Synthesis of enantiomerically pure pyrrolidinones as endothelin receptor antagonists

Tetrahedron Letters

Volumn 37, Issue 27, 1996, Pages 4627-4630

  Bhagwat, Shripad S ^a,b   Gude, Candido ^a   Chan, Kenneth ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

^b ABBOTT LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENDOTHELIN RECEPTOR ANTAGONIST; PYRROLIDINE DERIVATIVE;

ARTICLE; DRUG STRUCTURE; DRUG SYNTHESIS; ENANTIOMER; MASS SPECTROMETRY; NUCLEAR MAGNETIC RESONANCE; REACTION ANALYSIS; TECHNIQUE;

EID: 0030199644     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/0040-4039(96)00919-7     Document Type: Article

References (7)

1. 1. Warner, T. D. Cardiovasc. Drug Rev. 1994, 12, 105-122.
2. 2. Georg, G. I., Ed.; The Organic Chemistry of β-Lactams, Verlag Chemie, New York, 1992, chapter 6, p. 295-368.
3. X), 3.79 (s, 3H), 3.65 (s, 3H), 3.6-2.9 (m, 7H), 1.52 (sextet, J=7.4 Hz, 2H), 0.87 (t, J=7.4 Hz, 3H).
4. 4. Browne, M.; Burnett, D. A.; Caplen, M. A.; Chen, L.-Y.; Clader, J. W.; Domalski, M.; Dugar, S.; Pushpavanam, P.; Sher, R.; Vaccaro, W.; Viziano, M.; Zhao, H. Tetrahedron Lett. 1995, 36, 2555-2558.
5. 4), 3.55-3.3 (m, 4H), 3.29, (s, 3H), 2.85 (m, 1H), 1.59 (sextet, J=7.4 Hz, 2H), 0.93 (t, J=7.4 Hz, 3H).
6. 3), 3.98 (m, 1H), 3.79 (s, 3H), 3.65-3.25 (m, 5H), 2.78 (m, 1H), 1.59 ( sextet, J=7.4 Hz, 2H), 0.95 (t, J=7.4 Hz, 3H).
7. 4), 2.78 (m, 3H), 1.75 (br, 1H), 1.57 (sextet, J=7.4 Hz, 2H), 0.91 (t, J=7.4 Hz, 3H).