Synthesis of enantiomerically pure (1R,2S)- and (1S,2R)-2-amino-1,2-bis(pentafluorophenyl)ethanols

Tetrahedron Asymmetry

Volumn 7, Issue 7, 1996, Pages 1883-1886

  Sakai, Takashi ^a   Kubo, Kazuhiro ^a   Kashino, Setsuo ^a   Uneyama, Kenji ^a  

^a OKAYAMA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

PHENETHYLAMINE DERIVATIVE;

ARTICLE; CHIRALITY; DRUG PURITY; DRUG SYNTHESIS; ENANTIOMER; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; REACTION ANALYSIS; X RAY CRYSTALLOGRAPHY;

EID: 0030200569     PISSN: 09574166     EISSN: None     Source Type: Journal    
DOI: 10.1016/0957-4166(96)00221-2     Document Type: Article

References (21)

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10. 8. Pathways involving benzoin condensation [Adams, R.; Marvel, C. S. Org. Synth. Coll. Vol. 1, 1932, 94] and Erlenmeyer reaction [Harada, K. Bull. Chem. Soc. Jpn. 1985, 42, 2059] resulted to give merely a mixture of unidentified products .
11. 9. Coe, P. L.; Stephens, R.; Tatlow, J. C. J. Chem. Soc. 1962, 3227.
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15. 13. a) Davis, F. A.; Haque. M. S.; Przeslawski, R. M. J. Org. Chem. 1989, 54, 2021.
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20. 3) 0.33-0.77 (m, 4F), 7.38 (t, 1F, J = 20.3 Hz), 8.41 (t, 1F, J = 20.3 Hz), 17.96 (dd, 2F, J = 7.20 and 21.7 Hz), 18.98 (dd, 2F, J = 7.20 and 21.7 Hz). Acceptable analytical data were obtained.
21. 18. Expected catalytic activity has been demonstrated and the utilities are now under the active investigation.