Release of slL-2Rα from and activation of native human peripheral blood mononuclear cells by recombinant IL-15

Clinical Immunology and Immunopathology

Volumn 80, Issue 1, 1996, Pages 67-75

  Treiber Held, Stephanie ^a   Stewart, Donn M ^a   Barraclough, Holly A ^a   Kurman, Carole C ^a   Nelson, David L ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

RECOMBINANT INTERLEUKIN 15; RECOMBINANT INTERLEUKIN 2; INTERLEUKIN 15; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR; INTERLEUKIN DERIVATIVE; MESSENGER RNA; RECOMBINANT PROTEIN;

ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; LEUKOCYTE; LEUKOCYTE ACTIVATION; MONONUCLEAR CELL; PRIORITY JOURNAL; SERUM; BIOSYNTHESIS; CELL CULTURE; CELL DIVISION; CYTOLOGY; DOSE RESPONSE; DRUG EFFECT; IMMUNOLOGY; INTERPHASE; LYMPHOCYTE ACTIVATION; METABOLISM; TIME; UPREGULATION;

CELL DIVISION; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, IMMUNOLOGIC; HUMANS; INTERLEUKIN-15; INTERLEUKIN-2; INTERLEUKINS; INTERPHASE; LEUKOCYTES, MONONUCLEAR; LYMPHOCYTE ACTIVATION; RECEPTORS, INTERLEUKIN-2; RECOMBINANT PROTEINS; RNA, MESSENGER; TIME FACTORS; UP-REGULATION;

EID: 0030176925     PISSN: 00901229     EISSN: None     Source Type: Journal    
DOI: 10.1006/clin.1996.0095     Document Type: Article

References (14)

1. 1. Grabstein, K. H., Eisenman, J., Shanebeck, K., Rauch, C., Srinivasan, S., Fung, V., Beers, C., Richardson, R., Schoenborn, M. A., Ahdieh, M., Johnson, L., Alderson, M. R., Watson, J. D., Anderson, D. M., and Giri, J. G., Cloning of a T cell growth factor that interacts with the β chain of the interleukin-2 receptor. Science 264, 965-968, 1994.
2. 2. Giri, J. G., Ahdieh, M., Eisenman, J., Shanebeck, K., Grabstein, K., Kumaki, S., Namen, A., Park, L. S., Cosman, D., and Anderson, D., Utilization of the beta and gamma chains of the IL-2 receptor by the novel cytokine IL-15. EMBO J. 13, 2822-2830, 1994.
3. 3. Giri, J. G., Kumaki, S., Ahdieh, M., Friend, D. J., Loomis, A., Shanebeck, K., DuBose, R., Cosman, D., Park, L. S., and Anderson, D. M., Identification and cloning of a novel IL-15 binding protein that is structurally related to the d chain of the IL-2 receptor. EMBO J. 14, 3654-3663, 1995.
4. 4. Treiber-Held, S., Stewart, D. M., Kurman, C. C., and Nelson, D. L., IL-15 induces the release of soluble IL-2Rα from human peripheral blood mononuclear cells. Clin. Immunol. Immunopathol. 79, 71-78, 1996.
5. 5. Robb, R. J., Munck, A., and Smith, K. A., T cell growth factor receptors: Quantitation, specificity and biological relevance. J. Exp. Med. 154, 1455-1470, 1981.
6. 6. Uchiyama, T., Broder, S., and Waldmann, T. A., A monoclonal antibody (anti-Tac) reactive with activated and functionally mature human T cells: Production of anti-Tac monoclonal antibody and distribution of Tac (+) cells. J. Immunol. 126, 1393-1397, 1981.
7. 7. Depper, J. M., Leonard, W. J., Robb, R. J., and Waldmann, T. A., Blockade of the interleukin-2 receptor by anti-Tac antibody: Inhibition of human lymphocyte activation. J. Immunol. 131, 690-696, 1983.
8. 8. Madsen, M., and Johnsen, H. E., A methodological study of E-rosette formation using AET-treated sheep red blood cells. J. Immunol. Methods 27, 61-74, 1979.
9. 9. Brown, T., Analysis of RNA by Northern and slot blot hybridization. In "Current Protocols in Molecular Biology" (F. M. Ausubel, R. Brent, R. E. Kingston, D. D. Moore, J. G. Seidman, J. A. Smith, and K. Struhl, Eds.), pp. 4.9.1-4.9.13, Wiley, New York, 1994.
10. 10. Leonard, W. J., Depper, J. M., Crabtree, G. R., Rudikoff, S., Pumphrey, J., Robb, R. J., Kroenke, M., Svetlik, P. B., Peffer, N. J., Waldmann, T. A., and Greene, W. C., Molecular cloning and expression of cDNAs for the human interleukin-2 receptor. Nature311, 626-631, 1984.
11. 11. Rubin, L. A., Kurman, C. C., Fritz, M. E., Biddison, W. E., Boutin, B., Yarchoan, R., and Nelson, D. L., Soluble interleukin 2 receptors are released from activated human lymphoid cells in vitro. J. Immunol. 135, 3172-3177, 1985.
12. 12. Williams, J. M., Abbud-Filho, M., Kelley, V. E., and Strom, T. B., Interleukin-2 apparently upregulates its receptor and induces proliferation of various resting mononuclear leukocytes in the absence of antigen. Cell. Immunol. 94, 383-393, 1985.
13. 13. Kedar, E., Rezai, A. R., Giorgi, J. V., Gale, R. P., Champlin, R. E., Mitsuyasu, R. T., and Fahey, J. L. Immunomodulating effects in vitro of interleukin-2 and interferon-gamma on human blood and bone marrow mononuclear cells. Nat. Immun. Cell Growth Regul. 7, 13-30, 1988.
14. 14. Carson, W. E., Giri, J. G., Lindemann, M. J., Linett, M. L., Ahdieh, M., Paxton, R., Anderson, D., Eisenmann, J., Grabstein, K., and Caligiuri, M. A., Interleukin (IL) 15 is a novel cytokine that activates human natural killer cells via components of the IL-2 receptor. J. Exp. Med. 180, 1395-1403, 1994.