The autoimmune basis of adrenocortical destruction in Addison's disease

Molecular Medicine Today

Volumn 2, Issue 7, 1996, Pages 282-289

  Winqvist, Ola ^a   Söderbergh, Annika ^a   Kämpe, Olle ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; AUTOANTIGEN; STEROID;

ADDISON DISEASE; ADRENAL CORTEX; AUTOIMMUNE POLYENDOCRINOPATHY; AUTOIMMUNITY; B LYMPHOCYTE; BIOSYNTHESIS; CLASSIFICATION; ENZYMOLOGY; FEMALE; HUMAN; IMMUNOLOGY; MAJOR HISTOCOMPATIBILITY COMPLEX; MALE; PATHOLOGY; REVIEW; T LYMPHOCYTE;

ADDISON DISEASE; ADRENAL CORTEX; AUTOANTIBODIES; AUTOANTIGENS; AUTOIMMUNITY; B-LYMPHOCYTES; FEMALE; HUMANS; MAJOR HISTOCOMPATIBILITY COMPLEX; MALE; POLYENDOCRINOPATHIES, AUTOIMMUNE; STEROIDS; T-LYMPHOCYTES;

EID: 0030186791     PISSN: 13574310     EISSN: None     Source Type: Journal    
DOI: 10.1016/1357-4310(96)10024-1     Document Type: Review

References (41)

1. Bigazzi, P.E. (1985) Autoimmunity of the adrenals, in Autoimmunity and Endocrine Disease (Volpe, R., ed.), pp. 345-373, Marcel Dekker
2. Miller, W.L. (1988) Molecular biology of steroid hormone synthesis, Endocr. Rev. 9, 295-318
3. Bright, G.M. and Singh, I. (1990) Adrenal autoantibodies bind to adrenal subcellular fractions enriched in cytochrome c reductase and 5′-nucleotidase, J. Clin. Endocrinol. Metab. 70, 95-99
4. Furmaniak, J. et al. (1988) Immunoprecipitation of human adrenal microsomal antigen, FEBS Lett. 231, 25-28
5. Winqvist, O., Karlsson, F.A. and Kämpe, O. (1992) 21-hydroxylase, a major autoantigen in idiopathic Addison's disease, Lancet 339, 1559-1562
6. Bauman-Antczak, A. et al. (1992) Autoimmune Addison's disease and 21-hydroxylase, Lancet 340, 429-430
7. Wedlock, N. et al. (1993) Autoimmune Addison's disease. Analysis of autoantibody binding sites on human steroid 21-hydroxylase, FEBS Lett. 332, 123-126
8. Song, Y-H. et al. (1994) Autoantibody epitope mapping of the 21-hydroxylase antigen in autoimmune Addison's disease, J. Clin. Endocrinol. Metab. 78, 1108-1112
9. Asawa, T. et al. (1994) Naturally occurring mutations in human steroid 21-hydroxylase influence adrenal autoantibody binding, J. Clin. Endocrinol. Metab. 79, 372-376
10. Blizzard, R.M. and Kyle, M. (1963) Studies of the adrenal antigens and antibodies in Addison's disease, J. Clin. Invest. 42, 1653-1660
11. Hayashi, Y. et al. (1989) Focal lymphocytic infiltration in the adrenal cortex of the elderly: immunohistological analysis of infiltrating lymphocytes, Clin. Exp. Immunol. 77, 101-105
12. Fujji, Y. et al. (1992) Experimental autoimmune adrenalitis: a murine model for Addison's disease, Autoimmunity 12, 47-52
13. Rabinowe, S.L., Jackson, R.A., Dluhy, R.G. and Williams, G.H. (1984) Ia-positive T lymphocytes in recently diagnosed idiopathic Addison's disease, Am. J. Med. 77, 597-601
14. Freeman, M. and Weetman, A.P. (1992) T and B cell reactivity to adrenal antigens in autoimmune Addison's disease, Clin. Exp. Immunol 88, 275-279
15. Weetman, A.P. (1994) HLA association in Addison's disease, in Advances in Thomas Addison's Diseases (Bhatt, E., Besser, J., Bottazzo, G.F. and Keen, H., eds), pp. 27-36, Journal of Endocrinology Ltd
16. Todd, J.A., Bell, J.I. and McDevitt, H.O. (1987) HLA-DQB gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus, Nature 329, 599-604
17. Partanen, J. et al. (1994) Major histocompatibility complex class II and III in Addison's disease, Hum. Immunol. 41, 135-140
18. White, P.C. and New, M.I. (1992) Genetic basis of endocrine disease 2: congenital adrenal hyperplasia due to 21-hydroxylase defiency, J. Clin. Endocrinol. Metab. 74, 6-11
19. Ahonen, P., Myllärniemi, S., Sipilä, I. and Perheentupa, J. (1990) Clinical variation of autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) in a series of 68 patients, New Engl. J. Med. 322, 1829-1836
20. Neufeld, M., Maclaren, N. and Blizzard, R. (1980) Autoimmune polyglandular syndromes, Pediatr. Ann. 9, 154-156
21. Aaltonen, J. et al. (1994) An autosomal locus causing autoimmune disease: autoimmune polyglandular disease type I assigned to chromosome 21, Nat. Genet. 8, 83-87
22. Winqvist, O. et al. (1993) Two different cytochrome P450 enzymes are the adrenal antigens in autoimmune polyendocrine syndrome type I and Addison's disease, J. Clin. Invest. 92, 2377-2385
23. Krohn, K. et al. (1992) Identification by molecular cloning of an autoantigen associated with Addison's disease as steroid 17α-hydroxylase, Lancet 339, 770-773
24. Uibo, R. et al. (1994) Autoantibodies to cytochrome P450 enzymes P450scc, P450c17 and P450c21 in autoimmune polyglandular disease types I and II and in isolated Addison's disease, J. Clin. Endocrinol. Metab. 78, 323-328
25. Arulanantham, K., Dwyer, J.M. and Genel, M. (1979) Evidence for defective immunoregulation in the syndrome of familial candidiasis endocrinopathy, New Engl. J. Med. 300, 164-168
26. Shull, M.M. et al. (1992) Targeted disruption of the mouse transforming growth factor β1 gene results in multifocal inflammatory disease, Nature 359, 693-699
27. Moncayo, R. and Moncayo, H.E. (1992) Autoimmunity and the ovary, Immunol. Today 13, 255-258
28. Betterle, C. et al. (1993) Premature ovarian failure: autoimmunity and natural history. Clin. Endocrinol. 39, 35-43
29. Anastasi, J.N., Flack, M.R., Froehlich, J. and Nelson, L.M. (1995) The use of human recombinant gonadotropin receptors to search for immunoglobulin G-mediated premature ovarian failure, J. Clin. Endocrinol. Metab. 80, 824-828
30. Ahonen, P., Miettinen, A. and Perheentupa, J. (1987) Adrenal and steroidal cell antibodies in patients with autoimmune polyglandular disease type I and risk of adrenocortical and ovarian failure, J. Clin. Endocrinol. Metab. 64, 494-500
31. Winqvist, O. et al. (1995) Identification of the main adrenal autoantigens in patients with adrenal insufficiency and associated ovarian failure, J. Clin. Endocrinol Metab. 80, 1717-1723
32. Irvine, W.J. and Barnes, E.W. (1974) Addison's disease and autoimmune ovarian failure, J. Reprod. Fertil. (Suppl.) 21, 1-31
33. Epstein, F.H. (1990) Receptor autoimmunity in endocrine disorders, New Engl. J. Med. 323, 1318-1324
34. Protti, M.P. et al. (1993) Myasthenia gravis: recognition of a human autoantigen at the molecular level, Immunol. Today 14, 363-368
35. Tan, E.M. (1991) Autoantibodies in pathology and cell biology, Cell 67, 841-842
36. Björk, E., Velloso, L.A., Kämpe, O. and Karlsson, FA. (1994) GAD-autoantibodies in insulin-dependent diabetes mellitus, stiff-man syndrome and autoimmune polyendocrine syndrome type I recognize different epitopes, Diabetes 43, 161-165
37. Manns, M. (1989) Autoantibodies and antigens in liver diseases - updated, J. Hepatol. 9, 272-280
38. Boscaro, M. et al. (1994) Early adrenal hypofunction in patients with organspecific autoantibodies and no clinical adrenal insufficiency, J. Clin. Endocrinol. Metab. 79, 452-455
39. Kämpe, O. et al. (1989) High glucose stimulation of 64,000-Mr islet cell autoantigen expression. Diabetes 38, 1326-1328
40. Keller, R.J., Eisenbarth, G.S. and Jackson, R.A. (1993) Insulin prophylaxis in individuals at high risk of type I diabetes, Lancet 341, 927-928
41. Falorni, A. et al. (1995) High diagnostic accuracy for idiopathic Addison's disease with a sensitive radiobinding assay for autoantibodies against recombinant human 21-hydroxylase, J. Clin. Endocrinol. Metab. 80, 2752-2755