Isolation alters striatal met-enkephalin immunoreactivity in rat pups

Physiology and Behavior

Volumn 60, Issue 1, 1996, Pages 51-53

  Carden, Susan E ^a,b   Tempel, Ann ^c,d   Hernandez, Noreen ^a,b   Hofer, Myron A ^a,b  

^a NEW YORK STATE PSYCHIATRIC INSTITUTE   (United States)

^b Long Island Jewish Medical Center ^*  (United States)

^c ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^d LONG ISLAND JEWISH MEDICAL CENTER   (United States)

Author keywords

Attachment; Endogenous opioids; Isolation distress; Maternal separation; Met enkephalin; Ultrasonic vocalization

Indexed keywords

DELTA OPIATE RECEPTOR; METENKEPHALIN; MU OPIATE RECEPTOR;

ANIMAL; AROUSAL; ARTICLE; CORPUS STRIATUM; METABOLISM; NEWBORN; PHYSIOLOGY; RADIOIMMUNOASSAY; RAT; SOCIAL ENVIRONMENT; SOCIAL ISOLATION; VOCALIZATION; WISTAR RAT;

ANIMALS; ANIMALS, NEWBORN; AROUSAL; CORPUS STRIATUM; ENKEPHALIN, METHIONINE; RADIOIMMUNOASSAY; RATS; RATS, WISTAR; RECEPTORS, OPIOID, DELTA; RECEPTORS, OPIOID, MU; SOCIAL ENVIRONMENT; SOCIAL ISOLATION; VOCALIZATION, ANIMAL;

EID: 0030184507     PISSN: 00319384     EISSN: None     Source Type: Journal    
DOI: 10.1016/0031-9384(95)02243-0     Document Type: Article

References (15)

1. Barr, G. A.; Wang, S. Tolerance and withdrawal to chronic morphine treatment in the week-old rat pup. Eur. J. Pharmacol. 215:35-42; 1992.
2. Barr, G. A.; Wang, S. Morphine's suppression of separation induced ultrasonic vocalizations is mediated by ventral forebrain structures. Dev. Brain Res. (under review).
3. Basheer, R.; Tempel, A. Reciprocal alterations in G and opioid peptide mRNA levels in discrete brain regions following morphine treatment. J. Neurosci. Res. 38:551-557; 1993.
4. Carden, S. E.; Barr, G. A.; Hofer, M. A. Differential effects of specific opioid receptor agonists on rat pup isolation calls. Dev. Brain Res. 62:17-22; 1991.
5. Carden, S. E.; Hernanadez, N.; Hofer, M. A. The isolation and companion comfort responses of 7-and 3-day old rat pups are modulated by drugs active at the opiate receptors. Behav. Neurosci. 110:1-7; 1996.
6. Carden, S. E.; Hofer, M. A. Independence of benzodiazepine and opiate actions in the suppression of isolation distress in rat pups. Behav. Neurosci. 104:160-166; 1990.
7. Carden, S. E.; Hofer, M. A. Isolation-induced vocalization in Wistar rat pups is not increased by naltrexone. Physiol. Behav. 49:1279-1282; 1991.
8. Carden, S. E.; Hofer, M. A. Socially mediated reduction of isolation distress in rat pups can be blocked by naltrexone but not by RO 15-1788. Behav. Neurosci. 104:457-463; 1990.
9. Hofer, M. A.; Shair, H. Ultrasonic vocalization during social interaction and isolation in 2-week-old rats. Dev. Psychobiol. 11:495-504; 1978.
10. Kehoe, P.; Blass, E. M. Behaviorally functional opioid systems in infant rats: II. Evidence for pharmacological, physiological, and psychological mediation of pain and stress. Behav. Neurosci. 100:624-630; 1986.
11. Mansour, A.; Khachaturian, H.; Lewis, M. E.; Akil, H.; Watson, S. J. Anatomy of CNS opioid receptors. Trends Neurosci. 11:308-314; 1988.
12. Panksepp, J.; Herman, B. H.; Vilberg, T.; Bishop, P.; DeEskinazi, F. G. Endogenous opioids and social behavior. Neurosci. Biobehav. Rev. 4:473-487; 1980.
13. Shoemaker, W. J.; Kehoe, P. Effect of isolation conditions on brain regional enkephalin and β-endorphin levels and vocalizations in 10-day-old pups. Behav. Neurosci. 109:117-122; 1994.
14. Tempel, A. Localization and ontogeny of opioid peptides and receptors. In: Szekely, J. I.; Ramabadran, K., eds. Opioid peptides, vol. 4. Boca Raton: CRC Press; 1990:133-170.
15. Tempel, A.; Gardner, E. L.; Zukin, R. S. Visualization of opiate receptor upregulation by light microscopy autoradiography. Proc. Natl. Acad. Sci. USA 81:3893-3897, 1984.