Problems of translating heterologous genes in expression systems: The role of tRNA

Biotechnology Progress

Volumn 12, Issue 4, 1996, Pages 417-422

  Smith, David W E ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

RECOMBINANT PROTEIN; TRANSFER RNA;

ANIMAL; ARTICLE; BIOSYNTHESIS; GENE EXPRESSION; GENETICS; HUMAN; PROTEIN SYNTHESIS;

ANIMALS; GENE EXPRESSION; HUMANS; PROTEIN BIOSYNTHESIS; RECOMBINANT PROTEINS; RNA, TRANSFER;

ANIMALIA;

EID: 0030199401     PISSN: 87567938     EISSN: None     Source Type: Journal    
DOI: 10.1021/bp950056a     Document Type: Article

References (37)

1. Alldread, R. M.; Nicholls, D. J.; Sundaram, T. K.; Scawen, M. D.; Atkinson, T. Overexpression of the Thermus aquaticus B malate dehydrogenase-encoding gene in Escherichia coli. Gene 1992, 114, 139-143.
2. Beier, H.; Barciszewska, M.; Sickinger, H.-D. The molecular basis for the differential translation of TMV RNA in tobacco protoplasts and wheat germ extracts. EMBO J. 1984, 3, 1091-1096.
3. Tyr does not. Nature 1981, 294, 188-190.
4. Bjork, G. R. The role of modified nucleosides in tRNA interactions. In Transfer RNA in Protein Synthesis; Hatfield, D. L., Lee, B. J., Pirtle, R. M., Eds.; CRC Publishing Co., Inc.: Boca Raton, FL, 1992.
5. Ser. FEBS Lett. 1993, 324, 162-166.
6. Bossi, L.; Ciampi, S. The expression of prokaryotic tRNA genes in frog oocytes. Nucleic Acids Res. 1983, 11, 3207-3226.
7. Brinkmann, U.; Mattes, R. E.; Buckel, P. High level expression of recombinant genes in Escherichia coli is dependent on the availability of the dna Y gene product. Gene 1989, 85, 109-114.
8. Cohen, J.; Dupuis, P.; Vigues, B. Expression of a ciliate gene in Escherichia roli using suppressor tRNA to read the UAA and UAG glutamine codons. J. Mol. Biol. 1990, 216, 189-194.
9. 6A Deficiency enhances proofreading in translation. J. Mol. Biol. 1991, 241, 1161-1171.
10. Dihanich, M. E.; Najarian, D.; Clark, R.; Gillman, E. C.; Martin, N. C.; Hopper, A. K. Isolation and characterization of M005, a gene required for isopentenylation of cytoplasmic and mitochondrial tRNAs of Saccharomyces cerevisiae. Mol. Cell. Biol. 1987, 7, 177-184.
11. Gallant, J. A.; Lindsley, D. Leftward ribosome frameshifting at a hungry codon. J. Mol. Biol. 1992, 223, 31-40.
12. Goeddel, D. V., Ed. Gene Expression Technology. Methods in Enzymology, Volume 185; Academic Press: San Diego, CA, 1990.
13. Hatfield, D. L.; Smith, D. W. E.; Lee, B. J.; Worland, P.; Oroszlan, S. Structure and function of suppressor tRNAs in higher eukaryotes. Crit. Rev. Biochem. Mol. Biol. 1990, 25, 71-96.
14. Hatfield, D. L.; Jung, J.-E.; Lee, B. J.; Choi, I. S. Aminoacyl-tRNA (anticodon): codon adaptation in higher eukaryotes. In Transfer RNA in Protein Synthesis; Hatfield, D. L., Lee, B. J., Pirtle, R. M., Eds.; CRC Publishing Co. Inc.: Boca Raton, FL, 1992.
15. Hoekema, A.; Kastelein, R. A.; Vasser, M.; DeBoer, H. A. Codon replacement in the PGK1 gene of Saccharomyces cerevisiae; Experimental approach to study the role of biased codon usage in gene expression. Mol. Cell. Biol. 1987, 7, 2914-2924.
16. Kane, J. F.; Violand, B. N.; Curran, D. F.; Staten, N. R.; Duffin, K. L.; Bogosian, G. Novel in-frame two codon translational hop during synthesis of bovine placental lactogen in a recombinant strain of Escherichia coli. Nucleic Acids Res. 1992, 20, 6707-6712.
17. Kawakami, K.; Pande, S.; Faiola, B.; Moore, D. P.; Boeke, J. D.; Farabaugh, P. J.; Strathern, J. N.; Nakamura, Y.; Garfinkel, D. J. A rare tRNA-Arg (CCU) that regulates Ty1 element ribosome frameshifting is essential for Ty1 retrotransposition in Saccharomyces cerevisiae. Genetics 1993, 135, 309-320.
18. Kurland, C. G. Codon bias and gene expression. FEBS Lett. 1991, 285, 165-169.
19. Noguchi, S.; Nishimura, Y.; Hirota, Y.; Nishimura, S. Isolation and characterization of an Escherichia coli mutant lacking tRNA-guanine transglycolase. Function and iosynthesis of queuosine in tRNA. J. Biol. Chem. 1982, 257, 6544-6550.
20. Oba, T.; Adachi, Y.; Muto, A.; Osawa, S. CGG, An unassigned or nonsense codon in Mycoplasma capricolum. Proc. Natl. Acad. Sci. U.S.A. 1991, 88, 921-925.
21. Trp aminoacylation and function in vivo. J. Biol. Chem. 1994, 269, 2277-2282.
22. Pande, S.; Vimiladithan, A.; Zhao, H.; Farabaugh, P. J. Pulling the ribosome out of frame by +1 at a programmed frameshift site by cognate binding of aminoacyl-tRNA. Mol. Cell. Biol. 1995, 15, 298-304.
23. Parker, J. Errors and alternatives in reading the universal genetic code. Microbiol. Rev. 1989, 53, 273-298.
24. Robinson, M.; Lilley, R.; Little, S.; Emtage, J. S.; Yarranton, G.; Stephens, P.; Millican, A.; Eaton, M.; Humphreys, G. Codon usage can affect efficiency of translation of genes from Escherichia coli. Nucleic Acids Res. 1984, 12, 6663-6671.
25. Trp in Escherichia coli. Proc. Natl. Acad. Sci. U.S.A. 1990, 87, 1511-1515.
26. Scorer, C. A.; Carrier, M. J.; Rosenberger, R. F. Amino acid misincorporation during high-level expression of mouse epidermal growth factor in Escherichia coli. Nucleic Acids Res. 1991, 19, 3511-3516.
27. Seidel, H. M.; Pompliano, O. L.; Knowles, J. R. Phosphonate biosynthesis: molecular cloning of the gene for phosphoenolpyruvate mutase from Tetrahymena pyriformis and overexpression of the gene product in Escherichia coli. Biochemistry 1992, 31, 2598-2608.
28. Skuzeski, J. M.; Nichols, L. M.; Gesteland, R. F.; Atkins, J. F. The signal for a leaky UAG stop codon in several plant viruses includes the two downstream codons. J. Mol. Biol. 1991, 218, 365-373.
29. Smith, D. W. E.; Hatfield, D. L. Effects of post-transcriptional base modifications on the site-specific function of transfer RNA in eukaryote translation. J. Mol. Biol. 1986, 189, 663-671.
30. Smith, D. W. E.; McNamara, A. L.; Mushinski, J. F.; Hatfield, D. L. Tumor-specific, hypomodified phenylalanyl-tRNA is utilized in translation in preference to the fully modified isoacceptor of normal cells. J. Biol. Chem. 1985, 260, 147-151.
31. Arg. Nucleic Acids Res. 1990, 18, 5031-5036.
32. Sprinzl, M.; Hartman, T.; Weber, J.; Blank, J.; Zeidler, R. Compilation of tRNA sequences and sequences of tRNA genes. Nucleic Acids Res. 1989, 18 (Supplement) r1-r172.
33. Lys and an AAG lysine codon. Genes Dev. 1992, 6, 511-519.
34. Varenne, S.; Lazdunski, C. Effect of distribution of unfavorable codons on the maximum rate of gene expression by ab heterologous organism. J. Theor. Biol. 1986, 120, 99-110.
35. Weise, R. B.; Dunn, D. M.; Shuh, M.; Atkins, J. F.; Gesteland, R, F. E. coli ribosomes re-phase on retroviral frameshift signals at rates ranging from 2 to 50 percent. New Biol. 1989, 1, 159-169.
36. Wilson, R. K.; Roe, B. A. Presence of the hypermodified nucleotide isopentenyladenosine prevents codon misreading by Escherichia coli phenylalanyl-transfer RNA. Proc. Natl. Acad. Sci. U.S.A. 1989, 86, 409-413.
37. Xu, H.; Boske, J. D. Host genes that influence transposition in yeast: the abundance of a rare tRNA regulates Ty1 transposition frequency. Proc. Natl. Acad. Sci. U.S.A. 1990, 87, 8360-8364.