Molecular cloning and characterization of the mouse CGT gene encoding UDP-galactose ceramide-galactosyltransferase (cerebroside synthetase)

Genomics

Volumn 35, Issue 1, 1996, Pages 223-226

  Bosio, Andreas ^a   Binczek, Erika ^a   Stoffel, Wilhelm ^a  

^a UNIVERSITY OF COLOGNE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CEREBROSIDE; GALACTOSYLCERAMIDE; GALACTOSYLTRANSFERASE; GLYCOSPHINGOLIPID; MYELIN; SULFATIDE; URIDINE DIPHOSPHATE GALACTOSE;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CENTRAL NERVOUS SYSTEM; EXON; GENE EXPRESSION; GENE ISOLATION; GENE LOCUS; GENE SEQUENCE; GENETIC ANALYSIS; MOLECULAR CLONING; MOUSE; NONHUMAN; OLIGODENDROGLIA; PERIPHERAL NERVOUS SYSTEM; PRIORITY JOURNAL; SCHWANN CELL; START CODON; TRANSCRIPTION INITIATION;

ANIMALIA;

EID: 0030201110     PISSN: 08887543     EISSN: None     Source Type: Journal    
DOI: 10.1006/geno.1996.0342     Document Type: Article

References (15)

1. 1. Bansal, R., and Pfeiffer, S. E. (1989). Reversible inhibition of oligodendrocyte progenitor differentiation by a monoclonal antibody against surface galactolipids. Proc. Natl. Acad. Sci. USA 86: 6181-6185.
2. 2. Bosio, A., Binzcek, E., Le Beau, M. M., Fernald, A. A., and Stoffel, W. (1995). The human gene CGT encoding the UDP-galactose ceramide galactosyl transferase (cerebroside synthase): Cloning, characterization and chromosomal assignment to human 4q26. Genomics 28: 607-609.
3. 3. Chomczynski, P., and Sacchi, N. (1987). Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162: 156-159.
4. 4. Diehl, H. J., Schaich, M., Budzinski, R. M., and Stoffel, W. (1986). Individual exons encode the integral membrane domains of human myelin proteolipid protein [published erratum appears in Proc. Natl. Acad. Sci. USA 1991, 86(6): 617-618]. Proc. Natl. Acad. Sci. USA 83: 9807-9811.
5. 2+ responses in oligodendrocytes. J. Neurosci. Res. 30: 699-711.
6. 6. Dyer, C. A. (1993). Novel oligodendrocyte transmembrane signaling systems. Investigations utilizing antibodies as ligands. Mol. Neurobiol. 7: 1-22.
7. 7. Hakomori, S. (1990). Bifunctional role of glycosphingolipids. J. Biol. Chem. 265: 18713-18716.
8. 8. Harouse, J. M., Bhat, S., Spitalnik, S. L., Laughlin, M., Stefano, K., Silberberg, D. H., and Gonzales-Scarano, F. (1991). Inhibition of entry of HIV-1 in neural cell lines by antibodies against galactosyl ceramide. Science 253: 320-323.
9. 9. McNight, S. L., and Kingsbury, R. (1982). Transcription control signals of a eukaryotic protein-coding gene. Science 217: 316-324.
10. 10. Morell, P., and Radin, N. S. (1969). Synthesis of cerebroside by brain from uridine diphosphate galactose and ceramide containing hydroxy fatty acid. Biochemistry 8: 506-512.
11. 11. Morell, P., Quarles, R. H., and Norton, W. T. (1994). In "Myelin Formation, Structure, and Biochemistry" (G. J. Siegel, B. W. Agranoff, R. W. Albers, and P. B. Molinoff, Eds.), pp. 117-143, Raven Press, New York.
12. 12. Raff, M. C., Mirsky, R., Fields, K. L., Lisak, R. P., Dorfman, S. H., Silberberg, D. H., Gregson, D. H., Leibowitz, S., and Kennedy, M. C. (1978). Galactocerebroside is a specific cell-surface antigenic marker for oligodendrocytes in culture. Nature 274: 813-816.
13. 13. Raff, M. C., Fields, K. L., Hakomori, S., Mirsky, R., Pruss, R. M., and Winter, J. (1979). Cell-type-specific markers for distinguishing and studying neurons and the major classes of glial cells in culture. Brain Res. 174: 283-308.
14. 14. Sanger, F., Nicklen, S., and Coulson, A. (1977). DNA sequencing with chain-terminating inhibitors. Proc. Natl. Acad. Sci. USA 74: 5463-5467.
15. 15. Schulte, S., and Stoffel, W. (1993). Ceramide UDPgalactosyl-transferase from myelinating rat brain: Purification, cloning, and expression. Proc. Natl. Acad. Sci. USA 90: 10265-10269.