Pharmacokinetics of intraarterial mitomycin C in the chemoembolisation treatment of liver metastases

General Pharmacology

Volumn 27, Issue 4, 1996, Pages 669-671

  Rump, A F E ^a   Botvinik Helling, S ^a   Theisohn, M ^a   Biederbick, W ^a   Schierholz, J M ^a   Stemmler, M ^a   Fischbach, R ^a   Heindel, W ^a   Lackner, K ^a   Klaus, W ^a  

^a UNIVERSITY OF COLOGNE   (Germany)

Author keywords

chemoembolization; Mitomycin C; Pharmacokinetics

Indexed keywords

MITOMYCIN C;

AREA UNDER THE CURVE; ARTERY BLOOD FLOW; ARTICLE; ARTIFICIAL EMBOLISM; BLOOD SAMPLING; BONE MARROW TOXICITY; CLINICAL ARTICLE; COLORECTAL CANCER; DRUG EFFECT; HEPATIC ARTERY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; INTRAARTERIAL DRUG ADMINISTRATION; LIVER METASTASIS; PRIORITY JOURNAL; VENOUS BLOOD;

EID: 0030176319     PISSN: 03063623     EISSN: None     Source Type: Journal    
DOI: 10.1016/0306-3623(95)02088-8     Document Type: Article

References (22)

1. Andersson M., Aronsen K. F., Balch C., Domellöf L., Eksborg S., Hafström L. O., Howell S. B., Karesen R., Midander J. and Teder H.(1987)Pharmacokinetics of intra-arterial mitomycin C with or without degradable starch microspheres (DSM) in the treatment of non-resectable liver cancer. Acta Oncol. 28, 219-222.
2. Bachur N. R., Gordon S. L. and Gee M. V. (1978) A general mechanism for microsomal activation of quinone anticancer agents to free radicals. Cancer Res. 38, 1745-1750.
3. Chen H.-S. G. and Gross J. F. (1980) Intra-arterial infusion of anti-cancer drugs: Theoretic aspects of drug delivery and review of responses. Cancer Treat. Rep. 64, 31-40.
4. Crooke S. T. and Bradner W. T. (1976) Mitomycin C: A review. Cancer Treat. Rev. 3, 121-139.
5. Czejka M., Jäger W., Schüller J. and Schernthaner G. (1991) Pharmakokinetik und lokale Verfügbarkeit von Mitomycin. Drug Res. 41, 260-263.
6. Den Hartigh J., McVie J. G., Van Oort W. J. and Pinedo H. M. (1983) Pharmacokinetics of mitomycin C in humans. Cancer Res. 43, 5017-5021.
7. Dorr, R. T. (1988) New findings in the pharmacokinetic, metabolic and drug-resistance aspects of mitomycin. C. Sem. Oncol. 15(Suppl. 4), 32-41.
8. Ensminger W. D. and Gyves J. W. (1984) Regional cancer chemotherapy. Cancer Treat. Rep. 68, 101-115.
9. Ensminger W. D., Byves J. W., Stetson P. and Walker-Andrews S. (1985) Phase I study of hepatic arterial degradable starch microspheres and mitomycin. Cancer Res. 45, 4464-4467.
10. Glaubiger D. and Ramu A. (1982) Antitumor antibiotics. In: Edited by Chabner B. A. Pharmacologic principles of cancer treatment. WB Saunders, Philadelphia, pp. 402-415.
11. Gyves J. W., Ensminger W. D., VanHarken D., Neiderhuber J., Stetson P. and Walker S. (1983) Improved regional selectivity of hepatic arterial mitomycin by starch microspheres. Clin. Pharmac. Ther. 34, 259-265.
12. Hu E. and Howell S. B. (1983) Pharmacokinetics of intra-arterial mitomycin C in humans. Cancer Res. 43, 4474-4477.
13. Iyer V. N. and Szybalski W. (1963) A molecular mechanism of mitomycin action: Linking of complementary DNA strands. Proc. Nat. Acad. Sci. USA 50, 355-362.
14. Kennedy K. A., Rockwell S. and Sartorelli A. C. (1980) Preferential activation of mitomycin C to cytotoxic metabolites by hypoxic tumor cells. Cancer Res. 40, 2356-2360.
15. Lown J. (1979) The molecular mechanism of antitumor action of the mitomycins. In: Mitomycin C: Current status and New Developments. (Edited by Carter S. K. and Crooke S. T.) Academic Press, San Diego, CA, pp. 5-26.
16. Lown J. S. and Chen H. H. (1981) Evidence for the generation of free hydroxyl radicals from certain quinone antitumor antibiotics upon reductive activation in solution. Can. J. Chem. 59, 390-395.
17. Nomura F., Ohnishi K. and Koen H. (1985) Effects of hypoxia and phenobarbital treatment on the metabolism of mitomycin C in experimental animals. Hepatology 5, 1190-1193.
18. Rump A. F. E., Rösen R. and Klaus W. (1993a) Cardioprotection by superoxide anion radicals: A catecholamine-dependent process? Anest. Analg. 76, 239-246.
19. Rump A. F. E. and Klaus W. (1993b) L'ischémie myocardique et les radicaux libres oxygénés. L'Inform. Cardiol. 17, 411-417.
20. Rump A. F. E. and Klaus W. (1994) Evidence for norepinephrine cardiotoxicity mediated by superoxide anion radicals in isolated rabbit hearts. Naunyn-Schmiedeberg's Arch. Pharmac. 349, 295-300.
21. Tomasz M. and Lipman R. (1981) Reductive metabolism and alkylating activity of mitomycin C induced by rat liver microsomes. Biochemistry 20, 5056-5061.
22. Verweij J. and Pinedo H. M. (1990) Mitomycin C: mechanism of action, usefulness and limitations. Anti-Cancer Drugs 1, 5-13.