(+)-Cavicularin: A novel optically active cyclic bibenzyl-dihydrophenanthrene derivative from the liverwort Cavicularia densa Steph.

Tetrahedron Letters

Volumn 37, Issue 27, 1996, Pages 4745-4748

  Toyota, Masao ^a   Yoshida, Tatsuhiko ^a   Kan, Yukiko ^a   Takaoka, Shigeru ^a   Asakawa, Yoshinori ^a  

^a TOKUSHIMA BUNRI UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CAVICULARIN; PHENANTHRENE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; DRUG ISOLATION; DRUG STRUCTURE; NUCLEAR MAGNETIC RESONANCE; PHYTOCHEMISTRY; X RAY CRYSTALLOGRAPHY;

CAVICULARIA DENSA;

EID: 0030200009     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/0040-4039(96)00956-2     Document Type: Article

References (8)

1. 1. (a) Asakawa, Y. Chemical Constituents of Hepaticae in "Progress in the Chemistry of Organic Natural Products" (Herz, W.; Kirby, G. W.; Moore, R. E.; Steglich, W.; Tamm, Ch. eds.) 1995, Vol. 65, P. 1, Springer, Wien.
2. (b) Asakawa, Y. Biologically Active Terpenoids and Aromatic Compounds from Liverworts and the Inedible Mushroom Cryptoporus volvatus. in "Bioactive Natural Products: Detection, Isolation, and Structural Determination" (Colegate, S. M.; Molyneux, R. J. eds.) 1993, P. 319, CRC Press, Florida.
3. 2. Asakawa, Y.; Toyota, M.; Taira, Z.; Takemoto, T.; Kido, M. J. Org. Chem. 1983, 48, 2164-2167.
4. w were 0.091 and 0.083 for 3398 reflections with I > 3σ(I). The structure was solved by direct method (Monte-Carlo Multan) and refined by full-matrix least-squares techniques. The final R value did not decrease to less than 0.091, since the crystals contain solvent of crystallization, which is probably n-hexane, although disorder within the solvent region makes it difficult to be absolutely certain about the composition of the solvent. Diffraction data were obtained using a Mac Science MXC18 diffractiotometer at room temperature. The supplementary materials have been deposited at the Cambridge Crystallographic Data Center.
5. 4. (a) Brown, C. J.; Farthing, A. C. Nature 1949, 164, 915-916.
6. (b) Brown, C. J. J. Chem. Soc. 1953, 3265-3270.
7. 2 (0.3 ml) solution at room temperature (3 days, y. 19.3%).
8. 6. Hashimoto, T.; Yoshida, T.; Kan, Y.; Takaoka, S.; Tori, M.; Asakawa, Y. Tetrahedron Lett. 1994, 35, 909-910.