Tolfenamic acid in the control of ocular inflammation in the dog: Pharmacokinetics and clinical results obtained in an experiment al model

Journal of Small Animal Practice

Volumn 37, Issue 8, 1996, Pages 371-375

  Roze, M ^a   Thomas, E ^b   Davot, J L ^b  

^a CLINIQUE VÉTÉRINAIRE   (France)

^b Laboratoire Vetoquinol   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CANIS FAMILIARIS;

ANTHRANILIC ACID DERIVATIVE; NONSTEROID ANTIINFLAMMATORY AGENT; PROSTAGLANDIN E2; PROSTAGLANDIN RECEPTOR BLOCKING AGENT; TOLFENAMIC ACID;

ANIMAL; ANIMAL DISEASE; AQUEOUS HUMOR; ARTICLE; BIOLOGICAL MODEL; BIOSYNTHESIS; BLOOD; CHEMISTRY; CORNEA; DOG; DOG DISEASE; DRUG ANTAGONISM; ENDOPHTHALMITIS; FEMALE; MALE;

ANIMALS; ANTHRANILIC ACIDS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; AQUEOUS HUMOR; CORNEA; DINOPROSTONE; DOG DISEASES; DOGS; ENDOPHTHALMITIS; FEMALE; MALE; MODELS, BIOLOGICAL; PROSTAGLANDIN ANTAGONISTS;

EID: 0030202912     PISSN: 00224510     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1748-5827.1996.tb02418.x     Document Type: Article

References (12)

1. BRADFORD, M. (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Analytical Biochemistry 72, 248-254
2. HIGGINS, A. J & LEES, P. (1984) The acute inflammatory process, arachidonic acid metabolism and the mode of action of anti-inflammatory drugs. Equine Veterinary Journal 16, 163-175
3. HIGGINS, A. J., LEES, P., TAYLOR, J. B. O. & EWINS, C. P. (1986) Flunixin meglumine: quantitative determination in and effects on composition of equine inflammatory exudate. British Veterinary Journal 142, 163-169
4. KROHNE, S. D. & VESTRE, W. A. (1987) Ocular use of anti-inflammatory drugs in companion animals. Compendium on Continuing Education for the Practicing Veterinarian 9, 1085-1095
5. LEES, P., MAY, S. A. & MCKELLAR, Q. A. (1991) Pharmacology and therapeutics of non-steroidal anti-inflammatory drugs in the dog and cat: 1 General pharmacology. Journal of Small Animal Practice 32, 183-193
6. MCKELLAR, Q. A., GALBRAITH, E. A. & SIMMONS, R. D. (1991) Pharmacokinetics and serum thromboxane inhibition of two NSAIDs when administered to dogs by the intravenous or subcutaneous route. Journal of Small Animai Practice 32, 335-340
7. MCKELLAR, Q. A., LEES, P. & GETTINGBY, G. (1994) Pharmacodynamics of tolfenamic acid in dogs. Evaluation of dose response relationships. European Journal of Pharmacology 253, 191-200
8. REGNIER, A., BONNEFOI, M. & LESCURE, R. (1984) Effect of lysine-acetylsalicylate and phenylbutazone premedication on the protein content of secondary aqueous humour in the dog. Research in Veterinary Science 37, 26-29
9. ROZE, M. (1992) Valeur de l'anide tolfénamique dans le traitement des uvéites leishmaniennes. Pratique Médicale et Chirurgicale de l'Animal de Compagnie 27, 307-315
10. SANDERS, D. R. & KRAFF, M. (1984) Steroidal and non-steroidal anti-inflammatory agents. Effect on postsurgical inflammation and blood-aqueous humour barrier breakdown. Archives of Ophthalmology 102, 1453-1456
11. VAPAATALO, H., PARANTAINEN, J., LINDEN, I. B. & HAKKARAINEN, H. (1977) Prostaglandins and vascular headache: Action of tolfenamic acid - a new anti-inflammatory analgesic on migraine. In: Headache: New Vistas. Ed F. Scicuteri, Biomedical Press, Florence. pp 287-300
12. WARD, D. A., FERGUSON, D. C., WARD, S. L., GREEN, K. & KASWAN, R. L. (1992) Comparison of the blood-aqueous barrier stabilizing effects of steroidal and nonsteroidal anti-inflammatory agents in the dog. Progress in Veterinary and Comparative Ophthalmology 2, 117-123