Lack of monomeric IgM anti-hepatitis C virus (HCV) core antibodies in patients with chronic HCV infection

Journal of Virological Methods

Volumn 60, Issue 2, 1996, Pages 179-182

  Negro, Francesco ^a   Troonen, Hugo ^b   Michel, Gerd ^b   Giostra, Emiliano ^a   Albrecht, Monika ^b   Perrin, Luc ^a   Hadengue, Antoine ^a  

^a GENEVA UNIVERSITY HOSPITALS   (Switzerland)

^b ABBOTT GMBH AND CO KG   (Germany)

Author keywords

Chronic hepatitis; Hepatitis C virus; IgM anti core

Indexed keywords

HEPATITIS ANTIGEN; HEPATITIS C ANTIBODY; IMMUNOGLOBULIN M;

ACUTE HEPATITIS; ARTICLE; CENTRIFUGATION; CHRONIC HEPATITIS; CLINICAL ARTICLE; CONTROLLED STUDY; HEPATITIS C; HUMAN; HUMAN TISSUE; PRIORITY JOURNAL; SEDIMENTATION RATE;

HEPATITIS C VIRUS;

EID: 0030200514     PISSN: 01660934     EISSN: None     Source Type: Journal    
DOI: 10.1016/0166-0934(96)02058-7     Document Type: Article

References (21)

1. Chau, K.H., Dawson, G.J., Mushahwar, I.K., Gutierrez, R.A., Johnson, R.G., Lesniewski, R.R., Mattson, L. and Weiland, O. (1991) IgM-antibody response to hepatitis C virus antigens in acute and chronic post-transfusion non-A, non-B hepatitis. J. Virol. Methods 35, 343-352.
2. Chen, P.-J., Wang, J.-T., Hwang, L.-H., Yang, Y.-H., Hsieh, C.-L., Kao, J.-H., Sheu, J.-C., Lai, M.-Y., Wang, T.-H. and Chen, D.-S. (1992) Transient immunoglobulin M antibody response to hepatitis C virus capsid antigen in post-transfusion hepatitis C: putative serological marker for acute viral infection. Proc. Natl. Acad. Sci. USA 89, 5971-5975.
3. Clemens, J.M., Taskar, S., Chau, K., Vallari, D., Shih, J.W.-K., Alter, H.J., Schleicher, J.B. and Mimms, L.T. (1992) IgM antibody response in acute hepatitis C viral infection. Blood 1992, 79, 169-172.
4. Connolly, J.H., Simpson, D.M., Trudgett, A. and Hopkins, A.P. (1985) Low molecular weight measles immunoglobulin M in subacute sclerosing panencephalitis and acute measles. Postgrad. Med. J. 61, 407-411.
5. Durand, J.M., Lefevre, P., Harle, J.R., Boucrat, J., Vitvitski, L. and Soubeyrand, J. (1991) Cutaneous vasculitis and cryoglobulinemia type II associated with hepatitis C virus infection, Lancet 337, 449-450.
6. Harisdangkul, V., McDougal, J.S., Knapp, M. and Christian, C.L. (1984) Naturally occurring low molecular weight IgM in patients with rheumatoid arthritis, systemic lupus erythematosus and macroglobulinemia. I. Purification and immunologic studies. J. Rheumatol. 11, 638-644.
7. Hellström, U.B., Sylvan, S.P.E., Decker, R.H. and Sönnerborg, A. (1993) Immunoglobulin M reactivity towards the immunologically active region sp75 of the core protein of hepatitis C virus (HCV) in chronic HCV infection, J. Med. Virol. 39, 325-332.
8. Kato, N., Sekiya, H., Nakazawa, T., Yamauchi, K., Ohkoshi, S., Gunji, T., Hijikata, M. and Shimotohno, K. (1994) In: K. Nishioka, H. Suzuki, S. Mishiro and T. Oda (Eds.), Viral Hepatitis and Liver Disease, Tokyo, Springer-Verlag, pp. 329-333.
9. Koziel, M.J., Dudley, D., Wong, J.T., Dienstag, J., Houghton, M., Ralston, R. and Walker, B.D. (1994) Intrahepatic cytotoxic T-lymphocytes specific for hepatitis C virus in patients with chronic hepatitis, J. Immunol. 149, 3339-3344.
10. Macagno, S., Smedile, A., Caredda, F., Ottobrelli, A. and Rizzetto, M. (1990) Monomeric (7S) immunoglobulin M antibodies to hepatitis delta virus in hepatitis type D. Gastroenterology 98, 1582-1586.
11. Martinelli, A.L.C., Brown, D., Braun, H.B. and Dusheiko, G.M. (1994) Quantitative assessment of hepatitis C virus (HCV) RNA and HCV core IgM antibodies. J. Hepatol. 21 (Suppl 1), S61.
12. Nagington, J., Smith, D.J. and Cranage, M.P. (1982) Low molecular weight IgM in cytomegalovirus infections and cardiac patients. J. Med. Virol. 10, 101-108.
13. Negro F., Abate M.L., Mondardini A., Baldi, M., Leandro, G., Lombardi, S., Wolfe, L., Ryff, J.-C., Verme, G., Brunetto, M.R. and Bonino F. (1995a) The fluctuations of hepatitis C virus (HCV)-RNA and IgM anti-HCV (core) serum levels correlate with those of alanine aminotransferases during the hepatitis relapses of patients treated with interferon. J. Viral Hep. 2, 171-174.
14. Negro, F., Giostra, E., Rubbia-Brandt, L., Troonen, H., Mentha, G., Albrecht, M., Michel, G., Perrin, L., Morel, P. and Hadengue, A. (1995b) Diagnostic significance of IgM anti-HCV core in liver graft recipients. Hepatology 22, 354A
15. Pawlotsky, J.M., Darthuy, F., Rémiré, J., Pellet, C., Udin, L., Stuyver, L., Roudot-Thoraval, F., Duvoux, C., Douvin, C., Mallat, A., Mavier, J.-P., Métreau, J.-M., Duval, J. and Dhumeaux, D. (1995) Significance of anti-hepatitis C virus core IgM antibodies in patients with chronic hepatitis C. J. Med. Virol. 47, 285-91.
16. Sjögren, M.H., Bancroft, W.H., Hoofnagle, J.H., Sosebee, J.L. and Lemon, S.M. (1986) Clinical significance of low molecular weight (7-8S) immunoglobulin M antibody to hepatitis B core antigen in chronic hepatitis B virus infections. Gastroenterology 91, 168-173.
17. Tabone, M., Galatola, G., Secreto, P., Marini, C., Molinaro, G. and Arico', S. (1994) Serum levels of anti-hepatitis C virus IgM core antibodies may predict the response to α-interferon therapy in chronic hepatitis C. J. Viral Hep. 1, 155-157.
18. Tsai, J.-F., Jeng, J.-E., Chang, W.-Y., Ho, M.-S., Lin, Z.-Y. and Tsai, J.-H. (1995) Increased IgM-containing circulating immune complexes in patients co-infected with hepatitis C and hepatitis B. Medicine 74, 136-143.
19. Tsuda, F., Naito, S., Takai, E., Akahane, Y., Furuta, S., Miyakawa, Y. and Mayumi, M (1984) Low molecular weight (7S) immunoglobulin M antibody against hepatitis B core antigen in the serum for differentiating acute from persistent hepatitis B virus infection. Gastroenterology 87, 159-164.
20. Xu, H.J., Lou, F.C. and Kong, X.T. (1988) Non-specific and specific low molecular weight IgM in the sera of patients with chronic hepatitis B infection. Proc. Sino-Am. Conf. Inf. Dis. Shanghai, p. 7.
21. Xu, H. and Roberts-Thomson, P.J. (1992) Circulating low molecular weight IgM - A disease marker in autoimmune, immunodeficient and B cell lymphoproliferative disorders. Dis. Markers 10, 115-141.