Stretch-induced modifications of myocardial performance: From ventricular function to cellular and molecular mechanisms

Cardiovascular Research

Volumn 32, Issue 1, 1996, Pages 25-37

  Crozatier, Bertrand ^a  

^a INSERM   (France)

Author keywords

Inositol 1,4,5 triphosphate; Myocardial function; Pressure; Protein kinase C; Proto oncogenes; Stretch; Stretch activated channels; Volume area

Indexed keywords

PROTEIN KINASE C;

HEART FUNCTION; MUSCLE STRETCHING; PRIORITY JOURNAL; REVIEW; STARLING LAW;

ANIMALS; CALCIUM; CONTRACTILE PROTEINS; HUMANS; ION CHANNELS; MYOCARDIAL CONTRACTION; MYOCARDIUM; PROTEIN KINASE C; VENTRICULAR FUNCTION;

EID: 0030200990     PISSN: 00086363     EISSN: None     Source Type: Journal    
DOI: 10.1016/0008-6363(96)00090-9     Document Type: Review

References (143)

1. [1] Guz A. Chairman's introduction. In: Porter R, Fitzsimons DW, eds., The Physiological Basis of Starling's Law of the Heart. Amsterdam: Associated Scientific Publishers, 1974;1-6.
2. [2] Huxley AF. Muscle structure and theories of contraction. Prog Biophys Chem 1957;7:255-318.
3. [3] Sarnoff SJ, Berglund E. Starling's law of the heart studied by means of simultaneous right and left ventricular function curves in the dog. Circulation 1954;9:706-718.
4. [4] Sagawa K. The end systolic pressure-volume relation of the ventricle: definition, modifications and clinical use. Circulation 1981;63:1223-1227.
5. [5] Freeman GL, Little WC, O'Rourke RA. Influence of heart rate on left ventricular performance in conscious dogs. Circ Res 1987;61:455-464.
6. [6] Freeman GL, Little WC, O'Rourke RA. The effect of vasoactive agents on the left ventricular end-systolic pressure-volume relation in closed-chest dogs. Circulation 1986;74:1107-1113.
7. [7] Suga H, Yamakoshi K. Effects of stroke volume and velocity of ejection on end-systolic pressure of canine left ventricle. End-systolic volume clamping. Circ Res 1977;40:445-450.
8. [8] Burkhoff D, Sugiura S, Yue D, Sagawa K. Contractility dependent curvilinearity of end-systolic pressure-volume relations. Am J Physiol 1987;252:H1218-H1227.
9. [9] Lakatta EG, Length modulation of muscle performance. Frank-Starling law of the heart. In: Fozzard HA, ed., The Heart and Cardiovasculair System, 2nd edn. New York: Raven Press, Ltd., 1992;1325-1351.
10. [10] Lakata EG. Starling's law of the heart is explained by an intimate interaction of muscle length and myofilament calcium activation. J Am Coll Cardiol 1987;10:1157-1164.
11. [11] Hainsworth R. Reflexes from the heart. Physiol Rev 1991;71:617-636.
12. [12] Lang RE, Tholken H, Ganten D, Luft FC, Ruskoaho H, Unger T. Atrial natriuretic factor: a circulating hormone stimulated by volume loading. Nature 1985;314:264-266.
13. [13] Lab MJ, Allen DG, Orchard CH. The effects of shortening on myoplasmic calcium concentration and on the action potential in mammalian ventricular muscle. Circ Res 1984;55:825-829.
14. [14] Starling EH. The Linacre Lecture on the Law of the Heart. London: Longmans, Green and Co., 1918.
15. [15] Sarnoff SJ, Mitchell JH. The control of the function of the heart. In: Hamilton WF, ed.. Handbook of Physiology. Section 2: Circulation, Vol. 1. Washington, DC: American Physiological Society. 1962;489-532.
16. [16] Glower DD, Spratt JA, Snow ND, et al. Linearity of the Frank-Starling relationship in the intact heart: the concept of preload recruitable stroke work. Circulation 1985;71:994-1009.
17. [17] Guyton AC. Determination of cardiac output by equating venous return curves with cardiac response curves. Physiol Rev 1955;35:123-129.
18. [18] Ross J Jr. Alfterload mismatch and preload reserve: a conceptual framework for the analysis of ventricular function. Prog Cardiovasc Dis 1976;18:255-264.
19. [19] Monroe RG, French GN. Left ventricular pressure-volume relationships and myocardial oxygen consumption in the isolated heart. Circ Res 1961;9:362-374.
20. [20] Monroe RG, Strange RH, Lafrage CG, Levy J. Ventricular performance pressure-volume relationships and oxygen consumption during hypothermia. Am J Physiol 1964;206:67-73.
21. [21] Suga H. Time course of left ventricular pressure-volume relationship under various end-diatolic volumes. Jpn Heart J 1969;10:509-515.
22. [22] Suga H. Time course of left ventricular pressure-volume relationship under various extents of aortic occlusion. Jpn Heart J 1970;11:373-378.
23. [23] Suga H. Left ventricular time-varying pressure/volume ratio in systole as an index of myocardial inotropism. Jpn Heart J 1971;12:153-160.
24. [24] Suga H, Sagawa K, Shoukas AA. Load independence of the instantaneous pressure-volume ratio of the canine left ventricle and effects of epinephrine and heart rate on the ratio. Circ Res 1973;32:314-322.
25. [25] Suga H, Sagawa K. Instantaneous pressure-volume relationships and their ratio in the excised, supported canine left ventricle. Circ Res 1974;34:117-126.
26. [26] Sonnenblick EH. Determinants of active state in heart muscle: force, velocity, instantaneous muscle length, time. Fed Proc 1965;24:1396-1409.
27. [27] Sonnenblick EH. Active state in heart muscle: its delayed onset and modification by inotropic agent.s. J Gen Physiol 1967;50:661-676.
28. [28] Brutsaert DL, Sonnenblick EH. Force-velocity-length-time relations of the contractile elements in heart muscle of the cat. Circ Res 1969;24:137-149.
29. [29] Brutsaert DL, Claes VA, Sonnenblick EH. Effects of abrupt load alterations on force-velocity-length and time relations during isotonic contractions of heart muscle: load clamping. J Physiol (Lond) 1971;216:319-330.
30. [30] Brutsaert DL, Claes VA, Goethals MA. Effect of calcium on force-velocity-length relations of heart muscle of the cat. Circ Res 1973;32:385-392.
31. [31] Huxley AF, Gordon AM. Striation patterns in active and passive shortening of muscle. Nature (Lond) 1962;193:280-281.
32. [32] Gordon AM, Huxley AF, Julian FJ. The variation of isometric tension with sarcomere length in vertebrate muscle fibres. J Physiol (Lond) 1966;184:170-192.
33. [33] Sonnenblick EH, Spiro D, Cottrell TS. Fine structural changes in heart muscle in relation to the length-tension curve. Proc Natl Acad Sci USA 1963;49:193-200.
34. [34] Spotnitz HM, Sonnenblick EH, Spiro D. Relation of ultrastructure of function in the intact heart: sarcomere structure relative to pressure-volume curves of intact left ventricles of dog and cat. Circ Res 1966;18:49-66.
35. [35] Laks MM, Nisenson MJ, Swan HJC. Myocardial cell and sarcomere lengths in the normal dog heart. Circ Res 1967;21:671-678.
36. [36] Sonnenblick EH, Roos J Jr, Covell JW. Spotnitz HM, Spiro D. The ultrastructure of the heart in systole and diastole. Changes in sarcomere length. Circ Res 1967;21:423-431.
37. [37] Yoran C, Covell JW, Ross J. Structural basis for the ascending limb of left ventricular function. Circ Res 1973;32:297-303.
38. [38] Weber KT, Janicki JS, Hefner LL. Left ventricular force-length relations of isovolumic and ejecting contractions. Am J Physiol 1976;231:337-343.
39. [39] Weber KT, Janicki JS. Instantaneous force-velocity-length relations in isolated dog heart. Am J Physiol 1977;232:H241-H249.
40. max-end-systolic volume relation in closed-chest dogs. Circ Res 1985;56:808-815.
41. [41] Suga H, Yasumura Y, Nozawa T. Prospective prediction of oxygen consumption from pressure-volume area (PVA) in dog hearts. Am J Physiol 1987;252:H1258-H1268.
42. [42] Hunter WC, Janicki JS, Weber KT, Noordergraat A. Flow pulse response: a new method for the characterization of ventricular mechanics. Am J Physiol 1979;237:H282-H292.
43. [43] Hunter WC, Janicki JS, Weber KT, Noordergraat A. Systolic mechanical properties of the left ventricle: effects of volume and contractile state. Circ Res 1983;52:319-327.
44. [44] Su JB, Crozatier B. Preload-induced curvilinearity of left ventricular end-systolic pressure-volume relations. Effects on derived indexes in closed-chest dogs. Circulation 1989;79:431-440.
45. [45] Hunter WC. End-systolic pressure as a balance between opposing effects of ejection. Circ Res 1989;64:265-275.
46. [46] Lakatta EG, Jewell BR. Length-dependent activation. Its effect on the length-tension relation in cat ventricular muscle. Circ Res 1977;40:251-257.
47. [47] Parmley W. Chuck L. Length-dependent changes in myocardial contractile state. Am J Physiol 1973;224:1195-1199.
48. [48] Allen DG, Jewell BR, Murray JW. The contribution of activation processes to the length-tension relation of cardiac muscle. Nature 1974;248:606-607.
49. [49] Krueger JW, Pollack GH. Myocardial sarcomere dynamics during isometric contractions. J Physiol (Lond) 1975;251:627-643.
50. [50] Julian FJ, Sollins MR. Sarcomere length-tension relations in living rat papillary muscle. Circ Res 1975;37:299-308.
51. [51] Julian FJ, Sollins MR, Moss RL. Absence of a plateau in the length-tension relationship of rabbit papillary muscle when internal shortening is prevented. Nature (Lond) 1976;260:340-342.
52. [52] Fabiato A, Fabiato F. Dependence of the contractile activation of skinned cardiac muscle cells on the sarcomere length. Nature (Lond) 1975;256:54-56.
53. [53] Jewell BR. A reexamination of the influence of muscle length on myocardial performance. Circ Res 1977;40:221-230.
54. [54] ter Keurs HEDJ, Rijnsburger WH, Henuingen RV, Nagelsmit MJ. Tension development and sarcomere length in rat cardiac trabeculae. Evidence of length-dependent activation. Circ Res 1980;46:703-714.
55. [55] Sugiura S, Hunter WC, Sagawa K. Long-term versus intrabeal history of ejection as determinants of canine ventricular end-systolic pressure. Circ Res 1989;64:255-264.
56. [56] Tucci PJF, Bregagnollo EA, Spadaro J, Cicogna AC, Ribeiro MCL. Length dependent of activation studied in the isovolumic blood-perfused dog heart. Circ Res 1984;55:59-66.
57. [57] Allen DG, Kurihara S. The effects of muscle length on intracellular calcium transients in mammalian cardiac muscle. J Pysiol (Lond) 1982;327:79-94.
58. [58] Allen DG, Kentish JC. The cellular basis of the length-tension relation in cardiac muscle. J Mol Cell Cardiol 1985;17:821-840.
59. [59] Cooper G. Load and length regulation of cardiac energetics, Annu Rev Physiol 1990;52:505-522.
60. [60] Housmans PR, Lee NKM, Blinks JR. Active shortening retards the decline of the intracellular calcium transient in mammalian heart muscle. Science 1983;221:159-161.
61. [61] Allen DG, Kentish JC. Calcium concentration in the myoplasm of skinned ferret ventricular muscle following changes in muscle length. J Physiol (Lond) 1988;407:489-503.
62. [62] Saeki Y, Kurihara S, Hongo K, Tanaka E. Alterations in intracellular calcium and tension of activated ferret papillary muscle in response to step length changes. J Physiol (Lond) 1993;463:291-306.
63. [63] Babu A, Sonnenblick E, Gulati J. Molecular basis for the influence of muscle length on myocardial performance. Science 1988;240:74-76.
64. [64] Fabiato A, Fabiato F. Myofilament-generated tension oscillations during partial calcium activation during partial activation and activation dependence of the sarcomere length-tension relation of skinned cardiac cells. J Gen Physiol 1978;72:667-699.
65. 2+ sensitivity of tension. J Physiol 1991;440:273-289.
66. 2+ sensitivity of tension at short sarcomere length. Circ Res 1995;77:199-205.
67. [67] Fabiato A. Myoplasmic free calcium concentration reached during the twitch of an intact isolated cardiac cell and during calcium-induced release of calcium from the sarcoplasmic reticulum of a skinned cardiac cell from the adult rat or rabbit ventricle. J Gen Physiol 1981;78:457-497.
68. [68] Fabiato A. Appendix (Sarcoplasmic reticulum calcium release). In: ter Keurs HEDJ, Noble MIM, eds., Starling's Law of the Heart Revisited. Dordrecht: Kluwer Academic, 1988;14-17.
69. 2+ loading of sarcoplasmic reticulum in rat ventricular muscle. Cardiovasc Res 1992;26:865-870.
70. ++ from permeabilized cardiac myocytes and sarcoplasmic reticulum. FEBS Lett 1985;185:328-332.
71. [71] Nosek TM, Williams MF, Zeigler ST, Godt RE. Inositol trisphosphate enhances calcium release in skinned cardiac and skeletal muscle. Am J Physiol 1986;250:C807-C811.
72. [72] Von Harsdorf R, Lang RE, Fullerton M, Woodcock EA. Myocardial stretch stimulates phosphatidylinositol turnover. Circ Res 1989;65:494-501.
73. [73] Dassouli A, Sulpice JC, Roux S, Crozatier B. Stretch-induced inositol trisphosphate and tetrakisphosphate production in rat cardiomyocytes. J Mol Cell Cardiol 1993;25:973-982.
74. [74] Komuro I, Katoh Y, Kaida T, et al. Mechanical loading stimulates cell hypertrophy and specific gene expression in cultured rat cardiac myoscytes. J Biol Chem 1991;266:1265-1268.
75. + channels. Nature (Lond) 1987;330:653-655.
76. 2+ transient. FEBS Lett 1987;219:125-129.
77. [77] Kentish JC, Davey R, Largen P. Isoprenaline reverses the slow force responses to a length change in isolated rabbit papillary muscle. Pflügers Arch 1992;421:519-521.
78. [78] Nishizuka Y. Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C. Science 1992;258:607-614.
79. [79] Kaku T, Lakata E, Filburn C. α-Adrenergic regulation of phospho-inositide metabolism and protein kinase C in isolated cardiac myocytes. Am J Physiol 1991;260:C635-C642.
80. 1-adrenoceptor-mediated positive inotropic effect. Am J Physiol 1992;260:H27-H36.
81. [81] Movsesian MA, Nishikawa M, Adelstein RS. Phosphorylation of phospholamban by calcium-activated, phospholipid-dependent protein kinase. J Biol Chem 1984;259:8029-8032.
82. [82] Clément O, Pucéat M, Walsh MP, Vassort G. Protein kinase C enhances myosin light-chain kinase effects on force development and ATPase activity in rat single skinned cardiac cells. J Biochem 1992;285:311-317.
83. [83] Murry CE, Jennings RB, Reimer KA. Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium. Circulation 1986;74:1124-1136.
84. [84] Gross GJ, Auchampach JA. Blockade of ATP-sensitive potassium channels prevents myocardial preconditioning in dogs. Circ Res 1992;70:223-233.
85. [85] Murry CE, Jennings RB, Reimer KA. New insights into potential mechanism of ischemic preconditioning. Circulation 1991;84:442-445.
86. 1-adrenergic mechanism. Circ Res 1993;73:656-670.
87. [87] Ovize M, Kloner RA, Przyklenk K. Stretch preconditions canine myocardium. Am J Physiol 1994;266:H137-H146.
88. [88] Ytrehus K, Yongge L, Downey JM. Preconditioning protects ischemic rabbit heart by protein kinase C activation. Am J Physiol 1994;266:H1145-H1152.
89. [89] Mitchell MB, Meng X, Ao L, Brown JM, Harken AH, Banerjee A. Preconditioning of isolated rat heart is mediated by protein kinase C. Circ Res 1995;76:73-81.
90. [90] White E, Le Guennec JY, Nigretto JM, Gannier F, Argibay JA, Garnier D. The effects of increasing cell length on auxotonic contractions; membrane potential and intracellular calcium transients in single guinea-pig ventricular myocytes. Exp Physiol 1993;78:65-78.
91. [91] Guharay F, Sachs F. Stretch-activated single ion channel currents in tissue-cultured embryonic chick skeletal muscle. J Physiol (Lond) 1984;352:685-701.
92. [92] Craelius W, Chen V, El-Sherif N. Stretch-activated ion channels in ventricular myocytes. Biosci Rep 1988;8:407-414.
93. [93] Sigurdson W, Ruknudin A, Sachs F. Calcium imaging of mechanically induced fluxes in tissue-cultured chick heart: role of stretch-activated ion channels. Am J Physiol 1992;262:H1110-H1115.
94. [94] Ruknudin A, Sachs F, Bustamante JO. Stretch-activated ion channels in tissue-cultured chick heart. Am J Physiol 1993;264:H960-H972.
95. [95] Yang XC, Sachs F. Block of stretch-activated ion channels in Xenopus oocytes by gadolinium and calcium ions. Science 1989;243:1068-1071.
96. [96] Biagi BA, Enyeart JJ. Gadolinium blocks low and high threshold calcium currents in pituitary cells. Am J Physiol 1990;259:C515-C520.
97. [97] Morris CE, Horn R. Failure to elicit neuronal macroscopic mechanosensitive currents anticipated by single-channel studies. Science 1991;251:1246-1249.
98. [98] Lab MJ, Zhou BY, Spencer CI, Horner SM, Seed WA. Effects of gadolinium on length-dependent force in guinea-pig papillary muscle. Exp Physiol 1994;79:249-255.
99. i in isolated guinea-pig ventricular myocytes. Cardiovasc Res 1994;28:1193-1198.
100. [100] Hagiwara N, Masuda H, Shoda M, Irisawa H. Stretch-activated anion currents of rabbit cardiac myocytes. J Physiol (Lond) 1992;456:285-302.
101. 2+ regulation of mechanical properties of striated muscle: mechanistic studies using extraction and replacement of regulatory proteins. Circ Res 1992;70:865-884.
102. [102] Ezzaher A, El Ouazzani T, Crozatier B. Timing and velocity of ejection as major determinants of end-systolic pressure in isolated rabbit hearts. Circulation 1994;90:3055-3062.
103. [103] Hunter WC, Janicki JS, Weber KT. Systolic mechanical properties of the left ventricle during systole. Fed Proc 1980;39:169-174.
104. [104] Shroff SG, Janicki JS, Weber KT. Left ventricular systolic dynamics in terms of its chamber mechanical properties. Am J Physiol 1983;245:H110-H124.
105. [105] Brutsaert DL, Rademakers FE, Sys SU. Triple control of relaxation: implications in cardiac disease. Circulation 1983;69:190-196.
106. [106] Hori M, Inoue M, Kitakaze M, et al. Ejection timing as a major determinant of left ventricular relaxation rate in isolated perfused canine heart. Circ Res 1984;55:31-38.
107. [107] Hori M, Inoue M, Kitakaze M, et al. Loading sequence is a major determinant of afterload-dependent relaxation in intact canine heart. Am J Physiol 1985;249:H747-H757.
108. [108] Gillebert TC, Lew WYW. Influence of systolic pressure profile on rate of left ventricular pressure fall. Am J Physiol 1991;271:H805-H813.
109. [109] Crozatier B, Bical O, Belot JP, Caillet D. End-systolic left ventricular pressure-dimension shift during acute relief of volume overload in the conscious dog. Am J Cardiol 1985;55:1102-1106.
110. [110] Le Winter MM, Engler R, Pavelec RS. Time-dependent shifts of the left ventricular diastolic filling relationship in conscious dogs. Circ Res 1979;45:641-653.
111. [111] Edman KAP. The velocity of unloaded shortening and its relation to sarcomere length and isometric force in vertebrate muscle fibres. J Physiol (Lond) 1979;291:143-159.
112. [112] de Tombe PP, ter Keurs HEDJ. An internal viscous element limits unloaded velocity of sarcomere shortening in rat myocardium. J Physiol (Lond) 1992;454:619-642.
113. [113] Kent RL, Mann DL, Urabe Y, et al. Contractile function of isolated feline cardiocytes in response to viscous loading. Am J Physiol 1989;257:H1717-H1727.
114. [114] Sweitzer NK, Moss RL. Determinants of loaded shortening velocity in single cardiac myocytes permeabilized with α-hemolysin. Circ Res 1993;73:1150-1162.
115. [115] ter Keurs HEDJ, de Tombe PP. Determinants of velocity of sarcomere shortening in mammalian myocardium. In: Sugi H, Pollack GH, eds., Mechanism of Myofilament Sliding in Muscle Contraction. New York: Plenum Press, 1993.
116. [116] Ross J Jr, Sonnenblick EH, Taylor RR, Spotnitz HM, Covell JW. Diastolic geometry and sarcomere lengths in the chronically dilated canine left ventricle. Circ Res 1971;28:49-61.
117. [117] Ross J Jr, McCullagh WH. Nature of enhanced performance of the dilated left ventricle in the dog during chronic volume overloading. Circ Res 1972;30:549-556.
118. [118] Rushmer RF, Smith O, Franklin D. Mechanism of cardiac control in exercise. Circ Res 1959;7:602-627.
119. [119] Boettcher DH, Vatner SF, Heyndrickx GR, Braunwald E. Extent of utilization of the the Frank-Starling mechanism in conscious dogs. Am J Physiol 1978;234:H338-H345.
120. [120] Crozatier B, Caillet D, Chevrier JL, Hatt PY. Nonsympathetic increased inotropic state early after aortic insufficiency. Am J Physiol 1982;242:H973-H979.
121. [121] Crozatier B, Caillet D, Bical O. Left ventricular adaptation to sustained pressure overload in the conscious dog. Circ Res 1984;54:21-29.
122. [122] Crozatier B, Hittinger L, Chavance M. Modification of force-interval relations during early adaptation to pressure overload in dogs. Am J Physiol 1987;253:H1506-H1513.
123. [123] Izumo S, Lompre AM, Matsuoka R, et al. Myosin heavy chain mRNA and protein isoform transitions during cardiac hypertrophy. J Clin Invest 1987;79:970-977.
124. [124] Schwartz K, de la Bastie D, Bouveret P, Oliviero P, Alonso S, Buckingham M. α-Skeletal muscle actin mRNA's accumulate in hypertrophied adult rat hearts. Circ Res 1986;59:551-555.
125. [125] Delcayre C, Samuel JL, Marotte F, Best-Belpomme M, Mercadier JJ, Rappaport L. Synthesis of stress proteins in rat cardiac myocytes 2-4 days after imposition of hemodynamic overload. J Clin Invest 1988;82:460-468.
126. [126] Knowlton AA, Eberli FR, Brecher P, Romo GM, Owen A, Apstein CS. A single myocardial stretch or decreased systolic fiber shortening stimulates the expression of heat shock protein 70 in the isolated, erythrocyte-perfused rabbit heart. J Clin Invest 1991;88:2018-2025.
127. [127] Vandenburgh HH, Kaufman S. In vitro model for stretch-induced hypertrophy of skeletal muscle. Science 1979;203:265-268.
128. [128] Mann DL, Kent RL, Cooper IVG. Load regulation of the properties of adult feline cardiocytes: growth induction by cellular deformation. Circ Res 1989;64:1079-1090.
129. [129] Komuro I, Kaida T, Shibazaki Y, et al. Stretching cardiac myocytes stimulates protooncogene expression. J Biol Chem 1990;265:3595 3598.
130. [130] Izumo S, Nadal-Ginard B, Mahdavi V. Protooncogene induction and reprogramming of cardiac gene expression produced by pressure overload. Proc Natl Acad Sci USA 1988;85:339-343.
131. [131] Sadoshima J, Jahn L, Takahashi T, Kulik TJ, Izumo S. Molecular characterization of the stretch-induced adaptation of cultured cardiac cells. An in vitro model of load-induced cardiac hypertrophy. J Biol Chem 1992;267:10551-10560.
132. [132] Sadoshima J, Takahashi T, Jahn L, Izumo S. Roles of mechano-sensitive ion channels, cytoskeleton, and contractile activity in stretch-induced immediate-early gene expression and hypertrophy of cardiac myocytes. Proc Natl Acad Sci USA 1992;89:9905-9909.
133. [133] Watkins SC, Samuel JL, Marotte F, Bertier-Savalle B, Rappaport L. Microtubules and desmin filaments during the onset of heart hypertrophy in rat: a double immunoelectron microscope study. Circ Res 1987;60:327-336.
134. [134] Tsutsui H, Ishihara K, Cooper IVG. Cytoskeletal role in the contractile dysfunction of hypertrophied myocardium. Science 1993;260:682-687.
135. [135] Schunkert H, Jahn L, Izumo S, Apstein CS, Lorell BH. Localization and regulation of c-fos and c-jun protooncogene induction by systolic wall stress in normal and hypertrophied rat hearts. Proc Natl Acad Sci USA 1991;88:11480-11484.
136. [136] Samarel AM, Engelmann GL. Contractile activity modulates myosin heavy chain-β expression in neonatal rat heart cells. Am J Physiol 1991;261:H1067-H1077.
137. [137] Yamazaki T, Tobe K, Hoh E, et al. Mechanical loading activates mitogen-activated protein kinase and S6 peptide kinase in cultured rat cardiac myocytes. J Biol Chem 1993;268:12069-12076.
138. [138] Sadoshima J, Izumo S. Mechanical stretch rapidly activates multiple signal transduction pathways in cardiac myocytes: potential involvement of an autocrine-paracrine mechanism. EMBO J 1993;12:1681-1692.
139. [139] Yamazaki TY, Komuro I, Kudoh S, et al. Mechanical stress activates protein kinase cascade of phosphorylation in neonatal rat cardiac myocytes. J Clin Invest 1995;96:438-446.
140. [140] Sadoshima J, Xu Y, Slayter HS, Izumo S. Autocrine release of angiotensin II mediates stretch-induced hypertrophy of cardiac myocytes in vitro. Cell 1993;75:977-984.
141. [141] Kojima M, Shiojima I, Yamazaki T, et al. Angiotensin II receptor antagonist TCV-116 induces regression of hypertensive left ventricular hypertrophy signaling pathway of stretch-mediated cardiomyocyte hypertrophy in vitro. Circulation 1994;89:2204-2211.
142. 1-adrenergic and stretch-induced c-fos mRNA expression in myocardial cells. Circ Res 1994;75:8-14.
143. 1 inhibition on rapid protooncogene induction by systolic load in normal adult rat hearts. Circulation 1995;92(suppl I)62(Abstract).