Differential efficacy of serotonergic drugs FG5974, FG5893, and amperozide in reducing alcohol drinking in P Rats

Alcohol

Volumn 13, Issue 4, 1996, Pages 399-404

  Lankford, M F ^a   Bjork A K ^b   Myers, R D ^a  

^a EAST CAROLINA UNIVERSITY   (United States)

^b Pharmacia Therapeutics AB   (Sweden)

Author keywords

5 HT(1A) receptors; 5 HT(2A) receptors; Alcohol Intake; Amperozide(FG5606); Ethanol preference; FG5893; FG5974; Genetics; P rats; Serotonin

Indexed keywords

2 [4 [4,4 BIS(4 FLUOROPHENYL)BUTYL] 1 PIPERAZINYL]NICOTINIC ACID; AMPEROZIDE; FG 5893; SEROTONIN AGONIST; UNCLASSIFIED DRUG;

ALCOHOL WITHDRAWAL; ALCOHOLISM; ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRINKING BEHAVIOR; DRUG EFFICACY; DRUG POTENCY; MALE; NONHUMAN; RAT; SEROTONINERGIC SYSTEM; STRUCTURE ACTIVITY RELATION; SUBCUTANEOUS DRUG ADMINISTRATION;

EID: 0030198943     PISSN: 07418329     EISSN: None     Source Type: Journal    
DOI: 10.1016/0741-8329(96)00061-4     Document Type: Article

References (34)

1. 1. Adell, A.; Myers, R. D. Selective destruction of midbrain raphe nuclei by 5,7-DHT: Is brain 5-HT involved in alcohol drinking in Sprague-Dawley rats? Brain Res. 693:70-79; 1995.
2. 2 receptor antagonistic properties, on male rat sexual behavior. Eur. J. Pharmacol. 255:131-137; 1994.
3. 3. Björk, A.; Bergman, I.; Gustavsson, G. Amperozide in the treatment of schizophrenic patients. A preliminary report. In: Meltzer, H. Y., ed. Novel antipsychotic drugs. New York: Raven Press; 1992:47-57.
4. 4. Collins, D.M.; Myers, R. D. Buspirone attenuates volitional alcohol intake in the chronically drinking monkey. Alcohol 4:49-56; 1987.
5. 3H-serotonin uptake I: A study in fawn-hooded rats. Life Sci. 48:1969-1976; 1991.
6. 6. Gongwer, M. A.; Murphy, J. M.; McBride, W. J.; Lumeng, L.; Li, T. K. Regional brain contents of serotonin, dopamine and their metabolites in the selectively bred high-and low-alcohol drinking lines of rats. Alcohol 6:317-320; 1989.
7. 7. Gustafsson, B.; Christensson, E. Amperozide and emotional behaviour. Pharmacol. Toxicol. 66(Suppl. 1):34-39; 1990.
8. 1A autoreceptor-mediated effects of the amperozide congeners, FG5865 and FG5893, on rat brain 5-hydroxytryptamine neurochemistry in vivo. Eur. J. Pharmacol. 238:357-367; 1993.
9. 9. Jankowska, E.; Bidzinski, A.; Kostowski, W. Alcohol drinking in rats treated with 5,7-dihydroxytryptamine: Effect of 8-OH-DPAT and tropisetron (ICS 205-930). Alcohol 11:283-288; 1994.
10. 10. Lankford, M. F.; Myers, R. D. Genetics of alcoholism: Simultaneous presentation of a chocolate drink diminishes alcohol preference in high drinking HAD rats. Pharmacol. Biochem. Behav. 49:417-425; 1994.
11. 2A receptors in alcohol drinking: Preference in HAD rats is inhibited by combination treatment with naltrexone and amperozide. Alcohol 13:53-57; 1996.
12. 12. Lankford, M. F.; Roscoe, A.; Pennington, S.; Myers, R. D. Drinking of high concentrations of ethanol vs. palatable fluids in alcohol-preferring (P) rats: Valid animal model of alcoholism. Alcohol 8:293-299; 1991.
13. 13. LeMarquand, D.; Pihl, R.; Benkelfat, C. Serotonin and alcohol intake, abuse, and dependence: Findings on animal studies. Biol. Psychiatry 36:395-421; 1994.
14. 14. Li, T. K.; Lumeng, L.; McBride, W.; Murphy, J. Genetic and neurobiological basis of alcohol-seeking behavior. Alcohol Alcohol. 29:697-700; 1994.
15. 2 receptors in the CNS of alcohol-preferring and -non preferring rats. Pharmacol. Biochem. Behav. 46:631-646; 1993.
16. 2 antagonists amperozide and trazodone on preference for alcohol in rats. Alcohol 11:203-206; 1994.
17. 17. Meert, T. F.; Awouters, F.; Niemegeers, C. J. E.; Schellekens, K. H. L.; Janssen, P. A. J. Ritanserin reduces abuse of alcohol, cocaine, and fentanyl in rats. Pharmacopsychiatry 24:159-163; 1991.
18. 18. Myers, R. D. Psychopharmacology of alcohol. Annu. Rev. Pharmacol. Toxicol. 18:125-144; 1978.
19. 19. Myers, R. D. New drugs for the treatment of experimental alcoholism. Alcohol 11:439-451; 1994.
20. 2 antagonist, ritanserin, to alter preference for alcohol in drinking rats. Pharmacol. Biochem. Behav. 45:233-237; 1993.
21. 21. Myers, R. D.; Lankford, M. F. Suppression of alcohol preference in high alcohol drinking rats: Efficacy of amperozide vs. naltrexone. Neuropsychopharmacology 14:139-149; 1996.
22. 22. Myers, R. D.; Lankford, M. F.; Björk, A. Selective reduction by the 5-HT antagonist amperozide of alcohol preference induced in rats by systemic cyanamide. Pharmacol. Biochem. Behav. 43:661-667; 1992.
23. 2 receptor blockade by amperozide suppresses ethanol drinking in genetically preferring (P) rats. Pharmacol. Biochem. Behav. 45:741-747; 1993.
24. 2 antagonist amperozide. Alcohol 10:117-125; 1993.
25. 25. Myers, R. D.; McMillen, B. A.; Adell, A. Neurotransmitter and neuromodulatory mechanisms involved in alcohol abuse and alcoholism: Epitome of cerebral complexity. Neurochem. Int. 26:337-342; 1995.
26. 26. Myers, R. D.; Quarfordt, S. Alcohol drinking attenuated by sertraline in rats with 6-OHDA or 5,7-DHT lesions of N. accumbens: A caloric response? Pharmacol. Biochem. Behav. 40:923-928; 1991.
27. 27. Nevo, I.; Hamon, M. Neurotransmitter and neuromodulatory mechanisms involved in alcohol abuse and alcoholism. Neurochem. Int. 26:305-336; 1995.
28. 2 receptor antagonists do not reduce ethanol preference in Sardinian alcohol-preferring (sP) rats. Pharmacol. Biochem. Behav. 46:853-856; 1993.
29. 29. Privette, T. H.; Hornsby, R. L.; Myers, R. D. Buspirone alters alcohol drinking induced in rats by tetrahydropapaveroline injected into brain monoaminergic pathways. Alcohol 5:147-152; 1988.
30. 30. Quarfordt, S. D.; Kalmus, G. W.; Myers, R. D. Ethanol drinking following 6-OHDA lesions of nucleus accumbens and tuberculum olfactorium of the rat. Alcohol 8:211-217; 1991.
31. 1A receptors. Psychopharmacology (Berlin) 112: 100-110; 1993.
32. 2 antagonist FG 5893. Alcohol 10:243-248; 1993.
33. 33. Svensson, L.; Fahlke, C.; Hard, E.; Engel, J, A. Involvement of the serotonergic system in ethanol intake in the rat. Alcohol 10:219-224; 1993.
34. 1A receptor in some brain areas of alcohol-preferring (P) rats compared to nonpreferring (NP) rats. Pharmacol. Biochem. Behav. 46:173-177; 1993.