structure, extensive antisense transcription, and function in male and female fertility. Development 121, 1373-1385.
23. Munroe, S. H. and Lazar, M. A. (1991) Inhibition of c-erb mRNA splicing by a naturally occuring antisense RNA. J. Biol. Chem. 266, 22,083-22,086.
24. Noguchi, M., Silverman, T. A., and Safer, B. (1994) Characterization of an antisense Inr element in the eIF-2 alpha gene. J. Biol. Chem. 269, 29,161-29,167.
25. Silverman, T. A., Noguchi, M., and Safer, B. (1992) Role of sequences within the first intron in the regulation of expression of eucaryotic initiation factor 2a. J. Biol. Chem. 267, 9738-9742.
26. Hildebrandt, M. and Nellen, W. (1992) Differential antisense transcription from the Dictyostelium EB4 gene locus: implications on antisense-mediated regulation of mRNA stability. Cell 69, 197-204.
27. Kimelman, D. and Kirschner, M. W. (1989) An antisense mRNA directs the covalent modification of the transcript encoding fibroblast growth factor in Xenopus oocytes. Cell 59, 687-696.
28. Saccomanno, L. and Bass, B. L. (1994) The cytoplasm of Xenopus oocytes contains a factor that protects double-stranded RNA from adenosine-to-inosine modification. Mol. Cell. Biol. 14, 5425-5432.
29. Kim, S. K. and Wold, B. J. (1985) Stable reduction of thymidine kinase activity in cells expressing high levels of anti-sense RNA. Cell 42, 129-138.
30. Pontius, P. W. (1993) Close encounters: why unstructured, polymeric domains can increase rates of specific macromolecular association. Trends Biochem. Sci. 18, 181-186.
31. Ben-Artzi, H., Zeelon, E., Gorecki, M., and Panel, A. (1992) Double-stranded RNA-dependent RNase activity associated with human immunodeficiency virus type 1 reverse transcriptase. Proc. Natl. Acad. Sci. USA 89, 927-931.
32. D'Alessio, G., Parente, A., Guida, C., and Leone, E. (1972) Dimeric structure of seminal ribonuclease. FEBS Lett. 27, 285-288.
33. Hall, S. H. and Crouch, R. J. (1977) Isolation and characterization of two enzymatic activities from chick embryos which degrade double-stranded RNA. J. Biol. Chem. 252, 4092-4097.
34. Meegan, J. M. and Marcus, P. I. (1989) Double-stranded ribonuclease coinduced with interferon. Science 244, 1089-1091.
35. Rech, J., Cathala, G., and Jeanteur, Ph. (1978) Partial purification of a double-stranded RNA specific ribonuclease (RNase D) from Krebs II ascites cells. Nucleic Acids Res. 3, 2055-2065.
36. lino, Y., Sugimoto, A., and Yamamoto, M. (1991) S. pombe pac1+, whose overexpression inhibits sexual development, encodes a ribonucleaselll-like RNase. EMBO J. 10, 221-226.
37. Rotondo, G., Gillespie, M., and Frendeway, D. (1995) Rescue of the fission yeast snRNA synthesis mutant snml by overexpression of the double-strand-specific Pacl ribonuclease. Mol. Gen. Genet. 247, 698-708.
38. St. Johnston, D., Brown, N. H., Gall, J. G., and Jantsch, M. (1992) A conserved double-stranded RNA-binding domain. Proc. Natl. Acad. Sci. USA 89, 10,979-10,983.
39. Wilson, R., Ainscough, R., Anderson, K., Baynes, C., Berks, M., Bonfield, J., Burton, J., Connel, M., Copsey, T., Cooper, J., et al. (1994) 2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans. Nature 368, 32-38.
40. Gibson, T. J. and Thompson, J. D. (1994) Detection of dsRNA-binding domains in RNA helicase A and Drosophila maleless: implications for monomeric RNA helicases. Nucleic Acids Res. 22, 2552-2556.
41. Bass, B. L. (1992) The double-stranded RNA unwinding/modifying activity, in Antisense RNA and DNA (Murray, J. A. H., ed.), Wiley-Liss, New York, pp. 159-174.
42. Sadiq, M., Hildebrandt, M., Maniak, M., and Neuen, W. (1994) Developmental regulation of antisense-mediated gene silencing in Dictyostelium. Antisense Res. Dev. 4, 263-267.
43. 42a. Funamoto, S. and Ochiai, H. (1996) Antisense RNA activation of gene expression of a cell-cell adhesion protein (gp64) in the cellular slime mold Polysphodylium pallidum. J. Cell Sci., in press.
44. Hildebrandt, M. and Nellen (1996) Effects of endogenous antisense RNA on RNA stability and translation in Dictyostelium, in Mechanisms and Applications of Gene Silencing. (Grierson, D., Lycette, G., Tucker, D., eds.), Nottingham University Press, Nottingham, UK.
45. Matousek, J., Trnena, L., Oberhauser, R., Lichtenstein, C. P., and Nellen, W. (1994) dsRNA degrading nucleases are differentially expressed in tobacco anthers. Biol. Chem. Hoppe-Seyler 375, 261-269.
46. Proud, C. G. (1995) PKR: a new name and new roles. TIBS 20, 241-246.
47. Rittner K., Burmester C, and Sczakiel G. (1993) In vitro selection of fast-hybridizing antisense RNAs directed against the human immunodeficiency virus type 1. Nucleic Acids Res. 21, 1381-1387.
48. Sczakiel, G., Homann, M., and Rittner, K. (1993) Computer-aided search for effective antisense RNA target sequences of the human immunodeficiency virus type 1. Antisense Res. Dev. 3, 45-52.
49. Southern, E. M., Maskos, U., and Elder, K. (1992) Analyzing and comparing nucleic acid sequences by hybridization to arrays of oligonucleotides: evaluation using experimental models. Genomics 13, 1008-1017.