Primary epithelial tumors of salivary glands - histogenesis, histomorphological and immunohistochemical implications - diagnosis and clinical management

Critical Reviews in Oncology/Hematology

Volumn 23, Issue 3, 1996, Pages 239-260

  Shrestha, Prashanta ^a   Huang, Jian Wen ^a   Takai, Yoshiaki ^a   Mori, Masahiko ^a  

^a ASAHI UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; BLEOMYCIN; CISPLATIN; CYCLOPHOSPHAMIDE; DOXORUBICIN; FLUOROURACIL; METHOTREXATE; MITOMYCIN;

CELL KINETICS; DNA DETERMINATION; EPITHELIUM TUMOR; HISTOGENESIS; HISTOPATHOLOGY; HUMAN; IMMUNOHISTOCHEMISTRY; ONCOGENE; REVIEW; SALIVARY GLAND TUMOR;

EID: 0030200699     PISSN: 10408428     EISSN: None     Source Type: Journal    
DOI: 10.1016/1040-8428(96)00203-X     Document Type: Review

References (281)

1. [1] Ellis GL, Auclair PL. Classification of salivary gland neoplasms. In: Surgical Pathology of Salivary Glands. Philadelphia, PA: Saunders, 1991; 129.
2. [2] Seifert G. Histological typing of salivary gland tumours. World Health Organization International Histological Classification of Tumours, 2nd edn. Berlin: Springer, 1991.
3. [3] Seifert G. Histopathology of malignant salivary gland tumours. Eur J Cancer Part B Oral Oncol 28B:49-56, 1992.
4. [4] Seifert G, Sobin LH. The World Health Organization's Histological Classification of Salivary Gland Tumors. A commentary on the second edition. Cancer 70:379-385, 1992.
5. [5] Seifert G, Brocheriou C, Cardesa A, Eveson JW. WHO International Histological Classification of Tumours: Tentative Histological Classification of Salivary Gland Tumours. Pathol Res Pract 186:555-581, 1990.
6. [6] Caselitz J, Loning T, Staguet MJ, Seifert G, Thivolet J. Immunocytochemical demonstration of filamentous structures in the parotid gland. Occurrence of keratin and actin in normal and tumoral parotid gland with special respect to the myoepithelial cells. J Cancer Res Clin Oncol 100:59-68, 1981.
7. [7] Dardick I, van Nostrand AW. Morphogenesis of salivary gland tumors. A prerequisite to improving classification. Pathol Annu 22:1-53, 1987.
8. [8] Norberg L, Dardick I, Leung R, Burford-Mason AP, Rippstein P. Immunogold localization of actin and cytokeratin filaments in myoepithelium of human parotid salivary gland. Ultrastruct Pathol 16:555-568, 1992.
9. [9] Eversole LR. Histogenetic classification of salivary gland tumors. Arch Pathol 92:433-443, 1971.
10. [10] Regezi JA, Batsakis JG. Histogenesis of salivary gland neoplasms. Orolaryngol Clin North Am 10:297-307, 1977.
11. [11] Batsakis JG, Regezi JA, Luna MA, El-Naggar A. Histogenesis of salivary gland neoplasms: a postulate with prognostic implications. J Laryngol Otol 103:939-944, 1989.
12. [12] Batsakis JG. Letter to the Editor, salivary gland neoplasms stem cell histogenesis? Reply. J Laryngol Otol 104:521-523, 1990.
13. [13] Takai Y, Dardick I, Mackay A, Burford-Mason A, Mori M. Diagnostic criteria for neoplastic myoepithelial cells in pleomorphic adenomas and myoepitheliomas. Immunocytochemical detection of muscle-specific action, cytokeratin 14, vimentin and glial fibrillary acidic protein. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 79:330-341, 1995.
14. [14] Takai Y, Mori M, Dardick I, MacKay A, Leung R, Wattimena D, Christensen H, Burdford-Mason A. Myofilament localization and immunoelectron microscopic detection of muscle-specific actin in neoplastic myoepithelial cells in pleomorphic adenoma and myoepitheliomas. Ultrastruct Pathol 18:575-591, 1994.
15. [15] Dardick I, Dardick AM, MacKay AJ, Pastolero GC, Gullane PJ, Burford-Mason AP. Pathology of salivary glands IV. Histogenetic concepts and cycling cells in human parotid and submandibular glands cultured in floating collagen gels. Oral Surg Oral Pathol Oral Med 76:307-318, 1993.
16. [16] Bassett RE, Dardick I, Burford-Mason A, MacKay A, Burgess K, Gullane PJ. Postirradiated submandibular gland: a potential model to study salivary gland radioprotection and tumorigenesis. J Otolaryngol 24:184-190, 1995.
17. [17] Redmann RS. Myoepithelium of salivary glands. Microsc Res Tech 27:25-45, 1994.
18. [18] Dardick I, Mardick AM, MacKay AJ, Pastolero GC, Gullane PJ, Burford-Mason AP. Pathobiology of salivary glands. IV. Histogenetic concepts and cycling cells in human parotid and submandibular gland cultured in collagen gels. Oral Surg Oral Med Oral Pathol 76:307-318, 1993.
19. [19] Dardick I, Burford-Mason AP. Current status of histogenetic and morphogenetic concepts of salivary gland tumorigenesis. Crit Rev Oral Biol Med 4:339-677, 1993.
20. [20] Dardick I, Jeans MTD, Sinnott NM, Wittkuhn JF, Kanh HJ, Baumal R. Salivary gland components in the formation of squamous metaplasia. Am J Pathol 119:33-43, 1985.
21. [21] Matthews TW, Dardick I. Morphological alterations of salivary gland parenchyma in chronic sialadenitis. J Otolaryngol 17:385-394, 1988.
22. [22] Testa Riva F, Riva A, Puxeddu P. Ciliated cells in the main excretory duct of the submandibular gland in obstructive sialadenitis: a SEM and TEM study. Ultrastruct Pathol 11:1-10, 1987.
23. [23] Dardick I, van Nostrand AWP, Jeans MTD, Rippenstein P, Edwards V. Pleomorphic adenoma: I. Ultrastructural organization of 'stroma' regions. Hum Pathol 14:780-797, 1983.
24. [24] Dardick I, van Nostrand AWP, Jeans MTD, Rippenstein P, Edwards V. Pleomorphic adenoma: II. Ultrastructural organization of 'epithelial' regions. Hum Pathol 14:798-809, 1983.
25. [25] Mori M, Murase N, Hyun KW, Sumitomo S, Kawamura K. Immunohistochemical studies of keratin distribution in salivary gland tumors. Acta Histochim Cytochim 18:21-32, 1985.
26. [26] Saku T, Okabe H, Yagi Y, Sato E, Tsuda N. A comparative study on the immunolocalization of keratin and myosin in salivary gland tumors. Acta Pathol Jpn 34:1031-1040, 1984.
27. [27] Yamada K, Shinohara H, Tanaka T, Okada Y, Mori M. Heterogeneity of keratin distribution as revealed by monoclonal antibodies in salivary pleomorphic adenomas. Acta Histochim Cytochim 22:173-186, 1989.
28. [28] Tatemoto Y, Kumasa S, Watanabe Y, Mori M. Immunohistochemical expression of monoclonal antibody against epithelial membrane antigen in salivary gland tumors. Acta Histochim Cytochim 20:113-124, 1987.
29. [29] Tatemoto Y, Kumasa S, Watanabe Y, Mori M. Epithelial membrane antigen as a marker of human salivary gland acinar and ductal cell function. Acta Histochim 82:219-226, 1987.
30. [30] Takai Y, Yamada K, Shinohara H, Orito T, Tsukitani K, Mori M. Monoclonal antibodies against keratins bind to intercalated duct and ductal basal cells of normal salivary glands in paraffin sections. Acta Histochim Cytochim 21:575-584, 1988.
31. [31] Shinohara H, Yamada K, Tanaka T, Meenaghan MA, Takai Y, Mori M. Monoclonal antibody keratin to K8.12 expression in ductal basal cells of obstructive lesions and in outer tumor cells of salivary gland pleomorphic adenomas. Acta Histochim Cytochim 22:375-384, 1989.
32. [32] Shinohara H, Yamada K, Tanaka T, Meenaghan MA, Takai Y, Mori M. Coexpression of keratin and vimentin in salivary pleomorphic adenomas. J Oral Pathol Med 18:133-139, 1989.
33. [33] Mori M, Yamada K, Tanaka T, Okada Y. Multiple expression of keratins, vimentin and S-100 protein in pleomorphic salivary adenomas. Virchows Arch B Cell Pathol 58:435-444, 1990.
34. [34] Morinaga S, Nakajima T, Shimosato Y. Normal and neoplastic myoepithelial cells in salivary glands: An immunohistochemical study. Hum Pathol 18:1218-1226, 1987.
35. [35] Mori M, Tsukitani K, Ninomiya T, Okada Y. Various expression of modified myoepithelial cells in salivary pleomorphic adenoma. Immunohistochemical studies. Pathol Res Pract 182:632-646, 1987.
36. [36] Mori M, Ninomiya T, Okada Y, Tsukitani K. Myoepitheliomas and myoepithelial adenomas of salivary gland origin. Immunohistochemical evaluation of filament proteins, S-100 A and B, glial fibrillary acidic proteins, neuron specific enolase, and lactoferrin. Pathol Res Pract 184:168-178, 1989.
37. [37] Gusterson BA, Lucas RB, Ormerod MG. Distribution of epithelial membrane antigen in benign and malignant lesions of the salivary glands. Virchows Arch A Pathol Anat Histopathol 397:227-233, 1982.
38. [38] Gustafsson H, Virtanen I, Thornell LE. Expression of cytokeratins and vimentin in salivary gland carcinomas as revealed with monoclonal antibodies. Virchows Arch A Pathol Anat Histopathol 412:515-524, 1988.
39. [39] Geiger S, Geiger B, Leitner O, Marshak G. Cytokeratin polypeptides expression in different elements of human salivary gland. Virchows Arch A Pathol Anat Histopathol 410:403-414, 1987.
40. [40] Dardick I, Rippstein P, Skimming L, Boivin M, Parks WR, Dairkee SH. Immunohistochemistry and ultrastructure of myoepithelium and modified myoepithelium of the ducts of human major salivary glands: histogenetic implications of salivary gland tumors. Oral Surg Oral Med Oral Pathol 64:703-715, 1987.
41. [41] Dardick I, Parks WR, Little J, Brown DL. Characterization of cytoskeletal proteins in basal cells of human parotid gland ducts. Virchows Arch A Pathol Anat Histopathol 412:525-532, 1988.
42. [42] Burns BF, Dardick I, Parks WR. Intermediate filament expression in normal parotid glands and pleomorphic adenomas. Virchows Arch A Pathol Anat Histopathol 413:103-122, 1988.
43. [43] Marshak G, Leitner O. Cytokeratin polypeptides in normal and metaplastic human salivary glands epithelia. J Oral Pathol 16:442-449, 1987.
44. [44] Huang JW, Sakamoto F, Kunikata M, Yamada K, Mori M. Immunohistochemical study of neuron specific enolase expression in salivary gland tumors. Int J Oncol 1:593-600, 1992.
45. [45] Mori M, Takai Y, Sumitomo S. Salivary gland tumors: a possible origin of modified myoepithelial cells is ductal basal cells. Cancer J 5:316-320, 1992.
46. [46] Nakazato Y, Ishida Y, Takahashi K, Suzuki K. Immunohistochemical distribution of S-100 protein and glial fibrillary acidic protein in normal and neoplastic salivary glands. Virchows Arch A Pathol Anat Histopathol 405:299-310, 1985.
47. [47] Ninomiya T, Naito R, Okada Y, Kobayashi K, Mori M, Tsukitani K. Immunohistochemical localization of the A and B subunits of S-100 protein in pleomorphic adenoma of the salivary glands. Virchows Arch B Cell Pathol 57:63-76, 1989.
48. [48] Siar CH, Ng KH. Immunohistochemical study of the distribution of S-100 protein in pleomorphic adenomas of minor salivary glands. J Nihon Univ Sch Dent 34:96-105, 1992.
49. [49] Nishimura T, Furukawa M, Kawahara E, Miwa A. Differential diagnosis of pleomorphic adenoma by immunohistochemical means. J Laryngol Otol 105:1057-1060, 1991.
50. [50] Azumi N, Battifora H. The distribution of vimentin and keratin in epithelial and nonepithelial neoplasms. A comprehensive immunohistochemical study on formalin-and alcohol-fixed tumors. Am J Clin Pathol 88:286-296, 1987.
51. [51] Gustafsson H, Virtanen I, Thornell L-E. Glial fibrillary acidic protein and desmin in salivary gland neoplasms: expression of four different types of intermediate filament proteins within the same cell type. Virchows Arch B Cell Pathol 57:303-313, 1989.
52. [52] Dardick I, Ostrynski VL, Ekem JK, Leung R, Burford-Mason AP. Immunohistochemical and ultrastructural correlates of muscle-actin expression in pleomorphic adenomas and myoepitheliomas based on comparison of formalin and methanol fixation. Virchows Arch A Pathol Anat Histopathol 421:95-104, 1992.
53. [53] Jones H, Moshtael F, Simpson RH. Immunoreactivity of alpha smooth muscle actin in salivary gland tumours: a comparison with S100 protein. J Clin Pathol 45:938-940, 1992.
54. [54] Zarbo RJ, Bacchi CE, Gown AM. Muscle-specific protein expression in normal salivary glands and pleomorphic adenomas: an immunohistochemical study with biochemical correlation. Mod Pathol 4:621-626, 1991.
55. [55] Dardick I, Burford-Mason A. Pathology of the salivary glands: the contribution of electron microscopy. Microsc Res Tech 27:56-60, 1994.
56. [56] Huang JW, Zhao M, Shrestha P, Mori M, Elg E, Schaler BW, Heizmann CW. Immunohistochemical evaluation of the Ca2 + binding S100 proteins. S100A1, S100A2, S100A4, S100A6 and S100B in salivary gland tumors. J Oral Pathol Med (in press, 1996).
57. [57] Landry CF, Khan HJ, Baumal R, Marks A, Brown IR. Heterogeneity in expression of S100 beta mRNA in human melanoma and pleomorphic adenoma demonstrated by in situ hybridization. Am J Pathol 139:1151-1156, 1991.
58. [58] Dardick I, Stratis M, Parks WR, Denardi FG, Kahn HJ. S-100 protein antibodies do not label normal salivary gland myoepithelium. Histogenetic implication for salivary gland tumors. Am J Pathol 138:619-628, 1991.
59. [59] Kahn HJ, Baumal R, Marks A, Dardick I, van Nostrand AWP. Myoepithelial cells in salivary gland tumors. Arch Pathol Lab Med 109:190-195, 1985.
60. [60] Erlandson RA, Cardon-Cardo C, Higgins PJ. Histogenesis of benign pleomorphic adenoma (mixed tumor) of the major salivary glands. An ultrastructural and immunohistochemical study. Am J Surg Pathol 8:803-820, 1984.
61. [61] Franquemont DW, Mills SE. Plasmacytoid monomorphic adenoma of salivary glands. Absence of myogenous differentiation and comparison to spindle cell myoepithelioma. Am J Surg Pathol 17:146-153, 1993.
62. [62] Dardick I. Histogenesis and morphogenesis of salivary gland neoplasms. In: Ellis GL. Auclair PL. Gnepp DR. eds. Surgical Pathology of Salivary Glands. Philadelphia. PA: Saunders. 1991: 108-128.
63. [63] Mori M, Yamada K, Takagi H, Shrestha P, Lee SK. Protein gene product 9.5 (PGP9.5) immunoreactivity in salivary gland tumors. Oncol Rep 3:249-254, 1996.
64. [64] Dardick I. Myoepithelioma: definitions and diagnostic criteria. Ultrastruct Pathol 19:335-345, 1995.
65. [65] Takahashi M, Hokunan K, Unno T. Immunohistochemical study of basement membrane in pleomorphic adenomas of the parotid gland: comparison between treated tumor and recurrent tumor. Nippon Jibiinkoka Gakkai Kaiho 95:1759-1764, 1992.
66. [66] Caselitz J, Schmitt P, Seifert G, Wustrow J, Schuppan D. Basal membrane associated substances in human salivary glands and salivary gland tumors. Pathol Res Pract 183:386-394, 1988.
67. [67] Line SRP, Torloni H, Junqueira LCU. Diversity of collagen expression in the pleomorphic adenoma of the parotid gland. Virchows Arch A Pathol Anat Histopathol 414:477-483, 1989.
68. [68] Saku T, Cheng J, Okabe H, Koyama Z. Immunolocalization of basement membrane molecules in the stroma of salivary gland pleomorphic adenoma. J Oral Pathol Med 19:208-214, 1990.
69. [69] Soini Y, Pakko P, Virtanen I, Lehto V-P. Tenascin in salivary gland tumours. Virchows Arch A Pathol Anat Histopathol 421:217-222, 1992.
70. [70] Sunardhi-Widyaputra S, van Damme B. Immunohistochemical expression of tenascin in normal salivary glands and in pleomorphic adenomas. Pathol Res Pract 189:138-143, 1993.
71. [71] Shrestha P, Sakamoto F, Takagi H, Ogata K, Takai Y, Mori M. Tenascin in salivary gland tumors: evidence for enhanced expression in the stroma and production by epithelial tumor cells. Eur J Cancer B Oral Oncol 30B:393-399, 1994.
72. [72] Luo M, Takagi H, Tsubone M, Ando C, Ogata K, Shrestha P, Mori M. Fibronectin expression in salivary gland pleomorphic adenoma. Arch Anat Cytol Pathol 41:68-74, 1993.
73. [73] Shibutani T, Iwayama Y, Tsubone M, Ando C, Yamada K, Mori M. Immunohistochemical localization of glycosaminoglycans with the use of monoclonal antibodies in salivary pleomorphic adenomas. Anticancer Res 10:1533-1542, 1990.
74. [74] Yang LJ, Jin Y, Nakamine H, Sumitomo S, Kamegai A, Mori M. An immunohistochemical study of bone morphogenetic protein (BMP) in pleomorphic adenoma of salivary gland. Virchows Arch A Pathol Anat Histopathol 422:437-443, 1993.
75. [75] Hatakeyama S, Satoh M, Yoshimura N, Otsu T. Immunocytochemical localization of bone morphogenetic proteins (BMPs) in salivary gland pleomorphic adenoma J Oral Pathol Med 23:232-236, 1994.
76. [76] Orenstein JM, Dardick I, van Nostrand AW. Ultrastructural similarities of adenoid cystic carcinoma and pleomorphic adenoma. Histopathology 9:623-638, 1985.
77. [77] Dardick I, Harie J, Thomas MJ, van Nostrand AWP. Ultrastructural contributions to the study of morphological differentiation in malignant mixed (pleomorphic) tumors of salivary gland. Head Neck Surg 11:5-21, 1989.
78. [78] Daley TD, Wysocki GP, Smout MS, Slinger RP. Epithelial-myoepithelial carcinoma of salivary glands. Oral Surg Oral Med Oral Pathol 57:512-519, 1984.
79. [79] Dardick I, Daley TD, van Nostrand AW. Basal cell adenoma with myoepithelial cell-derived 'stroma': a new major salivary gland tumor entity. Head Neck Surg 8:257-267, 1986.
80. [80] Dardick I, Lytwyn A, Bourne AJ, Byard RW. Trabecular and solid-cribriform types of basal cell adenoma. A morphologic study of two cases of an unusual variant of monomorphic adenoma. Oral Surg Oral Med Oral Pathol 73:75-83, 1992.
81. [81] Williams SB, Ellis GL, Auclair PL. Immunohistochemical analysis of basal cell carcinoma. Oral Surg Oral Med Oral Pathol 75:64-69, 1993.
82. [82] Dardick I, Burford-Mason AP, Garlick DS, Carney WP. The pathology of salivary gland. II Morphological evaluation of acinic cell carcinomas in the parotid gland of male transgenic (MMTV/v-Ha-ras) mice as a model for human tumours. Virchows Arch A Pathol Anat Histopathol 421:105-113, 1992.
83. [83] Dardick I, George D, Jeans MT, Wittkuhn JF, Skimming L, Rippstein P, van Nostrand AW. Ultrastructural morphology and cellular differentiation in acinic cell carcinoma. Oral Surg Oral Med Oral Pathol 63:325-334, 1987.
84. [84] Warner TFCS, Seo IS, Azen EA, Hafez GR, Zarling TA. Immunocytochemistry of acinic cell carcinomas and mixed tumors of salivary glands. Cancer 56:2221-2227, 1985.
85. [85] Takahashi H, Fujita S, Okabe H, Tsuda N, Tezuka F. Distribution of tissue markers in acinic cell carcinomas of salivary gland. Pathol Res Pract 188:692-700, 1992.
86. [86] Morley DJ, Hodes JE, Calland J, Hodes ME. Immunohistochemical demonstration of ribonuclease and amylase in normal and neoplastic salivary glands. Hum Pathol 14:969-973, 1983.
87. [87] Hara K, Ito JM, Takeuchi J, Iijima S, Endo T, Hidaka H. Distribution of S-100b protein in normal salivary glands and salivary gland tumors. Virchows Arch A Pathol Anal Histopathol 401:237-249, 1983.
88. [88] Zarbo RJ, Regezi JA, Batsakis JG. S-100 protein in salivary gland tumors: An immunohistochemical study of 129 cases. Head Neck Surg 8:268-275, 1986.
89. [89] Hayashi Y, Nishida T, Yoshida H, Yanagawa T, Yura Y, Sato M. Immunoreactive vasoactive intestinal polypeptide in acinic cell carcinoma of the parotid gland. Cancer 60:962-968, 1988.
90. [90] Dardick I, Gliniecki MR, Heathcote JG, Burford-Mason A. Comparative histogenesis and morphogenesis of mucoepidermoid carcinoma and pleomorphic adenoma. An ultrastructural study. Virchows Arch A Pathol Anal Histopathol 417:405-417, 1990.
91. [91] Mori M, Huang JW, Yamada K, Isono K, Shinohara M, Harada T, Oka M, Tsubura A, Morii S, Hilgers J. Immunohistochemical characteristics of polymorphic epithelial mucin in mucoepidermoid carcinoma of salivary gland using MAM-3 and MAM-6 antigens. Acta Histochim Cytochim 25:473-482, 1992.
92. [92] Huang JW, Mori M, Yamada K, Isono K, Ueno K, Shinohara M, Harada T, Oka M. Mucoepidermoid carcinoma of the salivary glands: Immunohistochemical distribution of intermediate filament proteins, involuerin and secretory proteins. Anti-cancer Res 12:811-820, 1992.
93. [93] Regezi JA, Zarbo RJ, Batsakis JG. Immunoprofile of mucoepidermoid carcinomas of minor salivary glands. Oral Surg Oral Med Oral Pathol 71:189-192, 1991.
94. [94] Caselitz J, Becker J, Seifert G, Weber K, Osborn M. Coexpression of keratin and vimentin filaments in adenoid cystic carcinomas of salivary glands. Virchows Arch A Pathol Anat Histopathol 403:337-344, 1984.
95. [95] Chomette G, Auriol M, Vaillant JM, Kasai T, Okada Y, Mori M. Basaloid carcinoma of salivary glands, a variety of undifferentiated adenocarcinoma. Immunohistochemical study of intermediate filament proteins in 24 cases. J Pathol 163:39-45, 1991.
96. [96] Chomette G, Auriol M, Vaillant JM, Kasai T, Okada Y Mori M. Heterogeneity and co-expression of intermediate filament proteins in adenoid cystic carcinoma of salivary glands. Pathol Biol 39:110-116, 1991.
97. [97] Mori M, Kasai T, Yuba R, Chomette G, Auriol M, Vaillant JM. Immunohistochemical studies of S-100 protein a and B in adenocystic carcinoma of salivary glands. Virchows Arch B Cell Pathol 59:115-123, 1990.
98. [98] Yamada K, Kunikata M, Mori M, Chomette G, Auriol M, Vaillant JM, Tubura A, Morii S, Hilgers J. Immunohistochemical localization of MAM-3 and MAM-6 antigen in adenoid cystic carcinoma. J Oral Pathol Med 20:57-63, 1991.
99. [99] Cheng J, Saku T, Okabe H, Furthmayr H. Basement membranes in adenoid cystic carcinoma. An immunohistochemical study. Cancer 69:2631-2640, 1992.
100. [100] Chang A, Harawi SJ. Oncocytes, oncocytosis, and oncocytic tumors. Pathol Annu 27:263-304, 1992.
101. [101] Davy CL, Dardick I, Hammond E, Thomas MJ. Relationship of clear cell oncocytoma to mitochondrial-rich (typical) oncocytomas of parotid salivary gland. An ultrastructural study. Oral Surg Oral Med Oral Pathol 77:469-479, 1994.
102. [102] Taxy JB. Necrotizing squamous mucinous metaplasia in oncocytic salivary gland tumors. A potential diagnostic problem. Am J Clin Pathol 97:40-45, 1992.
103. [103] Mark J, Dahlenfors R, Havel G, Bockmann P. Benign parotid oncocytoma with the chromosomal abnormality trisomy 7. Anticancer Res 11:1735-1737, 1991.
104. [104] Hsueh C, Gonzalez-Crussi F. Sialoblastoma: a case report and review of the literature on congenital epithelial tumors of salivary gland origin. Pediatr Pathol 12:205-214, 1992.
105. [105] Cherian T, Sebastian P, Abraham EK, Ahmed IM, Jayakumar KL, Sivaramakrishnan P. Unusual multiple metastases from malignant pleomorphic adenoma of the parotid gland. J Laryngol Otol 106:652-655, 1992.
106. [106] Pitman MB, Thor AD, Goodman ML, Rosenberg AE. Benign metastasizing pleomorphic adenoma of salivary gland: diagnosis of bone lesions by fine-needle aspiration biopsy. Diagn Cytopathol 8:384-387, 1992.
107. [107] Granger JK, Houn HY. Malignant mixed tumor (carcinosarcoma) of parotid gland diagnosed by fine needle aspiration biopsy. Diagn Cytopathol 7:427-432, 1991.
108. [108] Di Palma S, Pilotti S, Rilke F. Malignant myo-epithelioma of the parotid gland arising in a pleomorphie adenoma. Histopathology 19:273-275, 1991.
109. [109] Gnepp DR. Malignant mixed tumors of the salivary glands: a review. Pathol Annu 28:279-328, 1993.
110. [110] Tan PH, Chew CT, Cheah ES. Malignant mixed tumour arising from minor salivary gland tissue of the right parapharyngeal space with metastasis to the scalp. Ann Acad Med Singapore 21:382-385, 1992.
111. [111] Takeda Y. Malignant myoepithelioma of minor salivary gland origin. Acta Pathol Jpn 42:518-522, 1992.
112. [112] Wenig BM, Hitchcock CL, Ellis GL, Gnepp DR. Metastasizing mixed tumor of salivary glands. A clinicopathologic and flow cytometric analysis. Am J Surg Pathol 16:845-858, 1992.
113. [113] Seifert G, Hennings K, Caselitz J. Metastatic tumours to the parotid and submandibular glands - analysis and differential diagnosis of 188 cases. Pathol Res Pract 181:684-692, 1986.
114. [114] O'Brien CJ, Soong SJ, Herrera GA, Urist MM, Maddox WA. Malignant salivary tumors analysis of prognostic factors and survival. Head Neck Surg 9:82-92, 1986.
115. [115] Farman AG, George DI Jr, Clear RM. Computerized tomography of combined carcinomas arising in pleomorphic adenoma. Oral Surg Oral Med Oral Pathol 59:96-101, 1985.
116. [116] Bleiweiss IJ, Huvos AG, Lara J, Strong EW. Carcinosarcoma of the submandibular salivary gland. Immunohistochemical findings. Cancer 69:2031-2035, 1992.
117. [117] Suzuki J, Takagi M, Okada N, Hatakeyama S, Yamamoto H. Carcinosarcoma of the submandibular gland: An autopsy case. Acta Pathol Jpn 40:827-831, 1990.
118. [118] Yamashita Y, Kameda N, Katayama K, Hiruta N, Nakada M, Takeda Y. True malignant mixed tumor of the submandibular gland. Acta Pathol Jpn 40:137-142, 1990.
119. [119] Chen KTK, Weinberg RA, Moseley D. Carcinosarcinoma of the salivary gland. Am J Otolaryngol 5:415-417, 1984.
120. [120] Herrera GA. Light microscopic, ultrastructural and immunohistochemical spectrum of malignant myoepithelial lacrimal and salivary gland tumors, including malignant mixed tumors. Pathobiology 58:312-322, 1990.
121. [121] Dardick I, Hardie J, Thomas J, van Nostrand AWP. Ultrastructural contributions to the study of morphological differentiation in malignant mixed (pleomorphic) tumors of salivary gland. Head Neck 11:5-21, 1989.
122. [122] Auclair PL, Langloss JM, Weiss SW, Corio RL. Sarcomas and sarcomatoid neoplasms of the major salivary gland regions: a clinicopathologic and immunohistochemical study of cases and review of the literature. Cancer 58:1305-1315, 1986.
123. [123] Luna MA, Tortoledo E, Ordonez NG, Frankenthaler RA, Batsakis JG. Primary sarcomas of the major salivary glands. Arch Otolaryngol Head Neck Surg 117:302-306, 1991.
124. [124] Stimson PG, Valenzuela-Espinoza A, Tortoledo ME, Luna MA, Ordonez NG. Primary osteosarcoma of the parotid gland. Oral Surg Oral Pathol Oral Med 68:80-86, 1989.
125. [125] Manning JT, Raymond AK, Batsakis JG. Estraosseous osteogenic sarcoma of the parotid gland. J Laryngol Otol 100:239-242, 1986.
126. [126] Stephen J, Batsakis JG, Luna MA, von der Heyden U, Byers RM. True malignant mixed tumors (carcinosarcoma) of salivary glands. Oral Surg Oral Pathol Oral Med 61:597-602, 1986.
127. [127] Eveson JW. Troublesome tumours 2: borderline tumours of salivary glands. J Clin Pathol 45:369-377, 1992.
128. [128] Ellis GL, Auclair PL, Gnepp DR, Goode RK. Other malignant epithelial neoplasms. In: Surgical Pathology of Salivary Glands. Philadelphia, PA: Saunders, 1991: 455.
129. [129] Seifert G, Oehne H. Mesenchymal (non-epithelial) salivary gland tumors. Analysis of 167 tumor cases of the salivary gland register. Laryngo-Rhino-Otol 65:485-491, 1986.
130. [130] Melnick SJ, Amazon K, Dembrow V. Metastatic renal cell carcinoma presenting as a parotid tumor: a case report with immunohistochemical findings and review of the literature. Hum Pathol 20:195-197, 1989.
131. [131] Shrestha P, Yang LJ, Liu BL, Namba M, Qin CL, Jsono K, Tsukitani K, Mori M. Clear cell carcinoma of salivary glands: immunohistochemical evaluation of clear tumor cells. Anticancer Res 14:825-836, 1994.
132. [132] Hayashi K, Ohtsuki Y, Sonobe H, Takahashi K, Iwata J, Nishioaka E, Kawakami T. Glycogen rich clear cell carcinoma arising from minor salivary glands of the uvula: A case report. Acta Pathol Jpn 38:1227-1234, 1988.
133. [133] Chaudhry AP, Cutler LS, Satchitanand S, Labay G, Sunder M, Lin C. Glycogen rich tumor of the oral minor salivary glands: a histochemical and ultrastructural study. Cancer 52:105-111, 1983.
134. [134] Ogawa I, Nikai H, Takata T, Ijuhin N, Miyauchi M, Ito H, Vuhahula E. Clear cell tumors of minor salivary gland origin. An immunohistochemical and ultrastructural analysis. Oral Surg Oral Med Oral Pathol 72:200-207, 1991.
135. [135] Palmer RM. Epithelial-myoepithelial carcinoma: an immunocytochemical study. Oral Surg Oral Med Oral Pathol 59:511-515, 1985.
136. [136] Noel S, Brozna JP. Epithelial-myoepithelial carcinoma of salivary gland with metastasis to lung: report of a case and review of the literature. Head Neck 14:401-406, 1992.
137. [137] Brocheriou C, Auriol M, de Roquancourt A, Gaulard P, Fornes P. Epithelial-myoepithelial carcinoma of the salivary glands. Study of 15 cases and review of the literature. Ann Pathol 11:316-325, 1991.
138. [138] Luna MA, Ordonez NG, Mackay B, Batsakis JG, Guillamondegur O. Salivary epithelial-myoepithelial carcinomas of intercalated ducts: a clinical, electron microscopic and immunohistochemical study. Oral Surg Oral Med Oral Pathol 59:482-490, 1985.
139. [139] Corio RL, Sciubba JJ, Brannon RB, Batsakis JG. Epithelial-myoepithelial carcinoma of intercalated duct origin: a clinico-pathologic and ultrastructural assessment of sixteen cases. Oral Surg Oral Med Oral Pathol 53:280-287, 1982.
140. [140] Norberg LE, Burford-Mason AP, Dardick I. Cellular differentiation and morphologic heterogeneity in polymorphous low grade adenocarcinoma of minor salivary glands. J Oral Pathol Med 20:373-379, 1991.
141. [141] Norberg L, Dardick I. The need for clinical awareness of polymorphous low-grade adenocarcinoma: a review. J Otolaryngol 21:149-152, 1992.
142. [142] Brocheriou C. Polymorphous low-grade adenocarcinoma of the minor salivary glands. Seven cases. Arch Anat Cytol Pathol 40:66-72, 1992.
143. [143] Mark J, Wedell B, Dahlenfors R, Stenman G. Karyotypic variability and evolutionary characteristics of a polymorphous low grade adenocarcinoma in the parotid gland. Cancer Genet Cytogenet 55:19-29, 1991.
144. [144] Shrestha P, Namba M, Yang LJ, Liu B, Oosumi H, Mori M. Papillary cystadenocarcinoma of salivary glands: an immunohistochemical study. Int J Oncol 4:587-697, 1994.
145. [145] Weinig BM, Harpaz N, Delbridge C. Polymorphous low grade adenocarcinoma of sero-mucous glands of the nasopharynx: a report of a case and a discussion of the morphologic and immunohistochemical features. Am J Clin Pathol 92:104-109, 1989.
146. [146] Anderson C, Krutchkoff D, Pedersen C, Cartum R, Berman M. Polymorphous low grade adenocarcinoma of minor salivary gland: a clinicopathologic and comparative immunohistochemical study. Mod Pathol 3:76-82, 1990.
147. [147] Gnepp DR, Chen JC, Warren C. Polymorphous low grade adenocarcinoma of minor salivary gland: an immunohistochemical and clinicopathologic study. Am J Surg Pathol 12:461-468, 1988.
148. [148] Luna MA, Batsakis JG, Ordonez NG, Mackay B, Tortoledo E. Salivary gland adenocarcinomas: a clinicopathologic analysis of three distinctive types. Semin Diagn Pathol 4:117-135, 1987.
149. [149] Zarbo RJ, Regezi JA, Hatfield JS, Maisel H, Trojanowski JQ, Batsakis JG, Crissman JD. Immunoreactive glial fibrillary acidic protein in normal and neoplastic salivary glands: a combined immunohistochemical and immunoblot study. Surg Pathol 1:55-63, 1988.
150. [150] Nicolatou O, Kakarantza-Angleopoulou E, Angelopoulos AG, Anagnostopoulou S. Polymorphous low grade adenocarcinoma of the palate: report of a case with electron microscopy. J Oral Maxillofac Surg 46:1008-1013, 1988.
151. [151] Dardick I, Van Nostrand AWP. Polymorphous low grade adenocarcinoma: a case report with ultrastructural findings. Oral Surg Oral Med Oral Pathol 66:459-465, 1988.
152. [152] Garland TA, Innes DJ Jr, Fechner RE. Salivary duct carcinoma: an analysis of four cases with review of literature. Am J Clin Pathol 81:436-441, 1984.
153. [153] George MK, Mansour P, Pahor AL. Terminal parotid duct carcinoma. J Laryngol Otol 105:780-781, 1991.
154. [154] Anderson C, Muller R, Piorkowski R, Knibbs DR, Vignoti P. Intraductal carcinoma of major salivary gland. Cancer 69:609-614, 1992.
155. [155] Afzelius LE, Cameron WR, Svensson C. Salivary duct carcinoma - a clinicopathologic study of 12 cases. Head Neck Surg 9:151-156, 1987.
156. [156] Gal R, Strauss M, Zohar Y, Kessler E. Salivary duct carcinoma of the parotid gland. Cytologic and histopathologic study. Acta Cytol 29:454-456, 1985.
157. [157] de Araujo VC, de Souze SOM, Sesso A. Sotto MN, de Arajuo NS. Salivary duct carcinoma: Ultrastructural and histogenetic considerations. Oral Surg Oral Med Oral Pathol 63:592-596, 1987.
158. [158] Hui KK, Batsakis JG. Luna MA, Mackay B, Byers RM. Salivary duct adenocarcinoma: a high grade malignancy. J Laryngol Otol 100:105-114, 1986.
159. [159] Brandwein MS, Jagirdar J, Patil J, Biller H, Kaneko M. Salivary duct carcinoma (cribiform salivary carcinoma of excretory ducts). A clinicopathologic and immunohistochemical study of 12 cases. Cancer 65:2307-2314, 1990.
160. [160] Dardick I. van Nostrand AWP. Myoepithelial cells in salivary gland tumors - revisited. Head Neck Surg 7:395-408, 1985.
161. [161] Batsakis JG, El-Naggar AK, Luna MA, 'Adenocarcinoma, not otherwise specified': a diminishing group of salivary carcinomas. Ann Otol Rhinol Laryngol 101:102-104, 1992.
162. [162] Takata T, Caselitz J, Seifert G. Undifferentiated tumors of salivary glands. Immunocytochemical investigations and differential diagnosis of 22 cases. Pathol Res Pract 182:161-168, 1987.
163. [163] Shrestha P, Yang L-J, Liu B, Namba M, Takagi H, Hosaka M, Mori M. Neuroblastoma of parotid gland: report of a case with immunohistochemical characteristics. Eur J Cancer Part B Oral Oncol 30B:356-361, 1994.
164. [164] Goji J, Sano K, Murakami R, Nakamura H, Ninomiya M, Ito H. A case of small round cell tumor of the thoracopulmonary region with myogenic and neurogenic elements. Acta Paediatr Jpn 34:65-71, 1992.
165. [165] Hayashi Y, Nagamine S, Yanagawa T, Yoshida H, Yura Y, Azuma M, Sato M. Small cell undifferentiated carcinoma of the minor salivary gland containing exocrine, neuroendocrine, and squamous cells. Cancer 60:1583-1588, 1987.
166. [166] Gnepp DR, Corio RL, Brannon RB. Small cell carcinoma of the major salivary glands. Cancer 58:705-714, 1986.
167. [167] Sato M, Yoshida H, Hayashi Y, Miyakami K, Bando T, Yanagawa T, Yura Y, Azuma M, Ueno A. Expression of epidermal growth factor and transforming growth factor-B in a human salivary gland adenocarcinoma cell line. Cancer Res 45:6160-6167, 1985.
168. [168] Hayashi Y, Yanagawa T, Azuma M, Yura Y, Yoshida H, Sato M. Induction of cells with a myoepithelial cell phenotype by treatment with dibutyryl cyclin AMP in human salivary adenocarcinoma cells grown in athymic nude mice. Virchows Arch B Cell Pathol 50:1-11, 1985.
169. [169] Hayashi Y, Yanagawa T, Yoshida H, Yura Y, Nitta T, Sato M. Induction of other differentiation stages in neoplastic epithelial duct and myoepithelial cells from the human salivary gland grown in athymic nude mice. Cancer 55:2575-2583, 1985.
170. [170] Hayashi Y, Yoshida H, Nagamine S, Yanagawa T, Yura Y, Azuma M, Sato M. Induction of cells with acinar phenotype including presence of intracellular amylase. Treatment with 12-0-tetradecanoyl-phorbol-13-acetate in a neoplastic human salivary intercalated duct cell line grown in athymic nude mice. Cancer 60:1000-1008, 1987.
171. [171] Yanagawa T, Hayashi Y, Nagamine S, Yoshida H, Yura Y, Sato M. Generation of cells with phenotype of both intercalated duct-type and myoepithelial cells in human parotid gland adenocarcinoma clonal cells grown in athymic nude mice. Virchows Arch B Cell Pathol 51:187-195, 1986.
172. [172] Hatakeyama S, Sashima M, Shirasuna K, Satoh M, Suzuki A. Glucocorticoid-induced growth inhibition with enhanced expression of ductal epithelium of human salivary gland adenocarcinoma cells transplanted into athymic nude mouse. Cancer 62:716-722, 1988.
173. [173] Shirasuna K, Sato M, Miyazaki T. A neoplastic epithelial duct cell line established from an irradiated human salivary gland. Cancer 48:745-752, 1981.
174. [174] Azuma M, Hayashi Y, Yoshida H, Yanagawa T, Yura Y, Ueno A, Sato M. Emergence of differentiated subclones from a human salivary adenocarcinoma cell clone in culture after treatment with sodium butyrate. Cancer Res 46:770-777, 1986.
175. [175] Sato M, Hayashi Y, Yanagawa T, Yoshida H, Yura Y, Azuma M, Ueno A. Intermediate-sized filaments and specific markers in a human salivary gland adenocarcinoma cell line and its nude mouse tumors. Cancer Res 45:3878-3890, 1985.
176. [176] Aladib W, Yoshida H, Sato M. Effect of epidermal growth factor on the cellular proliferation and phenotype of a neoplastic human salivary intercalated duct cell line or its derivatives. Cancer Res 50:7650-7661, 1990.
177. [177] Nagamine S, Yanagawa T, Bando T, Yura Y, Yoshida H, Sato M. Induction of cells with phenotypic features of neuronal cells by treatment with dibutyryl cyclic adenosine 3′,5′-monophosphate in a human parotid gland adenocarcinoma cell line in culture. Cancer Res 50:6396-6404, 1990.
178. [178] Sato M, Azuma M, Hayashi Y, Yoshida H, Yanagawa T, Yura Y. 5-Azactidine induction of stable myoepithelial and acinar cells from a human salivary intercalated duct cell clone. Cancer Res 47:4453-4459, 1987.
179. [179] Azuma M, Kawamata H, Kasai Y, Yanagawa T, Yoshida H, Sato M. Induction of cells with a chondrocyte-like phenotype by treatment with 1a,25-dihydroxyvitamin D3 in a human salivary acinar cell line. Cancer Res 49:5435-5442, 1989.
180. [180] Azuma M, Kawamata H, Kasai Y, Nagamine S, Yoshida H, Yanagawa T, Sato M. Effects of retinoic acid on morphological features and biological markers of a neoplastic human salivary intercalated duct cell line in culture. Cancer Res 48:7219-7225, 1988.
181. [181] Kurokawa R, Kyakumoto S, Ota M. Retinoic acid receptor in subclone of human salivary gland adenocarcinoma cell line HSG and effect of retinoic acid on cellular growth. Biochim Biophys Acta 1095:63-74, 1991.
182. [182] Sato M, Yoshida H, Azuma M, Kawamata H, Yura Y, Shirakami N, Iga H, Furumoto N. 5-Azacytidine induction of neuron-like cells from a neoplastic human salivary intercalated duct cell line and effect of dibutyryl cyclic adenosine 3′,5′-monophosphate on proliferation and phenotype of the induced cells. Cancer J 6:26-36, 1993.
183. [183] Iga H, Azuma M, Nagamine S, Kaji R, Takase M, Yanagawa T, Yoshida H, Sato M. Expression of neurofilaments in a neoplastic human salivary intercalated duct cell line or its derivatives and effect of nerve growth factor on the cellular proliferation and phenotype. Cancer Res 49:6708-6719, 1989.
184. [184] Ballagh RH, Kudryk KG, Lampe HB, Moriarty B, Mackay A, Burford-Mason A, Dardick I. The pathobiology of salivary glands III. PCNA-localization of cycling cells induced in rat submandibular gland by low-dose X-radiation. Oral Surg Oral Med Oral Pathol 77:27-35, 1994.
185. [185] Burford-Mason AP, Cummins MM, Brown DH, Mackay AJ, Dardick I. Immunohistochemical analysis of proliferative capacity of duct and acinar cells during ligation-induced atrophy and subsequent regeneration of rat parotid gland. J Oral Pathol Med 22:440-446, 1993.
186. [186] Fujita S, Takahashi H, Okabe H. Proliferative activity in normal salivary gland and pleomorphic adenoma. A study by argyrophilic nucleolar organizer region (AgNOR) staining. Acta Pathol Jpn 42:573-578, 1992.
187. [187] Fujita S, Takahashi H, Okabe H. Nucleolar organizer regions in malignant salivary gland tumors. Acta Pathol Jpn 42:727-733, 1992.
188. [188] Cardillo MR. Ag-NOR technique in fine needle aspiration cytology of salivary gland masses. Acta Cytol 36, 147-151. 1992.
189. [189] Carrillo R, el-Naggar AK, Luna MA, Rodriguez-Peralto JL, Batsakis JG. Nucleolar organizer regions (NORs) and myoepitheliomas: a comparison with DNA content and clinical course. J Laryngol Otol 106:616-620, 1992.
190. [190] Chomette G, Auriol M, Wann A, Guilbert F. Acinic cell carcinomas of salivary glands histoprognosis. Value of NORs stained with AgNOR technique and examined with semi-automatic image analysis. J Biol Buccale 19:205-210, 1991.
191. [191] Fonseca I, Soares J. Adenoid cystic carcinoma: a study of nucleolar organizer regions (AgNOR) counts and their relation to prognosis. J Pathol 169:255-258, 1993.
192. [192] Yang LJ, Liu B, Qin CL, Hashimura K, Yamada T, Sumitomo S, Mori M. Comparison of proliferating cell nuclear antigen index in benign and malignant pleomorphic adenoma. Eur J Cancer B Oral Oncol 30B:56-60, 1994.
193. [193] Yang LJ, Hashimura K, Qin C, Shrestha P, Sumitomo S, Mori M. Immunoreactivity of proliferating cell nuclear antigen in salivary gland tumors: an assessment of growth potential. Virchows Arch A Pathol Anat Histopathol 422:481-486, 1993.
194. [194] Fearon ER, Vogelstein B. A genetic model for colorectal tumorigenesis. Cell 61:759-767, 1990.
195. [195] Birek C, Lui E, Dardick I. c-fos Oncogene underexpression in salivary gland tumors as measured by in situ hybridization. Am J Pathol 142:917-923, 1993.
196. [196] Spandidos DA, Lamothe A, Field JK. Multiple transcriptional activation of cellular oncogenes in human head and neck solid tumors. Cancer Res 5:221-224, 1985.
197. [197] Riviere A, Becker J, Loning T. Comparative investigation of c-erbB-2 neu expression in head and neck tumors and mammary cancer. Cancer 67:2142-2149, 1991.
198. [198] Muller S, Vingeswaran N, Gansler T, Gramlich T, DeRose PB, Cohen C. c-erbB-2 oncoprotein expression and amplification in pleomorphic adenoma and carcinoma ex pleomorphic adenoma: relationship to prognosis. Mod Pathol 7:628-632, 1994.
199. [199] Shrestha P, Huang JW, Tsuji T, Shinozaki F, Maeda K, Sasaki K, Ueno K, Yamada K, Mori M. Rare expression of the c-erbB-2 oncoprotein in salivary gland tumors: an immunohistochemical study. J Oral Pathol Med 21:477-480, 1992.
200. [200] Kernohan NM, Blessing K, King G, Corbett IP, Miller ID. Expression of c-erbB-2 oncoprotein in salivary gland tumors: an immunohistochemical study. J Pathol 163:77-80, 1991.
201. [201] Sugano S, Mukai K, Tsuda H, Hirohashi S, Furuya S, Shimosato Y, Ebihara S, Takeyama I. Immunohistochemical study of c-erbB-2 oncoprotein overexpression in human major salivary gland carcinoma: an indicator of aggressiveness. Laryngoscope 102:923-927, 1992.
202. [202] Press MF, Mike MC, Hung G, Zhou JY, Ma Y, George J, Dietz-Band J, James W, Slamon DJ, Batsakis JG et al. Amplification and overexpression of HER-2 neu in carcinomas of the salivary gland: correlation with poor prognosis. Cancer Res 54:5675-5682, 1994.
203. [203] Semba K, Kamata N, Toyoshima K, Yamamoto T. A v-erbB related oncogene, c-erbB-2 is distinct from c-erbB-1 epidermal growth factor receptor gene and is amplified in a human salivary gland adenocarcinoma. Proc Natl Acad Sci USA 82:6497-6501, 1985.
204. [204] Jordan R, Dardick I, Lui E, Birek C. Demonstration of c-erbB-2 oncogene overexpression in salivary gland neoplasms by in situ hybridization. J Oral Pathol Med 23:226-231, 1994.
205. [205] Birek C, Lui E, Jordan RCK, Dardick I. Analysis of c-erbB-2 amplification in salivary gland tumours by differential polymerase chain reaction. Eur J Cancer B Oral Oncol 30B:47-50, 1994.
206. [206] Soini Y, Kamel D, Nuorva K, Lane DP, Vahakangas K, Paakko P. Low p53 protein expression in salivary gland tumours compared with lung carcinomas. Virchows Arch A Pathol Anat Histopathol 421:415-420, 1992.
207. [207] Azuma M, Kasai Y, Tamatani T, Sato M. Involvement of p53 mutation in the development of human salivary gland pleomorphic adenomas. Cancer Lett 65:61-71, 1992.
208. [208] Azuma M, Yoshida H, Kawamata H, Yanagawa T, Furumoto N, Sato M. Cellular proliferation and ras oncogene of p21 21.2000 expression in relation to the intracellular cyclic adenosine 3′:5′-monophosphate levels of a human salivary gland adenocarcinoma cell line in culture. Cancer Res 48:2898-2903, 1988.
209. [209] Stenman G, Mark J, Ekedhal C. Relationships between chromosomal patterns and protooncogenes in human benign salivary gland tumors. Tumor Biol 5:103-117, 1984.
210. [210] Dourov N, Duquene L. Nuclear ultrastructure of human parotid gland tumors with special focus on nuclear bodies. J Oral Pathol Med 20:490-492, 1991.
211. [211] Eibling DE, Johnson JT, McCoy JP Jr. Barnes EL, Syms CA, Wagner RL, Campbell J. Flow cytometric evaluation of adenoid cystic carcinoma: correlation with histologic subtype and survival. Am J Surg 162:367-372, 1991.
212. [212] Cho KJ, el-Naggar AK, Ordonez NG, Luna MA, Austin J, Batsakis JG. Epithelial-myoepithelial carcinoma of salivary glands. A clinicopathologic, DNA flow cytometric, and immunohistochemical study of Ki-67 and HER-2/neu oncogene. Am J Clin Pathol 103:432-437, 1995.
213. [213] Oliveria P, Fonseca I, Soares J. Acinic cell carcinoma of the salivary glands. A long term follow-up study of 15 cases. Eur J Surg Oncol 18:7-15, 1992.
214. [214] Taira S, Okuda M, Osato T, Mizuno F. Detection of Epstein-Barr virus DNA in salivary gland tumors. Nippon Jibiinkoka Gakkai Kaiho 95:860-868, 1992.
215. [215] Karameris A, Gorgoulis V, Iliopoulos A, Frangia C, Kontomerkos T, Ioakeimidis D, Kalogeropoulos N, Sfikakis P, Kanavaros P. Detection of the Epstein Barr viral genome by an in situ hybridization method in salivary gland biopsies from patients with secondary Sjogren's syndrome. Clin Exp Rheumatol 10:327-332, 1992.
216. [216] Lamey PJ, Ferguson MM, Marshall W. Sex hormone involvement in the development of experimental virally induced murine salivary gland tumors. J Oral Pathol 14:414-421, 1985.
217. [217] Lee SK, Hwang JO, Chi JG, Yamada K, Mori M. Prenatal development of myoepithelial cells of human submandibular gland observed by immunohistochemistry and smooth muscle actin and rhodamine phalloidin fluorescence. Pathol Res Pract 189:332-341, 1993.
218. [218] Stead RH, Qizilbash AH, Kontozoglou T, Daya AD, Ridell RH. An immunohistochemical study of pleomorphic adenoma of the salivary gland: glial fibrillary acidic protein-like immunoreactivity identifies a major myoepithelial component. Hum Pathol 19:32-40, 1988.
219. [219] Born IA, Schwechheimer K, Maier H, Otto HF. Cytokeratin expression in normal salivary glands and in cystade-nolymphomas demonstrated by monoclonal antibodies against selective cytokeratin polypeptides. Virchows Arch A Pathol Anat Histopathol 411:583-589, 1987.
220. [220] Yamada K, Shinohara H, Takai Y, Mori M. Monoclonal antibody-detected vimentin distribution in pleomorphic adenomas of salivary glands. J Oral Pathol Med 17:348-353, 1988.
221. [221] O'Dwyer P, Farrar WB, James AG, Finkelmeier W, McCabe DP. Needle aspiration biopsy of major salivary gland tumors. Its value. Cancer 57:554-557, 1986.
222. [222] Heller KS, Dubner S, Chess Q, Attie JN. Value of fine needle aspiration biopsy of salivary gland masses in clinical decision making. Am J Surg 164:667-670, 1992.
223. [223] Duckwiler G, Lufkin RB, Teresi L, Spickler E, Dion J, Vinuela F, Bentson J, Hanafee W. Head and neck lesions: MR guided aspiration biopsy. Radiology 179:519-522, 1989.
224. [224] Derias NW, Chong WH, O'Connor AF. Fine needle aspiration cytology of a head and neck swelling in a child: a non-invasive approach to diagnosis. J Laryngol Otol 106:755-757, 1992.
225. [225] Cohen MB, Reznicek MJ, Miller TR. Fine-needle aspiration biopsy of the salivary glands. Pathol Annu 27:213-245, 1992.
226. [226] Chan MK, McGuire LJ, King W, Li AK, Lee JC. Cytodiagnosis of 112 salivary gland lesions. Correlation with histologic and frozen section diagnosis. Acta Cytol 36:353-363, 1992.
227. [227] Weber AL. Imaging of the salivary glands. Curr Opin Radiol 4:117-122, 1992.
228. [228] Swartz J. Saluk P, Lansman A, Marlowe F, Popky G. High resolution computed tomography. Part 2. The salivary glands and oral cavity. Head Neck Surg 7:150-161, 1984.
229. [229] Casselman JW, Mancuso AA. Major salivary gland masses: comparison of MR imaging and CT. Radiology 165:183-189, 1987.
230. [230] Van Mieghem F, Corthouts B, Degryse H, De Schepper A. Computed tomography of major salivary gland tumors. A retrospective study of 31 cases. J Belge Radiol 74:193-199, 1991.
231. [231] Kassel EE. CT sialography. Part II. Parotid masses. J Otolaryngol 11:11-24, 1982.
232. [232] Som PM. Lymph nodes of the neck. Radiology 165:593-600, 1987.
233. [233] McGahan JP, Walter JP, Bernstein L. Evaluation of the parotid gland. Radiology 152:453-458, 1984.
234. [234] Mandelblatt SM, Braun IF, Davis PC, Fry SM, Jacobs MD, Hoffman JC Jr. Parotid masses: MR imaging. Radiology 163:411-414, 1987.
235. [235] Schaeffer SD, Maravilla KR, Close LG, Burns DK, Merkel MA, Suss RA. Evaluation of NMR versus CT for parotid masses: a preliminary report. Laryngoscope 95:945-950, 1985.
236. [236] Teresi LM, Lufkin RB, Worthham DG, Abemayor E, Hanafee WN. Parotid masses: MR imaging. Radiology 163:405-409. 1987.
237. [237] Hinshaw DB, Holshouser BA, Engstrom HIM, Tjan AHL, Christiansen EL, Catelli WF. Dental material artifacts on MR images. Radiology 166:777-779, 1988.
238. [238] Robinson JD, Crawford SC, Teresi LM, Schiller VL, Lufkin RB, Harnsberger HR, Gietrich RB, Crim JR, Duckwiler GR, Spickler EM, Hanafee WN. Extracranial lesions of the head and neck: Preliminary experience with Gd-DTPA-enhanced MR imaging. Radiology 172:165-170, 1989.
239. [239] Vogl TJ, Dresel SHJ, Spath M, Grevers G, Wilimzig C, Schedel HK, Lissner J. Parotid gland: Plain and gadolinium-enhanced MR imaging. Radiology 177:667-674, 1990.
240. [240] Holliday RA, Cohen WA, Schinella RA, Rothstein SG, Persky MS, Jacobs JM, Som PM. Benign lymphoepithelial parotid cysts and hyperplastic cervical adenopathy in AIDS-risk patients: a new CT appearance. Radiology 168:439-441, 1988.
241. [241] Wittich GR, Scheible WF, Hajek PC. Ultrasonography of the salivary glands. Radiol Clin North Am 23:29-37, 1985.
242. [242] Yasumoto M, Shibuya H, Suzuki S, Ishii J, Amagasa T, Ida M, Okada N. Computed tomography and ultrasonography in submandibular tumours. Clin Radiol 46:114-120, 1992.
243. [243] Watkin GT, Hobsley M. Influence of local surgery and radiotherapy on the natural history of pleomorphic adenoma. Br J Surg 73:74-76, 1986.
244. [244] Ravasz LA, Terhaard CHJ, Hordijk GJ. Radiotherapy in epithelial tumors of the parotid gland: case presentation and literature review. Int J Radiat Oncol Biol Phys 19:55-59, 1990.
245. [245] Barton J, Slevin NJ, Cleave EN. Radiotherapy for pleomorphic adenoma of the parotid gland. J Radiat Oncol Biol Phys 22:925-928, 1992.
246. [246] Buchholz TA, Laramore GE, Griffin BR. Fast neutron radiation for recurrent pleomorphic adenomas of the parotid gland. Am J Clin Oncol 15:441-445, 1992.
247. [247] Singh R, Cawson RA. Malignant myoepithelial carcinoma (myoepithelioma) arising in a pleomorphic adenoma of the parotid gland: an immunohistochemical study and review of the literature. Oral Surg Oral Med Oral Pathol 66:65-70, 1988.
248. [248] Wang CC. Unnecessary morbidity following irradiation of lateralized head and neck carcinoma. Int J Radial Oncol Biol Phys 22:1155-1156, 1992.
249. [249] Griffin TW. Optimal treatment for salivary gland tumors. Int J Radiat Oncol Biol Phys 21:857-858, 1991.
250. [250] Batterman JJ, Breur K, Hart GAM, Van jPeperzeel HA. Observations on pulmonary metastasis in patients after single doses and multiple fractions of fast neutrons and cobalt-60-gamma rays. Eur J Cancer 17:539-548, 1981.
251. [251] Buchholz TA, Larmore GE, Griffin BR, Koh W-J, Grifin TW. The role of fast neutron radiation therapy in the management of advanced salivary gland malignant neoplasms. Cancer 69:2779-2788, 1992.
252. [252] Buchholz TA, Shimotakahara SG, Weymuller EA Jr, Laramore GE, Griffin TW. Neutron radiotherapy for adenoid cystic carcinoma of the head and neck. Arch Otolaryngol Head Neck Surg 119:747-752, 1993.
253. [253] Witten J, Hybert F, Hansen HS. Treatment of malignant tumors of the parotid glands. Cancer 65:2515-2520, 1990.
254. [254] Wang CC, Goodman M. Photon irradiation of unresectable carcinomas of salivary glands. Int J Radiat Oncol Biol Phys 21:569-576, 1991.
255. [255] Potter R, Naszaly A, Hemprich A, Haverkamp U, Al-Dandashi C, Hover K-H, Loncar I. Neutron radiotherapy in adenoid cystic carcinoma: preliminary experience at the Munster neutron facility. Strahlenther Onkol 166:78-85, 1990.
256. [256] Wendt TG, Rube C, Lissner J. Ergebnisse der photonentherapie von malignen tumoren der ohrspeicheldruse. Strahlenther Onkol 168:311-317, 1992.
257. [257] Pedersen D, Overgaard J, Sogaard H, Elbrond O, Overgaard M. Malignant parotid tumors in 110 consecutive patients: treatment results and prognosis. Laryngoscope 102:1064-1069, 1992.
258. [258] Linstadt DE, Castro JR, Phillips TL. Neon ion radiotherapy: results of the phase I/II clinical trial. Int J Radiat Oncol Biol Phys 20:761-769, 1991.
259. [259] Mijohe J, Tsuji H, Morita K. Present status of charged particle therapy for head and neck cancer in Japan (Abstr.). In: 4th International Congress on Oral Cancer, Ogaki, Japan, September 20-23, 1995, p. 111.
260. [260] Armstrong JG, Harrison LB, Thaler HT, Friedlander-Klar H, Pass DE, Zelefsky MJ, Shah JP, Strong EW, Spiro RH. The indications for elective treatment of the neck in cancer of the major salivary glands. Cancer 69:615-619, 1992.
261. [261] Rentchler R, Burgess MA, Byers R. Chemotherapy of malignant major salivary gland neoplasms: a 25-year review of M.D. Anderson Hospital experience. Cancer 40:619-624, 1977.
262. [262] Tannock I, Sutherland D. Chemotherapy for adenocystic carcinoma. Cancer 46:452-454, 1980.
263. [263] Posner MR, Ervin TJ, Weichselbaum RR, Fabian RL, Miller D. Chemotherapy of advanced salivary gland neoplasms. Cancer 50:2261-2264, 1982.
264. [264] Alberts DS, Manning MR, Coulthard SW, Koopmann CF Jr, Herman TS. Adriamycin/cis-platinum/cyclophosphamide combination chemotherapy for advanced carcinoma of the parotid gland. Cancer 47:645-648, 1981.
265. [265] Kaplan MJ, Johns ME, Cantrell RW. Chemotherapy for salivary gland cancer. Otolaryngol Head Neck Surg 95:165-170, 1986.
266. [266] Dreyfuss AI, Clark JR, Fallon BG, Posner MR, Norris CM Jr, Miller D. Cyclophosphamide, adriamycin and cisplatin (CAP) combination chemotherapy for advanced carcinomas of salivary gland origin. Abstract presented at Second International Head and Neck Oncology Research Conference, Arlington, Virginia, September 10-12, 1987.
267. [267] Creagan ET, Woods JE, Schutt AJ, O'Fallon JR. Cyclophosphamide, adriamycin, and cis-diaminedichloroplatinum (II) in the treatment of advanced nonsquamous cell head and neck cancer. Cancer 52:2007-2010, 1983.
268. [268] Venook AP, Tseng A Jr, Meyers FJ, Silverberg I, Boles R, Fu KK, Jacobs CD. Cisplatin, doxorubicin, and 5-fluorouracil chemotherapy for salivary gland malignancies: a pilot study of the Northern California Oncology Group. J Clin Oncol 5(6):951-955, 1987.
269. [269] Budd GT, Groppe CW. Adenoid cystic carcinoma of the salivary gland: sustained complete response to chemotherapy. Cancer 51:589-590, 1983.
270. [270] Creagan ET, Woods JE, Rubin J, Schaid DJ. Cisplatin-based chemotherapy for neoplasms arising from salivary glands and contiguous structures in the head and neck. Cancer 62:2313-2319, 1988.
271. [271] Creagan ET, Fleming TR, Edmonson JH, Ingle JN, Woods JE. Cyclophosphamide, adriamycin, and cis-diaminedichloroplatinum (II) in the treatment of patients with advanced head and neck cancer. Cancer 47:240-244, 1981.
272. [272] Creagan ET, Fleming TR, Edmonson JH, Ingle JN, Woods JE. Chemotherapy for advanced head and neck cancer with the combination adriamycin, cyclophosphamide and cis-diaminedichloroplatinum (II): preliminary assessment of a one-day vs. three-day regimen. Cancer 47:2549-2551, 1981.
273. [273] Creagan ET, O'Fallon JR, Woods JE, Ingle JN, Schutt AJ, Nichols WC. Cis-diaminedichloroplatinum (II) administered by 24-hour infusion in the treatment of patients with advanced upper aerodigestive cancer. Cancer 51:2020-2023, 1983.
274. [274] Cregan ET, Ingle JN, Schutt AJ, O'Fallon JR. A Phase II study of cis-diaminedichloroplatinum and 5-fluorouracil in advanced upper aerodigestive neoplasms. Head Neck Surg 6:1020-1023, 1984.
275. [275] Creagan ET, O'Fallon JR, Schutt AJ, Rubin J, Woods JE. Cyclophosphamide, adriamycin, and 24-hour infusion of cis-diaminedichloroplatinum (II) in the management of patients with advanced head and neck neoplasms. Head Neck Surg 6:738-743, 1984.
276. [276] Creagan ET, Chang M, Long HJ, O'Fallon HJ, Rubin A. Phase II clinical trial of the combination of VP-16, bleomycin, and cis-diaminedichloroplatinum in patients with advanced upper aerodigestive squamous cell carcinoma. Head Neck Surg 9:223-226, 1987.
277. [277] Creagan ET, Chang M, Long HJ, Rubin A. A Phase II clinical trial of the combination mitomycin C, adriamycin, and cis-diaminedichloroplatinum in patients with advanced upper aerodigestive cancer. Head Neck Surg 8:153-158, 1987.
278. [278] Dreyfuss AI, Clark JR, Fallon BG, Posner MR, Norris CM, Miller D. Cyclophosphamide, doxorubicin, and cisplatin combination chemotherapy for advanced carcinomas of salivary gland origin. Cancer 60:2869-2872, 1987.
279. [279] Final Report of the Head and Neck Contracts Program: Adjuvant chemotherapy for advanced head and neck squamous carcinoma. Cancer 60:301-311, 1987.
280. [280] Dimery IW, Legha SS, Shirinian M, Hong WK. Fluorouracil, doxorubicin, cyclophosphamide, and cisplatinum combination chemotherapy in advanced or recurrent salivary gland carcinoma. J Clin Oncol 8:1056-1062, 1990.
281. [281] Licitra L, Marchini S, Spinazze S, Rossi A, Rocca A, Grandi C, Molinari R. Cisplatin in advanced salivary gland carcinoma. A phase II study of 25 patients. Cancer 68:1874-1877, 1991.