Is point mutagenesis a mechanism for antigenic variation in Trypanosoma brucei?

Molecular and Biochemical Parasitology

Volumn 79, Issue 1, 1996, Pages 35-45

  Graham, Vincent S ^a   Barry, J David ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

Antigenic variation; Mutation; Trypanosome; VSG

Indexed keywords

ANTIGEN DETECTION; ANTIGEN EXPRESSION; ANTIGENIC VARIATION; ANTIGENICITY; ARTICLE; GENE EXPRESSION; GENE SEQUENCE; GLOSSINA; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; TRYPANOSOMA BRUCEI;

GLOSSINA (PROPER); TRYPANOSOMA; TRYPANOSOMA BRUCEI;

EID: 0030200035     PISSN: 01666851     EISSN: None     Source Type: Journal    
DOI: 10.1016/0166-6851(96)02642-4     Document Type: Article

References (43)

1. [1] Borst, P. and Rudenko, G. (1994) Antigenic variation in African trypanosomes. Science 264, 1872-1873.
2. [2] Pays, E., Vanhamme, L. and Berberof, M. (1994) Genetic controls for the expression of surface antigens in African trypanosomes. Annu. Rev. Microbiol. 48, 25-52.
3. [3] Capbern, A., Giroud, C., Baltz, T. and Mattern, P. (1977) Trypanosoma equiperdum: Etude des variations antigeniques au cours de la trypanosomose experimentale du lapin. Exp. Parasitol. 42, 6-13.
4. [4] Van der Ploeg, L.H.T., Valerio, D., de Lange, T., Bernards, A., Borst, P. and Grosveld, F.G. (1982) An analysis of cosmid clones of nuclear DNA from Trypanosoma brucei shows that the genes for variant surface glycoproteins are clustered in the genome. Nucl. Acids Res. 10, 5905-5923.
5. [5] Vickerman, K. and Barry, J.D. (1982) African Trypanosomiasis. In: Immunology of Parasitic Infections (Cohen, S. and Warren, K.S., eds.), 2nd edn. pp. 204-260. Blackwell Scientific Publishers, Oxford.
6. [6] Cross, G.A.M. (1990) Cellular and genetic aspects of antigenic variation in trypanosomes. Annu. Rev. Immunol. 8, 83-110.
7. [7] Blum, M.L., Down, J.A., Gurnett, A.M., Carrington, M., Turner, M.J. and Wiley, D.C. (1993) A structural motif in the variant surface glycoproteins of Trypanosoma brucei. Nature 362, 603-609.
8. [8] Hall, T. and Esser, K. (1984) Topologic mapping of protective and nonprotective epitopes on the variant surface glycoprotein of the WRATat 1 clone of Trypanosoma brucei rhodesiense. J. Immunol. 132, 2059-2063.
9. [9] Masterson, W.J., Taylor, D. and Turner, M.J. (1988) Topologic analysis of the epitopes of a variant surface glycoprotein of Trypanosoma brucei. J. Immunol. 140, 3194-3199.
10. [10] Miller, E.N., Allan, L.M. and Turner, M.J. (1984) Mapping of antigenic determinants within peptides of a variant surface glycoprotein of Trypanosoma brucei. Mol. Biochem. Parasitol. 13, 309-322.
11. [11] Pays, E., Van Assel, S., Laurent, M., Dero, B., Michiels, F., Kronenberger, P., Matthyssens, G., Van Meirvenne, N., Le Ray, D. and Steinert, M. (1983) At least 2 transposed sequences are associated in the expression site of a surface-antigen gene in different trypanosome clones. Cell 34, 359-369.
12. [12] Barbet, A.F. and Kamper, S.M. (1993) The importance of mosaic genes to trypanosome survival. Parasitol. Today 9, 63-66.
13. [13] Thon, G., Baltz, T., Giroud, C. and Eisen, H. (1990) Trypanosome variable surface glycoproteins: composite genes and order of expression. Genes Dev. 9, 1374-1383.
14. [14] Myler, P.J., Aline, R.F., Scholler, J.K. and Stuart, K.D. (1988) Multiple events associated with antigenic switching in Trypanosoma brucei. Mol. Biochem. Parasitol. 29, 227-241.
15. [15] Barry, J.D. and Turner, C.M.R. (1991) The dynamics of antigenic variation and growth of African trypanosomes. Parasitol. Today 7, 207-211.
16. [16] Graham, S.V., Matthews, K.R., Shiels, P.G. and Barry, J.D. (1990) Distinct, developmental stage-specific activation mechanisms of trypanosome VSG genes. Parasitology 101, 361-367.
17. [17] Barry, J.D., Crowe, J.S. and Vickerman, K. (1983) Instability of the Trypanosoma brucei rhodesiense metacyclic variable antigen repertoire. Nature 306, 699-701.
18. [18] Esser, K.M., Schoenbechler, M.J. and Gingrich, J.B. (1982) Trypanosoma rhodesiense blood forms express all antigen specificities relevant to protection against metacyclic (insect form) challenge. J. Immunol. 129, 1715-1718.
19. [19] Graham, S.V. and Barry, J.D. (1995) Transcriptional regulation of metacyclic variant surface glycoprotein gene expression during the life cycle of Trypanosoma brucei. Mol. Cell. Biol. 15, 5945-5956.
20. [20] Matthews, K.R., Shiels, P.G., Graham, S.V., Cowan, C. and Barry, J.D. (1990) Duplicative activation mechanisms of 2 trypanosome telomeric VSG genes with structurally simple 5′ flanks. Nucl. Acids Res. 18, 7219-7227.
21. [21] Lu, Y., Hall, T., Gay, L.S. and Donelson, J.E. (1993) Point mutations are associated with a gene duplication leading to the bloodstream reexpression of a trypanosome metacyclic VSG. Cell 72, 397-406.
22. [22] Lu, Y., Alarcon, C.M., Hall, T., Reddy, L.V. and Donelson, J.E. (1994) A strand bias occurs in point mutations associated with variant surface glycoprotein gene conversion in Trypanosoma rhodesiense. Mol. Cell. Biol. 14, 3971-3980.
23. [23] Alarcon, C.M., Son, H.J., Hall, T. and Donelson, J.E. (1994) A monocistronic transcript for a trypanosome variant surface glycoprotein. Mol. Cell. Biol. 14, 5579-5591.
24. [24] Rice-Ficht, A.C., Chen, K.K. and Donelson, J.E. (1982) Point mutations during generation of expression linked extra copy of trypanosome surface glycoprotein gene. Nature 298, 676-679.
25. [25] Baltz, T., Giroud, C., Bringaud, F., Eisen, H., Jacquemot, C. and Roth, C.W. (1991) Exposed epitopes on a Trypanosoma equiperdum variant surface glycoprotein altered by point mutations. EMBO J. 10, 1653-1659.
26. [26] Kamper, S.M. and Barbet, A.F. (1992) Surface epitope variation via mosaic gene formation is potential key to long-term survival of Trypanosoma brucei. Mol. Biochem. Parasitol. 53, 33-44.
27. [27] Borst, P., Bernards, A., Van der Ploeg, L.H.T., Michels, P.A.M., Liu, A.Y.C., de Lange, T., Sloof, P., Veeneman, G.H., Tromp, M.C. and Van Boom, J.H. (1983) DNA rearrangements controlling the expression of genes for variant surface antigens in trypanosomes. In: Genetic Rearrangement. Proceedings of the Fifth John Innes Symposium on Biological Consequences of DNA Structure and Genome Arrangement (Chater, K.F., Cullis, C.A., Hopwood, D.A., Johnston, A.W.B. and Woolhouse, H.W., eds.), pp. 207-233. Croom Helm., London and Canberra.
28. [28] Barbet, A.F., Myler, P.J., Williams, R.O. and McGuire, T.C. (1989) Shared surface epitopes among trypanosomes of the same serodeme expressing different variable surface glycoprotein genes. Mol. Biochem. Parasitol. 32, 191-199.
29. [29] Turner, C.M.R., Barry, J.D., Maudlin, I. and Vickerman, K. (1988) An estimate of the size of the metacyclic variable antigen repertoire of Trypanosoma brucei rhodesiense. Parasitology 97, 269-276.
30. [30] Bernards, A., Vanderploeg, L.H.T., Frasch, A.C.C., Borst, P., Boothroyd, J.C., Coleman, S. and Cross, G.A.M. (1981) Activation of trypanosome surface glycoprotein genes involves a duplication-transposition leading to an altered 3′ end. Cell 27, 497-505.
31. [31] Chomczynski, P. and Sacchi, N. (1987) Single-step method of RNA isolation by acid guanidinium thiocyanate phenol chloroform extraction. Anal. Biochem. 162, 156-159.
32. [32] Sambrook, J., Fritsch, E.F. and Maniatis, T. (1989) Molecular cloning: a laboratory manual, Cold Spring Laboratory Press, Cold Spring Harbor, NY.
33. [33] Greaves, D.R. and Borst, P. (1987) Trypanosoma brucei variant-specific glycoprotein gene chromatin is sensitive to single strand-specific endonuclease digestion. J. Mol. Biol. 197, 471-483.
34. [34] Carrington, M., Miller, N., Blum, M., Roditi, I., Wiley, D. and Turner, M. (1991) Variant specific glycoprotein of Trypanosoma brucei consists of 2 domains each having an independently conserved pattern of cysteine residues. J. Mol. Biol. 221, 823-835.
35. [35] Kawasaki, E.S. and Wang, A.M. (1989) Detection of gene expression. In: PCR Technology: Principles and Applications for DNA amplification, pp. 89-97. Stockton Press, New York.
36. [36] Turner, C.M.R. and Barry, J.D. (1989) High frequency of antigenic variation in Trypanosoma brucei rhodesiense infections. Parasitology 99, 67-75.
37. [37] Perler, F., Efstratiadis, A., Lomedico, P., Gilbert, W., Kolodner, R. and Dodgson, J. (1980) The evolution of genes: the chicken preproinsulin gene. Cell 20, 555-566.
38. [38] Datta, A. and Jinks-Robertson, S. (1995) Association of increased spontaneous mutation rates with high levels of transcription in yeast. Science 268, 1616-1619.
39. [39] Roth, C., Bringaud, F., Layden, R.E., Baltz, T. and Eisen, H. (1989) Active late-appearing variable surface-antigen genes in Trypanosoma equiperdum are constructed entirely from pseudogenes. Proc. Natl. Acad. Sci. USA 86, 9375-9379.
40. [40] Le Ray, D., Barry, J.D. and Vickerman, K. (1978) Antigenic heterogeneity of metacyclic forms of Trypanosoma brucei. Nature 273, 300-302.
41. [41] Barry, J.D., Hajduk, S.L., Vickerman, K. and Le Ray, D. (1979) Detection of multiple variable antigen types in metacyclic populations of Trypanosoma brucei. Trans. R. Soc. Trop. Med. Hyg. 73, 205-208.
42. [42] Barry, J.D. (1986) Antigenic variation during Trypanosoma vivax infections of different host species. Parasitology 92, 51-65.
43. [43] Nantulya, V.M., Musoke, A.J., Rurangirwa, F.R. and Moloo, S.K. (1984) Resistance of cattle to tsetse-transmitted challenge with Trypanosoma brucei and Trypanosoma congolense after spontaneous recovery from syringe-passaged infections. Infect. Immun. 43, 735-738.