Cardiac sarcoplasmic reticulum Ca2+ pump as a target for benzoquinones

General Pharmacology

Volumn 27, Issue 5, 1996, Pages 873-878

  Floreani, M ^a   Forlin, A ^a   Bellin, S ^a   Carpenedo, F ^a  

^a UNIVERSITY OF PADOVA   (Italy)

Author keywords

Benzoquinones; Ca2+ pump; Cardiac sarcoplasmic reticulum

Indexed keywords

1,4 BENZOQUINONE; 2,5 DIMETHYLBENZOQUINONE; ADENOSINE TRIPHOSPHATASE (CALCIUM); BENZOQUINONE DERIVATIVE; DUROQUINONE; THIOL GROUP; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CATTLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; ENZYME INHIBITION; HEART VENTRICLE; MEMBRANE VESICLE; NONHUMAN; PRIORITY JOURNAL; SARCOPLASMIC RETICULUM;

EID: 0030198953     PISSN: 03063623     EISSN: None     Source Type: Journal    
DOI: 10.1016/0306-3623(95)02130-2     Document Type: Article

References (21)

1. Carafoli E. (1987) Intracellular calcium homeostasis. Annu. Rev. Biochem. 56, 395-433.
2. 50) of an enzymatic reaction. Biochem. Pharmac. 22, 3099-3108.
3. Cornish-Bowden A. (1974) A simple graphical method for determining the inhibition constants of mixed, uncompetitive and non-competitive inhibitors. Biochem. J. 137, 143-144.
4. Di Monte D., Ross D., Bellomo G., Eklow L. and Orrenius S. (1984) Alterations in intracellular thiol homeostasis during the metabolism of menadione by isolated rat hepatocytes. Arch. Biochem. Biophys. 235, 334-342.
5. Dixon M. and Webb E. C. (1979) Enzymes. 3rd edn. Longman, London.
6. Fiske C. H. and Subbarow Y. (1925) The colorimetric determination of phosphorus. J. Biol. Chem. 66, 375-400.
7. 2+-ATPase activity by menadione. Arch. Biochem. Biophys. 270, 33-41.
8. Floreani M. and Carpenedo F. (1991) Modifications of cardiac contractility by redox cycling, alkylating and mixed redox cycling/alkylating quinones. J. Pharmac. Exp. Ther. 256, 243-248.
9. Floreani M. and Carpenedo F. (1992) One-and two-electron reduction of menadione in guinea-pig and rat cardiac tissue. Gen. Pharmac. 23, 757-762.
10. Floreani M., Santi Soncin E. and Carpenedo F. (1989) Effects of 2-methyl-1,4-naphthoquinone (menadione) on myocardial contractility and cardiac sarcoplasmic reticulum Ca-ATPase Naunyn-Schmiedeberg's Arch. Pharmac. 339, 448-455.
11. 2+ pump of sarcoplasmic reticutum. Nature 342, 90-92.
12. 2+ uptake by cardiac membrane vesicles. J. Biol. Chem. 252, 3315-3323.
13. Lowry O. H., Rosebrough N. J., Farr A. L. and Randall R. J. (1951) Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193, 265-275.
14. 2+-ATPase activity by menadione metabolism and its restoration by thiols. FEBS Lett. 181, 149-153.
15. Orrenius S. (1985) Biochemical mechanisms of cytotoxicity. Trends Pharmac. Sci. 6 (FEST suppl.), S15-S20.
16. Pozzan T., Rizzuto R., Volpe P. and Meldolesi J. (1994) Molecular and cellular physiology of intracellular calcium stores. Physiol. Rev. 74, 595-636.
17. Robert V., Ayoub S. and Berson G. (1991) Effects of hydroxyl radicals on ATPase and protein structures of myofibrils from rat heart. Am. J. Physiol. 261, H1785-H1790.
18. Ross D., Thor H., Threadgill M. D., Sandy M. S., Smith M. T., Moldeus P. and Orrenius S. (1986) The role of oxidative processes in the cytotoxicity of substituted 1,4-naphthoquinones in isolated hepatocytes. Arch. Biochem. Biophys. 248, 460-466.
19. Rossi L., Moore G. A., Orrenius S. and O'Brien P. (1986) Quinone toxicity in hepatocytes without oxidative stress. Arch. Biochem. Biophys. 251, 25-35.
20. Vassalle M. (1986) Cardiac glycosides: regulation of force and rhythm. In Cardiac Muscle: The Regulation of Excitation and Contraction. (Edited by R. D. Nathan), pp. 237-267. Academic Press, New York.
21. Wilson I., Wardman P., Lin T. and Sartorelli A. C. (1987) Reactivity of thiols toward derivatives of 2-and 6-methyl-1,4-naphthoquinone bioreductive alkylating agents. Chem.-Biol. Interact. 61, 229-240.