Inhibition of Ferrous-induced lipid peroxidation by dipyridamole, RA-642 and mopidamol in human lung tissue

General Pharmacology

Volumn 27, Issue 5, 1996, Pages 855-859

  De La Cruz, J P ^a   Olveira, C ^b   Gonzalez Correa, J A ^a   Benitez A ^b   Sanchez De La Cuesta F S ^a  

^a UNIVERSITY OF MÁLAGA   (Spain)

^b HOSPITAL REGIONAL UNIVERSITARIO DE MÁLAGA   (Spain)

Author keywords

Dipyridamole; Lipid peroxidation; Lung tissue; Mopidamol; Oxygen derived free radials; Pyrimido pyrimidine derivatives; RA 642

Indexed keywords

4,8 BIS(DIETHYLAMINO) 2,6 BIS(2 HYDROXYETHYL 2 METHOXYETHYLAMINO)PYRIMIDO[5,4 D]PYRIMIDINE; ANTIOXIDANT; ASCORBIC ACID; DIPYRIDAMOLE; FERROUS SULFATE; MALONALDEHYDE; MOPIDAMOL; PYRIMIDINE DERIVATIVE; THIOBARBITURIC ACID REACTIVE SUBSTANCE;

ADULT; AGED; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN TISSUE; LIPID PEROXIDATION; LUNG; LUNG CARCINOMA; LUNG RESECTION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SPECIES DIFFERENCE;

EID: 0030198611     PISSN: 03063623     EISSN: None     Source Type: Journal    
DOI: 10.1016/0306-3623(95)02098-5     Document Type: Article

References (30)

1. Asakawa T. and Matsushita S. (1979) Thiobarbituric acid test for detecting lipid peroxides. Lipids 14, 401-405.
2. Beisenherz G., Flanagan M., Pelzer H. and Watabe J. (1969) Inhibition of lipid peroxidation formation in mitochondria and fatty emmulsion by dipyridamole. Drug, Res, 19, 1681-1684.
3. Bell D. Y., Haseman J. A., Spock A., McLenan G. and Hook G. E. (1981) Plasma proteins of the bronchoalveolar surface of the lungs of smokers and non-smokers. Am. J. Respir. Dis. 124, 72-79.
4. Bellido I., De la Cruz J. P. and Sánchez de la Cuesta F. (1990) RA-642, a potent inhibitor of ferrous-induced lipid peroxidation in cell membranes. Meth. Find. Exp. Clin. Pharmacol. 13, 371-375.
5. Bossmann H. B. and Hemsworth B. A. (1969) Structure and Function of Nervous Tissue, 2nd ed., pp. 1-24 Academic Press, New York.
6. Bulkley G. B. (1983) The role of oxygen free radicals in human disease processes. Surgery 94, 407-411.
7. Burdon R. H. and Gill V. (1990) Oxidative stress and tumour cell proliferation. Free Rad. Res. Comms. 11, 65-76.
8. De la Cruz J. P., Moron D. and Sánchez de la Cuesta F. (1991a) Antiplatelet effect of the pyrimido-pyrimidine derivative RA-642. Thromb. Res. 63, 463-468.
9. De la Cruz J. P., Sintas A., Moreno A., Garcia-Campos J. and Sánchez De la Cuesta F. (1991b) Dipyridamole and RA-642 inhibit the production of superoxide anion and free radical damage to rat lens. Pharmacol. Toxicol. 69, 201-204.
10. De la Cruz J. P., Carrasco T., Ortega G. and Sánchez De la Cuesta F. (1992a) Inhibition of ferrous-induced lipid peroxidation by pyrimido-pyrimidine derivatives in human liver membranes. Lipids 27, 192-194.
11. De la Cruz J. P., García P. J., and Sánchez De la Cuesta F. (1992b) Dipyridamole inhibits platelet aggregation induced by oxygen free radicals. Thromb. Res. 66, 277-285.
12. De la Cruz J. P., Villalobos M. A., Carrasco T., Smith-Agreda J. M. and Sánchez de la Cuesta F. (1992c) The pyrimido-pyrimidine derivative RA-642 protects from brain ischemia and global ischemia-reperfusion. Brain Res. 597, 250-256.
13. Demling R. H. and Lalonde C. (1990) Early postburn lipid peroxidation: effect of ibuprofen and allopurinol. Surgery 107, 1118-1124.
14. Duncan C. J. (1990) Biochemical events associated with rapid cellular damage during the oxygen and calcium paradoxes of the mamalian heart. Experientia 46, 41-48.
15. Emerit J., Fechmer J., Galli A., Clavel J. P. and Congy F. (1986) Les radicaux libres derives de l'oxygene et la peroxydation lipidique. Role in biologic cellulaire et en physiopathologie. Presse Med. 15, 751-754.
16. Franco D. P. and Jenkinson S. G. (1986) Rat lung microsomal lipid peroxidation: effects of vitamin E and reduced glutathione. J. Appl. Physiol. 61, 785-790.
17. Fridovich I. Oxygen radicals, (1986) In: Free Radicals in Biology. (Edited by Pryor M. A.) pp. 239-240. Academic Press, New York.
18. Goldstein B. D. and Witz G. (1990) Free radicals and carcinogenesis. Free Rad. Res. Comms. 11, 3-10.
19. Hajimohammadreza I. and Brammer M. (1990) Brain membrane fluidity and lipid peroxidation in Alzheimer's disease. Neurosri. Lett. 112, 333-337.
20. Halliwell B. (1987) Oxydants and human disease: some new concepts. FA-SEB J. 1, 358-364.
21. Halliwell B. (1990) How to characterize a biological antioxidant. Free Rad. Res. Comms. 9, 1-32.
22. Iuliano L., Violi F., Ghiselli A., Alessandri C. and Balsano F. (1989) Dipyridamole inhibits lipid peroxidation and scavenges oxygen radicals. Lipids 24, 430-433.
23. Iuliano L., Practico D., Ghiselli A., Bonavita M. S. and Violi F. (1992) Reaction of dipyridamole with the hydroxyl radical. Lipids 27, 349-353.
24. Jamieson A. D. (1991) Lipid peroxidation in brain and lungs from mice exposed to hiperoxia. Biochem. Pharmac. 43, 749-756.
25. Lee A. G. (1987) Interactions of lipids and proteins. Some general principles. J. Bioenerg. Biomembr. 19, 581-603.
26. Lowry O., Rosebrough H., Farr A. and Randall R. (1951) Protein measurement with the Folin Phenol reagent. J. Biol. Chem. 193, 265-275.
27. McCord J. M. (1983) The superoxide free radical: its biochemistry and pathophysiology. Surgery 94, 412-414.
28. Moldeus P., Cotgreave I. A. and Berggren M. (1986) Lung protection by a thiol-containing antioxidant: N-acetilcysteine. Respiration 50, 31-42.
29. Sun Y. (1980) Free radicals, antioxidant enzymes, and carcinogenesis. Free Rad. Biol. Med. 8, 583-599.
30. Takeda K., Shimada Y., Amano M., Sakai T., Okada T. and Yoshida I. (1984) Plasma lipid peroxides and α-tocopherol in critically ill patients. Crit. Care Med. 12, 957-959.