Clinical applications of fundus reflection densitometry

Survey of Ophthalmology

Volumn 41, Issue 1, 1996, Pages 37-50

  Liem, Albert T A ^a,b   Keunen, Jan E E ^a   Van Norren, Dirk ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b Utrecht Universital Hospital   (Netherlands)

Author keywords

aging human eye; chorioretinal inflammations; clinical applications; commotio retinae; density difference spectrum; fundus reflection densitometry; macular dystrophies; myotonic dystrophy; night blinding disorders; photopigment density difference; photopigment regeneration; retinal detachment

Indexed keywords

RHODOPSIN;

AGING; ARTICLE; CHORIORETINITIS; CHORIORETINOPATHY; CHOROIDEREMIA; DARK ADAPTATION; DENSITOMETRY; DRUSEN; EYE DISEASE; EYE FUNDUS; HUMAN; LIGHT ADAPTATION; MYOTONIC DYSTROPHY; NIGHT BLINDNESS; PHOTORECEPTOR; PIGMENT DISORDER; PRIORITY JOURNAL; RETINA DETACHMENT; RETINITIS PIGMENTOSA; RETINOL DEFICIENCY; USHER SYNDROME; VOGT KOYANAGI SYNDROME;

EID: 0030198683     PISSN: 00396257     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0039-6257(97)81994-7     Document Type: Article

References (108)

1. 1. Abelsdorff G: Die ophthalmoskopische Erkennbarkeit des Sehpurpers. Z Psychol Physiol Sinnesorg 14: 77-90, 1897
2. 2. Abelsdorff G: Physiologische Beobachtungen am Auge der Krokodille. Arch Anat Physiol (Physiol Abt) 155, 1898
3. 3. Alpern M, Holland MG, Ohba N: Rhodopsin bleaching signals in essential night blindness. J Physiol (Lond) 225: 457-476, 1972
4. 4. Alpern M, Krantz H: Visual pigment kinetics in abnormalities of the uvea retinal pigment epithelium interface in man. Invest Ophthalmol Vis Sci 20: 183-203, 1981
5. 5. Alpern M: Lack of uniformity in colour matching. J Physiol (Lond) 288: 85-105, 1979
6. 6. Boll FH: Zur Anatomie und Physiologie der Retina. Monatsbl Preuss Akad Wiss Berl 41: 783-787, 1876
7. 7. Boughman JA, Vernon M, Shaver KA: Usher syndrome: definition and estimate of prevalence from two high-risk populations. J Chron Dis 36: 595-603, 1983
8. 8. Bowmaker JK, Dartnall HJA, and Mollon JD: Microspectrophotometric demonstration of four classes of photoreceptor in an old world primate macaca fascicularis. J Physiol (Lond) 298, 131-143, 1980
9. 9. Brown PK, Wald G: Visual pigments in human and monkey retinas. Nature 200: 37, 1963
10. 10. Burns SA, Elsner AE: Color matching at high illuminances: Photopigment optical density and pupil entry. J Opt Soc Am A 10: 221-230, 1993
11. 11. Campbell FW, Rushton WAH: The measurement of rhodopsin in the human eye. J Physiol (Lond) 126: 36P, 1954
12. 12. Carr RE, Ripps H, Siegel M, Weale RA: Rhodopsin and the electrical activity of the retina in congenital night blindness. Invest Ophthalmol Vis Sci 5:497-507, 1966
13. 13. Carr RE, Ripps H, Siegel M, Weale RA: Visual functions in congenital night blindness. Invest Ophthalmol Vis Sci 5: 508-514, 1966
14. 14. Carr RE, Ripps H: Rhodopsin kinetics and rod adaptation in Oguchi's disease. Invest Ophthalmol Vis Sci 6:426-436, 1967
15. 15. Carr RE, Ripps H, Siegel IM: Visual pigment kinetics and adaptation in fundus albipunctatus. Doc Opthalmol Proc Ser 4: 193-204, 1974
16. 16. Chuang EL, Sharp DM, Fitzke FW, et al: Retinal dysfunction in central serous retinopathy. Eye 1:120-125, 1987
17. 17. Curcio CA, Sloan KR, Packer O, et al: Distribution of cones in human and monkey retina: Individual variability and radial asymmetry. Science 236:579-582, 1987
18. 18. Curcio CA, Sloan KR, Kalina RE, Hendrickson AE: Human photoreceptor topography. J Comput Neurol 292: 497-523, 1990
19. 19. Curcio CA, Millican CL, Allen KA, Kalina RE: Aging of the human photoreceptor mosaic: Evidence for selective vulnerability of rods in central retina. Invest Ophthalmol Vis Sci 34: 3278-3296, 1993
20. 20. Deutman AF, Lion F: Choriocapillaris nonperfusion in acute multifocal placoid pigment epitheliopathy. Am J Ophthalmol 84: 652-658, 1977
21. 21. Elsner AE, Burns SA, Webb RH: Photopigment densitometry with a scanning laser ophthalmoscope. J Optical Soc Am, Technical Digest Series 11:122, 1988
22. 22. Elsner AE, Burns SA, Webb RH: Photopigment concentration in normal and photocoagulated retina (abstract). Invest Ophthalmol Vis Sci 30 (suppl):370, 1989
23. 23. Elsner AE, Burns SA, Delori FC, Webb RH: Quantitative reflectometry with the SLO, in: Nasemann JE, Burk ROW (eds): Laser Scanning Opthalmoscopy and Tomography. Berlin: Quintessenz-Verlag; 1990: 109-121
24. 24. Elsner AE, Burns SA, Hughes GW, Webb RH: Reflectometry with a scanning laser ophthalmoscope. Applied Optics 31: 3697-3710, 1992
25. 25. Elsner AE, Burns SA, Weiter JJ: Retinal densitometry in retinal tears and detachments. Clin Vis Sci 7: 489-500, 1992
26. 26. Elsner AE, Burns SA, Webb RH: Mapping cone photopigment density in humans. J Optical Soc Am A 10: 52-58, 1993
27. 27. Faulkner DJ, Kemp CM: Human rhodopsin measurement using a TV-based imaging fundus reflectometry. Vis Res 24: 221-231, 1984
28. 28. Fram I, Read JS, McCormick BH, Fishman GA: In vivo study of the photolabile visual pigment utilizing the television ophthalmoscope image processor, in: Greenfield RH, Colenbrander A, (eds): Computers in Ophthalmology. St Louis: IEEE Computer Society, 1979, pp 133-144
29. 29. Fulton AB, Hansen RM, Underwood BA, et al: Scotopic thresholds and plasma retinol in cystic fibrosis. Invest Ophthalmol Vis Sci 23: 366-370, 1982
30. 30. Fulton AB, Hansen RM: Foveal cone pigments and sensitivity in young patients with Usher's syndrome. Am J Ophthalmol 103: 150-160, 1987
31. 31. Fulton AB, Hansen RM: The relation of rhodopsin and scotopic sensitivity in choroideremia. Am J Ophthalmol 104: 524-532, 1987
32. 32. Gartner S, Henkind P: Aging and degeneration of the human macula. I. outer nuclear layer and photo receptors. Br J Ophthalmol 65:23-28, 1981
33. 33. Gass JDM: Pathogenesis of disciform detachment of the neuroepithelium. II. Idiopathic central serous choroidopathy. Am J Ophthalmol 63: 587-615, 1967
34. 34. Gass JDM: Acute posterior multifocal placoid pigment epitheliopathy. Arch Ophthalmol 80: 177-185, 1968
35. 35. Geller AM, Sieving PA: Assessment of foveal photoreceptors in Stargardt macular dystrophy using a small dot detection task. Vision Res 33: 1509-1524, 1993
36. 36. Goodman G, Bornschein H: Comparitive electroretinographic studies in congenital night blindness and total color blindness. Arch Ophthalmol 58: 174, 1957
37. 37. Goodman G, Ripps H, Siegel IM: Cone dysfunction syndromes. Arch Ophthalmol 70: 214-231, 1963
38. 38. Hansen RM, Fulton AB: Cone pigments in acute posterior multifocal placoid pigment epitheliopathy. Am J Ophthalmol 91: 465-468, 1981
39. 39. Heckenlively JR: Retinitis Pigmentosa. Philadelphia, PA: Lippincott, 1987
40. 40. Highman VN, Weale RA: Rhodopsin density and visual threshold in retinitis pigmentosa. Am J Ophthalmol 75: 822-832, 1973
41. 41. Hood C, Rushton WAH: The Florida retinal densitometer. J Physiol (Lond) 217: 213-229, 1971
42. 42. Hosoya Y: Über den Sehpurper in tapezierten Auge. Tohoku J Exp Med 12: 146, 1929
43. 43. Jacobson SG, Kemp CM, Sung C-H, Nathans J: Retinal function and rhodopsin levels in autosomal dominant retinitis pigmentosa with rhodopsin mutations. Am J Ophthalmol 112: 256-271, 1991
44. 44. Jampol LM, Sieving PA, Pugh D, et al: Multiple evanescent white dot syndrome: I. Clinical findings. Arch Ophthalmol 102: 671-674, 1984
45. 45. Kemp CM, Faulkner DJ, Jacobson, SG: Visual pigment levels in retinitis pigmentosa. Trans Med Soc Lond 103: 453-457, 1984
46. 46. Kemp CM, Faulkner DJ: Rhodopsin measurement in human disease: Fundus reflectometry using television. Dev Ophthalmol 2: 130-134, 1981
47. 47. Kemp CM, Jacobson SG, Faulkner DJ, Walt RW: Visual function and rhodopsin levels in humans with vitamin A deficiency. Exp Eye Res 46: 185-197, 1988
48. 48. Kemp CM, Jacobson SG, Faulkner DJ: Two types of visual dysfunction in autosomal dominant retinitis pigmentosa. Invest Ophthalmol Vis Sci 29: 1235-1241, 1988
49. 49. Keunen JEE, van Norren D, van Meel GJ: Density of foveal cone pigments at older age. Invest Opthalmol Vis Sci 28: 985-991, 1987
50. 50. Keunen JEE, and van Norren D: Foveal densitometry in the Multiple Evanescent White Dot Syndrome. Am J Opthalmol 105: 561-562, 1988
51. 51. Keunen JEE, Tan KWEP, van Meel GJ, van Norren D: Rhodopsin kinetics in presumed vitamin A transport impairment, in: Keunen JEE (ed): Densitometry in Diseases and Senescence of the Human Retina (Thesis). Utrecht: Elinkwijk, 1988, pp 85-97
52. 52. Keunen JEE, Van Meel GJ, and Van Norren D: Rod densitometry in congenital stationary night blindness. Applied Optics 27: 1050-1056, 1988
53. 53. Keunen JEE, van Meel GJ, van Norren D: Rod densitometry in night blindness: a review and two puzzling cases. Doc Ophthalmol 68: 375-387, 1988
54. 54. Keunen JEE, van Meel GJ, van Norren D, et al: Retinal densitometry in APMPPE. Invest Ophthalmol Vis Sci 30: 1515-1521, 1989
55. 55. Keunen JEE, van Everdingen JAM, Went LN, et al: Color matching and foveal densitometry in patients and carriers of an X-linked progressive cone dystrophy. Arch Ophthalmol 108: 1713-1719, 1990
56. 56. Kilbride PE, Read JS, Fishman GA, Fishman M: Determination of human cone pigment density difference spectra in spatially resolved regions of the fovea. Vision Res 23: 1341-1350, 1983
57. 57. Kilbride PE, Hutman LP, Fishman M, Read JS: Foveal cone pigment density difference in the aging human eye. Vision Res 26: 321-325, 1986
58. 58. Kilbride PE, Fishman M, Fishman GA, Hutman LP: Foveal cone pigment density difference and reflectance in retinitis pigmentosa. Arch Ophthalmol 104: 220-224, 1986
59. 59. Kilbride PE, Alexander KR, Fishman M, Fishman GA: Human macular pigment assessed by imaging fundus reflectometry. Vision Res 29: 663-674, 1989
60. 60. Kilbride PE, Keehan KM: Visual pigments in the human macula assessed by imaging fundus reflectometry. Applied Optics 29: 1427-1435, 1990
61. 61. Kötggen Abelsdorff G: Z. Psychol Physiol Sinnes 12: 161, 1896
62. 62. Kuhne W: Zur Photochemie der Netzhaut. Untersuch Physiol Inst Univ Heidelb 1:1-14, 1878
63. 63. Liem ATA, Keunen JEE, van Norren D, van de Kraats J: Rod densitometry in the aging human eye. Invest Ophthalmol Vis Sci 32: 2676-2682, 1991
64. 64. Liem ATA, Keunen JEE, van Norren D: Foveal densitometry in adult-onset diffuse drusen. Am J Ophthalmol 114: 149-157, 1992
65. 65. Liem ATA, Keimen JEE, van Meel GJ, van Norren D: Serial foveal densitometry and visual function after retinal detachment surgery with macular involvement Ophthalmology 101:1945-1952, 1994
66. 66. Liem ATA, Keunen JEE, van Norren D: Reversible cone photoreceptor injury in commotio retinae of the macula. Retina 15: 58-61, 1995
67. 67. Mansour AM, Green WR, Hogge C: Histopathology of commotio retinae. Retina 12:24-28, 1992
68. 68. Marshall J. Ageing changes in human cones, in Shimuzu K (ed): Ophthalmology, Vol 1. Kyoto: Proc XXIII International Congr, 1979: 375-378
69. 69. Marshall J, Grindle J, Ansell PL, Borwein B: Convolutions in human rods: an ageing process. Br J Ophthalmol 63: 181-187, 1979
70. 70. Mizuno K, Majima A, Ozawa K, Ito H: Fundus photography in red-free light (rhodopsin photography). Vision Res 8: 481-482, 1968
71. 71. Mizuno K, Majima A, Ozawa K, Ito H: Red-free light fundus photography. Invest Ophthalmol Vis Sci 7: 241-249, 1968
72. 72. Müller H: Vhdl. phys.-med. Ges., Würzburg, 2: 216, 1851
73. 73. Osterberg G: The topography of the layer of rods and cones in the human retina. Acta Ophthalmol 13 (suppl): 1-102, 1935
74. 74. Perlman I, Auerbach E: The relationship between visual sensitivity and rhodopsin density in retinitis pigmentosa. Invest Ophthalmol Vis Sci 20: 758-765, 1981
75. 75. Pokorny J, Smith VC, Ernest JT: Macular color vision defects. Specialized psychophysical testing in acquired and hereditary chorioretinal diseases. Int Ophthalmol Clin 20: 53-81, 1980
76. 76. Ripps H, Weale RA. Analysis of foveal densitometry. Nature 205:52-56, 1965
77. 77. Ripps H, Brin KP, Weale RA: Rhodopsin and visual threshold in retinitis pigmentosa. Invest Opthhalmol Vis Sci 17: 735-745, 1978
78. 78. Ripps H, Noble KG, Greenstein VC, et al: Progressive cone dystrophy. Ophthalmology 94:1401-1409, 1987
79. 79. Rushton WAH: Apparatus for analysing the light reflected from the eye of the cat. J Physiol (Lond) 117: 47-48, 1952
80. 80. Rushton WAH: Rhodopsin measurement and dark-adaptation in a subject deficient in cone vision. J Physiol (Lond) 156: 193-205, 1961
81. 81. Sheory UB: Clinical assessment of rhodopsin in the eye. Br J Ophthalmol 60: 135-141, 1976
82. 82. Smith VC, Pokorny J, Ernest JT, Starr SJ: Visual function in acute posterior multifocal placoid pigment epitheliopathy. Am J Ophthalmol 85: 192-199, 1978
83. 83. Smith VC, Pokorny J, Diddle KR: Color matching and Stiles-Crawford effect in central serous choroidopathy. Mod Probl Ophthalmol 19: 284-295, 1978
84. 84. Smith VC, Pokorny J, van Norren D: Densitometric measurement of human cone photopigment kinetics. Vision Res 23: 517-524, 1983
85. 85. Tannino T, Ohba N: Photographic retinal densitometry in the living human eye. Jpn J Ophthalmol 21 : 227-241, 1977
86. 86. Ter Bruggen JP, van Meel GJ, Paridaens ADA, et al: Foveal phtopigment kinetics-abnormality: an early sign in myotonic dystrophy? Br J Ophthalmol 76:594-597, 1992
87. 87. Van Buskirk EM, Lessell S, Friedman E: Pigmentary epitheliopathy and erythema nodosum. Arch Ophthalmol 85: 369-372, 1971
88. 88. Van Meel GJ, van Norren D: Foveal densitometry in retinitis pigmentosa. Invest Opthalmol Vis Sci 24: 1123-1130, 1983
89. 89. Van Meel GJ, Smith VC, Pokorny J, van Norren D: Foveal densitometry in central serous choroidopathy. Am J Opthalmol 95: 359-368, 1984
90. 90. Van Meel GJ, van Norren D: Foveal densitometry as a diagnostic technique in Stargardt's disease. Am J Ophthalmol 102: 353-362, 1986
91. 91. Van Meel GJ, van Norren D, van de Kraats J: Scanning laser densitometry in two patients with retinitis pigmentosa. Clin Vis Sci 7: 501-509, 1992
92. 92. Van Meel GJ, Keunen JEE, van Norren D, van de Kraats J: Scanning laser densitometry in the multiple evanescent white dot syndrome. Retina 13:29-35, 1993
93. 93. Van Norren D, van de Kraats J: A continuously recording retinal densitometer. Vision Res 21: 897-905, 1981
94. 94. Van Norren D, van Meel GJ: Density of human cone photopigments as a function of age. Invest Opthalmol Vis Sci 26: 1014-1016, 1985
95. 95. Van Norren D: Towards improved instrumentation for retinal densitometry, in: Zrenner E, Krastel H, Boebel H-H (eds): Research in Retinitis Pigmentosa. Oxford: Pergamon; 1987, pp 177-178
96. 96. Van Norren D, van de Kraats J: Retinal densitometer with the size of a fundus camera. Vision Res 29: 369-374, 1989
97. 97. Van Norren D, van de Kraats J: Imaging retinal densitometry with a confocal scanning laser ophthalmoscope. Vision Res 29: 1825-1830, 1989
98. 98. Vernon M: Usher's syndrome: deafness and progressive blindness - clinical cases, prevention, theory, and literature review. J Chron Dis 22: 133-151, 1969
99. 99. Wald G: Photo-labile pigments of the chicken retina. Nature 140: 545, 1937
100. 100. Weale RA: The spectral reflectivity of the cat's tapetum measured in situ. J Physiol (Lond) 119: 30-42, 1953
101. 101. Weale RA: Photolabile pigments in normal and cone-monochromatic foveae. J Physiol (Lond) 148: 47-48, 1959
102. 102. Weale RA: Photosensitive reactions in foveae of normal and cone-monochromatic observers. Optica Acta 6: 158-174, 1959
103. 103. Weale RA: Vision and fundus reflectometry: a review. Photochem Photobiol 4: 67-87, 1965
104. 104. Weale RA: Vision and fundus reflectometry. Doc Ophthalmol 19: 252-286, 1965
105. 105. Webb RH, Hughes GW, Delori FC: Confocal scanning laser ophthalmoscope. Applied Optics 26:1492-1499 1987
106. 106. Webb RH, Hughes GW, Pomerantzeff O: Flying spot TV ophthalmoscope. Applied Optics 19: 1991-1997, 1980
107. 107. Westheimer G: Dependence of the Stiles-Crawford effect on retinal location. J Physiol (Lond) 192: 309-315, 1967
108. 108. Young RSL, Fishman GA: Color matches of patients with retinitis pigmentosa. Invest Ophthulmol Vis Sci 19: 545-549, 1980