T3 potentiates the adrenergic stimulation of type II 5'-deiodinase activity in cultured rat brown adipocytes

American Journal of Physiology - Endocrinology and Metabolism

Volumn 271, Issue 1 34-1, 1996, Pages

  Hernandez A ^a   Obregon M J ^a  

^a CSIC   (Spain)

Author keywords

3,5,3' triiodothyronine; adenosine 3',5'cyclic monophosphate; brown adipose tissue; uncoupling protein

Indexed keywords

ALPRENOLOL; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; CYCLIC AMP; FORSKOLIN; ISOPRENALINE; LIOTHYRONINE; NORADRENALIN; PHENYLEPHRINE; RETINOIC ACID; THYROXINE DEIODINASE; ADRENERGIC RECEPTOR STIMULATING AGENT; CYCLOHEXIMIDE; DACTINOMYCIN; DRUG DERIVATIVE; IODIDE PEROXIDASE; THYROXINE;

ADRENERGIC STIMULATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BROWN ADIPOSE TISSUE; CELL DIFFERENTIATION; CONTROLLED STUDY; DRUG POTENTIATION; ENZYME ACTIVATION; GENE AMPLIFICATION; HORMONAL REGULATION; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR BINDING; ADIPOCYTE; ANIMAL; CELL CULTURE; CYTOLOGY; DRUG ANTAGONISM; ENZYMOLOGY; FUNCTIONS OF THE HEMIC, LYMPHATIC AND RETICULOENDOTHELIAL SYSTEMS; HALF LIFE TIME; KINETICS; METABOLISM; SPRAGUE DAWLEY RAT;

ADIPOCYTES; ADIPOSE TISSUE, BROWN; ADRENERGIC AGENTS; ANIMALS; BLOOD PHYSIOLOGY; CELLS, CULTURED; CYCLIC AMP; CYCLOHEXIMIDE; DACTINOMYCIN; HALF-LIFE; IODIDE PEROXIDASE; KINETICS; NOREPINEPHRINE; RATS; RATS, SPRAGUE-DAWLEY; THYROXINE; TRIIODOTHYRONINE;

EID: 0030191799     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.1996.271.1.e15     Document Type: Article

References (30)

1. Bianco, A. C., X. Sheng, and J. E. Silva. Triiodothyronine amplifies norepinephrine stimulation of uncoupling protein gene transcription by a mechanism not requiring protein synthesis. J. Biol. Chem. 263: 18168-18175, 1988.
2. Bianco, A. C., and J. E. Silva. Intracellular conversion of thyroxine to triiodothyronine is required for the optimal thermogenic function of brown adipose tissue. J. Clin. Invest. 79: 295-300, 1987.
3. Boteho, L. H. P., J. D. Rothermel, R. V. Coombs, and B. Jastorff. cAMP analog antagonists of cAMP action. Methods Enzymol. 159: 159-172, 1988.
4. Courtin, F., F. Chantoux, J.-M. Gavaret, D. Toru-Delbauffe, C. Jacquemin, and M. Pierre. Induction of type II 5′-deiodinase activity in cultured rat astroglial cells by 12-O-tetradecanoylphorbol-13-acetate: dependence on glucocorticoids. Endocrinology 125: 1277-1281, 1989.
5. Courtin, F., F. Chantoux, M. Pierre, and J. Francon. Induction of type II 5′-deiodinase activity by cyclic adenosine 3′, 5′-monophophate in cultured rat astroglial cells. Endocrinology 123: 1577-1581, 1988.
6. García-Jimenez, C., A. Hernández, M. J. Obregón, and P. Santisteban. Malic enzyme gene expression in differentiating brown adipocytes: regulation by insulin and triiodothyronine. Endocrinology 132: 1537-1543, 1993.
7. Hernández, A., C. García-Jimenez, P. Santisteban, and M. J. Obregón. Regulation of malic-enzyme-gene expression by cAMP and retinoic acid in differentiating brown adipocytes. Eur. J. Biochem. 215: 285-290, 1993.
8. Hernández, A., and M. J. Obregón. The expression of thermogenin (UCP) mRNA in cultured brown adipocytes. Regulation by thyroid hormones. J. Endocrinol. Invest. 15, Suppl. 2: 17, 1992.
9. Jones, R., L. Henschen, N. Mohell, and J. Nedergaard. Requirement of gene transcription and protein synthesis for cold and norepinephrine-induced stimulation of thyroxine deiodinase in rat brown adipose tissue. Biochim. Biophys. Acta 889: 366-373, 1986.
10. Leonard, J. L. Dibutyryl cAMP induction of type II 5′ deiodinase activity in rat brain astrocytes in culture. Biochem. Biophys. Res. Commun. 151: 1164-1172, 1988.
11. Leonard, J. L., S. A. Mellen, and P. R. Larsen. Thyroxine 5′-deiodinase activity in brown adipose tissue. Endocrinology 112: 1153-1155, 1983.
12. Leonard, J. L., C. A. Siegrist-Kaiser, and C. Zuckerman. Regulation of type II iodothyronine 5′deiodinase by thyroid hormone. Inhibition of actin polymerization blocks enzyme inactivation in cAMP-stimulated glial cells. J. Biol. Chem. 265: 940-946, 1990.
13. Lowell, B. B., V. S-Susulic, A. Hamann, J. A. Lawitts, J. Himms-Hagen, B. B. Boyer, L. P. Kozak, and J. S. Flier. Development of obesity in transgenic mice after genetic ablation of brown adipose tissue. Nature Lond. 366: 740-742, 1993.
14. Mills, I., A. Raasmaja, N. Moolten, G. Lemack, J. E. Silva, and P. R. Larsen. Effect of thyroid status on catecholamine stimulation of thyroxine 5′-deiodinase in brown adipocytes. Am. J. Physiol. 256 (Endocrinol. Metab. 19): E74-E79, 1989.
15. 3[H]CGP-12177, generally classified as an antagonist, is a thermogenic agonist in brown adipose tissue. Biochem. J. 261: 401-405, 1989.
16. Néchad, M., P. Kuusela, C. Carneheim, P. Björntorp, J. Nedergaard, and B. Cannon. Development of brown fat cells in monolayer culture. 1. Morphological and biochemical distinction from white fat cells in culture. Exp. Cell. Res. 149: 105-118, 1983.
17. Obregón, M. J., I. Mills, J. E. Silva, and P. R. Larsen. Catecholamine stimulation of iodothyronine 5′-deiodinase activity in rat dispersed brown adipocytes. Endocrinology 120: 1069-1072, 1987.
18. Obregón, M. J., C. Ruiz de Oña, A, Hernández, R. Calvo, F. Escobar del Rey, and G. Morreale de Escobar. Thyroid hormones and 5′-deiodinase in rat brown adipose tissue during fetal life. Am. J. Physiol. 257 (Endocrinol. Metab. 20): E625-E631, 1989.
19. Pavelka, S., J. Hermanska, M. Baudysova, and J. Houstek. Adrenergic control of induction of type II iodothyronine 5′-deiodinase activity in cultured mouse brown adipocytes Biochem. J. 292: 303-308, 1993.
20. Raasmaja, A., and P. R. Larsen. α1- and β-Adrenergic agents cause synergistic stimulation of the iodothyronine deiodinase in rat brown adipocytes. Endocrinology 125: 2502-2509, 1989.
21. Rabelo, R., A. Schifman, A. Rubio, X. Sheng, and J. E. Silva. Delineation of thyroid hormone-responsive sequences within a critical enhancer in the rat uncoupling protein gene. Endocrinology 136: 1003-1013, 1995.
22. Ricquier, D., and F. Bouillaud. The brown adipose tissue mitochondrial uncoupling protein In: Brown Adipose Tissue, edited by P. Trayhurn and D. G. Nicholls. London: Arnold, 1986, p. 86-104.
23. Rubio, A., A. Raasmaja, and J. E. Silva. Thyroid hormone and norepinephrine signaling in brown adipose tissue. II. Differential effects of thyroid hormone on β3-adrenergic receptors in brown and white adipose tissue. Endocrinology 136: 3277-3284, 1995.
24. Samuels, H. H., F. Stanley, and J. Casanova. Depletion of L-3,5,3′-triiodo-thyronine and L-thyroxine in euthyroid calf serum for use in cell culture studies of action of thyroid hormone. Endocrinology 105: 80-85, 1979.
25. Siegrist-Kaiser, C. A., C. Juge-Aubry, M. P. Tranter, D. M. Ekenbarger, and J. L. Leonard. Thyroxine-dependent modulation of actin polymerization in cultured astrocytes. A novel extranuclear action of thyroid hormone. J. Biol. Chem. 265: 5296-5302, 1990.
26. Silva, J. E., and P. R. Larsen. Adrenergic activation of triiodothyronine production in brown adipose tissue. Nature Lond. 305: 712-713, 1983.
27. Silva, J. E., and P. R. Larsen. Potential of brown adipose tissue type II thyroxinc 5′-deiodinase as a local systemic source of triiodothyronine in rats. J. Clin. Invest. 76: 2296-2305, 1985.
28. Silva, J. E., and P. R. Larsen. Hormonal regulation of iodothyronine 5′-deiodinase in rat brown adipose tissue. Am. J. Physiol. 251 (Endocrinol. Metab. 14): E639-E643, 1986.
29. Silva, J. E., and P. R. Larsen. Interrelationships among thyroxine, growth hormone, and the sympathetic nervous system in the regulation of 5′-iodothyronine deiodinase in rat brown adipose tissue. J. Clin. Invest. 77: 1214-1223, 1986.
30. Silva, J. E., and J. L. Leonard. Regulation of rat cerebrocortical and adenohypophyseal type II 5′-deiodinase by thyroxine, triiodothyronine and reverse triiodothyronine. Endocrinology 116: 1627-1635, 1985.