Functional characteristics of the hypermetabolic isolated perfused liver

Shock

Volumn 6, Issue 1, 1996, Pages 52-56

  Dahn, Michael S ^a   Lange, M Patricia ^b   Berberoglu, E Deniz ^b  

^a DETROIT RECEIVING HOSPITAL   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ADENINE NUCLEOTIDE; AMINO ACID; FIBRINOGEN; GLUCAGON; GLUCOSE; LACTIC ACID DERIVATIVE; SERUM ALBUMIN; UREA;

ANIMAL; ARTICLE; BIOLOGICAL MODEL; BIOSYNTHESIS; DRUG EFFECT; ENERGY METABOLISM; IN VITRO STUDY; INJURY; LIVER; MALE; METABOLISM; OXYGEN CONSUMPTION; PERFUSION; RAT; SEPSIS; SPRAGUE DAWLEY RAT;

ADENINE NUCLEOTIDES; AMINO ACIDS; ANIMALS; ENERGY METABOLISM; FIBRINOGEN; GLUCAGON; GLUCOSE; LACTATES; LIVER; MALE; MODELS, BIOLOGICAL; OXYGEN CONSUMPTION; PERFUSION; RATS; RATS, SPRAGUE-DAWLEY; SEPSIS; SERUM ALBUMIN; UREA; WOUNDS AND INJURIES;

EID: 0030183986     PISSN: 10732322     EISSN: None     Source Type: Journal    
DOI: 10.1097/00024382-199607000-00011     Document Type: Article

References (35)

1. Dahn MS, Lange P, Lobdell K, Hans B, Jacobs LA, Mitchell RA: Splanchnic and total body oxygen consumption differences in septic and injured patients. Surgery 101:69-80, 1987.
2. Dahn MS, Wilson RF, Lange MP, Stone A, Jacobs LA: Hepatic parenchymal oxygen tension following injury and sepsis. Arch Surg 125:441-443, 1990.
3. Fleming A, Bishop M Shoemaker W, et al: Prospective trial of supranormal values as goals of resuscitation in severe trauma. Arch Surg 127: 1175-81, 1992.
4. Hayes MA, Timmins AC, Yau EHS, Palazzo M, Hinds CJ, Watson D: Elevations of systemic oxygen delivery in the treatment of critically ill patients. New Eng J Med 330:1717-1722, 1994.
5. Boyd D, Grounds RM, Bennett ED: A randomized clinical trial of the effect of deliberate perioperative increase of oxygen delivery on mortality in high risk surgical patients. JAMA 270:2699-2707, 1993.
6. Kimmig R, Mauch TJ, Scholz R: Actions of glucagon on flux rates in perfused rat liver. 2. Relationship between inhibition of glycolysis and stimulation of respiration by glucagon. Eur J Biochem 136:617-20, 1983.
7. Roe JH, Dailey RE: Determination of glycogen with the anthrone reagent. Anal Biochem 15:245-250, 1966.
8. Stumpo DJ, Kletzien RF: Gluconeogenesis in rat liver parenchymal cells in primary culture: Permissive effect of the glucocorticoids on glucagon stimulation of gluconeogenesis. J Cell Physiol 107:11-19, 1981.
9. Laurell CB: Electroimmuno assay. Scand J Clin Lab Invert Suppl 124: 21-37, 1972.
10. Ferrari G, Fabucci C: Improved electroimmunodiffusion assay of fibrinogen. Clin Chem 22:1390-1392, 1976.
11. Bergmeyer HU (ed): Methods of Enzymatic Analysis, Vol 7. Deerfield Beach FL: VCH Publishers, 1985, pp 340-370.
12. Dahn MS, Mitchell RA, Lange MP, Smith S, Jacobs LA: Hepatic metabolic response to injury and sepsis. Surgery 117:520-530, 1995.
13. Tuchschmidt J, Fried J, Swinney R, Sharma OP: Early hemodynamic correlates of survival in patients with septic shock. Crit Care Med 17;719-723, 1989.
14. Lang CH, Bagby GJ, Spitzer JJ: Glucose kinetics and body temperature after lethal and nonlethal doses of endotoxin. Am J Physiol 248:R471-R478, 1985.
15. Pederson P, Saljo A, Hasselgren PO: Protein and energy metabolism in liver tissue following intravenous infusion of live E. Coli bacteria in rats. Circ Shock 21:59-64, 1987.
16. West MA, Billiar TR, Mazuski JE, Curran RJ, Cerra FB, Simmons RL: Endotoxin modulation of hepatocyte secretory and cellular protein synthesis is mediated by Kupffer cells. Arch Surg 123:1400-1405, 1988.
17. Ayuso MS, Vega P, Manchon CG, Parrilla R: Interrelation between gluconeogenesis and hepatic protein synthesis. Biochim Biophys Acta 883:33-40, 1986.
18. Woodside KH, Ward WF, Mortimore GE: Effects of glucagon on general protein degradation and synthesis in perfused rat livers. J Biol Chem 249:5458-5463, 1974.
19. Woodside KH: Effect of cycloheximide on protein degradation and gluconeogenesis in the perfused rat liver. Biochim Biophys Acto 421:70-79, 1976.
20. 2+-fatty acid interaction in the control of hepatic gluconeogenesis. Biochim Biophys Acta 1051:215-220, 1990.
21. Steffes CP, Dahn MS, Lange MP: Oxygen transport-dependent splanchnic metabolism in the sepsis syndrome. Arch Surg 129:46-52, 1994.
22. Tanaka A, Chance B, Quistorff B: A possible role of inorganic phosphate as a regulator of oxidative phosphorylation in combined urea synthesis and gluconeogenesis in perfused rat liver. J Biol Chem 264:10034-10040, 1989.
23. Gump FE, Price JB, Kinney JM: Whole body and splanchnic blood flow and oxygen consumption measurements in patients with intraperitoneal infection. Ann Surg 171:321-28, 1970.
24. 2 saturation in patients with septic shock. In Vaupel P (ed): Oxygen Transport to Tissue Vol 15. New York: Plenum Press, 1994, pp 701-707.
25. Ruokonen E, Takala J, Kari A, et al: Regional blood flow and oxygen transport in septic shock. Crit Care Med 21:1296-1303, 1993.
26. Dahn Ms, Lange MP, Jacobs LA: Central mixed and splanchnic venous oxygen saturation monitoring. Crit Care Med 14:373-378, 1988.
27. Hirai F, Aoyama H, Ohtoshi M, Kawashima S, Ozawa K, Tobe T: Significance of mitochondrial enhancement in hepatic energy metabolism in relation to alterations in hemodynamics in septic pigs with severe peritonitis. Eur Surg Res 16:148-155, 1984.
28. Iles RA, Baron PG, Cohen RD: The effect of reduction of perfusion rate on lactate and oxygen uptake, glucose output and energy supply in the isolated perfused liver of starved rats. Biochem J 184:635-642, 1979.
29. Tygstrup N: Aspects of hepatic hypoxia: Observations on the isolated, perfused pig liver. Bull NY Acad Med 51:551-55, 1975.
30. Kitai T, Tanaka A, Tokuka A, et al: Changes in hepatic oxygenation state during hemorrhage and following epinephrine or dextran infusion as assessed by near-infrared spectroscopy. Circ Shock 41:197-205, 1993.
31. Landow L, Phillips DA, Heard SO, Prevost D, Vandersalm TJ, Fink MP: Gastric tonometry and venous oximetry in cardiac surgery patients. Crit Care Med 19:1226-1233, 1991.
32. Matsuda H, Takano H, Nakano S, et al: Analysis of acute and chronic heart failure in view of hepatic oxygen supply-demand relationship using hepatic venous oxygen saturation. Jpn Circ J 53:175-179, 1989.
33. Flaim KE, Peavy DE, Everson WV, Jefferson LS: The role of amino acids in the regulation of protein synthesis. J Biol Chem 257:2932-2938, 1982.
34. Kovats E, Karnes J, Simmel A, Funovics J, Roth E: Influence of sepsis on perfused rat liver metabolism. Prog Clin Biol Res 308:589-593, 1989.
35. Perez-Sala D, Parrilla R, Ayuso MS: Key role of L-alanine in the control of hepatic protein synthesis. Biochem J 241:491-498, 1987.