메뉴 건너뛰기




Volumn 7, Issue 2, 1996, Pages 119-134

Famciclovir, from the bench to the patient - a comprehensive review of preclinical data

Author keywords

Aciclovir; Famciclovir; Penciclovir; Preclinical; Valaciclovir

Indexed keywords

ACICLOVIR; DNA POLYMERASE; FAMCICLOVIR; PENCICLOVIR; VALACICLOVIR;

EID: 0030199335     PISSN: 09248579     EISSN: None     Source Type: Journal    
DOI: 10.1016/0924-8579(96)00303-2     Document Type: Article
Times cited : (16)

References (98)
  • 1
    • 0024416237 scopus 로고
    • Selection of an oral prodrug (BRL 42810; famciclovir) for the antiherpesvirus agent BRL 39123 [9-(4-hydroxy-3-hydroxymethylbut-1-yl)guanine; penciclovir]
    • [1] Vere Hodge RA, Sutton D, Boyd MR et al. Selection of an oral prodrug (BRL 42810; famciclovir) for the antiherpesvirus agent BRL 39123 [9-(4-hydroxy-3-hydroxymethylbut-1-yl)guanine; penciclovir]. Antimicrob Agents Chemother 1989;33:1765-1773.
    • (1989) Antimicrob Agents Chemother , vol.33 , pp. 1765-1773
    • Vere Hodge, R.A.1    Sutton, D.2    Boyd, M.R.3
  • 2
    • 0027133478 scopus 로고
    • Pharmacokinetics of famciclovir in man
    • [2] Pue MA, Benet LZ. Pharmacokinetics of famciclovir in man. Antiviral Chem Chemother 1993;4(suppl 1):47-55.
    • (1993) Antiviral Chem Chemother , vol.4 , Issue.SUPPL. 1 , pp. 47-55
    • Pue, M.A.1    Benet, L.Z.2
  • 3
    • 0027117028 scopus 로고
    • Acyclovir: A decade later
    • [3] Whitley RJ, Gnann JW. Acyclovir: a decade later. N Engl J Med 1992;327:782-789.
    • (1992) N Engl J Med , vol.327 , pp. 782-789
    • Whitley, R.J.1    Gnann, J.W.2
  • 5
    • 0001582588 scopus 로고
    • Some biological properties of BRL 42810, a well absorbed oral prodrug of the antiherpes agent BRL 39123
    • abstract II-38
    • [5] Boyd MR, Boon R, Fowles SE et al. Some biological properties of BRL 42810, a well absorbed oral prodrug of the antiherpes agent BRL 39123. Antiviral Res, 1988;9:146, abstract II-38.
    • (1988) Antiviral Res , vol.9 , pp. 146
    • Boyd, M.R.1    Boon, R.2    Fowles, S.E.3
  • 6
    • 84966093299 scopus 로고
    • The role of aldehyde oxidase in the biotransformation of famciclovir to penciclovir as determined by a human in vitro system
    • Tours, France
    • [6] Clarke SE, Harrell AW, Chenery RJ. The role of aldehyde oxidase in the biotransformation of famciclovir to penciclovir as determined by a human in vitro system. Proc 5th Eur Int Soc Study Xenobiotics, Tours, France, 1993;3:61.
    • (1993) Proc 5th Eur Int Soc Study Xenobiotics , vol.3 , pp. 61
    • Clarke, S.E.1    Harrell, A.W.2    Chenery, R.J.3
  • 7
    • 0027146271 scopus 로고
    • 13C NMR to identify the chiral monoacetylated intermediates in the conversion of famciclovir to penciclovir by human intestinal wall extract
    • 13C NMR to identify the chiral monoacetylated intermediates in the conversion of famciclovir to penciclovir by human intestinal wall extract. Chirality 1993;5:577-582.
    • (1993) Chirality , vol.5 , pp. 577-582
    • Vere Hodge, R.A.1    Darlison, S.J.2    Readshaw, S.A.3
  • 9
    • 0027972736 scopus 로고
    • Linear pharmacokinetics of penciclovir following administration of single oral doses of famciclovir 125, 250, 500 and 750 mg to healthy volunteers
    • [9] Pue MA, Pratt SK, Fairless AJ et al. Linear pharmacokinetics of penciclovir following administration of single oral doses of famciclovir 125, 250, 500 and 750 mg to healthy volunteers. J Antimicrob Chemother 1994;33:119-127.
    • (1994) J Antimicrob Chemother , vol.33 , pp. 119-127
    • Pue, M.A.1    Pratt, S.K.2    Fairless, A.J.3
  • 10
    • 0000078245 scopus 로고
    • A further study of the effect of food on the bioavailability and pharmacokinetics of penciclovir after oral administration of famciclovir
    • [10] Fowles SE, Fairless AJ, Pierce DM et al. A further study of the effect of food on the bioavailability and pharmacokinetics of penciclovir after oral administration of famciclovir. Br J Clin Pharmacol 1991;32:657P.
    • (1991) Br J Clin Pharmacol , vol.32
    • Fowles, S.E.1    Fairless, A.J.2    Pierce, D.M.3
  • 11
    • 0027768955 scopus 로고
    • Pharmacokinetics of the acyclovir pro-drug valaciclovir after escalating single-and multiple-dose administration to normal volunteers
    • [11] Weller S, Blum MR, Doucette M et al. Pharmacokinetics of the acyclovir pro-drug valaciclovir after escalating single-and multiple-dose administration to normal volunteers. Clin Pharm Ther 1993;54:595-605.
    • (1993) Clin Pharm Ther , vol.54 , pp. 595-605
    • Weller, S.1    Blum, M.R.2    Doucette, M.3
  • 12
    • 0021089633 scopus 로고
    • Pharmacokinetics of acyclovir after intravenous and oral administration
    • [12] de Miranda P, Blum MR. Pharmacokinetics of acyclovir after intravenous and oral administration. J Antimicrob Chemother 1983;1(suppl B):29-37.
    • (1983) J Antimicrob Chemother , vol.1 , Issue.SUPPL. B , pp. 29-37
    • De Miranda, P.1    Blum, M.R.2
  • 13
    • 0023619194 scopus 로고
    • The influence of food on the absorption of acyclovir: A pharmacokinetic and scintigraphic assessment
    • [13] Wilson CG, Washington N, Hardy JG et al. The influence of food on the absorption of acyclovir: a pharmacokinetic and scintigraphic assessment. Int J Pharm 1987;38:221-225.
    • (1987) Int J Pharm , vol.38 , pp. 221-225
    • Wilson, C.G.1    Washington, N.2    Hardy, J.G.3
  • 14
    • 0026541051 scopus 로고
    • Species differences in the metabolism and disposition of antiviral nucleoside analogues: 1
    • [14] de Miranda P, Good SS. Species differences in the metabolism and disposition of antiviral nucleoside analogues: 1. Acyclovir. Antiviral Chem Chemother 1992;3:1-8.
    • (1992) Acyclovir. Antiviral Chem Chemother , vol.3 , pp. 1-8
    • De Miranda, P.1    Good, S.S.2
  • 15
    • 0019640845 scopus 로고
    • Disposition of intravenous radioactive acyclovir
    • [15] de Miranda P, Good SS, Laskin OL et al. Disposition of intravenous radioactive acyclovir. Clin Pharmacol Ther 1981;30: 662-672.
    • (1981) Clin Pharmacol Ther , vol.30 , pp. 662-672
    • De Miranda, P.1    Good, S.S.2    Laskin, O.L.3
  • 16
    • 0029076466 scopus 로고
    • Purification and characterization of a rat liver enzyme that hydrolyzes valaciclovir, the L-valyl ester prodrug of acyclovir
    • [16] Burnette TC, Harrington JA, Reardon JE et al. Purification and characterization of a rat liver enzyme that hydrolyzes valaciclovir, the L-valyl ester prodrug of acyclovir. J Biol Chem 1995;270:15 827-15 831.
    • (1995) J Biol Chem , vol.270 , pp. 15827-15831
    • Burnette, T.C.1    Harrington, J.A.2    Reardon, J.E.3
  • 17
    • 0028124221 scopus 로고
    • Valaciclovir - A review of a promising new antiherpes agent
    • [17] Crooks RJ, Murray A. Valaciclovir - a review of a promising new antiherpes agent. Antiviral Chem Chemother 1994;5(suppl 1):31-37.
    • (1994) Antiviral Chem Chemother , vol.5 , Issue.SUPPL. 1 , pp. 31-37
    • Crooks, R.J.1    Murray, A.2
  • 18
    • 0023633215 scopus 로고
    • Antiherpesvirus activity of 9-(4-hydroxy-3-hydroxymethylbut-1-yl)guanine (BRL 39123) in cell culture
    • [18] Boyd MR, Bacon TH, Sutton D et al. Antiherpesvirus activity of 9-(4-hydroxy-3-hydroxymethylbut-1-yl)guanine (BRL 39123) in cell culture. Antimicrob Agents Chemother 1987;31:1238-1242.
    • (1987) Antimicrob Agents Chemother , vol.31 , pp. 1238-1242
    • Boyd, M.R.1    Bacon, T.H.2    Sutton, D.3
  • 19
    • 0024595771 scopus 로고
    • Mode of action of 9-(4-hydroxy-3-hydroxymethylbut-1-yl)guanine (BRL 39123) against herpes simplex virus in MRC-5 cells
    • [19] Vere Hodge RA, Perkins RM. Mode of action of 9-(4-hydroxy-3-hydroxymethylbut-1-yl)guanine (BRL 39123) against herpes simplex virus in MRC-5 cells. Antimicrob Agents Chemother 1989;33:223-229.
    • (1989) Antimicrob Agents Chemother , vol.33 , pp. 223-229
    • Vere Hodge, R.A.1    Perkins, R.M.2
  • 20
    • 0026493737 scopus 로고
    • Mode of antiviral action of penciclovir in MRC-5 cells infected with herpes simplex virus type 1 (HSV-1), HSV-2 and varicella-zoster virus
    • [20] Earnshaw DL, Bacon TH, Darlison SJ et al. Mode of antiviral action of penciclovir in MRC-5 cells infected with herpes simplex virus type 1 (HSV-1), HSV-2 and varicella-zoster virus. Antimicrob Agents Chemother 1992;36:2747-2757.
    • (1992) Antimicrob Agents Chemother , vol.36 , pp. 2747-2757
    • Earnshaw, D.L.1    Bacon, T.H.2    Darlison, S.J.3
  • 21
    • 0019321437 scopus 로고
    • Phosphorylation of acyclovir (acycloguanosine) monophosphate by GMP kinase
    • [21] Miller WH, Miller RL. Phosphorylation of acyclovir (acycloguanosine) monophosphate by GMP kinase. J Biol Chem 1980;255:7204-7207.
    • (1980) J Biol Chem , vol.255 , pp. 7204-7207
    • Miller, W.H.1    Miller, R.L.2
  • 22
    • 0020408238 scopus 로고
    • Phosphorylation of acyclovir diphosphate by cellular enzymes
    • [22] Miller WH, Miller RL. Phosphorylation of acyclovir diphosphate by cellular enzymes. Biochem Pharmacol 1982;31:3879-3884.
    • (1982) Biochem Pharmacol , vol.31 , pp. 3879-3884
    • Miller, W.H.1    Miller, R.L.2
  • 23
    • 85030278029 scopus 로고    scopus 로고
    • Inhibition of varicella-zoster virus by penciclovir in cell culture and mechanism of action
    • in press
    • [23] Bacon TH, Gilbart J, Howard BA et al. Inhibition of varicella-zoster virus by penciclovir in cell culture and mechanism of action. Antiviral Chem Chemother, in press.
    • Antiviral Chem Chemother
    • Bacon, T.H.1    Gilbart, J.2    Howard, B.A.3
  • 24
    • 0027511640 scopus 로고
    • Famciclovir and penciclovir. The mode of action of famciclovir including its conversion to penciclovir
    • [24] Vere Hodge RA. Famciclovir and penciclovir. The mode of action of famciclovir including its conversion to penciclovir. Antiviral Chem Chemother 1993;4:67-84.
    • (1993) Antiviral Chem Chemother , vol.4 , pp. 67-84
    • Vere Hodge, R.A.1
  • 25
    • 0022504259 scopus 로고
    • Mode of action, toxicity, pharmacokinetics and efficacy of some new antiherpesvirus guanosine analogs related to buciclovir
    • [25] Larsson A, Stenberg K, Ericson A-C et al. Mode of action, toxicity, pharmacokinetics and efficacy of some new antiherpesvirus guanosine analogs related to buciclovir. Antimicrob Agents Chemother, 1986;30:598-605.
    • (1986) Antimicrob Agents Chemother , vol.30 , pp. 598-605
    • Larsson, A.1    Stenberg, K.2    Ericson, A.-C.3
  • 26
    • 0023179232 scopus 로고
    • Critical determinants of antiherpes efficacy of buciclovir and related acyclic guanosine analogs
    • [26] Datema R, Ericson A-C, Field HJ et al. Critical determinants of antiherpes efficacy of buciclovir and related acyclic guanosine analogs. Antiviral Res, 1987;7:303-316.
    • (1987) Antiviral Res , vol.7 , pp. 303-316
    • Datema, R.1    Ericson, A.-C.2    Field, H.J.3
  • 27
    • 0029098966 scopus 로고
    • Mode of action of (R)-9[4-hydroxy-2-(hydroxymethyl)butyl]guanosine against herpesviruses
    • [27] Lowe, D.M., Alderton, W.K., Ellis, M.R. et al. Mode of action of (R)-9[4-hydroxy-2-(hydroxymethyl)butyl]guanosine against herpesviruses. Antimicrob Agents Chemother 1995;39:1802-1808.
    • (1995) Antimicrob Agents Chemother , vol.39 , pp. 1802-1808
    • Lowe, D.M.1    Alderton, W.K.2    Ellis, M.R.3
  • 28
    • 0027145142 scopus 로고
    • 13C NMR to determine the specificity and absolute configuration of penciclovir phosphate esters formed in HSV-1-and HSV-2-infected cells and by HSV-1-encoded thymidine kinase
    • 13C NMR to determine the specificity and absolute configuration of penciclovir phosphate esters formed in HSV-1-and HSV-2-infected cells and by HSV-1-encoded thymidine kinase. Chirality 1993;5: 583-588.
    • (1993) Chirality , vol.5 , pp. 583-588
    • Vere Hodge, R.A.1    Darlison, S.J.2    Earnshaw, D.L.3
  • 29
    • 0028905944 scopus 로고
    • A comparative study of the in vitro and in vivo antiviral activities of acyclovir and penciclovir
    • [29] Ertl P, Snowden W, Lowe D et al. A comparative study of the in vitro and in vivo antiviral activities of acyclovir and penciclovir. Antiviral Chem Chemother 1995;6:89-97.
    • (1995) Antiviral Chem Chemother , vol.6 , pp. 89-97
    • Ertl, P.1    Snowden, W.2    Lowe, D.3
  • 30
    • 85030280200 scopus 로고    scopus 로고
    • Penciclovir is a selective inhibitor of hepatitis B virus replication in cultured human hepatoblastoma cells
    • in press
    • [30] Korba BE, Boyd MR. Penciclovir is a selective inhibitor of hepatitis B virus replication in cultured human hepatoblastoma cells. Antimicrob Agents Chemother, in press.
    • Antimicrob Agents Chemother
    • Korba, B.E.1    Boyd, M.R.2
  • 31
    • 0028205505 scopus 로고
    • In vitro antiviral activity of penciclovir, a novel purine nucleoside, against duck hepatitis B virus
    • [31] Shaw T, Amor P, Civitico G et al. In vitro antiviral activity of penciclovir, a novel purine nucleoside, against duck hepatitis B virus. Antimicrob Agents Chemother 1994;38:719-723.
    • (1994) Antimicrob Agents Chemother , vol.38 , pp. 719-723
    • Shaw, T.1    Amor, P.2    Civitico, G.3
  • 32
    • 0024506174 scopus 로고
    • An in vitro system for screening anti-hepatitis B virus drugs
    • [32] Ueda K, Tsurimoto T, Nagahata T et al. An in vitro system for screening anti-hepatitis B virus drugs. Virology 1989;169: 213-216.
    • (1989) Virology , vol.169 , pp. 213-216
    • Ueda, K.1    Tsurimoto, T.2    Nagahata, T.3
  • 33
    • 13344267580 scopus 로고
    • Preferential inhibition of human hepatitis B virus (HBV) DNA polymerase by the (R)-enantiomer of penciclovir triphosphate
    • Abstract H66:191, San Francisco, CA, 17-20 September
    • [33] Mok SS, Shaw T, Locarnini S. Preferential inhibition of human hepatitis B virus (HBV) DNA polymerase by the (R)-enantiomer of penciclovir triphosphate. Abstract H66:191, 35th ICAAC, San Francisco, CA, 17-20 September 1995.
    • (1995) 35th ICAAC
    • Mok, S.S.1    Shaw, T.2    Locarnini, S.3
  • 35
    • 0022350376 scopus 로고
    • Cytoplasmic 5′-nucleotidase catalyzes acyclovir phosphorylation
    • [35] Keller PM, McKee SA, Fyfe JA. Cytoplasmic 5′-nucleotidase catalyzes acyclovir phosphorylation. J Biol Chem 1985;260: 8664-8667.
    • (1985) J Biol Chem , vol.260 , pp. 8664-8667
    • Keller, P.M.1    McKee, S.A.2    Fyfe, J.A.3
  • 36
    • 0027274023 scopus 로고
    • IMP-GMP 5′-nucleotidase
    • [36] Itoh R. IMP-GMP 5′-nucleotidase. Comp Biochem Physiol 1993;105B:13-19.
    • (1993) Comp Biochem Physiol , vol.105 B , pp. 13-19
    • Itoh, R.1
  • 37
    • 0028928572 scopus 로고
    • Acyclic guanosine analogs inhibit DNA polymerases, α, δ and ε with very different potencies and have unique mechanisms of action
    • [37] Ilsley DD, Lee S-H, Miller WH et al. Acyclic guanosine analogs inhibit DNA polymerases, α, δ and ε with very different potencies and have unique mechanisms of action. Biochemistry 1995;34:2504-2510.
    • (1995) Biochemistry , vol.34 , pp. 2504-2510
    • Ilsley, D.D.1    Lee, S.-H.2    Miller, W.H.3
  • 38
    • 0018733296 scopus 로고
    • Inhibition of herpes simplex virus-induced DNA polymerase activity and viral DNA replication by 9-(2-hydroxyethoxymethyl)guanine and its triphosphate
    • [38] Furman PA, St Clair MH, Fyfe JA et al. Inhibition of herpes simplex virus-induced DNA polymerase activity and viral DNA replication by 9-(2-hydroxyethoxymethyl)guanine and its triphosphate. J Virol, 1979;32:72-77.
    • (1979) J Virol , vol.32 , pp. 72-77
    • Furman, P.A.1    St Clair, M.H.2    Fyfe, J.A.3
  • 40
    • 0024584523 scopus 로고
    • Herpes simplex virus type 1 DNA polymerase
    • [40] Reardon JE, Spector T. Herpes simplex virus type 1 DNA polymerase. J Biol Chem, 1989;264:7405-7411.
    • (1989) J Biol Chem , vol.264 , pp. 7405-7411
    • Reardon, J.E.1    Spector, T.2
  • 41
    • 0023475103 scopus 로고
    • 3′-azido-3′-deoxythymidine triphosphate as an inhibitor and substrate of purified human immunodeficiency virus reverse transcriptase
    • [41] St Clair MH, Richards CA, Spector T et al. 3′-azido-3′-deoxythymidine triphosphate as an inhibitor and substrate of purified human immunodeficiency virus reverse transcriptase. Antimicrob Agents Chemother 1987;31:1972-1977.
    • (1987) Antimicrob Agents Chemother , vol.31 , pp. 1972-1977
    • St Clair, M.H.1    Richards, C.A.2    Spector, T.3
  • 42
    • 0026786397 scopus 로고
    • Human DNA polymerases α and β are able to incorporate anti-HIV deoxynucleotides into DNA
    • [42] Copeland WC, Chen MS, Wang TS-F. Human DNA polymerases α and β are able to incorporate anti-HIV deoxynucleotides into DNA. J Biol Chem 1992;267:21 459-21 464.
    • (1992) J Biol Chem , vol.267 , pp. 21459-21464
    • Copeland, W.C.1    Chen, M.S.2    Wang, T.s.-F.3
  • 43
    • 0023266214 scopus 로고
    • The toxicity of azidothymidine (AZT) in the treatment of patients with AIDS and AIDS-related complex
    • [43] Richman DD, Fischl MA, Grieco MH et al. The toxicity of azidothymidine (AZT) in the treatment of patients with AIDS and AIDS-related complex. N Engl J Med 1987;317:192-197.
    • (1987) N Engl J Med , vol.317 , pp. 192-197
    • Richman, D.D.1    Fischl, M.A.2    Grieco, M.H.3
  • 44
    • 0021243237 scopus 로고
    • Interaction of herpes simplex virus-induced DNA polymerase with 9-(1,3-dihydroxy-2-propoxymethyl)guanine triphosphate
    • [44] Frank KB, Chiou J-F, Cheng Y-C. Interaction of herpes simplex virus-induced DNA polymerase with 9-(1,3-dihydroxy-2-propoxymethyl)guanine triphosphate. J Biol Chem 1984;259: 1566-1569.
    • (1984) J Biol Chem , vol.259 , pp. 1566-1569
    • Frank, K.B.1    Chiou, J.-F.2    Cheng, Y.-C.3
  • 45
    • 84944367245 scopus 로고
    • Ganciclovir treatment of cytomegalovirus disease in transplant recipients and other immunocompromised hosts
    • [45] Erice A, Jordan MC, Chace BA et al. Ganciclovir treatment of cytomegalovirus disease in transplant recipients and other immunocompromised hosts. J Am Med Assoc 1987;257:3082-3087.
    • (1987) J Am Med Assoc , vol.257 , pp. 3082-3087
    • Erice, A.1    Jordan, M.C.2    Chace, B.A.3
  • 46
    • 0028111530 scopus 로고
    • A history of antiherpes research
    • [46] Darby G. A history of antiherpes research. Antiviral Chem Chemother 1994;5(suppl 1):3-9.
    • (1994) Antiviral Chem Chemother , vol.5 , Issue.SUPPL. 1 , pp. 3-9
    • Darby, G.1
  • 47
    • 85058206540 scopus 로고
    • Penciclovir (PCV) triphosphate (PCVTP) and acyclovir (ACV) triphosphate (ACVTP) in a human Schwannoma continuous cell line (SW) infected with varicella zoster virus (VZV)
    • [47] Bebault GM, Wall RA, Rennie BA, Sacks SL. Penciclovir (PCV) triphosphate (PCVTP) and acyclovir (ACV) triphosphate (ACVTP) in a human Schwannoma continuous cell line (SW) infected with varicella zoster virus (VZV). Can J Infect Dis 1995;6:287C.
    • (1995) Can J Infect Dis , vol.6
    • Bebault, G.M.1    Wall, R.A.2    Rennie, B.A.3    Sacks, S.L.4
  • 48
    • 0027131363 scopus 로고
    • Penciclovir: A review of its spectrum of activity, selectivity and cross-resistance pattern
    • [48] Boyd MR, Safrin S, Kern ER. Penciclovir: a review of its spectrum of activity, selectivity and cross-resistance pattern. Antiviral Chem Chemother 1993;4(suppl 1):3-11.
    • (1993) Antiviral Chem Chemother , vol.4 , Issue.SUPPL. 1 , pp. 3-11
    • Boyd, M.R.1    Safrin, S.2    Kern, E.R.3
  • 50
    • 85030280183 scopus 로고    scopus 로고
    • Further characterisation of the inhibition of herpes simplex virus replication in human cell lines by penciclovir and aciclovir
    • in press
    • [50] Bacon TH, Howard BA. Further characterisation of the inhibition of herpes simplex virus replication in human cell lines by penciclovir and aciclovir. Antiviral Chem Chemother, in press.
    • Antiviral Chem Chemother
    • Bacon, T.H.1    Howard, B.A.2
  • 51
    • 0026649044 scopus 로고
    • In vitro activities of penciclovir and acyclovir against herpes simplex virus types 1 and 2
    • [51] Weinberg A, Bate BJ, Masters HB et al. In vitro activities of penciclovir and acyclovir against herpes simplex virus types 1 and 2. Antimicrob Agents Chemother 1992;36:2037-2038.
    • (1992) Antimicrob Agents Chemother , vol.36 , pp. 2037-2038
    • Weinberg, A.1    Bate, B.J.2    Masters, H.B.3
  • 52
    • 85030270627 scopus 로고    scopus 로고
    • Comparison of a DNA probe assay with the plaque reduction assay for measuring the sensitivity of herpes simplex virus and varicella-zoster virus to penciclovir and acyclovir
    • in press
    • [52] Standring-Cox R, Bacon TH, Howard BA. Comparison of a DNA probe assay with the plaque reduction assay for measuring the sensitivity of herpes simplex virus and varicella-zoster virus to penciclovir and acyclovir. J Virol Methods, in press.
    • J Virol Methods
    • Standring-Cox, R.1    Bacon, T.H.2    Howard, B.A.3
  • 53
    • 0021988862 scopus 로고
    • Multiplicity dependence and sensitivity of herpes simplex virus isolates to antiviral compounds
    • [53] Harmenberg J, Wahren B, Sundqvist V-A et al. Multiplicity dependence and sensitivity of herpes simplex virus isolates to antiviral compounds. J Antimicrob Chemother 1985;15:567-573.
    • (1985) J Antimicrob Chemother , vol.15 , pp. 567-573
    • Harmenberg, J.1    Wahren, B.2    Sundqvist, V.-A.3
  • 54
    • 0029040490 scopus 로고
    • Activity of penciclovir against Epstein-Barr virus
    • [54] Bacon TH, Boyd MR. Activity of penciclovir against Epstein-Barr virus. Antimicrob Agents Chemother 1995;39:1599-1602.
    • (1995) Antimicrob Agents Chemother , vol.39 , pp. 1599-1602
    • Bacon, T.H.1    Boyd, M.R.2
  • 55
    • 8244219601 scopus 로고
    • Evaluation of penciclovir and its oral form, famciclovir against a chronic hepatitis infection in ducks
    • Abstract 1594:410, New Orleans, LA
    • [55] Sutton D, Boyd MR, Tsiquaye K. Evaluation of penciclovir and its oral form, famciclovir against a chronic hepatitis infection in ducks. Abstract 1594:410, 33rd ICAAC, New Orleans, LA, 1993.
    • (1993) 33rd ICAAC
    • Sutton, D.1    Boyd, M.R.2    Tsiquaye, K.3
  • 56
    • 85030273183 scopus 로고    scopus 로고
    • Antiviral activities and pharmacokinetics of penciclovir and famciclovir in Pekin ducks chronically infected with duck hepatitis virus
    • in press
    • [56] Tsiquaye KN, Sutton D, Maung M et al. Antiviral activities and pharmacokinetics of penciclovir and famciclovir in Pekin ducks chronically infected with duck hepatitis virus. Antiviral Chem Chemother, in press.
    • Antiviral Chem Chemother
    • Tsiquaye, K.N.1    Sutton, D.2    Maung, M.3
  • 57
    • 0028348905 scopus 로고
    • Oral famciclovir against duck hepatitis B virus replication in hepatic and nonhepatic tissues of ducklings infected in ovo
    • [57] Tsiquaye KN, Slomka MJ, Maung M. Oral famciclovir against duck hepatitis B virus replication in hepatic and nonhepatic tissues of ducklings infected in ovo. J Med Virol 1994;42:306-310.
    • (1994) J Med Virol , vol.42 , pp. 306-310
    • Tsiquaye, K.N.1    Slomka, M.J.2    Maung, M.3
  • 58
    • 0028070517 scopus 로고
    • Safety of famciclovir in patients with herpes zoster and genital herpes
    • [58] Saltzman R, Jurewicz R, Boon R. Safety of famciclovir in patients with herpes zoster and genital herpes. Antimicrob Agents Chemother 1994;38:2454-2457.
    • (1994) Antimicrob Agents Chemother , vol.38 , pp. 2454-2457
    • Saltzman, R.1    Jurewicz, R.2    Boon, R.3
  • 59
    • 0027142888 scopus 로고
    • An overview of the further evaluation of penciclovir against herpes simplex virus and varicella-zoster virus in cell culture highlighting contrasts with acyclovir
    • [59] Bacon TH, Schinazi RF. An overview of the further evaluation of penciclovir against herpes simplex virus and varicella-zoster virus in cell culture highlighting contrasts with acyclovir. Antiviral Chem Chemother 1993;4(suppl 1):25-36.
    • (1993) Antiviral Chem Chemother , vol.4 , Issue.SUPPL. 1 , pp. 25-36
    • Bacon, T.H.1    Schinazi, R.F.2
  • 60
    • 0028064966 scopus 로고
    • Activity of (S)-1-(3 hydroxy-2-phosphonylmethoxypropyl)cytosine against human cytomegalovirus when administered as single-bolus dose and continuous infusion in in vitro cell culture perfusion system
    • [60] Moore MR, Hamzeh FM, Lee FE-H et al. Activity of (S)-1-(3 hydroxy-2-phosphonylmethoxypropyl)cytosine against human cytomegalovirus when administered as single-bolus dose and continuous infusion in in vitro cell culture perfusion system. Antimicrob Agents Chemother 1994;38:2404-2408.
    • (1994) Antimicrob Agents Chemother , vol.38 , pp. 2404-2408
    • Moore, M.R.1    Hamzeh, F.M.2    Lee, F.E.-H.3
  • 61
    • 4244042250 scopus 로고
    • A pharmacokinetic/pharmacodynamic approach for the comparison of penciclovir and acyclovir: Utilization of an in vitro model which simulates in vivo pharmacokinetics
    • [61] Hamzeh FM, Schaad HJ, Lietman PS. A pharmacokinetic/pharmacodynamic approach for the comparison of penciclovir and acyclovir: utilization of an in vitro model which simulates in vivo pharmacokinetics. Antiviral Res 1995;26(suppl 1):A338.
    • (1995) Antiviral Res , vol.26 , Issue.SUPPL. 1
    • Hamzeh, F.M.1    Schaad, H.J.2    Lietman, P.S.3
  • 62
    • 0028156908 scopus 로고
    • 'The end of innocence' revisited: Resistance of herpesviruses to antiviral drugs
    • [62] Field A K, Biron KK. 'The end of innocence' revisited: resistance of herpesviruses to antiviral drugs. Clin Microb Rev 1994;7:1-13.
    • (1994) Clin Microb Rev , vol.7 , pp. 1-13
    • Field, A.K.1    Biron, K.K.2
  • 63
    • 0026515068 scopus 로고
    • The pathogenicity of drug-resistant variants of herpes simplex virus
    • [63] Field HJ, Goldthorpe SE. The pathogenicity of drug-resistant variants of herpes simplex virus. Res Virol 1992;143:120-124.
    • (1992) Res Virol , vol.143 , pp. 120-124
    • Field, H.J.1    Goldthorpe, S.E.2
  • 64
    • 0027757639 scopus 로고
    • Sensitivity monitoring of clinical isolates of herpes simplex virus to acyclovir
    • [64] Collins P and Ellis MN. Sensitivity monitoring of clinical isolates of herpes simplex virus to acyclovir. J Med Virol 1993(suppl 1):58-66.
    • (1993) J Med Virol , Issue.SUPPL. 1 , pp. 58-66
    • Collins, P.1    Ellis, M.N.2
  • 65
    • 0021796673 scopus 로고
    • Plaque autoradiography assay for the detection and quantitation of thymidine kinase-deficient and thymidine kinase-altered mutants of herpes simplex virus in clinical isolates
    • [65] Martin JL, Ellis MN, Keller PM et al. Plaque autoradiography assay for the detection and quantitation of thymidine kinase-deficient and thymidine kinase-altered mutants of herpes simplex virus in clinical isolates. Antimicrob Agents Chemother 1985;28:181-187.
    • (1985) Antimicrob Agents Chemother , vol.28 , pp. 181-187
    • Martin, J.L.1    Ellis, M.N.2    Keller, P.M.3
  • 66
    • 0023254664 scopus 로고
    • Clinical isolate of herpes simplex virus type 2 that induces a thymidine kinase with altered substrate specificity
    • [66] Ellis MN, Keller PM, Fyfe JA et al. Clinical isolate of herpes simplex virus type 2 that induces a thymidine kinase with altered substrate specificity. Antimicrob Agents Chemother 1987;31: 1117-1125.
    • (1987) Antimicrob Agents Chemother , vol.31 , pp. 1117-1125
    • Ellis, M.N.1    Keller, P.M.2    Fyfe, J.A.3
  • 67
    • 0024354415 scopus 로고
    • Progressive esophagitis from acyclovir-resistant herpes simplex. Clinical roles for DNA polymerase mutants and viral heterogeneity?
    • [67] Sacks SL, Wanklin RJ, Reece DE et al. Progressive esophagitis from acyclovir-resistant herpes simplex. Clinical roles for DNA polymerase mutants and viral heterogeneity? Ann Int Med, 1989;111:893-899.
    • (1989) Ann Int Med , vol.111 , pp. 893-899
    • Sacks, S.L.1    Wanklin, R.J.2    Reece, D.E.3
  • 68
    • 0024520120 scopus 로고
    • Characterization of a DNA polymerase mutant of herpes simplex virus from a severely immunocompromised patient receiving acyclovir
    • [68] Collins P, Larder BA, Oliver NM et al. Characterization of a DNA polymerase mutant of herpes simplex virus from a severely immunocompromised patient receiving acyclovir. J Gen Virol 1989;70:375-382.
    • (1989) J Gen Virol , vol.70 , pp. 375-382
    • Collins, P.1    Larder, B.A.2    Oliver, N.M.3
  • 69
    • 0027362888 scopus 로고
    • Brief report: Recurrent acyclovir resistant genital herpes in an immunocompetent patient
    • [69] Kost RG, Hill EL, Tigges M et al. Brief report: Recurrent acyclovir resistant genital herpes in an immunocompetent patient. N Engl J Med 1993;329:1777-1782.
    • (1993) N Engl J Med , vol.329 , pp. 1777-1782
    • Kost, R.G.1    Hill, E.L.2    Tigges, M.3
  • 70
    • 0028957257 scopus 로고
    • Chronic recurrent acyclovir-resistant genital herpes in an immunocompetent patient
    • [70] Mouly F, Baccard M, Scieux C et al. Chronic recurrent acyclovir-resistant genital herpes in an immunocompetent patient. Dermatology 1995;190:177.
    • (1995) Dermatology , vol.190 , pp. 177
    • Mouly, F.1    Baccard, M.2    Scieux, C.3
  • 71
    • 0022638910 scopus 로고
    • Recurrent genital herpes and suppressive oral acyclovir therapy
    • [71] Nusinoff Lehrman S, Douglas JM, Corey L et al. Recurrent genital herpes and suppressive oral acyclovir therapy. Ann Int Med 1986;104:786-790.
    • (1986) Ann Int Med , vol.104 , pp. 786-790
    • Nusinoff Lehrman, S.1    Douglas, J.M.2    Corey, L.3
  • 72
    • 0027472269 scopus 로고
    • Analysis of the thymidine kinase genes from acyclovir-resistant mutants of varicella-zoster virus isolated from patients with AIDS
    • [72] Talarico CL, Phelps WC, Biron KK. Analysis of the thymidine kinase genes from acyclovir-resistant mutants of varicella-zoster virus isolated from patients with AIDS. J Virol 1993;67:1024-1033.
    • (1993) J Virol , vol.67 , pp. 1024-1033
    • Talarico, C.L.1    Phelps, W.C.2    Biron, K.K.3
  • 73
    • 0029151329 scopus 로고
    • Penciclovir-resistance mutations in the herpes simplex virus DNA polymerase gene
    • [73] Chiou HC, Kumura K, Hu A et al. Penciclovir-resistance mutations in the herpes simplex virus DNA polymerase gene. Antiviral Chem Chemother 1995;6:281-288.
    • (1995) Antiviral Chem Chemother , vol.6 , pp. 281-288
    • Chiou, H.C.1    Kumura, K.2    Hu, A.3
  • 74
    • 0023976293 scopus 로고
    • Antiherpesvirus activity of 9-(4-hydroxy-3-hydroxymethylbut-1-yl)guanine (BRL 39123) in animals
    • [74] Boyd MR, Bacon TH, Sutton D. Antiherpesvirus activity of 9-(4-hydroxy-3-hydroxymethylbut-1-yl)guanine (BRL 39123) in animals. Antimicrob Agents Chemother 1988;32:358-363.
    • (1988) Antimicrob Agents Chemother , vol.32 , pp. 358-363
    • Boyd, M.R.1    Bacon, T.H.2    Sutton, D.3
  • 75
    • 0027145467 scopus 로고
    • Activity of famciclovir and penciclovir in HSV-infected animals: A review
    • [75] Sutton D, Kern ER. Activity of famciclovir and penciclovir in HSV-infected animals: a review. Antiviral Chem Chemother 1993;4(suppl 1):37-46.
    • (1993) Antiviral Chem Chemother , vol.4 , Issue.SUPPL. 1 , pp. 37-46
    • Sutton, D.1    Kern, E.R.2
  • 76
    • 0029018999 scopus 로고
    • Comparison of efficacies of famciclovir and valaciclovir against herpes simplex virus type 1 in a murine immunosuppression model
    • [76] Field HJ, Tewari D, Sutton D et al. Comparison of efficacies of famciclovir and valaciclovir against herpes simplex virus type 1 in a murine immunosuppression model. Antimicrob Agents Chemother 1995;39:1114-1119.
    • (1995) Antimicrob Agents Chemother , vol.39 , pp. 1114-1119
    • Field, H.J.1    Tewari, D.2    Sutton, D.3
  • 77
    • 0027537214 scopus 로고
    • Comparative activity of penciclovir and acyclovir in mice infected intraperitoneally with herpes simplex virus type 1 SC16
    • [77] Sutton D, Boyd MR. Comparative activity of penciclovir and acyclovir in mice infected intraperitoneally with herpes simplex virus type 1 SC16. Antimicrob Agents Chemother 1993;37: 642-645.
    • (1993) Antimicrob Agents Chemother , vol.37 , pp. 642-645
    • Sutton, D.1    Boyd, M.R.2
  • 78
    • 0028673489 scopus 로고
    • Antiviral activity of famciclovir and acyclovir in mice infected intraperitoneally with herpes simplex virus type 1 SC16
    • [78] Ashton RJ, Abbott KH, Smith GM et al. Antiviral activity of famciclovir and acyclovir in mice infected intraperitoneally with herpes simplex virus type 1 SC16. J Antimicrob Chemother 1994;34:287-290.
    • (1994) J Antimicrob Chemother , vol.34 , pp. 287-290
    • Ashton, R.J.1    Abbott, K.H.2    Smith, G.M.3
  • 79
    • 0026543390 scopus 로고
    • Effects of penciclovir and famciclovir in a murine model of encephalitis induced by intranasal inoculation of herpes simplex virus type 1
    • [79] Goldthorpe SE, Boyd MR, Field HJ. Effects of penciclovir and famciclovir in a murine model of encephalitis induced by intranasal inoculation of herpes simplex virus type 1. Antiviral Chem Chemother 1992;3:37-47.
    • (1992) Antiviral Chem Chemother , vol.3 , pp. 37-47
    • Goldthorpe, S.E.1    Boyd, M.R.2    Field, H.J.3
  • 80
    • 0028997407 scopus 로고
    • The effects of delayed-onset chemotherapy using famciclovir or valaciclovir in a murine immunosuppression model for HSV-1
    • [80] Field HJ, Thackray AM. The effects of delayed-onset chemotherapy using famciclovir or valaciclovir in a murine immunosuppression model for HSV-1. Antiviral Chem Chemother 1995;6:210-216.
    • (1995) Antiviral Chem Chemother , vol.6 , pp. 210-216
    • Field, H.J.1    Thackray, A.M.2
  • 81
    • 85030271894 scopus 로고
    • Famciclovir and valaciclovir: Comparative effects on cutaneous and neurological disease in mice infected with herpes simplex virus type 2
    • Abstract H105:198, San Francisco, CA, 17-20 September
    • [81] Field HJ, Thackray AM. Famciclovir and valaciclovir: comparative effects on cutaneous and neurological disease in mice infected with herpes simplex virus type 2. Abstract H105:198, 35th ICAAC, San Francisco, CA, 17-20 September 1995.
    • (1995) 35th ICAAC
    • Field, H.J.1    Thackray, A.M.2
  • 82
    • 85030277470 scopus 로고    scopus 로고
    • Differential effects of famciclovir and valaciclovir on the pathogenesis of herpes simplex virus in a murine infection model including reactivation from latency
    • in press
    • [82] Thackray AM, Field HJ. Differential effects of famciclovir and valaciclovir on the pathogenesis of herpes simplex virus in a murine infection model including reactivation from latency. J Infect, in press.
    • J Infect
    • Thackray, A.M.1    Field, H.J.2
  • 83
    • 85030267379 scopus 로고    scopus 로고
    • The guanine nucleoside analogue penciclovir is active against chronic duck hepatitis B virus infection in vivo
    • in press
    • [83] Lin E, Luscombe C, Wang YY et al. The guanine nucleoside analogue penciclovir is active against chronic duck hepatitis B virus infection in vivo. Antimicrob Agents Chemother, in press.
    • Antimicrob Agents Chemother
    • Lin, E.1    Luscombe, C.2    Wang, Y.Y.3
  • 84
    • 0343003915 scopus 로고
    • A double blind, placebo-controlled study to assess the effect of famciclovir on virus replication in patients with chronic hepatitis B virus infection
    • Abstract P1 C1/38 S32, East Hanover
    • [84] Main J, Brown JL, Karayianis P et al. A double blind, placebo-controlled study to assess the effect of famciclovir on virus replication in patients with chronic hepatitis B virus infection. Abstract P1 C1/38 S32, European Association for the Study of the Liver, East Hanover, 1994.
    • (1994) European Association for the Study of the Liver
    • Main, J.1    Brown, J.L.2    Karayianis, P.3
  • 85
    • 0028916329 scopus 로고
    • New nucleoside analogues for chronic hepatitis B
    • [85] Schalm SW, de Man RA, Heijtink RA et al. New nucleoside analogues for chronic hepatitis B. J Hepatol 1995;22(suppl 1):52-56.
    • (1995) J Hepatol , vol.22 , Issue.SUPPL. 1 , pp. 52-56
    • Schalm, S.W.1    De Man, R.A.2    Heijtink, R.A.3
  • 87
    • 0021022096 scopus 로고
    • Acyclovir and Epstein-Barr virus infection
    • [87] Pagano JS, Sixbey JW, Lin J-C. Acyclovir and Epstein-Barr virus infection. J Antimicrob Chemother 1983;12(suppl B):113-121.
    • (1983) J Antimicrob Chemother , vol.12 , Issue.SUPPL. B , pp. 113-121
    • Pagano, J.S.1    Sixbey, J.W.2    Lin, J.-C.3
  • 88
    • 0022623607 scopus 로고
    • Effect of acyclovir on infectious mononucleosis: A double-blind, placebo-controlled study
    • [88] Andersson J, Britton S, Ernberg I et al. Effect of acyclovir on infectious mononucleosis: a double-blind, placebo-controlled study. J Infect Dis 1986;153:283-290.
    • (1986) J Infect Dis , vol.153 , pp. 283-290
    • Andersson, J.1    Britton, S.2    Ernberg, I.3
  • 89
    • 0025953625 scopus 로고
    • Lack of effect of peroral acyclovir for the treatment of acute infectious mononucleosis
    • [89] van der Horst C, Joncas J, Ahronheim G et al. Lack of effect of peroral acyclovir for the treatment of acute infectious mononucleosis. J Infect Dis 1991;164:788-792.
    • (1991) J Infect Dis , vol.164 , pp. 788-792
    • Van Der Horst, C.1    Joncas, J.2    Ahronheim, G.3
  • 90
    • 0023818744 scopus 로고
    • Regression of oral hairy leukoplakia after orally administered acyclovir therapy
    • [90] Resnick L, Herbst JS, Ablashi DV et al. Regression of oral hairy leukoplakia after orally administered acyclovir therapy. J Am Med Assoc 1988;259:384-388.
    • (1988) J Am Med Assoc , vol.259 , pp. 384-388
    • Resnick, L.1    Herbst, J.S.2    Ablashi, D.V.3
  • 91
    • 0028028038 scopus 로고
    • Famciclovir, a new oral antiherpes drug: Results of the first controlled clinical study demonstrating its efficacy and safety in the treatment of uncomplicated herpes zoster in immunocompetent patients
    • [91] Degreef H. Famciclovir, a new oral antiherpes drug: results of the first controlled clinical study demonstrating its efficacy and safety in the treatment of uncomplicated herpes zoster in immunocompetent patients. Int J Antimicrob Agents 1994;4: 241-246.
    • (1994) Int J Antimicrob Agents , vol.4 , pp. 241-246
    • Degreef, H.1
  • 92
    • 0029062086 scopus 로고
    • Valaciclovir compared with acyclovir for improved therapy for herpes zoster in immunocompetent adults
    • [92] Beutner KR, Friedman DJ, Forszpaniak C et al. Valaciclovir compared with acyclovir for improved therapy for herpes zoster in immunocompetent adults. Antimicrob Agents Chemother 1995;39:1546-1553.
    • (1995) Antimicrob Agents Chemother , vol.39 , pp. 1546-1553
    • Beutner, K.R.1    Friedman, D.J.2    Forszpaniak, C.3
  • 93
    • 0029113580 scopus 로고
    • Famciclovir for the treatment of acute herpes zoster: Effects on acute disease and post herpetic neuralgia
    • [93] Tyring S, Barbarash RA, Nahik JE et al. Famciclovir for the treatment of acute herpes zoster: effects on acute disease and post herpetic neuralgia. Ann Int Med 1995;123:89-96.
    • (1995) Ann Int Med , vol.123 , pp. 89-96
    • Tyring, S.1    Barbarash, R.A.2    Nahik, J.E.3
  • 94
    • 84915473626 scopus 로고
    • Clinic-initiated treatment of early, culture positive (CP), recurrent genital herpes (RGH) with intravenous (IV) penciclovir (PCV;BRL 39123A) vs placebo (PLB): Clinical benefits of rapid-onset antiviral activity
    • Abstract 340:155, Chicago, IL
    • [94] Sacks SL, Varner T, Macintosh M et al. Clinic-initiated treatment of early, culture positive (CP), recurrent genital herpes (RGH) with intravenous (IV) penciclovir (PCV;BRL 39123A) vs placebo (PLB): clinical benefits of rapid-onset antiviral activity. Abstract 340:155, 31st ICAAC, Chicago, IL, 1991.
    • (1991) 31st ICAAC
    • Sacks, S.L.1    Varner, T.2    Macintosh, M.3
  • 95
    • 0342418663 scopus 로고
    • Patient-initiated treatment (Tx) of recurrent genital herpes (RGH) with oral famciclovir (FCV): A Canadian multicenter, placebo-controlled, dose-ranging study
    • Abstract H4:11, Orlando, FL, 4-7 October
    • [95] Sacks SL, Aoki FY, Diaz-Mitoma F et al. Patient-initiated treatment (Tx) of recurrent genital herpes (RGH) with oral famciclovir (FCV): a Canadian multicenter, placebo-controlled, dose-ranging study. Abstract H4:11, 34th ICAAC, Orlando, FL, 4-7 October 1994.
    • (1994) 34th ICAAC
    • Sacks, S.L.1    Aoki, F.Y.2    Diaz-Mitoma, F.3
  • 97
    • 0011894577 scopus 로고
    • Famciclovir for suppression of recurrent genital herpes
    • Abstract H3:11, Orlando, FL, 4-7 October
    • [97] Mertz GJ, Loveless MO, Kraus SJ et al. Famciclovir for suppression of recurrent genital herpes. Abstract H3:11, 34th ICAAC, Orlando, FL, 4-7 October 1994.
    • (1994) 34th ICAAC
    • Mertz, G.J.1    Loveless, M.O.2    Kraus, S.J.3
  • 98
    • 0024381506 scopus 로고
    • Effect of oral acyclovir treatment on symptomatic and asymptomatic virus shedding in recurrent genital herpes
    • [98] Straus SE, Seidlin M, Takiff HE et al. Effect of oral acyclovir treatment on symptomatic and asymptomatic virus shedding in recurrent genital herpes. Sex Transm Dis 1988;16:107-113.
    • (1988) Sex Transm Dis , vol.16 , pp. 107-113
    • Straus, S.E.1    Seidlin, M.2    Takiff, H.E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.